Protein Alignment Ptip and MDC1

DIOPT Version :10

• Sequence 1: NP_729947.2
• Gene: Ptip / 39552
• FlyBaseID: FBgn0052133
• Length: 2294
• Species: Drosophila melanogaster
• Sequence 2: XP_005249549.1
• Gene: MDC1 / 9656
• HGNCID: 21163
• Length: 2110
• Species: Homo sapiens
• Alignment Length: 2370
• Identity: 396/2370 - (16%)
• Similarity: 747/2370 - (31%)
• Gaps: 765/2370 - (32%)

  Fly   229 QQQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQIIQQQATATSAL----------SDILG------ 277
            ::..:.|.:.|.|:....:..:::.....:::::::..|.:|::          |.:||
Human   169 EETPRVQGETQPQRLLLAEDSEEEVDFLSERRMVKKSRTTSSSVIVPESDEEGHSPVLGGLGPPF 233

  Fly   278 -FG----------------EDSVAAKSIASIKSQLQASAEQIQQQQLPVPAQQQVVFVRPQPQPQ 325
             |.                |.|.||:..|::::: |:.||.:.:.||            .:.||.
Human   234 AFNLNSDTDVEEGQQPATEEASSAARRGATVEAK-QSEAEVVTEIQL------------EKDQPL 285

  Fly   326 QPAQQSPHQLQQGGPQAPTPAPHPQHQQQLIIQQQKIIPANLQQQPQNQQQIKNILQQRQMKTTQ 390
            ...:.:..::::|......||                                .::.:|.....:
Human   286 VKERDNDTKVKRGAGNGVVPA--------------------------------GVILERSQPPGE 318

  Fly   391 QSQQQQQIQMQLMQQEQQPHPQPLQQQLAQQHPQQIAQQLPQQLSQQHPQQIPQQQQSPRLPTTP 455
            .|...       :..:.:|..:|.:..|.:..|......             ....:..|:|.||
Human   319 DSDTD-------VDDDSRPPGRPAEVHLERAQPFGFIDS-------------DTDAEEERIPATP 363

  Fly   456 -------------TGRQTPRTPSTTPQPVQSPQHHQQIVQQQQVVQQQVGQQQTMVQQQQIVQQQ 507
                         .|.:.|..|...         |.|        :.|.| ..|.|::.:..|..
Human   364 VVIPMKKRKIFHGVGTRGPGAPGLA---------HLQ--------ESQAG-SDTDVEEGKAPQAV 410

  Fly   508 QIVQQQ---VVQQQQPQQQSVPVSPQIIHQHLMRQQQ--ILNQNQMQLQQIVQSGQALTPQQQQQ 567
            .:.:.|   |:......::.|..:..:.|   :::.|  |.|::               .::...
Human   411 PLEKSQASMVINSDTDDEEEVSAALTLAH---LKESQPAIWNRD---------------AEEDMP 457

  Fly   568 QRQIQQQLQQVMQQQQQLQMQMQQQQQQQNLQQQQSPRMVQNRSPVM------------------ 614
            ||.:..|..|.          ..::....::::::.|  |:||..|:
Human   458 QRVVLLQRSQT----------TTERDSDTDVEEEELP--VENREAVLKDHTKIRALVRAHSEKDQ 510

  Fly   615 PP------------STPSPSLQQQQHHATSNMLPPQSPRQLQSPAPQMTPPPPPSPQNAQQQHLR 667
            ||            |:|...|::.|...|.:         :.:...:..||      .:...|::
Human   511 PPFGDSDDSVEADKSSPGIHLERSQASTTVD---------INTQVEKEVPP------GSAIIHIK 560

  Fly   668 QQQQMQQNRQQHMMGSPQQPQPQSMMSPQQQQQMQPFQQPVHQQQRMQLQQQQQL---------- 722
            :.|...:...|..:.:...|....::|.::       ..|:|.......::...|
Human   561 KHQVSVEGTNQTDVKAVGGPAKLLVVSLEE-------AWPLHGDCETDAEEGTSLTASVVADVRK 618

  Fly   723 ---------------AQQQQQQQQQSPQHISPQSPQISQTPPMQAKLHQHQVVP----GQATQPQ 768
                           |..:|::..:......|...|:.|..|:..:.....||.    |::||||
Human   619 SQLPAEGDAGAEWAAAVLKQERAHEVGAQGGPPVAQVEQDLPISRENLTDLVVDTDTLGESTQPQ 683

  Fly   769 QSFSQQKPIDPTDPVQVAQV----LSRSALSSNQDSLIMRQQQLKQQQQMQQQQQMAPQPQQQQM 829
            :..:|.    ||...:...|    .|......::|..:...|...:.|.::..|.|..:|.|..|
Human   684 REGAQV----PTGREREQHVGGTKDSEDNYGDSEDLDLQATQCFLENQGLEAVQSMEDEPTQAFM 744

  Fly   830 AQQPQQQQQQQPQQQHTPSPRQSPLQQQPTTPTLQQQPNQQNAQQIQQQQQQQQQQQQQQQQQQQ 894
            ...||:.           .|.....|   ||.||.:.......|....::.:..:.|......:.
Human   745 LTPPQEL-----------GPSHCSFQ---TTGTLDEPWEVLATQPFCLRESEDSETQPFDTHLEA 795

  Fly   895 QQQVLTQQQPQPGQQQQVITQRHVINTSTAQGQQIIQSHMSLALQKQQQLLHVQQQAQQQP---- 955
            ....|:..:..||.|                                    |.:.....:|
Human   796 YGPCLSPPRAIPGDQ------------------------------------HPESPVHTEPMGIQ 824

  Fly   956 -QQQQQITQVQQLPPAQQQQQLPQQHQVQQQ-----QPQQVQFTQQQQIALGAGGQVRIIQQTIQ 1014
             :.:|.:.:|..:|....::..|::..::::     ..:|...|.::::..|.
Human   825 GRGRQTVDKVMGIPKETAERVGPERGPLERETEKLLPERQTDVTGEEELTKGK------------ 877

  Fly  1015 RPPTNVQQQQQVPQQQQQQIIGQFPQQQQLQQQPQQQISGVQQPQQQQQQQKTFIISQQHFNQLS 1079
                        ..::|:|::.:..|:|:..:..:.     ..|::.::..|..|
Human   878 ------------QDREQKQLLARDTQRQESDKNGES-----ASPERDRESLKVEI---------- 915

  Fly  1080 VQQQQQILAQNPQSQNVYVVNQTQQQLVQQQQMLQQQQIIPQQQQQQRMQMQQQPQQIVVNQQIL 1144
                                 :|.:: :|::|:  |:|.:|.:      ..:::.::.|.|::
Human   916 ---------------------ETSEE-IQEKQV--QKQTLPSK------AFEREVERPVANRE-- 948

  Fly  1145 SDPQRLQYLQQQQLMQKQQQQQQQQ---QQQQQQQQQQQQQQLVG-------------------- 1186
            .||..|:....:.::::..|:.:.:   |.|:.|......:..||
Human   949 CDPAELEEKVPKVILERDTQRGEPEGGSQDQKGQASSPTPEPGVGAGDLPGPTSAPVPSGSQSGG 1013

  Fly  1187 -------QQQQQILIQQQQTPQQQQI---LQQKLSNDNQQQQIMQLITQQQLPQRTPPPQQ---- 1237
                   ::.|:.|:..:..|.::..   ..:|:|..:|:..  .......:|:...|||:
Human  1014 RGSPVSPRRHQKGLLNCKMPPAEKASRIRAAEKVSRGDQESP--DACLPPTVPEAPAPPQKPLNS 1076

  Fly  1238 QQQQQL----LLQQQQQSPQHHPQMQQQHWSPQSPAGGQMASSTPGTP------TSVGMQSPLPG 1292
            |.|:.|    ||.....|.:...:..:|..|.::|.....:...|..|      ......:|.|.
Human  1077 QSQKHLAPPPLLSPLLPSIKPTVRKTRQDGSQEAPEAPLSSELEPFHPKPKIRTRKSSRMTPFPA 1141

  Fly  1293 GPTTPQPQPQ----QQFVPRGLRPQT-SWPGQPQQQQPQPTQQQQQIVLPPPQQQQPQQQQQHLG 1352
            ....|:|.|.    |...|:.....| |...:...:.|:|       |:|...:.||..
Human  1142 TSAAPEPHPSTSTAQPVTPKPTSQATRSRTNRSSVKTPEP-------VVPTAPELQPST------ 1193

  Fly  1353 QQQQLVMQQPQQQKIVVDEKTHAHLMSLDAHKRAEYITKLNQQNKPRVMLRQQVAYQPRPGAP-- 1415
            ...|.|..:|..| :....|:.:.:      |..|.:.....:.:|.....:.|..:|...|.
Human  1194 STDQPVTSEPTSQ-VTRGRKSRSSV------KTPETVVPTALELQPSTSTDRPVTSEPTSQATRG 1251

  Fly  1416 ----GSIVATRPAGPVPPGHIIVQHQMPPGLTQQQQVL---WLQQQQGKRQ---------VV--- 1461
                .|:....|..|..|       ::.|..:..|.|.   ..|..:|::.         ||
Human  1252 RKNRSSVKTPEPVVPTAP-------ELQPSTSTDQPVTSEPTYQATRGRKNRSSVKTPEPVVPTA 1309

  Fly  1462 --VRAGTPGLSPIQQQPGA---------------------GPQQQQQSPQQQPFNPNDPNQQMLM 1503
              :|..|....|:..:|.:                     .|:.|..:...||..|...::....
Human  1310 PELRPSTSTDRPVTPKPTSRTTRSRTNMSSVKTPETVVPTAPELQISTSTDQPVTPKPTSRTTRS 1374

  Fly  1504 QRQQLRVQQ----IPIQQQGP-----------------------QQLGKQTVQLITGPNGQLIEQ 1541
            :.....|:.    :||..:.|                       :..||....|:  |....:|.
Human  1375 RTNMSSVKNPESTVPIAPELPPSTSTEQPVTPEPTSRATRGRKNRSSGKTPETLV--PTAPKLEP 1437

  Fly  1542 QTIVQQPQQQSAPGTPTTPGAGGVLPGNANIMTQTLVMTSTTPDGQPQQSPQQMNLKTKTALANM 1606
            .|...||    ....||:....| ....:::.|...|: .|.|:.||..|..|......|:.|.
Human  1438 STSTDQP----VTPEPTSQATRG-RTNRSSVKTPETVV-PTAPELQPSTSTDQPVTPEPTSQAT- 1495

  Fly  1607 LSNRLGNNGAQTPQQQIIQLPDGQQPQQQQIVQQVVVTGAIQQQQQQLLLQQQQQQQQQQQMVV- 1670
             ..|...:..:||:..:   |...:.|......|.|.:....:..:.   ::.:...:..:.||
Human  1496 -RGRTDRSSVKTPETVV---PTAPELQASASTDQPVTSEPTSRTTRG---RKNRSSVKTPETVVP 1553

  Fly  1671 -----QQQLPPQQHVEPPSAAGALRMMGQQHNATAGVP------GP---PRTQQELLMLQQQQQQ 1721
                 |......|.|.|...:.|.|  |:.:.::...|      .|   |.|.:..| :..:...
Human  1554 AAPELQPSTSTDQPVTPEPTSRATR--GRTNRSSVKTPESIVPIAPELQPSTSRNQL-VTPEPTS 1615

  Fly  1722 QLLQQQQMRRVVALPQQ--QQAPQQH---LVQQQIVVAPTQSPQQQQQMAVGVGVGVPVQR---- 1777
            :..:.:..|..|..|:.  ..||:.|   ...|.:....|....:::.....|....||:.
Human  1616 RATRCRTNRSSVKTPEPVVPTAPEPHPTTSTDQPVTPKLTSRATRRKTNRSSVKTPKPVEPAASD 1680

  Fly  1778 -----------TPHGYIQTRPGQ---------QPIPMPQFYGHNPNLKLPADLFLVGCTFYIVEY 1822
                       ||....|  .||         :.:|:|.    .|..:.|            |..
Human  1681 LEPFTPTDQSVTPEAIAQ--GGQSKTLRSSTVRAMPVPT----TPEFQSP------------VTT 1727

  Fly  1823 DETDGDELPIWLDTIRQ--------FGGDIERVYCPRVTHVIC-----------RTQRHGVVMQA 1868
            |:      ||..:.|.|        ..|:...:..| :.|..|           |.||.|.|.
Human  1728 DQ------PISPEPITQPSCIKRQRAAGNPGSLAAP-IDHKPCSAPLEPKSQASRNQRWGAVR-- 1783

  Fly  1869 LRDAKRCVTAYWLSDICLKRQLMPPWQPLHLPFP---SQFGYRKPLERYIITSEGFEGEEVVRLQ 1930
               |...:||           :..|..|..|..|   ||....:|..|...|.|         ||
Human  1784 ---AAESLTA-----------IPEPASPQLLETPIHASQIQKVEPAGRSRFTPE---------LQ 1825

  Fly  1931 QMAEECGAIYTSYLSKVNTVVVCKQLEGNKFNAAKEWNIPMVNALWLSDVCIGNLSGLSQYENPK 1995
            ..|.:                                               .....|:..::|.
Human  1826 PKASQ-----------------------------------------------SRKRSLATMDSPP 1843

  Fly  1996 YQQYNLVAPFRIECNLVAHLLTAWKAPINLTQEAHERVKRHLSDPYGNEQKL---KRQKMNAFQQ 2057
            :|:    .|.|.|.:         :..:.:.:|..:..::.     |.|:.:   |..|....|.
Human  1844 HQK----QPQRGEVS---------QKTVIIKEEEEDTAEKP-----GKEEDVVTPKPGKRKRDQA 1890

  Fly  2058 EQLPEQIVCVEYPTT-----TKPPKVIFSQVADAEALKKAVLILGGIVVDSPADATHLVMTRESR 2117
            |:.|.:|.......|     :..|||:|:.|.||.. ::|||.|||.:..|.|:|:|||..|..|
Human  1891 EEEPNRIPSRSLRRTKLNQESTAPKVLFTGVVDARG-ERAVLALGGSLAGSAAEASHLVTDRIRR 1954

  Fly  2118 TCKLIQACCHVDYVLKSSWIADSAKAGKFVPTDPYRIQHIPVDENLQFNLNTVLCAPTRSTLFAG 2182
            |.|.:.|......:|...|:..|.|||.|:|.|.|.:.....::|..|:|...|.......|..|
Human  1955 TVKFLCALGRGIPILSLDWLHQSRKAGFFLPPDEYVVTDPEQEKNFGFSLQDALSRARERRLLEG 2019

  Fly  2183 KYFHVTPDVFPAREEIIRMIESSGGKVEPKRRSGASVAETHMQAPDSY----IIVTCPTDMHLCA 2243
            ...:|||.|.|...::..:|...||...|             ..|.||    :::|||.|...|:
Human  2020 YEIYVTPGVQPPPPQMGEIISCCGGTYLP-------------SMPRSYKPQRVVITCPQDFPHCS 2071

  Fly  2244 DLTRHGNPKCHIVSTEFVMSSILRQQLEIE 2273
            ...|.|.|   ::|.||:::.:|:|:.:.|
Human  2072 IPLRVGLP---LLSPEFLLTGVLKQEAKPE 2098

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptip	NP_729947.2	BRCT_PAXIP1_rpt1	11..87	CDD:349346
		BRCT_PAXIP1_rpt2	100..181	CDD:349342
		BRCT_PAXIP1_rpt3	1814..1893	CDD:349343	18/97 (19%)
		BRCT_PAXIP1_rpt4	1914..1986	CDD:349362	5/71 (7%)
		BRCT_PAXIP1_rpt5	2075..2147	CDD:349344	30/71 (42%)
		BRCT_PAXIP1_rpt6	2179..2271	CDD:349393	27/95 (28%)
MDC1	XP_005249549.1	FHA_MDC1	53..152	CDD:438717
		SMC_N	843..>983	CDD:481474	25/210 (12%)
		PTZ00449	<964..1397	CDD:185628	77/461 (17%)
		PHA03247	<1248..1778	CDD:223021	98/580 (17%)
		BRCT_MDC1_rpt1	1914..1984	CDD:349375	30/70 (43%)
		BRCT_MDC1_rpt2	2016..2096	CDD:349394	27/95 (28%)