DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ptip and mdc1

DIOPT Version :9

Sequence 1:NP_729947.2 Gene:Ptip / 39552 FlyBaseID:FBgn0052133 Length:2294 Species:Drosophila melanogaster
Sequence 2:NP_001352489.1 Gene:mdc1 / 569805 ZFINID:ZDB-GENE-060810-185 Length:1914 Species:Danio rerio


Alignment Length:2050 Identity:315/2050 - (15%)
Similarity:661/2050 - (32%) Gaps:638/2050 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   538 RQQQILNQNQMQLQQIVQSG------QALTP----QQQQQQRQIQQQLQQVMQQQQQLQMQMQQQ 592
            ::..:|..:..:|::.||:|      .||.|    ..::::..|..  .|...:|.::.:..:..
Zfish   162 KESPVLPNSDSKLRKSVQNGLNDKEKTALPPVPLWSPEEEEPSICS--PQSAHKQPEITLVPESD 224

  Fly   593 QQQQNLQQQQSPRMVQNRSPVMPPSTPSPSLQQQQHHATSNMLPPQSPRQLQSPAPQMTPPPPPS 657
            ...::...:        |...:..|..|.:|...   |:|:.|.|     .:...|:.......:
Zfish   225 SDGESATDE--------RKDFVSDSASSSNLSSS---ASSSFLTP-----AKKVIPESEDESSFT 273

  Fly   658 PQNAQQQHLRQQQ---QMQQNRQQH-----------------MMGSPQQPQPQSMMSPQQQQQMQ 702
            |.:|.....|:.:   :...|..:|                 |..|..:|    :.:|:...:::
Zfish   274 PSSASVNRFRRSESNCEPSSNSSKHGPLALNLDSGTDFEEEEMKTSKTEP----LATPEVAARIE 334

  Fly   703 PFQ-QPVHQQQRMQLQQQQ----------QLAQ----------------QQQQQQQQSPQHISPQ 740
            |.. ...|......:::::          |:|:                ::::..:..|:....|
Zfish   335 PVSLAEFHMDSDTDVEEEELETDNAGPEAQVAKKSVTSAGLRVDSDTDVEEEENNKTEPEAQIEQ 399

  Fly   741 SPQISQTPPMQAKLHQHQVVPGQATQPQQSFSQQKPIDPTDPVQVAQVLSRSALSSNQDSLIMRQ 805
            ||::.  |.....||...  .....:.::..|:..|:..|:..::|.| |.:.|..:.|:.:..:
Zfish   400 SPKVG--PVSSGDLHLES--DTDVEEEEEDKSKPDPVAQTETPRLAPV-SSADLHIDSDTDVEEE 459

  Fly   806 QQLKQQQQMQQQQQM-----APQP-----QQQQMAQQPQQQQQQQPQQQHTPSPRQSPLQQQPTT 860
            :....:.:.:....:     ||.|     ....:.:..:::.:.:.:.:...|...:.|.....|
Zfish   460 ESDASKAKPEAHNAVTLDKPAPSPGLHIDSDTDVEEDEEEKSKTKQKAEIIKSVASTDLHMDSDT 524

  Fly   861 PTLQQQPNQQNAQQIQQQQQQQQQQQQQQQQQQQQQQVLTQQQPQP------------------- 906
            ...:::|...||:.....:.:....|.........:.....|.|||                   
Zfish   525 DVEEEEPEASNAKPGDLDKSESSVGQCHMDSDTDVEDDNPVQVPQPIGKGIDVKPATSTPGTELN 589

  Fly   907 ---------GQQQQVITQRHVINTST-----------------------AQGQQIIQSHMSLALQ 939
                     ..:.:..|:.::.|..|                       ..|.:..||..|: |:
Zfish   590 MDSDTDVDEENEDKEKTKDYLSNGGTDDEDPFKPVARKTVKVFKSQEASGGGDEGEQSEGSI-LK 653

  Fly   940 KQQQLLHVQQQAQ-QQPQQ-------------------------------QQQITQVQQLPPAQQ 972
            ||.|  |.|.:|. ::|.|                               ..:.||...:...::
Zfish   654 KQDQ--HSQAKASLEEPTQAFGHLEDDWDFIPTQAYGAASTSAVLKPKRLDLEATQAYGIETDRE 716

  Fly   973 QQQLPQQHQVQQQQPQQVQFTQQQQIALGAGGQVRIIQQTIQRPPTNVQQQ-QQVPQQQQQQ--- 1033
            ::   |:..:...||.....|.:.|:.            .:.:|....::: ::.|......   
Zfish   717 EE---QEEPLSHIQPYTNLSTAETQLI------------PVAKPGDYAEEEDEETPNDSHLSTAD 766

  Fly  1034 --IIGQFPQQQQLQQ-----QPQQQISGVQQPQQQQQQQKTFIISQQHFNQLSVQQQQQILAQNP 1091
              ||...|::::..|     ..|.|:....:.::..|.:.|.:|..:..:::...:.::::.|..
Zfish   767 TVIIASTPRREEQTQAFSLFTAQTQLVWEGEGKEVDQSEPTQLIEAESNDEMQEGENEEMIKQGM 831

  Fly  1092 QSQNVYVVNQTQQQLVQQQQMLQQQQIIPQQQQQQRMQMQQQPQQIVVNQQILSDPQRLQYLQQQ 1156
            ::...        ..||..:......|||:.|     .|.:..:.|..:   ||..:        
Zfish   832 KTHGT--------GAVQNSKNSSSYLIIPETQ-----PMCEDEEAIAAD---LSGDE-------- 872

  Fly  1157 QLMQKQQQQQQQQQQQQQQQQQQQQQQLVGQQQQQILIQQQQTPQQQQILQQKLSNDNQQQQIMQ 1221
              .||...::|.::.......:......|...:.|.:....:.|.|..:|....:..:....|..
Zfish   873 --FQKPSIRKQDKKYDTSHYDKNIPSSHVTLAETQPMCDDDELPGQDDVLSSVQTEKHVSSHIAI 935

  Fly  1222 LITQQQLPQRTPPPQQQQQQQLLLQQQQQSPQHHPQMQQ--QHWSPQSPAGGQMASSTPGTPTSV 1284
            ..||....:     ::.|...|    :.::.:.|....:  |:....|.:|..::.:.|....:|
Zfish   936 AETQPMFEE-----EEVQDDDL----KTEASRRHTDKDEPVQYTEEASTSGFSISKTQPVCGENV 991

  Fly  1285 --------------------GMQSPLP----GGPTTPQPQP---QQQFVPRGLRPQTSWPGQPQQ 1322
                                |...|||    ..|...:.||   :::.....|:.:.| .|..:|
Zfish   992 RQELRSKTSSRRSCRGLSKKGKDVPLPDEAVSSPAITETQPICMEEKAPDDNLKGEVS-SGSTRQ 1055

  Fly  1323 Q----------QPQPTQQQQQIVLPPPQQQQPQQQQQHLGQQQQLVMQQPQQQKIVVDE------ 1371
            |          :.:|...:||   .|.:......:.:.:.:...:..|:|......:||      
Zfish  1056 QAGEFKSIELAETEPISDEQQ---APGEDMPDAARPRRIDEDNSIEFQKPSISHFTIDETQPVVE 1117

  Fly  1372 -----------KTHAHLMSLDAHKRAEYIT-------------------KLNQQNKPRVMLRQQV 1406
                       ||.:........|:.|.::                   :||.:.|.|...|.::
Zfish  1118 ENEGHEKMFSNKTASRRSCRGKAKKEEEVSQTAETAENQPIPEELIERAELNSEVKSRRSRRTRL 1182

  Fly  1407 AYQPRPGAPGSIVATRPAGPVPPGHIIVQHQMPPGLTQQQQVLWLQQQQGKRQVVVRA------- 1464
            ..:.:...|..:|    .|.|..            :::...|...:.::.:...|:|:       
Zfish  1183 IKEEKVPQPSDVV----IGSVST------------ISKTLSVYEDETERDEDLSVIRSKRSCRGR 1231

  Fly  1465 ----GTP--------GLSPI----------QQQPGAGPQQQQQSPQQQPFNPNDPNQQMLMQRQQ 1507
                |.|        ||:.:          |::|.:...::|...:.:       .:.::....:
Zfish  1232 QKDEGEPPKAAELNAGLTVVEAHHMFEENAQEEPSSRTSRRQGKDKAK-------EESVIPASSK 1289

  Fly  1508 LRVQQIPIQQQGPQQLGKQTVQLITGPNGQLIEQQTIVQQPQQQSAPGTPTTPGAGGVLPGNANI 1572
            ::|:...: |.|.::.||:            :.:..:..:.::....||..|.            
Zfish  1290 VQVKSRKV-QDGKRKRGKE------------LSEDEVESEEEKIIRKGTRRTG------------ 1329

  Fly  1573 MTQTLVMTSTTPDGQPQQSPQQMNL---KTKTALANMLSNRL-------------GNNGAQTPQQ 1621
                  :.....:.:.::|.::.|:   |.|.....:.:.||             .:..|:|.:|
Zfish  1330 ------LKQKCSEKEEEESVEERNVQEEKEKMKKEQVETERLQKEENERNEQEHEESERAETERQ 1388

  Fly  1622 QIIQLPDGQQPQQQQIVQQVVVTGAIQQQQQQLLLQQQQQQQQQQQMVVQQQLPPQQHVEPPSAA 1686
            ::      :|.|::|:.::     ..:::|:...:|:::.::::::..::::...|:........
Zfish  1389 KL------EQEQKEQLKRE-----EDEKRQENERIQREKDEEREEKERLERKRNEQEEQRQKEEE 1442

  Fly  1687 GALRMMGQQHNATAGVPGPPRTQQELLMLQQQQQQQLLQQQQMRRVVALPQQQQAPQQHLVQQQI 1751
            |..|...|:.|..        .|.|...|::::|:...:.|:.|...:|.:.|:..|....:.::
Zfish  1443 GIQRDKEQKENEI--------LQAEKEQLEKERQENEARAQKERDEGSLKKGQKNKQLDKNKSEL 1499

  Fly  1752 ---VVAPT--------------------QSPQQQQQMAVGVGVGVPVQRTPHGYIQTRPGQQPIP 1793
               ::.||                    |.|..|:....|.|.|...|.|         |:|||.
Zfish  1500 EPPLLPPTRRSRRCSSSSLNSDQSATSQQEPTSQRGRGRGRGRGRGKQTT---------GEQPIS 1555

  Fly  1794 MPQFYGHNPNLKLPADLFLVGCTFYIVEYDETDGDELPIWLDTIRQFGGDIERVYCPRVTHVICR 1858
            ..|.....|                ..|..:|:.|.........|......||            
Zfish  1556 ARQSSRRGP----------------AFEVADTEQDSSLTTRSRSRSSSRSSER------------ 1592

  Fly  1859 TQRHGVVM--QALRDAKRCVTAYWLSDICLKRQLMPPWQPLHLPFPSQFGYRKPLER---YIITS 1918
             ..:.|..  |..|...|.                  .:.::||.|.:....||.||   ....:
Zfish  1593 -SANSVQSSNQGTRGRGRA------------------RKSVNLPQPEEVSQTKPSERGRGRRGRT 1638

  Fly  1919 EGFEGEEVVRLQQMAEECGAIYTSYLSKVNTVVVCKQLEGNKFNA-----AKEWNIPMVNALWLS 1978
            .|.|..:|....::.::...:      :.||.|......|.|..|     |:|...|        
Zfish  1639 SGVENVDVGMSNELKQDAKMV------EDNTAVSQTNSRGRKRTAITSTTAEEALSP-------- 1689

  Fly  1979 DVCIGNLSGLSQYENPKYQQYNLVAPFRIECNLVAHLLTAWKAPINLTQEAHERVKRHLSDPYGN 2043
                          .||       .|.|                 :|..:||             
Zfish  1690 --------------TPK-------TPRR-----------------SLASQAH------------- 1703

  Fly  2044 EQKLKRQKMNAFQQEQLPEQIVCVEYPTTTKPPKVIFSQVADAEALKKAVLILGGIVVDSPADAT 2108
                                             ||:|:.:.| |:.::.|..|||.:.....|.|
Zfish  1704 ---------------------------------KVLFTGLTD-ESGERVVSRLGGTLAKGVNDMT 1734

  Fly  2109 HLVMTRESRTCKLIQACCHVDYVLKSSWIADSAKAGKFVPTDPYRIQHIPVDENLQFNLNTVLCA 2173
            |||..:..||.|.:.|......::...|:....|||.|:..|.|.::.|..::...|.|...|..
Zfish  1735 HLVTDKARRTVKFLCAVARGVPIVTPDWLKKCGKAGHFISADDYILKDIEQEKKFDFCLEKSLQT 1799

  Fly  2174 PTRSTLFAGKYFHVTPDVFPAREEIIRMIESSGGKVEPKRRSGASVAETHMQAPDSYIIVTCPTD 2238
            ....:|..|...||||.|.|...::..:|...|.:..||.   .|..:.|:      ::|:|..|
Zfish  1800 AQSQSLLKGYEIHVTPSVMPEPSQMKEIITCCGARFLPKM---PSAHKEHV------VVVSCEQD 1855

  Fly  2239 MHLCADLTRHGNPKCHIVSTEFVMSSILRQQLEIE 2273
            ..|||.......|   :|||||:::.||:|:::::
Zfish  1856 RVLCAKAVGMSLP---VVSTEFLLTGILQQRVDLQ 1887

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PtipNP_729947.2 BRCT 9..77 CDD:214602
BRCT 96..174 CDD:278934
BRCT 1814..1887 CDD:237994 10/74 (14%)
PTCB-BRCT 1914..1976 CDD:289507 12/66 (18%)
BRCT <2087..2142 CDD:237994 15/54 (28%)
BRCT 2175..2265 CDD:278934 26/89 (29%)
mdc1NP_001352489.1 FHA 30..139 CDD:238017
MDN1 <343..677 CDD:331582 47/341 (14%)
Neuromodulin_N <936..1498 CDD:331332 89/647 (14%)
BRCT 1681..1780 CDD:320726 35/191 (18%)
BRCT 1805..1876 CDD:214602 26/82 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2043
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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