Protein Alignment Ptip and Paxip1

DIOPT Version :9

• Sequence 1: NP_729947.2
• Gene: Ptip / 39552
• FlyBaseID: FBgn0052133
• Length: 2294
• Species: Drosophila melanogaster
• Sequence 2: XP_006535821.1
• Gene: Paxip1 / 55982
• MGIID: 1890430
• Length: 1071
• Species: Mus musculus
• Alignment Length: 1156
• Identity: 308/1156 - (26%)
• Similarity: 458/1156 - (39%)
• Gaps: 340/1156 - (29%)

  Fly  1165 QQQQQQQQQQQQQQQQQQQLVGQQQQQILIQQQQTPQQQQILQQKLSNDNQQQQIMQLITQQQLP 1229
            :::::::::...::|..|.....::..:......:|.:|                         |
Mouse   189 EEEEEEEEEGDNEEQDSQNEGSTEKSSVASSAVASPAEQ-------------------------P 228

  Fly  1230 QRTPPPQQQQQQQLLLQQQQQSPQHHPQMQQQ--HWSP-----------QSPAGGQMASSTPGTP 1281
            ....|..:..:.:|:......|   .|:.|::  :|:|           :.|.|     ..||..
Mouse   229 CSPKPRAEVSKGELMFDDSSDS---SPEKQERSLNWAPAEAPPLNTAQRRLPQG-----KGPGLI 285

  Fly  1282 TSVGMQSPLPGGPTTPQPQPQQQFVPRGLRPQTSWPGQPQQQQPQPTQQQQQIVLPPPQQQQPQQ 1346
            .......|:||           ..:|..:|.....||                     |..|..:
Mouse   286 NLCANVPPVPG-----------DILPPDMRGNLMAPG---------------------QNLQNSE 318

  Fly  1347 QQQHLGQQQQLVMQQPQQQKIVVDEKTHAHLMSLDAHKRAEYITKLNQQNKPRVMLRQQVA--YQ 1409
            :.:.||.....|       :.:.:...:|.:..::......:|  |...:.|...|.||||  .|
Mouse   319 RSEILGTWSPAV-------RTLRNITNNADIQQINRPSNVAHI--LQSLSAPTKSLEQQVARGQQ 374

  Fly  1410 PRPGAPGSIVATRPAGPVPPGHIIVQHQMP-------PGLTQQQQVLWLQQQQGKRQVVVRAGTP 1467
            ..|.|  |.|....|...|..|::.||..|       |.|..|.|::.|||||
Mouse   375 GHPNA--SAVLFGQAKGAPETHVLQQHHPPQQPQQQHPALHLQPQIMQLQQQQ------------ 425

  Fly  1468 GLSPIQQQPGAGPQQQQQSPQQQPFNPNDPNQQMLMQRQQLRVQQIPIQQQGPQQLGKQTVQLIT 1532
                 |||     |||||.||..|..|:                     .|.|||:.:.
Mouse   426 -----QQQ-----QQQQQQPQPYPQPPS---------------------HQFPQQVHQH------ 453

  Fly  1533 GPNGQLIEQQTIVQQPQQQSAPGTPTTPGAGGVLPGNANIMTQTLVMTSTTPDGQPQQSPQQMNL 1597
                |..:||  :|.||                                     ||....||::
Mouse   454 ----QFSQQQ--LQFPQ-------------------------------------QPLHPQQQLH- 474

  Fly  1598 KTKTALANMLSNRLGNNGAQTPQQQIIQLPDGQQPQQQQIVQQVVVTGAIQQQQQQLLLQQQQQQ 1662
                                .||||:       ||.|||        .|:|||..||   ||||.
Mouse   475 --------------------RPQQQL-------QPFQQQ--------HALQQQLHQL---QQQQL 501

  Fly  1663 QQQQQMVVQQQLPPQQHVEPPSAAGALRMMGQQHNATAGVPGPPRTQQELLMLQQQQQQQ----L 1723
            |..|...:|||   ||               ||||                :||||||||    |
Mouse   502 QHHQLAQLQQQ---QQ---------------QQHN----------------LLQQQQQQQQLQRL 532

  Fly  1724 LQQQQMRRVVA-LPQQQQAPQQHLVQQQIVVAPTQSPQQQQQMAVGVGVGVPVQRTPHGYIQTRP 1787
            .|||||:...| |.|..||.|..::.||.:....|.|.||||
Mouse   533 QQQQQMQNQAAHLSQASQALQHQVLPQQPLQLSLQPPPQQQQ----------------------- 574

  Fly  1788 GQQPIPMPQFYGHNPNLKLPADLFLVGCTFYIVEYDETDGDE--LPIWLDTIRQFGGDIERVYCP 1850
             ||     |.:||:|.:::|.:.||:||.|.|.:|.|...|:  |..|...|:..||.::..:..
Mouse   575 -QQ-----QLFGHDPAVEIPEESFLLGCVFAIADYPEQMSDKQLLATWKRIIQAHGGTVDPTFTS 633

  Fly  1851 RVTHVICRTQRHGVVMQALRDAKRCVTAYWLSDICLKRQLMPPWQPLHLP--FPSQFGYRKPLER 1913
            |.||::|.:|...:..||||:.||||||:||:.:..|::||||.:.||.|  ||..   .||..:
Mouse   634 RCTHLLCASQVSSMYTQALRERKRCVTAHWLNTVLKKKKLMPPHRALHFPVAFPPG---GKPCSQ 695

  Fly  1914 YIITSEGFEGEEVVRLQQMAEECGAIYTSYLSKVNTVVVCKQLEGNKFNAAKEWNIPMVNALWLS 1978
            :||:..||...:...|:.||...||.||.||.:.|||::||:..|.|:..||||.||.|||.||.
Mouse   696 HIISVTGFVDNDRDDLKLMAYLAGAKYTGYLCRSNTVLICKEPSGLKYEKAKEWRIPCVNAQWLG 760

  Fly  1979 DVCIGNLSGLSQYENPKYQQYNLVAPFRIECNLVAHLLTAWKAPINLTQEAHERVKRHLSDPYGN 2043
            |:.:||...|.|.:..:|..:|:..||....:||..||.||:.|:.:|.|....|:.
Mouse   761 DILLGNFEALRQVQYSRYTAFNMPDPFVPTPHLVLGLLDAWRTPVKVTAELLMGVRL-------- 817

  Fly  2044 EQKLKRQKMNAFQQ-------EQLPEQIVCVEYPTTTK-----PPKVIFS--QVADAEALKKAVL 2094
            ..|||..::...|.       |.||        |.|.|     .|.|:|:  :....:...|.:.
Mouse   818 PPKLKPNEVANIQPSSKRARIEDLP--------PPTKKLTPELTPLVLFTGFEPVQVQQYIKKLY 874

  Fly  2095 ILGGIVVDSPADATHLVMTRESRTCKLIQACCHVDYVLKSSWIADSAKAGKFVPTDPYRIQHIPV 2159
            ||||.|.:.....|||:.::.:||.|.:.|...|.:::...|:.:..|...|:....|.::....
Mouse   875 ILGGEVAECTKKCTHLIASKVTRTVKFLTAISVVKHIVTPDWLEECFKRQTFIDEQNYILRDAEA 939

  Fly  2160 DENLQFNLNTVLCAPTRSTLFAGKYFHVTPDVFPAREEIIRMIESSGGKVEPKRRSGASVAETHM 2224
            :....|:|...|.....|.||..|||::||.:.|:...:..::|.:||||..|:.|...:.| |.
Mouse   940 EVLFSFSLEESLKRAHVSPLFKTKYFYITPGICPSLATMKAIVECAGGKVLAKQPSFRKLME-HK 1003

  Fly  2225 Q--APDSYIIVTCPTDMHLCADLTRHGNPKCHIVSTEFVMSSILRQQLEIE 2273
            |  :....|:::|..|:|||.:....|   ..:.:.|||::.:|.|.|:.|
Mouse  1004 QNKSLSEIILISCENDLHLCREYFARG---IDVHNAEFVLTGVLTQTLDYE 1051

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptip	NP_729947.2	BRCT	9..77	CDD:214602
		BRCT	96..174	CDD:278934
		BRCT	1814..1887	CDD:237994	29/74 (39%)
		PTCB-BRCT	1914..1976	CDD:289507	29/61 (48%)
		BRCT	<2087..2142	CDD:237994	15/54 (28%)
		BRCT	2175..2265	CDD:278934	29/91 (32%)
Paxip1	XP_006535821.1	BRCT_PAXIP1_rpt1	13..87	CDD:349346
		BRCT_PAXIP1_rpt2	98..178	CDD:349342
		BRCT_PAXIP1_rpt3	595..676	CDD:349343	32/80 (40%)
		BRCT_PAXIP1_rpt4	696..768	CDD:349362	34/71 (48%)
		BRCT_PAXIP1_rpt5	853..927	CDD:349344	19/73 (26%)
		BRCT_PAXIP1_rpt6	959..1049	CDD:349393	30/93 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I9853
eggNOG	1	0.900	-	-		E1_KOG2043
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004880
OrthoInspector	1	1.000	-	-		oto93866
orthoMCL	1	0.900	-	-		OOG6_105904
Panther	1	1.100	-	-	LDO	PTHR23196
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R145
SonicParanoid	1	1.000	-	-		X3992
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.800