back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptip and ect2

DIOPT Version :9

Sequence 1:	NP_729947.2	Gene:	Ptip / 39552	FlyBaseID:	FBgn0052133	Length:	2294	Species:	Drosophila melanogaster
Sequence 2:	XP_005155774.1	Gene:	ect2 / 445406	ZFINID:	ZDB-GENE-040831-2	Length:	1012	Species:	Danio rerio

Alignment Length:	929	Identity:	146/929 - (15%)
Similarity:	303/929 - (32%)	Gaps:	243/929 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 IVHSAKLGRMASTRAFDPSPNQMRLMRGIRVAITNVVAGDRRRLYAMLTYH-GAVVTHSF-GATN 138
            ::|.|..|   ....|...|.....|..:.:..|.....|.......|.:| |..:...| .|..
Zfish   156 VMHCANKG---EPLPFSSRPLYSMTMLNLSLCFTGFRKKDEVVALVNLVHHMGGTIRKDFDSAKV 217

  Fly   139 THLVCGAANGGIYNKALALPKNAIIIVTPDWVTDSLKYKNCMPV----ETYHPRLLKP------- 192
            |||:..:.:|..|..|:.:   ...|:||||:..:.::::.:..    |.:......|
Zfish   218 THLIARSTHGEKYRLAVCM---GTPILTPDWIRKAWEHRDDINFHAGNELFRTEFKVPPFQDCVL 279

  Fly   193 -----IEKQRTQKQQATQQQQIQQQQQLQHQHQMQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ 252
                 .|:::...::.||          :|..:.|....::......::...::......::...
Zfish   280 SFLGFSEEEKNNMEERTQ----------KHGGRFQAVGDERCTHLVVEENSIKELPFTPSKRLYV 334

  Fly   253 QQQQHQQQIIQQQATATSALSDILGFGE--------DSVAAKSIASIKSQLQASAEQIQQQQLPV 309
            .:|:.....||..|.|          ||        :|.|.|...|:.|....::.:.:::....
Zfish   335 VKQEWFWGSIQMDARA----------GESMYSYEKPESPAMKKAVSLLSLTTPNSGRKRRRLRET 389

  Fly   310 PAQ-QQVVFVRPQPQPQQPAQQSPHQLQQGGPQAPTPAPHPQHQQQLIIQQQKIIPANLQQQPQN 373
            .|| .:...:.|.|..::|:.:  |.|..|               .|:             ...|
Zfish   390 LAQLTKETEISPFPPRKRPSAE--HSLSMG---------------SLL-------------DISN 424

  Fly   374 QQQIKNILQQRQMKTTQQSQQQQQIQMQLMQQEQQPHPQPLQQQLAQQHPQQIAQQLPQQLSQQH 438
            ....|:..::|..:::.:.:..:|.:.:.:|:...|..:...|....:.|:.....||:|.::..
Zfish   425 TPDTKSSGERRCRRSSGRRRSSRQSRSERLQRTSTPVCRHEDQTENAKIPKSSTPALPKQSARWQ 489

  Fly   439 PQQIPQQQQSPRLPTTPTGRQTPRTPSTTPQPVQSPQHHQQIVQQQQV----------------- 486
            ..:...|.:|..:....|..|..:.|......|..|     |:.|:::
Zfish   490 VSKELYQTESNYVDILATVLQLFKYPLEKEGQVGGP-----ILAQEEIKTIFGSIPDIYEVHTRI 549

  Fly   487 ------------VQQQVG------QQQTMVQQQQIVQQQQIVQQQVV--QQQQPQ-------QQS 524
                        .::.||      ..:.:......|...::.::.:|  ::|:|:       .||
Zfish   550 KADLEELVMNWSEERSVGDIILKYSGELVKAYPPFVNFFEMSKETIVRCERQKPRFHAFLKINQS 614

  Fly   525 VP-VSPQIIHQHLMRQQQILNQNQMQLQQIVQSGQALTPQQQQQQRQIQQQLQQVMQQQQQLQMQ 588
            .| ...|.:.:.|:|..|.|....:.|..|.:......|.:...::.| :.|::||....:.:.:
Zfish   615 KPECGRQTLVELLIRPVQRLPSVALLLNDIKKHTSDDNPDKLTLEKAI-ESLKEVMTHINEDKRK 678

  Fly   589 MQQQQQ-----------QQNLQQQQSPRMVQNRSPVMPPST----PSP----------------S 622
            .:.|:|           ..||       :..:||.|....|    ..|                .
Zfish   679 TEGQKQIFDVVYEVDGCPANL-------LSSHRSLVHRVETIALGDKPCDRGEHVTLFLFNDCLE 736

  Fly   623 LQQQQHHATSNMLPPQSPRQLQSPAPQMTPPPPPSPQNAQQQHLRQQQQMQQNRQQHMMGSPQ-Q 686
            :.:::|...:|         .:||..|..||       ||.:|:......|..|...:..:.: |
Zfish   737 IARKRHKVITN---------FRSPLGQTRPP-------AQLKHITLMPLSQIRRVLDIQDTEECQ 785

  Fly   687 PQPQSMMSPQQQQQMQPFQQPVHQQQRMQLQQQQQLAQQQ-----QQQQQQSPQHISPQSPQISQ 746
            .....::.|..:|:...|...:..:..::....:.|.:|.     :...:...|...|.|.|:|
Zfish   786 NAFALVVRPPTEQENLLFSFQLTAEDTLKTTWLRTLCRQVANTICRADAEDLIQSTDPDSVQVS- 849

  Fly   747 TPPMQAKLHQ-HQVVPGQATQPQQSFSQQKPIDPTDPVQVAQVLSRSALSSNQDSLIMRQQQLKQ 810
            |..|.:.|.: .:.:...:.:..::||..|        ...:||.|:.:::.
Zfish   850 TKDMDSTLSRASRAIKKTSKKVTRAFSFTK--------TPKRVLQRAFMANG------------- 893

  Fly   811 QQQMQQQQQMAPQPQQQQMAQQPQQQQ---------------------QQQPQQQHTPSPRQSPL 854
                 ...:.:|.|...:|::......                     |:.....|.|.||....
Zfish   894 -----TPDERSPCPDADRMSRMSSSSTLAMSRSASTFSLTGSIKSAVVQRSNSLDHAPRPRVPVC 953

  Fly   855 QQQPTTPTLQQQPNQQNAQ 873
            .:.|.:|....:|....:|
Zfish   954 VRTPCSPERADEPAAPKSQ 972

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.