Protein Alignment Ptip and topbp1

DIOPT Version :9

• Sequence 1: NP_729947.2
• Gene: Ptip / 39552
• FlyBaseID: FBgn0052133
• Length: 2294
• Species: Drosophila melanogaster
• Sequence 2: NP_001186667.1
• Gene: topbp1 / 407679
• ZFINID: ZDB-GENE-060626-1
• Length: 1526
• Species: Danio rerio
• Alignment Length: 1610
• Identity: 258/1610 - (16%)
• Similarity: 480/1610 - (29%)
• Gaps: 564/1610 - (35%)

  Fly    23 DEEIERFLKSGGAQSKLFL----------SDQITHMICATNYNEEELSMNLD-----LYSAIPVT 72
            |..|.:|::|.|.:|.:.|          |::...|:      :||.::.||     |:.....|
Zfish     7 DAYIVKFVESNGQKSDVALQAYKAIVELQSEKYVQMV------DEEAALELDHNDKSLFVFSDFT 65

  Fly    73 EQWIVHSAKLG-RMAS--------------TRAFDPSPNQMRLMRGIRVAITNVVAGDRRRLYAM 122
            .....|..:|| |:.|              .:|..|..|..  |..:.|:.||:....|..:..:
Zfish    66 SSAFDHCRRLGCRIVSPLVVLFCLQKQRCVPKAEQPVYNMS--MADVTVSCTNLDKEARSEVMDL 128

  Fly   123 LTYHGAVVTHSFGATNTHLVCGAANGGIYNKALALPKNAIIIVTPDWV-------TDSLKYKNCM 180
            :...|..|......:.||||.|......|..|.:|.|.   |:.|.||       .||:.:.:.:
Zfish   129 IQLMGGRVYRDLNVSVTHLVAGEVGSKKYLVAASLGKP---ILLPSWVKACWEKSQDSVFHHSEL 190

  Fly   181 PVETYHPRLLK----------PIEKQRTQK----QQATQQQQIQQQQQLQHQHQMQQQQQQQ--- 228
            ..|.|...:||          .:|::..|:    ..||...|::..   :..|.:..:...|
Zfish   191 NTEDYRCPVLKGCTVCVTGLSTVERKEVQRLCDQNGATYTGQLKMN---ECTHLIVNEPTGQKYE 252

  Fly   229 ------------------------QQQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQIIQQQATAT 269
                                    |.:.:...::..:::...:..:........|...::...:.
Zfish   253 FARKWNVYCVSLHWLFDSIEKGFCQDESRYAVERGDKRKTDDKSGRPNTSTPTGQSRSKEDGPSL 317

  Fly   270 SALSDI----LGFGEDSVAAKSIASIKSQLQASAEQIQQQQLPVPAQQ-QVVFVRPQPQPQQPAQ 329
            ..||.|    |...|.::....|:.|              ::|.|... .:...|...
Zfish   318 LGLSHISNISLNVNETALTTAGISHI--------------EMPDPVDSFDITVCRVDD------- 361

  Fly   330 QSPHQLQQGGPQAPTPAPHPQHQQQLIIQQQKIIPANLQQQPQNQQQIKNILQQRQMKTT----- 389
                                      ::...|:....|..        |.:.:.|:|..|
Zfish   362 --------------------------LLDGCKLYLCGLSG--------KKLEKLRRMVNTAGGLR 392

  Fly   390 --QQSQQ---------QQQIQMQLMQQEQQPHPQPLQQQLAQQHPQQIAQQLPQQLSQQHPQQIP 443
              |.:|:         .|.|:..|.....:||...:|..|.......:   ||:. ...||..:|
Zfish   393 FNQPTQELTHIVMGEADQGIKAFLDNATHRPHIVTVQWLLESFSRGSL---LPEN-GYFHPSFLP 453

  Fly   444 QQQQSPRLPTTPTGRQTPRTPSTTPQPVQSPQHHQQIVQQQQVVQQQVGQQQTMVQQQQIVQQQQ 508
            ....:..:|...........||..|.|..||.  :|...::.::.|.:|..||:...|....:..
Zfish   454 PAPAAVDIPALHKAAPRASRPSVAPPPAPSPA--RQSRAEEDLLSQYMGNDQTVELPQDTSSRHS 516

  Fly   509 IVQQQVVQQQQPQQQSVPVSPQIIHQHLMRQQQIL----NQNQMQLQQIV--QSGQALTPQQQQQ 567
            ::..:.:.:.:....:......:    ...::.||    .:.:.||.::|  .:|:.|..:.:..
Zfish   517 VLHPEPLVEGKDSTLAEASEGGL----FFGKRFILVGFGAEAEAQLSELVMENAGKILVGRSRAV 577

  Fly   568 QR---------QIQQQLQQVMQQQQQLQMQMQQQQQQQNLQQQQSPRMVQNRSPVMPPSTPSPSL 623
            ..         .::..:.:| .....|.|.::||                   .|:|
Zfish   578 AHYAIVPLLGCDVEATVDEV-ATDTWLAMCVEQQ-------------------CVLP-------- 614

  Fly   624 QQQQHHATSNMLPPQSPRQLQSP-------APQMTPPPPPSPQNAQQQHLRQQQQMQQNRQQHMM 681
                 .|:..:..|.:.|:..||       ..|.|        .|::..|.|       ..:|:.
Zfish   615 -----LASHPLFTPVAVREGFSPLKDCVLSVSQFT--------GAERDSLIQ-------LAKHLG 659

  Fly   682 GSPQQPQPQSMMSPQQQQQMQPFQQPVHQQQRMQLQQQQQLAQQQQQQQQQSPQHISPQSPQISQ 746
            .|.|                ..|.:..:|::.|       ||.          .|:..|:|:
Zfish   660 ASVQ----------------DYFVRTANQRKGM-------LAS----------THLVLQTPE--- 688

  Fly   747 TPPMQAKLHQHQVVPGQATQPQQSFSQQKPIDPTDPVQVAQVLSRSALSSNQDSLIMRQQQLKQQ 811
                           |...|..|.:.            :..|..|..|.|.:..        |:.
Zfish   689 ---------------GTKYQAAQKWG------------LPAVTIRWVLESARTG--------KRA 718

  Fly   812 QQMQQQQQMAPQPQQQQMAQQPQQQQQQQPQQQHTPSPRQSPLQQQPTTPTLQQQPNQQNAQQIQ 876
            .:.|....:.|.|::.:.:.....|:...|.:.|         |:.|..|.|    ..||:..|.
Zfish   719 DEGQYLVDLPPSPERTEDSFVGASQKDPPPLRLH---------QRSPELPLL----GPQNSDAIT 770

  Fly   877 -------QQQQQQQQQQQQQQQQQQQQQVLTQQQPQPGQQQQVITQRHVINTSTAQGQQIIQSHM 934
                   |.:..:...::.:|.:::|.:|.|     |||::             |:|.|  |...
Zfish   771 PLDTARFQSRSVRSAVRKLKQGEEEQAEVTT-----PGQEE-------------AKGAQ--QKDS 815

  Fly   935 SLALQKQQQLL-----------------HVQQQAQQQPQQQQQITQVQQLPPAQQQQQLPQQHQV 982
            ||.|....:.|                 |:|....:..|.|...|              |....:
Zfish   816 SLHLDTPSRFLSRDKLFGPSFNTKDVFDHLQTPGNKSQQGQGAET--------------PLSEVI 866

  Fly   983 QQQQPQQVQFTQQQQIALGAGGQVRIIQQTIQRPPTNVQQQQQVPQQQQQQIIGQFPQQQQLQQQ 1047
            ::.....|..:.:..:                   ||:......||      :|:.| :.:::|:
Zfish   867 ERNLKAAVANSNRSHV-------------------TNLAAMTASPQ------LGKEP-EPEVEQK 905

  Fly  1048 PQQQISGVQQPQQQQQQQKTFIISQQHFNQLSVQQ----------------QQQILAQNP----- 1091
            ....:|||.....::..:|     |...|.::...                .|..:..|.
Zfish   906 AAAPLSGVVVCVSKKLSKK-----QSELNAVAASLGAEFRWSCDDSVTHYIYQGKVGDNSKEYRA 965

  Fly  1092 -QSQNVYVVNQTQQQLVQQQQMLQQQQIIPQQQQQQRMQMQQQPQQIVVNQQILSDPQRLQYLQQ 1155
             :.:.:|:|:|...|....:|....:.:.|         ....|:..:...|:....||
Zfish   966 VKERGLYIVSQHWLQACADEQKHVSESLYP---------FTFNPKMSLTMSQMADSTQR------ 1015

  Fly  1156 QQLMQKQQQQQQQQQQQQQQQQQQQQQQLVGQQQQQILIQQQQTPQQQQILQQKLSNDNQQQQIM 1220
                    .......:.:.:...:.::..:|....   |....||:|..:        .:.::..
Zfish  1016 --------SPPSATPRTRLRAFAENEETRLGPDDD---ITDVSTPKQGSV--------GEPEKDQ 1061

  Fly  1221 QLITQQQLPQRTPPPQQQQQQQLLLQQQQQSPQHHPQMQQQHWSPQSPAGGQMASS--------- 1276
            .:.|:::....|...::..|:||                |:..|......|:..||
Zfish  1062 TISTEKKNLTETLEMRESLQRQL----------------QEIMSATKLTSGRRGSSRLAKTGPGG 1110

  Fly  1277 --TPGTPTSVGMQSPLPGG------------PTTPQPQPQQQFV---PRG------LRPQTSWPG 1318
              :|.||.|:|..|.....            ....:|...:|.|   |..      |.....|||
Zfish  1111 LDSPHTPDSLGRMSRRSRNLEAIRMSRQVCVDLNTEPSQSEQIVWDDPTAREERAKLADNLQWPG 1175

  Fly  1319 QPQQQQPQPTQQQQQIVLPPPQQQQPQQQQQHLGQQQQLVMQQPQQQKIVVDEKTHAHLMSLDAH 1383
                   .|:|..:.:.|.||    |.......|:                |..|.:.|:.:.|.
Zfish  1176 -------SPSQHSEPLALVPP----PHSDHTTNGR----------------DSMTDSELVEMAAF 1213

  Fly  1384 KRAEYITKLNQQNKPR-VMLRQQVAYQPR-PGAPGSI---VATRPAGPVP 1428
            :      .::.|.||: ...|....:.|: |.|| ||   ::...|.|:|
Zfish  1214 E------VIDAQLKPKGTSSRVDTLHNPKTPEAP-SIAFPISKTAALPLP 1256

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptip	NP_729947.2	BRCT	9..77	CDD:214602	15/68 (22%)
		BRCT	96..174	CDD:278934	22/84 (26%)
		BRCT	1814..1887	CDD:237994
		PTCB-BRCT	1914..1976	CDD:289507
		BRCT	<2087..2142	CDD:237994
		BRCT	2175..2265	CDD:278934
topbp1	NP_001186667.1	BRCT	109..178	CDD:237994	19/71 (27%)
		PTCB-BRCT	203..266	CDD:289507	7/65 (11%)
		BRCT	359..435	CDD:278934	15/116 (13%)
		PTCB-BRCT	636..707	CDD:289507	20/148 (14%)
		BRCT	909..982	CDD:278934	12/77 (16%)
		BRCT	1272..1339	CDD:237994
		BRCT	<1418..1479	CDD:214602

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D305707at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920