Protein Alignment Ptip and mu2

DIOPT Version :10

• Sequence 1: NP_729947.2
• Gene: Ptip / 39552
• FlyBaseID: FBgn0052133
• Length: 2294
• Species: Drosophila melanogaster
• Sequence 2: NP_523887.2
• Gene: mu2 / 38257
• FlyBaseID: FBgn0002872
• Length: 1280
• Species: Drosophila melanogaster
• Alignment Length: 1199
• Identity: 197/1199 - (16%)
• Similarity: 388/1199 - (32%)
• Gaps: 403/1199 - (33%)

  Fly  1190 QQILIQQQQTPQQQQILQQKLSNDNQQQQIMQLITQQQLPQRTPPPQQQQQQQLLLQQQQQSPQH 1254
            :|:::...:||       ....:.|.|::...:|..|:.|          :.:||...::.:.|:
  Fly   361 KQLVVATIETP-------TATPDTNSQEKNQDMIATQRFP----------RHKLLESDEEDNGQN 408

  Fly  1255 H-------------PQMQQQHWSPQSPAGGQMASSTPGTPTSVGMQSPLPGGPTTPQPQPQQQFV 1306
            :             ||..|::.:.|.....|..:..|  |..|  .||   .|:|......|.|:
  Fly   409 NQDFVATQAFNLGRPQAPQENEANQDLIATQAFNLAP--PQKV--DSP---KPSTANDASNQDFI 466

  Fly  1307 PRGLRPQTSWPGQPQQQQPQPTQQQQQIVLPPPQQQQPQQQQQHLGQQQQLVMQ-------QPQQ 1364
                                   :.|...|..||......:...:..|..:..|       ..:.
  Fly   467 -----------------------ETQAFNLGIPQANMASPENNEISNQDLIATQAFPAKINSSRC 508

  Fly  1365 QKIVVDEKTHA---HLMSLDAHKRAEYITKLNQQNKPRVMLRQQVA-------YQPRPGAPGSIV 1419
            |..|..:..|.   |.:||              |:|..:.|...|.       ::...|...:::
  Fly   509 QDFVATQPFHVVNQHSVSL--------------QDKENIPLDDSVKVASDSKFFEATCGEIDAVL 559

  Fly  1420 -----ATRPAGPVPPGHIIVQHQMPPGLTQQQQVLWLQQQQG---------------------KR 1458
                 .|....||.|....:....|..:..:.....:.|.:|                     ||
  Fly   560 NEMISGTVATSPVSPNEESIPFFEPCVIKDKNHYQKICQIEGVFSNVSNRSRGRTDGTGFGRLKR 624

  Fly  1459 QVVVRAGTPGLSPIQQQPGAGPQQQQQSPQQQPFNPNDPNQQMLMQRQQLRVQQIPIQQQG---- 1519
              |.::.:|..:||::      .:::....::|.:.:......|:.::...:.:..|::.|
  Fly   625 --VAKSESPPETPIRK------DRRRSEGSERPGSNSRERLNNLVDKKSEALNKSVIREHGIDSI 681

  Fly  1520 PQQLGKQTVQLITGPNGQLIEQQTIVQQPQQ-----QSAPGTPTTPGAGGVLPGNANIMTQTLVM 1579
            |:::.|:. :..:...|...  ..:|.|.:.     ||.||||.:......:  ||:::
  Fly   682 PEEITKED-KSDSEEKGDCF--NNVVNQWRSRKRRIQSRPGTPGSSSERNEV--NADVV------ 735

  Fly  1580 TSTTPDGQPQQSPQQMNL---KTKTALANMLSNRLGNNGAQTPQQ---QIIQLPD---GQQPQQQ 1635
                  .:|.:.|...|:   |.|.|.....|..:.....:|.:|   :.::.||   |::.:.
  Fly   736 ------DKPNEEPPTKNIRARKAKKAEKADSSKDIPKPTTRTRRQTSDEDVRTPDLGKGRKAKN- 793

  Fly  1636 QIVQQVVVTGAIQQQQQQLLLQQQQQQQQQQQMVVQQQLPPQQHVEPPSAAGALRMMGQQHNATA 1700
                    |.:.:....:.:.:..::..:|......:.|.....|:..|.....::...:...:.
  Fly   794 --------TASSKADTSKNIAKGSKRVTRQNSADDAELLEEDSSVQTESGKRVKKVKSSKGETSK 850

  Fly  1701 GVP-GPPRTQQ----ELLMLQQQQQQQLLQQQQ---MRRVVALPQQQQAPQQHLVQQQIVVAPTQ 1757
            .:| ..|||::    |..|..:.::::.:|.::   |.:..|..:::.:.::           |:
  Fly   851 DIPKAKPRTRRQTADEDAMTPKAEKERQIQGEETKDMSKPAARTRRKASAEE-----------TE 904

  Fly  1758 SPQQQQQMAVGVGVGVPVQRTPHGYIQTRPGQQPIPMPQFYGHNPNLKLPADLFLVGCTFYIVEY 1822
            |..|          .|..:|...|                                       :.
  Fly   905 SAAQ----------AVKPKRGGKG---------------------------------------KK 920

  Fly  1823 DETDGDELPIWLDTIRQFGGDIERVYCPRVTHVICRTQRHGVVMQALRDAKRCVTAYWLSDICLK 1887
            :||...|            ..:|:   |.|     ||:|     ..:.:....:|........:|
  Fly   921 NETTKAE------------ATVEK---PMV-----RTRR-----MTIAEDSSTLTEVKTGGALIK 960

  Fly  1888 RQLMPPWQPLHLPFPSQFGYRKPLERYIITSEGFEGEEVVRLQQMAEECGAIYTSYLSKVNTVVV 1952
            |                                    .|||:.:::.|
  Fly   961 R------------------------------------AVVRISRVSIE----------------- 972

  Fly  1953 CKQLEGNKFNAAKEWNIPMVNALWLSDVCIGN---LSGLSQYEN--PKYQQYNLVAPFRIECNLV 2012
              |||                    |....||   ::|.:|..:  |..::.:..:....|.|:.
  Fly   973 --QLE--------------------SSTSAGNNARVTGAAQSRSTTPSIEEPSSSSAAAKEPNVS 1015

  Fly  2013 -------AHLLTAWKAPINLTQEAHERVKRHLSDPYGNEQKLKRQKMNAFQQEQLPE-------Q 2063
                   |..||:.:.|.:.:....::.|..:     :|:.||.:......:...|:       .
  Fly  1016 TATTRRRAKRLTSGEEPTSSSDVPTKKPKMSV-----DEEVLKNRSGATTTRFSQPDADPLRAIN 1075

  Fly  2064 IVCVEYPTTTKPPKVIFSQVADAEALKKAVLILGGIV--VDSPADATHLVMTRESRTCKLIQACC 2126
            :...:..|||...||.|: :.:..||:..:..|..:|  .:.|.....|||.:..||.|.:....
  Fly  1076 LYVRKAKTTTGKIKVAFT-MCNRPALETVLKSLKHVVEITEDPLQCDLLVMDKGERTYKFLTVIA 1139

  Fly  2127 HVDYVLKSSWIADSAKAGKFVP-------TDPYRIQHIPVDENLQFNLNTVLCAPTRSTLFAGKY 2184
            ....||.::|: .|.|..:.:.       :||      ..:|..:|..::||..|   .|..|.:
  Fly  1140 SNKPVLSTNWL-HSVKKTRSIDIKADHLFSDP------TFEETYKFKPSSVLEHP---RLLYGLH 1194

  Fly  2185 FHVTPDVFPAREEIIRMIESSGGKVEPKRRSGASVAETHMQAP------DSYIIVTCPTDMHLCA 2243
            |.:..|:.|...|:..:|.|:||||             |.|.|      |.| :||...|.....
  Fly  1195 FMLGKDIVPKANEMKVIIHSAGGKV-------------HAQPPSLAISVDLY-VVTTSKDTKSKR 1245

  Fly  2244 DLTRHGNPKCHIVSTEFVMSSILRQQLEI 2272
            .|..:  .|.|.:.||.||.::::..:|:
  Fly  1246 RLNNY--EKVHFIKTEAVMQALVQHNIEM 1272

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptip	NP_729947.2	BRCT_PAXIP1_rpt1	11..87	CDD:349346
		BRCT_PAXIP1_rpt2	100..181	CDD:349342
		BRCT_PAXIP1_rpt3	1814..1893	CDD:349343	12/78 (15%)
		BRCT_PAXIP1_rpt4	1914..1986	CDD:349362	10/74 (14%)
		BRCT_PAXIP1_rpt5	2075..2147	CDD:349344	19/73 (26%)
		BRCT_PAXIP1_rpt6	2179..2271	CDD:349393	27/97 (28%)
mu2	NP_523887.2	MU2_FHA	5..98	CDD:375648
		BRCT_MDC1_rpt1	1088..1155	CDD:349375	18/68 (26%)
		BRCT_PAXIP1_rpt6_like	1189..1271	CDD:349385	27/97 (28%)