Protein Alignment Ptip and Topbp1

DIOPT Version :10

• Sequence 1: NP_729947.2
• Gene: Ptip / 39552
• FlyBaseID: FBgn0052133
• Length: 2294
• Species: Drosophila melanogaster
• Sequence 2: XP_063122517.1
• Gene: Topbp1 / 315969
• RGDID: 1562949
• Length: 1519
• Species: Rattus norvegicus
• Alignment Length: 503
• Identity: 108/503 - (21%)
• Similarity: 170/503 - (33%)
• Gaps: 152/503 - (30%)

  Fly  1876 VTAYWLSDICLKRQLM--PPWQPLHLPFPSQFGYRKPLERYIITSEGFEGEEVVRLQQMAEECGA 1938
            ||..||. .|:..|.:  |...||..|.....| ..|||..:|:.....|.|...|..:|...||
  Rat   617 VTNTWLV-TCIDNQTLVDPKSNPLFTPVSVMSG-MTPLEDCVISFSQCVGAERDSLVFLANHLGA 679

  Fly  1939 -IYTSYLSKVN--------TVVVCKQLEGNKFNAAKEWNIPMVNALWLSDVC-IGNLSGLSQY-- 1991
             :...::.|.|        |.::.|:..|:|:.|||:|::|.||..||.:.. :|..:..:.:
  Rat   680 SVQEFFVRKSNAKKGMLASTHLIVKEPTGSKYEAAKKWSLPAVNISWLLETARMGKRADENHFLV 744

  Fly  1992 -ENPKYQQY------NLVAPFRIECNLVAHLLTAWKAPINLTQEAHERVKRHLSDPYGNEQKLKR 2049
             ..||.:|.      |.|:|                   |....||.  ..||        ::.|
  Rat   745 DSAPKQEQVLETNIPNGVSP-------------------NPDSPAHP--DAHL--------EIHR 780

  Fly  2050 QK------MNAFQQEQLPEQIVCVEY-------PTTTKPPKVIFSQVADAEALKKAVLILGGIVV 2101
            ||      ||.||.:..  ..|..::       |...:|||            |:....|
  Rat   781 QKAVTPLDMNRFQSKAF--HAVISQHNRQGLASPPVRQPPK------------KEPSFHL----- 826

  Fly  2102 DSPADATHLVMTRESRTCKLIQACCHVDYVLKSSWIADSAKAGKFVPTDPYRIQHI--PVDENLQ 2164
            |:|:              |.:..    |.:.|.|:....|.|....|....:.:.:  |:.|.:.
  Rat   827 DTPS--------------KFLSK----DKLFKPSFDVTDALAALETPNAASQKRKLSSPLSEVIV 873

  Fly  2165 FNLNTVLCAPTRST--LFAG---KYFHVTPDVFP----------------AREEIIRMIESSG-- 2206
            .||.|.|...:|:|  |.|.   |..|:..:..|                .:.|:..:..|.|
  Rat   874 RNLTTALANSSRNTGCLSASPQLKGAHLEKEETPKPLDKVVVCVSKRLSKKQSELNGVAASLGAE 938

  Fly  2207 ---------------GKVEPKRRSGASVAETHMQAPDSYIIVTCPTD-MHLCADLTRHG-NPKCH 2254
                           |:.....|...|..|..:.....:.::.|..: .||...|..|. |||..
  Rat   939 YRWSFDETVTHYIYQGRANDSNREYKSAKERGVHVVSEHWLLECAQEYKHLPESLYPHTYNPKMS 1003

  Fly  2255 I-VST-------EFVMSSILRQQLEIEPNLIPYLYNNNNVNSCNSNKS 2294
            : :||       :..:.|.|....:.||:.:....|.......:|.:|
  Rat  1004 LDISTVQDGRLCDSRLPSALSASKDDEPDHLSVEENATETLGTHSRES 1051

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptip	NP_729947.2	BRCT_PAXIP1_rpt1	11..87	CDD:349346
		BRCT_PAXIP1_rpt2	100..181	CDD:349342
		BRCT_PAXIP1_rpt3	1814..1893	CDD:349343	6/18 (33%)
		BRCT_PAXIP1_rpt4	1914..1986	CDD:349362	23/81 (28%)
		BRCT_PAXIP1_rpt5	2075..2147	CDD:349344	13/71 (18%)
		BRCT_PAXIP1_rpt6	2179..2271	CDD:349393	24/137 (18%)
Topbp1	XP_063122517.1	None