Protein Alignment Ptip and Paxip1

DIOPT Version :10

• Sequence 1: NP_729947.2
• Gene: Ptip / 39552
• FlyBaseID: FBgn0052133
• Length: 2294
• Species: Drosophila melanogaster
• Sequence 2: XP_063142007.1
• Gene: Paxip1 / 311944
• RGDID: 1307547
• Length: 1117
• Species: Rattus norvegicus
• Alignment Length: 1186
• Identity: 313/1186 - (26%)
• Similarity: 470/1186 - (39%)
• Gaps: 325/1186 - (27%)

  Fly  1165 QQQQQQQQQQQQQQQQQQQLVGQQQQQILIQQQQTPQQQQILQQKLSNDNQQQQIMQLITQQQLP 1229
            ::::::::::...::|..|..|...:.......:.....|....|...:..:.::|...:....|
  Rat   189 EEEEEEEEEEGDNEEQDSQNEGSTDKSSAASSAEASPADQPCSPKARAEVSKGELMFDDSSDSSP 253

  Fly  1230 QRTPPPQQQQQQQLLLQQQQQSPQHHPQMQQQHWSPQSPAGG--QMASSTPGTPTSVGMQSPLPG 1292
            ::        |::.|.....::|   |....||..||....|  .:.::.|          |:||
  Rat   254 EK--------QERSLNWAPAEAP---PLSTAQHRLPQGKGPGLINLCANVP----------PVPG 297

  Fly  1293 GPTTPQPQPQQQFVPRGLRPQTSWPGQPQQQQPQPTQQQQQIVLPPPQQQQPQQQQQHLGQQQQL 1357
                       ..:|..:|......||..|...:|                     :.||.....
  Rat   298 -----------DILPPDMRGNLMAAGQNLQSSERP---------------------EMLGTWSPA 330

  Fly  1358 VMQQPQQQKIVVDEKTHAHLMSLDAHKRAEYITKLNQQNKPRVMLRQQVAY--QPRPGAPGSIVA 1420
            |       :.:.:...:|.:..:.......:|  |...:.|...|.||||:  |..|.|  |.|.
  Rat   331 V-------RTLRNITNNADIQQISRPSNVAHI--LQSLSAPTKNLEQQVAHVQQGHPSA--SAVL 384

  Fly  1421 TRPAGPVPPGHIIVQHQMP-------PGLTQQQQVLWLQQQQGKRQVVVRAGTPGLSPIQQQPGA 1478
            ...|...|..|.:.||..|       |.|..|.|::.|||||
  Rat   385 FGQAKGAPETHTLQQHHPPQQPQQQHPALHLQPQIMQLQQQQ----------------------- 426

  Fly  1479 GPQQQQQSPQQQPFNPNDPNQQMLMQRQQLRVQQIPIQQQGPQQLGKQTVQLITGPNGQLIEQQT 1543
              |||||.||..|..|:                     .|.|||:.:.          |..:||
  Rat   427 --QQQQQQPQPYPQPPS---------------------HQFPQQVHQH----------QFSQQQ- 457

  Fly  1544 IVQQPQQQSAPGTPTTPGAGGVLPGNANIMTQTLVMTSTTPDGQPQQSPQQMNLKTKTALANMLS 1608
             :|.||                                     ||....||::
  Rat   458 -LQFPQ-------------------------------------QPLHPQQQLH------------ 472

  Fly  1609 NRLGNNGAQTPQQQIIQLPDGQQPQQQQIVQQVVVTGAIQQQQQQLLLQQQQQQQQQQQMVVQQQ 1673
                     .||||:       ||.|||        .|:|||..||   ||||.||.|...:|||
  Rat   473 ---------RPQQQL-------QPFQQQ--------HALQQQLHQL---QQQQLQQHQLAQLQQQ 510

  Fly  1674 LPPQQHVEPPSAAGALRMMGQQHNATAGVPGPPRTQQELLMLQQQQQQQLL---QQQQMRRVVA- 1734
            ...||.              ||||                :|||||||||.   |||||:...|
  Rat   511 QQQQQQ--------------QQHN----------------LLQQQQQQQLQRLHQQQQMQNQAAH 545

  Fly  1735 LPQQQQAPQQHLVQQQIVVAPTQSPQQQQQMAVGVGVGVPVQRTPHGYIQTRPGQQPIPMPQFYG 1799
            |.|..||.|..::.||.:..|.|.|.||||.                  |.:..||.....|.:|
  Rat   546 LSQTSQALQHQVLPQQPLQLPLQPPPQQQQQ------------------QQQQQQQQQQQQQLFG 592

  Fly  1800 HNPNLKLPADLFLVGCTFYIVEYDETDGDE--LPIWLDTIRQFGGDIERVYCPRVTHVICRTQRH 1862
            |:|.:::|.:.||:||.|.|.:|.|...|:  |..|...|:..||.::..:..|.||::|.:|..
  Rat   593 HDPAVEIPEESFLLGCVFAIADYPEQMSDKQLLATWKRIIQAHGGTVDPTFTSRCTHLLCESQVS 657

  Fly  1863 GVVMQALRDAKRCVTAYWLSDICLKRQLMPPWQPLHLP--FPSQFGYRKPLERYIITSEGFEGEE 1925
            .:..||||:.||||||:||:.:..|::||||.:.||.|  ||..   .||..::||:..||...:
  Rat   658 SMYAQALRERKRCVTAHWLNTVLKKKKLMPPHRALHFPVAFPPG---GKPCSQHIISVTGFVDND 719

  Fly  1926 VVRLQQMAEECGAIYTSYLSKVNTVVVCKQLEGNKFNAAKEWNIPMVNALWLSDVCIGNLSGLSQ 1990
            ...|:.||...||.||.||.:.|||::||:..|.|:..||||.||.|||.||.|:.:||...|.|
  Rat   720 RDDLKLMAYLAGAKYTGYLCRSNTVLICKEPSGLKYEKAKEWRIPCVNAQWLGDILLGNFEALRQ 784

  Fly  1991 YENPKYQQYNLVAPFRIECNLVAHLLTAWKAPINLTQEAHERVK---RHLSDPYGNEQKLKRQK- 2051
            .:..:|..:||..||....:||..||.||:.|:.:|.|....::   :...:...|.|..||.:
  Rat   785 VQYSRYTAFNLPDPFVPTPHLVLSLLDAWRTPVKVTAELLMSIRLPPKLKPNEVANIQPSKRARG 849

  Fly  2052 -------------------MNAFQQEQLP-EQIVCVEY----------------PTTTK-----P 2075
                               .:.....||| ..::|..:                |.|.|     .
  Rat   850 WRDVIKSTDYSCRGPGFSSQHPHDSSQLPVTSVLCRHWAMHMVHRHTCRIEDLPPPTKKLTPELT 914

  Fly  2076 PKVIFS--QVADAEALKKAVLILGGIVVDSPADATHLVMTRESRTCKLIQACCHVDYVLKSSWIA 2138
            |.|:|:  :....:...|.:.||||.|.:|....|||:.::.:||.|.:.|...|.:::...|:.
  Rat   915 PYVLFTGFEPVQVQQYIKKLYILGGEVAESTKKCTHLIASKVTRTVKFLTAISVVKHIVTPDWLE 979

  Fly  2139 DSAKAGKFVPTDPYRIQHIPVDENLQFNLNTVLCAPTRSTLFAGKYFHVTPDVFPAREEIIRMIE 2203
            :..|...|:....|.::....:....|:|...|.....|.||..|||::||.:.|:...:..::|
  Rat   980 ECFKRQMFIDEQNYILRDAEAEVLFSFSLEESLKRAHVSPLFKTKYFYITPGICPSLATMKAIVE 1044

  Fly  2204 SSGGKVEPKRRSGASVAETHMQ--APDSYIIVTCPTDMHLCADLTRHGNPKCHIVSTEFVMSSIL 2266
            .:||||..|:.|...:.| |.|  :....|:::|..|:|||.:....|   ..:.:.|||::.:|
  Rat  1045 CAGGKVLAKQPSFRKLME-HKQNKSLSEIILISCENDLHLCREYFARG---IDVHNAEFVLTGVL 1105

  Fly  2267 RQQLEIEPNLIPYLYN 2282
            .|.|:.|    .|.:|
  Rat  1106 TQTLDYE----SYKFN 1117

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptip	NP_729947.2	BRCT_PAXIP1_rpt1	11..87	CDD:349346
		BRCT_PAXIP1_rpt2	100..181	CDD:349342
		BRCT_PAXIP1_rpt3	1814..1893	CDD:349343	32/80 (40%)
		BRCT_PAXIP1_rpt4	1914..1986	CDD:349362	34/71 (48%)
		BRCT_PAXIP1_rpt5	2075..2147	CDD:349344	20/73 (27%)
		BRCT_PAXIP1_rpt6	2179..2271	CDD:349393	30/93 (32%)
Paxip1	XP_063142007.1	None