Protein Alignment Ptip and Paxip1

DIOPT Version :9

• Sequence 1: NP_729947.2
• Gene: Ptip / 39552
• FlyBaseID: FBgn0052133
• Length: 2294
• Species: Drosophila melanogaster
• Sequence 2: XP_017448096.2
• Gene: Paxip1 / 311944
• RGDID: 1307547
• Length: 1067
• Species: Rattus norvegicus
• Alignment Length: 1149
• Identity: 312/1149 - (27%)
• Similarity: 466/1149 - (40%)
• Gaps: 301/1149 - (26%)

  Fly  1165 QQQQQQQQQQQQQQQQQQQLVGQQQQQILIQQQQTPQQQQILQQKLSNDNQQQQIMQLITQQQLP 1229
            ::::::::::...::|..|..|...:.......:.....|....|...:..:.::|...:....|
  Rat   189 EEEEEEEEEEGDNEEQDSQNEGSTDKSSAASSAEASPADQPCSPKARAEVSKGELMFDDSSDSSP 253

  Fly  1230 QRTPPPQQQQQQQLLLQQQQQSPQHHPQMQQQHWSPQSPAGG--QMASSTPGTPTSVGMQSPLPG 1292
            ::        |::.|.....::|   |....||..||....|  .:.::.|          |:||
  Rat   254 EK--------QERSLNWAPAEAP---PLSTAQHRLPQGKGPGLINLCANVP----------PVPG 297

  Fly  1293 GPTTPQPQPQQQFVPRGLRPQTSWPGQPQQQQPQPTQQQQQIVLPPPQQQQPQQQQQHLGQQQQL 1357
                       ..:|..:|......||..|...:|                     :.||.....
  Rat   298 -----------DILPPDMRGNLMAAGQNLQSSERP---------------------EMLGTWSPA 330

  Fly  1358 VMQQPQQQKIVVDEKTHAHLMSLDAHKRAEYITKLNQQNKPRVMLRQQVAY--QPRPGAPGSIVA 1420
            |       :.:.:...:|.:..:.......:|  |...:.|...|.||||:  |..|.|  |.|.
  Rat   331 V-------RTLRNITNNADIQQISRPSNVAHI--LQSLSAPTKNLEQQVAHVQQGHPSA--SAVL 384

  Fly  1421 TRPAGPVPPGHIIVQHQMP-------PGLTQQQQVLWLQQQQGKRQVVVRAGTPGLSPIQQQPGA 1478
            ...|...|..|.:.||..|       |.|..|.|::.|||||
  Rat   385 FGQAKGAPETHTLQQHHPPQQPQQQHPALHLQPQIMQLQQQQ----------------------- 426

  Fly  1479 GPQQQQQSPQQQPFNPNDPNQQMLMQRQQLRVQQIPIQQQGPQQLGKQTVQLITGPNGQLIEQQT 1543
              |||||.||..|..|:                     .|.|||:.:.          |..:||
  Rat   427 --QQQQQQPQPYPQPPS---------------------HQFPQQVHQH----------QFSQQQ- 457

  Fly  1544 IVQQPQQQSAPGTPTTPGAGGVLPGNANIMTQTLVMTSTTPDGQPQQSPQQMNLKTKTALANMLS 1608
             :|.||                                     ||....||::
  Rat   458 -LQFPQ-------------------------------------QPLHPQQQLH------------ 472

  Fly  1609 NRLGNNGAQTPQQQIIQLPDGQQPQQQQIVQQVVVTGAIQQQQQQLLLQQQQQQQQQQQMVVQQQ 1673
                     .||||:       ||.|||        .|:|||..||   ||||.||.|...:|||
  Rat   473 ---------RPQQQL-------QPFQQQ--------HALQQQLHQL---QQQQLQQHQLAQLQQQ 510

  Fly  1674 LPPQQHVEPPSAAGALRMMGQQHNATAGVPGPPRTQQELLMLQQQQQQQLL---QQQQMRRVVA- 1734
            ...||.              ||||                :|||||||||.   |||||:...|
  Rat   511 QQQQQQ--------------QQHN----------------LLQQQQQQQLQRLHQQQQMQNQAAH 545

  Fly  1735 LPQQQQAPQQHLVQQQIVVAPTQSPQQQQQMAVGVGVGVPVQRTPHGYIQTRPGQQPIPMPQFYG 1799
            |.|..||.|..::.||.:..|.|.|.||||.                  |.:..||.....|.:|
  Rat   546 LSQTSQALQHQVLPQQPLQLPLQPPPQQQQQ------------------QQQQQQQQQQQQQLFG 592

  Fly  1800 HNPNLKLPADLFLVGCTFYIVEYDETDGDE--LPIWLDTIRQFGGDIERVYCPRVTHVICRTQRH 1862
            |:|.:::|.:.||:||.|.|.:|.|...|:  |..|...|:..||.::..:..|.||::|.:|..
  Rat   593 HDPAVEIPEESFLLGCVFAIADYPEQMSDKQLLATWKRIIQAHGGTVDPTFTSRCTHLLCESQVS 657

  Fly  1863 GVVMQALRDAKRCVTAYWLSDICLKRQLMPPWQPLHLP--FPSQFGYRKPLERYIITSEGFEGEE 1925
            .:..||||:.||||||:||:.:..|::||||.:.||.|  ||..   .||..::||:..||...:
  Rat   658 SMYAQALRERKRCVTAHWLNTVLKKKKLMPPHRALHFPVAFPPG---GKPCSQHIISVTGFVDND 719

  Fly  1926 VVRLQQMAEECGAIYTSYLSKVNTVVVCKQLEGNKFNAAKEWNIPMVNALWLSDVCIGNLSGLSQ 1990
            ...|:.||...||.||.||.:.|||::||:..|.|:..||||.||.|||.||.|:.:||...|.|
  Rat   720 RDDLKLMAYLAGAKYTGYLCRSNTVLICKEPSGLKYEKAKEWRIPCVNAQWLGDILLGNFEALRQ 784

  Fly  1991 YENPKYQQYNLVAPFRIECNLVAHLLTAWKAPINLTQEAHERVK---RHLSDPYGNEQKLKRQKM 2052
            .:..:|..:||..||....:||..||.||:.|:.:|.|....::   :...:...|.|..||.::
  Rat   785 VQYSRYTAFNLPDPFVPTPHLVLSLLDAWRTPVKVTAELLMSIRLPPKLKPNEVANIQPSKRARI 849

  Fly  2053 NAFQQEQLPEQIVCVEYPTTTK-----PPKVIFS--QVADAEALKKAVLILGGIVVDSPADATHL 2110
                 |.||        |.|.|     .|.|:|:  :....:...|.:.||||.|.:|....|||
  Rat   850 -----EDLP--------PPTKKLTPELTPYVLFTGFEPVQVQQYIKKLYILGGEVAESTKKCTHL 901

  Fly  2111 VMTRESRTCKLIQACCHVDYVLKSSWIADSAKAGKFVPTDPYRIQHIPVDENLQFNLNTVLCAPT 2175
            :.::.:||.|.:.|...|.:::...|:.:..|...|:....|.::....:....|:|...|....
  Rat   902 IASKVTRTVKFLTAISVVKHIVTPDWLEECFKRQMFIDEQNYILRDAEAEVLFSFSLEESLKRAH 966

  Fly  2176 RSTLFAGKYFHVTPDVFPAREEIIRMIESSGGKVEPKRRSGASVAETHMQ--APDSYIIVTCPTD 2238
            .|.||..|||::||.:.|:...:..::|.:||||..|:.|...:.| |.|  :....|:::|..|
  Rat   967 VSPLFKTKYFYITPGICPSLATMKAIVECAGGKVLAKQPSFRKLME-HKQNKSLSEIILISCEND 1030

  Fly  2239 MHLCADLTRHGNPKCHIVSTEFVMSSILRQQLEIEPNLIPYLYN 2282
            :|||.:....|   ..:.:.|||::.:|.|.|:.|    .|.:|
  Rat  1031 LHLCREYFARG---IDVHNAEFVLTGVLTQTLDYE----SYKFN 1067

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptip	NP_729947.2	BRCT	9..77	CDD:214602
		BRCT	96..174	CDD:278934
		BRCT	1814..1887	CDD:237994	29/74 (39%)
		PTCB-BRCT	1914..1976	CDD:289507	29/61 (48%)
		BRCT	<2087..2142	CDD:237994	16/54 (30%)
		BRCT	2175..2265	CDD:278934	29/91 (32%)
Paxip1	XP_017448096.2	BRCT_PAXIP1_rpt1	13..87	CDD:349346
		BRCT_PAXIP1_rpt2	98..178	CDD:349342
		BRCT_PAXIP1_rpt3	607..688	CDD:349343	32/80 (40%)
		BRCT_PAXIP1_rpt4	708..780	CDD:349362	34/71 (48%)
		BRCT_PAXIP1_rpt5	864..938	CDD:349344	20/73 (27%)
		BRCT_PAXIP1_rpt6	970..1060	CDD:349393	30/93 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I9611
eggNOG	1	0.900	-	-		E1_KOG2043
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004880
OrthoInspector	1	1.000	-	-		oto97403
orthoMCL	1	0.900	-	-		OOG6_105904
Panther	1	1.100	-	-	LDO	PTHR23196
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3992
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.810