DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptip and Mdc1

DIOPT Version :9

Sequence 1:	NP_729947.2	Gene:	Ptip / 39552	FlyBaseID:	FBgn0052133	Length:	2294	Species:	Drosophila melanogaster
Sequence 2:	NP_001010833.2	Gene:	Mdc1 / 240087	MGIID:	3525201	Length:	1708	Species:	Mus musculus

Alignment Length:	2049	Identity:	382/2049 - (18%)
Similarity:	690/2049 - (33%)	Gaps:	618/2049 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   459 QTPRTPSTTPQPVQSPQHHQQIVQQQQVVQQQVGQQQTMVQQQQIVQQQQIVQQQVVQQQQPQQQ 523
            ::|......|.|..|.||        .|::.....:..::|....:...|||:...|
Mouse    58 RSPDCSVALPFPSISKQH--------AVIEISAWNKAPILQDCGSLNGTQIVKPPRV-------- 106

  Fly   524 SVPVSPQIIHQHLMRQQQIL-------NQNQMQLQQIVQSGQALTPQQQQQQRQIQQQLQQVMQQ 581
               :.|.:.|:  :|.|:::       ..:::.:...:.....||.::..:.| |:.|..:|:
Mouse   107 ---LPPGVSHR--LRDQELILFADFPCQYHRLDVPPPLVPRSLLTIEKTPRIR-IESQNSRVL-- 163

  Fly   582 QQQLQMQMQQQQQQQNLQQQQSPRMVQNRSPVMPPSTPSPSLQQQQHHATSNMLPPQSPRQLQSP 646
                   :....:::.  ...|.|.|.|..    .:|.|||       ||   :.|:|..::.||
Mouse   164 -------LAADSEEEG--DFPSGRCVANGQ----RNTASPS-------AT---VVPESDEEVSSP 205

  Fly   647 APQMTPPPPPSPQNAQQQHLRQQQQMQQNRQQHM------MGSPQQPQPQSMMSPQQQQQMQPFQ 705
            ||.:  |.|.||.........:|.|.....:..:      .|..:||:.....:..|.|..:
Mouse   206 APSV--PGPSSPFGLGSDTDEEQGQQPGVEESSLADSSGAAGEAEQPEANGTTAGIQAQPTE--- 265

  Fly   706 QPVHQQQRMQLQQQQQLAQQQQQQQQQSPQHISPQSPQISQTPPMQAKLHQHQVVPGQATQPQQS 770
               |:.:..:::::...|       ..|...:..:||.:.:....:.. ..|:  ||.|......
Mouse   266 ---HKLKDTKVKKEAGRA-------GVSDGSVLERSPTLGEDSDTEVD-EDHK--PGFADSETDV 317

  Fly   771 FSQQKPI-DPTDPVQVAQVL----------------------------SRSA----LSSNQDSLI 802
            ..::.|: .|..||:..|||                            .::|    |..|...::
Mouse   318 EEERIPVTPPVAPVKKNQVLLAVGIGDPEAPGVAHLQDCLAGSGTDVEDKTALDVPLERNHTPMV 382

  Fly   803 MRQQQLKQQQQMQQQQQMA---------------PQPQQQQMAQQPQ----QQQQQQPQQQHTPS 848
            :.....:::::.:::...|               ..|..:::..|||    |.|....:...|..
Mouse   383 INSDTDEEEEEEEEEVSAALTLAHLKERGIGLWSRDPGAEEVKSQPQVLVEQSQSASGRDSDTDV 447

  Fly   849 PRQSPLQQQPTTPTLQQQPNQQNAQQIQQQQQQQQQQQQQQQQQQQQQQVLTQQQPQPGQQQQVI 913
            ..:|..:::...|        .:...:.:.....|.:.|..::.....:.:....|   ....|:
Mouse   448 EEESSGRKREIIP--------DSPMDVDEALTVTQPESQPPRRPNDADEYMDMSSP---GSHLVV 501

  Fly   914 TQRH--VINTSTAQGQQIIQSHMSLALQKQQQLLHVQQQAQQQPQQQQQITQVQQ---------- 966
            .|..  |:..:.||.::.:.....:..:|.|    |..:..|.|::..: |.||:
Mouse   502 NQASFAVVGKTRAQVEEEVPGPSVILGEKHQ----VPLEGAQPPEEAWE-TAVQEGSSSPEAAAS 561

  Fly   967 LPPAQQ----------QQQLPQQH---QVQQQQPQQVQFTQQQQIALGAGGQVRIIQQTIQRPPT 1018
            :.|:||          ...:.:|.   :|:.|........:|..|.....|...:.|:...:.||
Mouse   562 VRPSQQPVAEDAGTECATAVSEQESTLEVRSQSGSPAAPVEQVVIHTDTSGDPTLPQREGAQTPT 626

  Fly  1019 NVQQQQQVPQQQQQQ------------------IIG--QFPQQ-QQLQQQPQQ------------ 1050
            ..:::..|.:.:..:                  :.|  |.|:. |.|:.:|.|
Mouse   627 GREREAHVGRTKSAKECCDAEPEDLCLPATQCFVEGESQHPEAVQSLENEPTQLFPCTLPQEPGP 691

  Fly  1051 -----QISGVQ-----------QPQQQQQQQKTFIISQQHFNQLSVQQQQQILAQNPQSQNVYVV 1099
                 |..|..           ||...::|.:|..:.:.|.:|.|:.::.      |..|::...
Mouse   692 SHLSLQTPGADTLDVPWEVLATQPFCLREQSETSELHEAHGSQPSLPREP------PGHQHLVHT 750

  Fly  1100 NQTQQQLV----QQQQMLQQQQIIPQQQQQQRMQMQQQPQQIVVNQQILSDPQRLQY-LQQQQLM 1159
            :....:|:    ::.|.:::...|| ::...||..:::|    :.::|....:..:. :..::|:
Mouse   751 SPVHTELLRIEGREIQTVEKAMGIP-KEMADRMTPEREP----LEREIRGRTENSERDVIGEELI 810

  Fly  1160 QKQQQQQQQQQQQQQQQQQQQQQQLVGQQQQ-QILIQQQQTPQQQQILQQKLSNDNQQQQIMQLI 1223
            |..:.::.::...:..|:::..:.|.|.::. ::.|:..:..|:::...:|
Mouse   811 QGTKDREPKKVLARDSQRKEADKDLEGNRESLEVEIEMSKDSQKRERKVEK-------------- 861

  Fly  1224 TQQQLPQRTPPPQQQQQQQLLLQQQQQSPQHHPQMQQQHWSPQSPAGGQMASST--PG------- 1279
                     |.|:::.:...|    :.:|......:..|     ...||:||.|  ||
Mouse   862 ---------PEPKREWEPADL----EVTPDRGVTEEGSH-----DQKGQIASLTLKPGVGVKDLE 908

  Fly  1280 ----TPTSVGMQSPLPGGPTTPQPQPQQQFVPRG-LRPQTSWPGQPQQQQPQPTQQQQQIVLPPP 1339
                .|...|.|:  .||...|....:||   || |..||:..|:..:..|:          ||.
Mouse   909 GLASAPIITGSQA--DGGKGDPLSPGRQQ---RGRLSCQTTPAGKASRGDPE----------PPD 958

  Fly  1340 Q---QQQPQQQQQHL--GQQQQLVMQQP----QQQKIVVDEKTHAHLMSLDAHKRAEYITKLNQQ 1395
            .   ...|:...|.|  .|.|:....||    ...:|.:.|..|
Mouse   959 HCLFSSVPEASTQSLLTSQSQKQSTPQPLFSTSSSEIPLPESLH--------------------- 1002

  Fly  1396 NKPRVMLRQQVAYQPRPGAPGSIVATRPAGPVPPGHIIVQHQMPPGLTQQQQVLWLQQQQGKRQV 1460
            .||.|..|:.....|   :|.|..|.:|....|              |.|
Mouse  1003 TKPNVRPRRSSRMTP---SPHSSAALKPNTTCP--------------TNQ--------------- 1035

  Fly  1461 VVRAGTPGLSPIQQQPGAGPQQQQQSPQQQPFNPNDPNQQMLMQRQQLRVQQIPIQQQGPQQLGK 1525
                  |..|....:|..|...:..:...:...|.||..|.....:|      |:..:...|:.:
Mouse  1036 ------PAASRPTSRPTRGRANRSSTRTPELIVPVDPELQPSTSTEQ------PVIPKLTSQVTE 1088

  Fly  1526 QTVQ----LITGPNGQ--LIEQQTIVQQPQQQSAPGTPTTPGAGGVLPGNANIMTQTLVMTSTTP 1584
            ..||    |:|||..|  ...:|::....:.::..|.|:.         :.|...:.|:  ||.|
Mouse  1089 GRVQMPEPLLTGPEIQSPTSTEQSVTPDRKPRATRGRPSK---------SPNKTPEPLI--STGP 1142

  Fly  1585 DGQPQQSPQQMNLKTKTALANMLSNRLGNNGAQTPQQQIIQLPDGQQPQQQQIVQQVVVTGAIQQ 1649
            :.||..|.:|..:...|  :.:...|...:..:||                   :.||.||
Mouse  1143 ELQPPTSIEQPVIPKPT--SRVTRGRPRKSSVRTP-------------------ESVVSTG---- 1182

  Fly  1650 QQQQLLLQQQQQQQQQQQMVVQQQLPPQQHVEPPSAAGALRMMGQQHNATAGVP------GPPRT 1708
                                  .:|.|...:|.|.........|:...::...|      ||  .
Mouse  1183 ----------------------PELQPLTSIEQPVIPEPRATRGRPSKSSIKTPESVVPTGP--E 1223

  Fly  1709 QQELLMLQQQQQQQLLQQQQMRR---VVALPQQ--QQAPQQH---LVQQQIVVAPTQSPQQQ--- 1762
            .|.|...:|.....|..:....|   .:..|:.  |..|:.|   ..:|    ..|:.|..|
Mouse  1224 LQPLTSAKQPVTPNLTSRASRGRSSKSIRTPEPVVQTGPEFHPSTSTEQ----PDTREPSSQART 1284

  Fly  1763 QQMAVGVGVGVPVQRTPHGYIQTRPGQQPI-----PMPQFYGHNPNLKLPADLFLVGCTFYIVEY 1822
            ::.||         :||...:.|.|..||.     |.|:          |..|...|.|:.....
Mouse  1285 RRSAV---------KTPEASVPTTPELQPFTSKKQPAPK----------PTALVTQGRTYKPSTE 1330

  Fly  1823 D-ETDGDELPIWLDTIRQFGGDIE------RVYCPRVTHVICRTQRHGVVMQALRDAKRCVTAYW 1880
            | |:.|...|           |.|      .:..|:||.            |:|......::|
Mouse  1331 DCESVGPVAP-----------DFEPSTSTDHLVTPKVTD------------QSLTLQSSPLSA-- 1370

  Fly  1881 LSDICLKRQLMPP---WQPL-HLPFPSQFGYRKPLERYIITSEGFEGEEVVRLQQMAEECGAIYT 1941
             |.:.....|.||   .||: ..|.|.....||.      .:.|.:|...|.|
Mouse  1371 -SPVSSTPDLKPPVPIAQPVTPEPIPQANHQRKR------RAAGKQGSRTVPL------------ 1416

  Fly  1942 SYLSKVNTVVVCKQLEGNKFNAAKEWNIPMVNALWLSDVCIGNLSGLSQYENPKYQQYNLVAPFR 2006
                            |:|..:|.....|..:|        ...||.|:.::|:.::....|..:
Mouse  1417 ----------------GHKSYSALSEPEPQSSA--------SQSSGASEADSPRQKRPRRQASQK 1457

  Fly  2007 IECNLVAHLLTAWKAPINLTQEAHERVKRHLSDPYGNEQKLKRQKMNAFQQEQLPEQIVCVEYPT 2071
                    .:...:.|:. |:...|..:..:..|    :|.||.......|.:          ||
Mouse  1458 --------TVVIKEEPVE-TEVKEEPQETAIPTP----EKRKRDHAEEVTQGK----------PT 1499

  Fly  2072 ---TTKP-----PKVIFSQVADAEALKKAVLILGGIVVDSPADATHLVMTRESRTCKLIQACCHV 2128
               .|||     |||:|:.|.|:.. ::|||.|||.:..|..:|:|||..|..||.|.:.|....
Mouse  1500 RSRRTKPNQETAPKVLFTGVMDSRG-ERAVLALGGSLASSVNEASHLVTDRIRRTVKFLCALGKG 1563

  Fly  2129 DYVLKSSWIADSAKAGKFVPTDPYRIQHIPVDENLQFNLNTVLCAPTRSTLFAGKYFHVTPDVFP 2193
            ..:|..:|:..|.|||.|:|.|.|.:.....::|..|:|...||......|......||||.|.|
Mouse  1564 IPILSLNWLYQSRKAGCFLPPDDYLVTDPEQEKNFSFSLRDSLCRARERRLLEDYEIHVTPGVQP 1628

  Fly  2194 AREEIIRMIESSGGKVEPKRRSGASVAETHMQAPDSY----IIVTCPTDMHLCADLTRHGNPKCH 2254
            ...::..:|...||...|             ..|.||    :|:||..|:..||..:|.|.|
Mouse  1629 PPPQMGEIISCCGGTFLP-------------SMPHSYKLHRVIITCTEDLPRCAIPSRLGLP--- 1677

  Fly  2255 IVSTEFVMSSILRQQLEIEPNLIPYLYNNNNVNS 2288
            ::|.||:::.:|:|:...|    .::.:|..::|
Mouse  1678 LLSPEFLLTGVLKQEATPE----AFVLSNLEMSS 1707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptip	NP_729947.2	BRCT	9..77	CDD:214602
		BRCT	96..174	CDD:278934
		BRCT	1814..1887	CDD:237994	15/79 (19%)
		PTCB-BRCT	1914..1976	CDD:289507	9/61 (15%)
		BRCT	<2087..2142	CDD:237994	19/54 (35%)
		BRCT	2175..2265	CDD:278934	26/93 (28%)
Mdc1	NP_001010833.2	Interaction with CHEK2. /evidence=ECO:0000250	1..150		18/112 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		Interaction with the MRN complex. /evidence=ECO:0000250	2..222		42/212 (20%)
		FHA	55..110	CDD:366133	12/70 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	166..328		37/195 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	418..498		12/90 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	521..643		21/126 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	680..700		1/19 (5%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	719..747		7/33 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	779..900		22/156 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	915..1511		160/849 (19%)
		PHA03247	<952..1429	CDD:223021	127/694 (18%)
		BRCT_MDC1_rpt1	1512..1582	CDD:349375	28/70 (40%)
		BRCT_MDC1_rpt2	1614..1693	CDD:349394	28/94 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2043
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900