DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptip and Topbp1

DIOPT Version :9

Sequence 1:	NP_729947.2	Gene:	Ptip / 39552	FlyBaseID:	FBgn0052133	Length:	2294	Species:	Drosophila melanogaster
Sequence 2:	XP_006511769.3	Gene:	Topbp1 / 235559	MGIID:	1920018	Length:	1541	Species:	Mus musculus

Alignment Length:	323	Identity:	74/323 - (22%)
Similarity:	120/323 - (37%)	Gaps:	72/323 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly  1876 VTAYWLSDICLKRQLM--PPWQPLHLPFPSQFGYRKPLERYIITSEGFEGEEVVRLQQMAEECGA 1938
            ||..||. .|:..|.:  |...||..|.....|. .|||..:|:.....|.|...|..:|...||
Mouse   689 VTNTWLV-TCIDNQTLVDPKSNPLFTPVSVMSGV-TPLEDCVISFSQCVGAERDSLVFLANHLGA 751

  Fly  1939 -IYTSYLSKVN--------TVVVCKQLEGNKFNAAKEWNIPMVNALWLSDVC-IGNLSGLSQY-- 1991
             :...::.|.|        |.::.|:..|:|:.|||:|::|.||..||.:.. ||..:..:.:
Mouse   752 SVQEFFVRKANAKKGMLASTHLIVKEPTGSKYEAAKKWSLPAVNISWLLETARIGKRADENHFLV 816

  Fly  1992 EN-PKYQQ-YNLVAPFRIECN--LVAHLLTAWKAPINLTQEAHERVKRHLSDPYGNEQKLKRQKM 2052
            :| ||.:| .....|..:..|  |.||            .:||..:.|        ::.:....|
Mouse   817 DNAPKQEQVLETKIPNGVSSNPDLPAH------------PDAHLEIHR--------KKAVTPLDM 861

  Fly  2053 NAFQQEQLPEQIVCVEYPTTTKPPKVIFSQVADAEALKKAVLILGGIVVDSPADATHLVMTRESR 2117
            |.||.......|........|.||            :::.:.....:.:|:|:
Mouse   862 NRFQSRAFRAVISQQRGQDPTFPP------------VRQPLTKEPSLHLDTPS------------ 902

  Fly  2118 TCKLIQACCHVDYVLKSSWIADSAKAGKFVPTDPYRIQHI--PVDENLQFNLNTVLCAPTRST 2178
              |.:..    |.:.|.|:....|.|....|....:.:.:  |:.|.:..||...|...:|:|
Mouse   903 --KFLSK----DKLFKPSFDVTDALAALETPNAASQKRKLSSPLSEVIVRNLTVALANSSRNT 959

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptip	NP_729947.2	BRCT	9..77	CDD:214602
		BRCT	96..174	CDD:278934
		BRCT	1814..1887	CDD:237994	5/10 (50%)
		PTCB-BRCT	1914..1976	CDD:289507	20/70 (29%)
		BRCT	<2087..2142	CDD:237994	6/54 (11%)
		BRCT	2175..2265	CDD:278934	2/4 (50%)
Topbp1	XP_006511769.3	BRCT_TopBP1_rpt1	183..254	CDD:349369
		BRCT_TopBP1_rpt2_like	273..349	CDD:349363
		BRCT_TopBP1_rpt3	427..508	CDD:349350
		BRCT_TopBP1_rpt4	631..714	CDD:349380	9/25 (36%)
		BRCT_TopBP1_rpt5	723..811	CDD:349387	27/87 (31%)
		BRCT_TopBP1_rpt6	982..1052	CDD:349359
		Streccoc_I_II	<1159..>1272	CDD:411384
		PHA01732	1228..>1297	CDD:222828
		BRCT_TopBP1_rpt7	1289..1363	CDD:349370
		BRCT_TopBP1_rpt8	1418..1496	CDD:349360
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	41	1.000	Domainoid score	I12452
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D305707at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920