DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ptip and PAXIP1

DIOPT Version :9

Sequence 1:NP_729947.2 Gene:Ptip / 39552 FlyBaseID:FBgn0052133 Length:2294 Species:Drosophila melanogaster
Sequence 2:NP_031375.3 Gene:PAXIP1 / 22976 HGNCID:8624 Length:1069 Species:Homo sapiens


Alignment Length:1148 Identity:306/1148 - (26%)
Similarity:475/1148 - (41%) Gaps:287/1148 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly  1158 LMQKQQQQQQQQQQQQQQQQQQQQQQLVGQQQQQILIQQQQTPQQQQILQQKLSNDNQQQQIMQL 1222
            ::.::::::::::::.:.::|..|.:....::......|:.:|...|....|.:.:..:.::|..
Human   186 IIYEEEEEEEEEEEEVENEEQDSQNEGSTDEKSSPASSQEGSPSGDQQFSPKSNTEKSKGELMFD 250

  Fly  1223 ITQQQLPQRTPPPQQQQQQQLLLQQQQQSPQHHPQMQQQHWSPQSPAGGQMASSTPGTPTSVGMQ 1287
            .:....|::       |::.|     ..:|...||:...  ..:.|.|.:     ||........
Human   251 DSSDSSPEK-------QERNL-----NWTPAEVPQLAAA--KRRLPQGKE-----PGLINLCANV 296

  Fly  1288 SPLPGGPTTPQPQPQQQFVPRGLRPQTSWPGQPQQQQPQPTQQQQQIVLPPPQQQQPQQQQQHLG 1352
            .|:||           ..:|..:|......|    |..|.:::.:.|....|..:..:....:..
Human   297 PPVPG-----------NILPPEVRGNLMAAG----QNLQSSERSEMIATWSPAVRTLRNITNNAD 346

  Fly  1353 QQQQLVMQQPQQQKIVVDEKTHAHLMSLDAHKRAEYITKLNQQNKPRVMLRQQVAYQPRPGAPGS 1417
            .||   |.:|...         ||:              |...:.|...|.|||.:..:.....:
Human   347 IQQ---MNRPSNV---------AHI--------------LQTLSAPTKNLEQQVNHSQQGHTNAN 385

  Fly  1418 IVATRPAGPVPPGHIIVQHQMPPGLTQQQQVLWLQQQQGKRQVVVRAGTPGLSPIQQQPGAGPQQ 1482
            .|........|..|::.|.|......||..||.||.||             :..:|||     ||
Human   386 AVLFSQVKVTPETHMLQQQQQAQQQQQQHPVLHLQPQQ-------------IMQLQQQ-----QQ 432

  Fly  1483 QQQSPQQQPFNPNDPNQQMLMQRQQLRVQQIPIQQQGPQQLGKQTVQLITGPNGQLIEQQTIVQQ 1547
            ||.|.|..|..|..|..|  .|:||        ||..|.|..:|.:|.                 
Human   433 QQISQQPYPQQPPHPFSQ--QQQQQ--------QQAHPHQFSQQQLQF----------------- 470

  Fly  1548 PQQQSAPGTPTTPGAGGVLPGNANIMTQTLVMTSTTPDGQPQQSPQQMNLKTKTALANMLSNRLG 1612
            ||||..|                                     |||::                
Human   471 PQQQLHP-------------------------------------PQQLH---------------- 482

  Fly  1613 NNGAQTPQQQIIQLPDGQQPQQQQIVQQVVVTGAIQQQQQQLLLQQQQQQQQQQQMVVQQQLPPQ 1677
                 .||||:       ||.|||        .|:|||..||     ||.|.|||.:.|.|    
Human   483 -----RPQQQL-------QPFQQQ--------HALQQQFHQL-----QQHQLQQQQLAQLQ---- 518

  Fly  1678 QHVEPPSAAGALRMMGQQHNATAGVPGPPRTQQELLMLQQQQQQQLLQQQQMRRVVALPQQQQAP 1742
                            |||:                :|||||||| :||||::|:....||||..
Human   519 ----------------QQHS----------------LLQQQQQQQ-IQQQQLQRMHQQQQQQQMQ 550

  Fly  1743 QQ---HLVQQ----QIVVAPTQSPQQQQQMAVGVGVGVPVQRTPHGYIQTRPGQQPIPMP---QF 1797
            .|   ||.|.    |..|.|.|.||||||                        |||.|.|   |.
Human   551 SQTAPHLSQTSQALQHQVPPQQPPQQQQQ------------------------QQPPPSPQQHQL 591

  Fly  1798 YGHNPNLKLPADLFLVGCTFYIVEYDETDGDE--LPIWLDTIRQFGGDIERVYCPRVTHVICRTQ 1860
            :||:|.:::|.:.||:||.|.|.:|.|...|:  |..|...|:..||.::..:..|.||::|.:|
Human   592 FGHDPAVEIPEEGFLLGCVFAIADYPEQMSDKQLLATWKRIIQAHGGTVDPTFTSRCTHLLCESQ 656

  Fly  1861 RHGVVMQALRDAKRCVTAYWLSDICLKRQLMPPWQPLHLP--FPSQFGYRKPLERYIITSEGFEG 1923
            ......||:|:.||||||:||:.:..|::::||.:.||.|  ||..   .||..::||:..||..
Human   657 VSSAYAQAIRERKRCVTAHWLNTVLKKKKMVPPHRALHFPVAFPPG---GKPCSQHIISVTGFVD 718

  Fly  1924 EEVVRLQQMAEECGAIYTSYLSKVNTVVVCKQLEGNKFNAAKEWNIPMVNALWLSDVCIGNLSGL 1988
            .:...|:.||...||.||.||.:.|||::||:..|.|:..||||.||.|||.||.|:.:||...|
Human   719 SDRDDLKLMAYLAGAKYTGYLCRSNTVLICKEPTGLKYEKAKEWRIPCVNAQWLGDILLGNFEAL 783

  Fly  1989 SQYENPKYQQYNLVAPFRIECNLVAHLLTAWKAPINLTQEAHERVKRHLSDPYGNEQKLKRQKMN 2053
            .|.:..:|..::|..||....:||.:||.||:.|:.::.|....::.        ..|||:.::.
Human   784 RQIQYSRYTAFSLQDPFAPTQHLVLNLLDAWRVPLKVSAELLMSIRL--------PPKLKQNEVA 840

  Fly  2054 AFQQEQLPEQIVCVEYPTTTKPPKVI-------FSQVADAEALKKAVLILGGIVVDSPADATHLV 2111
            ..|......:|..|..||....|::.       |..|...:.:|| :.||||.|.:|....|||:
Human   841 NVQPSSKRARIEDVPPPTKKLTPELTPFVLFTGFEPVQVQQYIKK-LYILGGEVAESAQKCTHLI 904

  Fly  2112 MTRESRTCKLIQACCHVDYVLKSSWIADSAKAGKFVPTDPYRIQHIPVDENLQFNLNTVLCAPTR 2176
            .::.:||.|.:.|...|.:::...|:.:..:..||:....|.::....:....|:|...|.....
Human   905 ASKVTRTVKFLTAISVVKHIVTPEWLEECFRCQKFIDEQNYILRDAEAEVLFSFSLEESLKRAHV 969

  Fly  2177 STLFAGKYFHVTPDVFPAREEIIRMIESSGGKVEPKRRSGASVAETHMQ--APDSYIIVTCPTDM 2239
            |.||..|||::||.:.|:...:..::|.:||||..|:.|...:.| |.|  :....|:::|..|:
Human   970 SPLFKAKYFYITPGICPSLSTMKAIVECAGGKVLSKQPSFRKLME-HKQNSSLSEIILISCENDL 1033

  Fly  2240 HLCADLTRHGNPKCHIVSTEFVMSSILRQQLEIEPNLIPYLYN 2282
            |||.:....|   ..:.:.|||::.:|.|.|:.|    .|.:|
Human  1034 HLCREYFARG---IDVHNAEFVLTGVLTQTLDYE----SYKFN 1069

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PtipNP_729947.2 BRCT 9..77 CDD:214602
BRCT 96..174 CDD:278934
BRCT 1814..1887 CDD:237994 28/74 (38%)
PTCB-BRCT 1914..1976 CDD:289507 29/61 (48%)
BRCT <2087..2142 CDD:237994 17/54 (31%)
BRCT 2175..2265 CDD:278934 29/91 (32%)
PAXIP1NP_031375.3 Interaction with PAGR1. /evidence=ECO:0000250 94..183
PTCB-BRCT 102..165 CDD:289507
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 188..271 11/94 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 428..494 37/162 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 543..592 24/72 (33%)
Interaction with TP53BP1 590..1069 161/498 (32%)
BRCT 601..677 CDD:278934 29/75 (39%)
Nuclear localization signal. /evidence=ECO:0000255 702..719 6/19 (32%)
PTCB-BRCT 710..771 CDD:289507 29/60 (48%)
BRCT 869..935 CDD:237994 19/66 (29%)
BRCT 970..1053 CDD:214602 28/86 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 66 1.000 Domainoid score I10000
eggNOG 1 0.900 - - E1_KOG2043
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0004880
OrthoInspector 1 1.000 - - oto90283
orthoMCL 1 0.900 - - OOG6_105904
Panther 1 1.100 - - LDO PTHR23196
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R145
SonicParanoid 1 1.000 - - X3992
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1110.800

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