Protein Alignment Ptip and PAXIP1

DIOPT Version :10

• Sequence 1: NP_729947.2
• Gene: Ptip / 39552
• FlyBaseID: FBgn0052133
• Length: 2294
• Species: Drosophila melanogaster
• Sequence 2: NP_031375.3
• Gene: PAXIP1 / 22976
• HGNCID: 8624
• Length: 1069
• Species: Homo sapiens
• Alignment Length: 1148
• Identity: 306/1148 - (26%)
• Similarity: 475/1148 - (41%)
• Gaps: 287/1148 - (25%)

  Fly  1158 LMQKQQQQQQQQQQQQQQQQQQQQQQLVGQQQQQILIQQQQTPQQQQILQQKLSNDNQQQQIMQL 1222
            ::.::::::::::::.:.::|..|.:....::......|:.:|...|....|.:.:..:.::|..
Human   186 IIYEEEEEEEEEEEEVENEEQDSQNEGSTDEKSSPASSQEGSPSGDQQFSPKSNTEKSKGELMFD 250

  Fly  1223 ITQQQLPQRTPPPQQQQQQQLLLQQQQQSPQHHPQMQQQHWSPQSPAGGQMASSTPGTPTSVGMQ 1287
            .:....|::       |::.|     ..:|...||:...  ..:.|.|.:     ||........
Human   251 DSSDSSPEK-------QERNL-----NWTPAEVPQLAAA--KRRLPQGKE-----PGLINLCANV 296

  Fly  1288 SPLPGGPTTPQPQPQQQFVPRGLRPQTSWPGQPQQQQPQPTQQQQQIVLPPPQQQQPQQQQQHLG 1352
            .|:||           ..:|..:|......|    |..|.:::.:.|....|..:..:....:..
Human   297 PPVPG-----------NILPPEVRGNLMAAG----QNLQSSERSEMIATWSPAVRTLRNITNNAD 346

  Fly  1353 QQQQLVMQQPQQQKIVVDEKTHAHLMSLDAHKRAEYITKLNQQNKPRVMLRQQVAYQPRPGAPGS 1417
            .||   |.:|...         ||:              |...:.|...|.|||.:..:.....:
Human   347 IQQ---MNRPSNV---------AHI--------------LQTLSAPTKNLEQQVNHSQQGHTNAN 385

  Fly  1418 IVATRPAGPVPPGHIIVQHQMPPGLTQQQQVLWLQQQQGKRQVVVRAGTPGLSPIQQQPGAGPQQ 1482
            .|........|..|::.|.|......||..||.||.||             :..:|||     ||
Human   386 AVLFSQVKVTPETHMLQQQQQAQQQQQQHPVLHLQPQQ-------------IMQLQQQ-----QQ 432

  Fly  1483 QQQSPQQQPFNPNDPNQQMLMQRQQLRVQQIPIQQQGPQQLGKQTVQLITGPNGQLIEQQTIVQQ 1547
            ||.|.|..|..|..|..|  .|:||        ||..|.|..:|.:|.
Human   433 QQISQQPYPQQPPHPFSQ--QQQQQ--------QQAHPHQFSQQQLQF----------------- 470

  Fly  1548 PQQQSAPGTPTTPGAGGVLPGNANIMTQTLVMTSTTPDGQPQQSPQQMNLKTKTALANMLSNRLG 1612
            ||||..|                                     |||::
Human   471 PQQQLHP-------------------------------------PQQLH---------------- 482

  Fly  1613 NNGAQTPQQQIIQLPDGQQPQQQQIVQQVVVTGAIQQQQQQLLLQQQQQQQQQQQMVVQQQLPPQ 1677
                 .||||:       ||.|||        .|:|||..||     ||.|.|||.:.|.|
Human   483 -----RPQQQL-------QPFQQQ--------HALQQQFHQL-----QQHQLQQQQLAQLQ---- 518

  Fly  1678 QHVEPPSAAGALRMMGQQHNATAGVPGPPRTQQELLMLQQQQQQQLLQQQQMRRVVALPQQQQAP 1742
                            |||:                :|||||||| :||||::|:....||||..
Human   519 ----------------QQHS----------------LLQQQQQQQ-IQQQQLQRMHQQQQQQQMQ 550

  Fly  1743 QQ---HLVQQ----QIVVAPTQSPQQQQQMAVGVGVGVPVQRTPHGYIQTRPGQQPIPMP---QF 1797
            .|   ||.|.    |..|.|.|.||||||                        |||.|.|   |.
Human   551 SQTAPHLSQTSQALQHQVPPQQPPQQQQQ------------------------QQPPPSPQQHQL 591

  Fly  1798 YGHNPNLKLPADLFLVGCTFYIVEYDETDGDE--LPIWLDTIRQFGGDIERVYCPRVTHVICRTQ 1860
            :||:|.:::|.:.||:||.|.|.:|.|...|:  |..|...|:..||.::..:..|.||::|.:|
Human   592 FGHDPAVEIPEEGFLLGCVFAIADYPEQMSDKQLLATWKRIIQAHGGTVDPTFTSRCTHLLCESQ 656

  Fly  1861 RHGVVMQALRDAKRCVTAYWLSDICLKRQLMPPWQPLHLP--FPSQFGYRKPLERYIITSEGFEG 1923
            ......||:|:.||||||:||:.:..|::::||.:.||.|  ||..   .||..::||:..||..
Human   657 VSSAYAQAIRERKRCVTAHWLNTVLKKKKMVPPHRALHFPVAFPPG---GKPCSQHIISVTGFVD 718

  Fly  1924 EEVVRLQQMAEECGAIYTSYLSKVNTVVVCKQLEGNKFNAAKEWNIPMVNALWLSDVCIGNLSGL 1988
            .:...|:.||...||.||.||.:.|||::||:..|.|:..||||.||.|||.||.|:.:||...|
Human   719 SDRDDLKLMAYLAGAKYTGYLCRSNTVLICKEPTGLKYEKAKEWRIPCVNAQWLGDILLGNFEAL 783

  Fly  1989 SQYENPKYQQYNLVAPFRIECNLVAHLLTAWKAPINLTQEAHERVKRHLSDPYGNEQKLKRQKMN 2053
            .|.:..:|..::|..||....:||.:||.||:.|:.::.|....::.        ..|||:.::.
Human   784 RQIQYSRYTAFSLQDPFAPTQHLVLNLLDAWRVPLKVSAELLMSIRL--------PPKLKQNEVA 840

  Fly  2054 AFQQEQLPEQIVCVEYPTTTKPPKVI-------FSQVADAEALKKAVLILGGIVVDSPADATHLV 2111
            ..|......:|..|..||....|::.       |..|...:.:|| :.||||.|.:|....|||:
Human   841 NVQPSSKRARIEDVPPPTKKLTPELTPFVLFTGFEPVQVQQYIKK-LYILGGEVAESAQKCTHLI 904

  Fly  2112 MTRESRTCKLIQACCHVDYVLKSSWIADSAKAGKFVPTDPYRIQHIPVDENLQFNLNTVLCAPTR 2176
            .::.:||.|.:.|...|.:::...|:.:..:..||:....|.::....:....|:|...|.....
Human   905 ASKVTRTVKFLTAISVVKHIVTPEWLEECFRCQKFIDEQNYILRDAEAEVLFSFSLEESLKRAHV 969

  Fly  2177 STLFAGKYFHVTPDVFPAREEIIRMIESSGGKVEPKRRSGASVAETHMQ--APDSYIIVTCPTDM 2239
            |.||..|||::||.:.|:...:..::|.:||||..|:.|...:.| |.|  :....|:::|..|:
Human   970 SPLFKAKYFYITPGICPSLSTMKAIVECAGGKVLSKQPSFRKLME-HKQNSSLSEIILISCENDL 1033

  Fly  2240 HLCADLTRHGNPKCHIVSTEFVMSSILRQQLEIEPNLIPYLYN 2282
            |||.:....|   ..:.:.|||::.:|.|.|:.|    .|.:|
Human  1034 HLCREYFARG---IDVHNAEFVLTGVLTQTLDYE----SYKFN 1069

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptip	NP_729947.2	BRCT_PAXIP1_rpt1	11..87	CDD:349346
		BRCT_PAXIP1_rpt2	100..181	CDD:349342
		BRCT_PAXIP1_rpt3	1814..1893	CDD:349343	29/80 (36%)
		BRCT_PAXIP1_rpt4	1914..1986	CDD:349362	34/71 (48%)
		BRCT_PAXIP1_rpt5	2075..2147	CDD:349344	21/78 (27%)
		BRCT_PAXIP1_rpt6	2179..2271	CDD:349393	30/93 (32%)
PAXIP1	NP_031375.3	BRCT_PAXIP1_rpt1	13..87	CDD:349346
		Interaction with PAGR1. /evidence=ECO:0000250	94..183
		BRCT_PAXIP1_rpt2	98..178	CDD:349342
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	188..271		11/94 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	428..494		37/162 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	543..592		24/72 (33%)
		Interaction with TP53BP1	590..1069		161/498 (32%)
		BRCT_PAXIP1_rpt3	608..689	CDD:349343	29/80 (36%)
		Nuclear localization signal. /evidence=ECO:0000255	702..719		6/19 (32%)
		BRCT_PAXIP1_rpt4	709..781	CDD:349362	34/71 (48%)
		BRCT_PAXIP1_rpt5	866..940	CDD:349344	20/74 (27%)
		BRCT_PAXIP1_rpt6	972..1062	CDD:349393	30/93 (32%)