DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment upSET and SETD1A

DIOPT Version :9

Sequence 1:	NP_001261819.1	Gene:	upSET / 39551	FlyBaseID:	FBgn0036398	Length:	3146	Species:	Drosophila melanogaster
Sequence 2:	NP_055527.1	Gene:	SETD1A / 9739	HGNCID:	29010	Length:	1707	Species:	Homo sapiens

Alignment Length:	1835	Identity:	329/1835 - (17%)
Similarity:	573/1835 - (31%)	Gaps:	592/1835 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   889 NIPEEYMCELCQPRAVDKARARALQRQKRKEHMLL--VATQAANGAAAVAAGTTLSGGLGSGLPM 951
            |:.|.::.::|: :..:......|...:.::|:.|  |...:..||........|:..:|:.:..
Human   104 NVRETFLKDMCR-KYGEVEEVEILLHPRTRKHLGLARVLFTSTRGAKETVKNLHLTSVMGNIIHA 167

  Fly   952 SEEL--QHRLASG---LNGGF---ATGTGMSKKSKKTKENSGSTSTLKKTKKS------------ 996
            ..::  |.|:...   :||.:   ...||....|:|.:.:..:|.|.:..::|
Human   168 QLDIKGQQRMKYYELIVNGSYTPQTVPTGGKALSEKFQGSGAATETAESRRRSSSDTAAYPAGTT 232

  Fly   997 AVGMGGEKNASGSGTPTGSSGKTSKKSSKRKSKSG----------GDGSSGGGSSPALTAAEKHA 1051
            |||      ..|:|||  .|..||..||::.:.|.          |...:..||:|
Human   233 AVG------TPGNGTP--CSQDTSFSSSRQDTPSSFGQFTPQSSQGTPYTSRGSTP--------- 280

  Fly  1052 ANLRQWIENYEYAVTNHYSPELRARLHAIQKQPSLLQSIQNTENKALRQIQQQLSTAGSAEQLEQ 1116
                       |:..:.||....:.....::..:   |.|:..::.........:||.:|.....
Human   281 -----------YSQDSAYSSSTTSTSFKPRRSEN---SYQDAFSRRHFSASSASTTASTAIAATT 331

  Fly  1117 RAQLIPYAGAKVLISSVDLSPHAPIHELRGKYMLTTQFRTQNPTVNMNTPPPSNYLNSFKAHKTP 1181
            .|.....|.:..|.||...|..:.          ::|||:.    :.|.|......|.::.|.:
Human   332 AATASSSASSSSLSSSSSSSSSSS----------SSQFRSS----DANYPAYYESWNRYQRHTS- 381

  Fly  1182 GQFVFFYQLPGVEAPMQTLRPDGSVPQVAQQPPSYLKGPEVCVDTRTYGNDARFVRRSCRPNAEL 1246
                        ..|.:..|         ::||.                         .|.||
Human   382 ------------YPPRRATR---------EEPPG-------------------------APFAE- 399

  Fly  1247 QHYFEKGTLHLYIVALTHIRAQTEITIRHEPHDLTAVEQKKSHAAVIQPTSTRCACDMGSDCLFA 1311
                                             .||.....|:.:.:.|..:|     .:|..:.
Human   400 ---------------------------------NTAERFPPSYTSYLPPEPSR-----PTDQDYR 426

  Fly  1312 LPLAVQQQLQAPPTQP-------------------RSSHRNKAAAAAAAAAAANSAAAIQLTMGL 1357
            .|.:     :|||.:|                   |:|.|..:.|.:.:.|...:..::......
Human   427 PPAS-----EAPPPEPPEPGGGGGGGGPSPEREEVRTSPRPASPARSGSPAPETTNESVPFAQHS 486

  Fly  1358 GVGATVAAGASVLPNSRNR------STSSSGESSQMGLNSPQLGQLNLGFKTSVTATS-----LT 1411
            .:.:.:   ..:|...|::      .|....|:|.|.|.:...|       :.|.:.|     ..
Human   487 SLDSRI---EMLLKEQRSKFSFLASDTEEEEENSSMVLGARDTG-------SEVPSGSGHGPCTP 541

  Fly  1412 APVPG----VHCNNSG--GSSSSSNNSCSVSMSSVLHDSGICTSSSSPSVS------IPSPTPTQ 1464
            .|.|.    |....||  |::..|..:...:.:|.      |:|.....:|      .|.|.||.
Human   542 PPAPANFEDVAPTGSGEPGATRESPKANGQNQASP------CSSGDDMEISDDDRGGSPPPAPTP 600

  Fly  1465 MQSPTLQQHPQQIPQQQLSLLQRSPTQQHQQQILAALPTPMLTPMLSPQLPKPAQQQAHVV---- 1525
            .|.|.....|...|...|:.|... ...||...|.. |.|...|  .|:.|.|.....|:.
Human   601 PQQPPPPPPPPPPPPPYLASLPLG-YPPHQPAYLLP-PRPDGPP--PPEYPPPPPPPPHIYDFVN 661

  Fly  1526 --------------LPQSQQTSLLQQQQSQQSQEPLAVIAAAAAAQQPMATY---FVRQPQQQQQ 1573
                          :|.|.|.......:..|.::...:|||:|.  .|...:   |:..|..|:.
Human   662 SLELMDRLGAQWGGMPMSFQMQTQMLTRLHQLRQGKGLIAASAG--PPGGAFGEAFLPFPPPQEA 724

  Fly  1574 QQSPKPQALVAQQQHVVGAQQQQHF-----LQQQQKQQQQQMADEARM------AVSALQTLHAA 1627
            ... .|.||.||.|...||..::.:     :..:.........:|||:      .::..:||
Human   725 AYG-LPYALYAQGQEGRGAYSREAYHLPMPMAAEPLPSSSVSGEEARLPPREEAELAEGKTL--- 785

  Fly  1628 PTSHIVSPIKVAAVQQQSQPQQQQQNTHQQPHNQQAVQQQS----NQLQQQQSQQPNYPQSPQRQ 1688
            ||:..|..:....|       |:.::..|:..|::.|:..:    :|..:.:.::....|:..:|
Human   786 PTAGTVGRVLAMLV-------QEMKSIMQRDLNRKMVENVAFGAFDQWWESKEEKAKPFQNAAKQ 843

  Fly  1689 QKPQPVQHQPQIVISTGAQAIPATMPTKLSSP--------TKSAAPVISNNNITVSAQSSVVGG- 1744
            |..:..:.:                 |||..|        .||.    ....|...|..|.:.|
Human   844 QAKEEDKEK-----------------TKLKEPGLLSLVDWAKSG----GTTGIEAFAFGSGLRGA 887

  Fly  1745 ---------KKTPAKHPQQQQQQQQQPVTPVSAATAPAATPSSSESKEDD----VSASSTTTPTT 1796
                     :|.|::..:..::::.:|.||             :|..|||    ..|.....|.|
Human   888 LRLPSFKVKRKEPSEISEASEEKRPRPSTP-------------AEEDEDDPEQEKEAGEPGRPGT 939

  Fly  1797 RTPAKDKPKQSREDRKLEAILRAIEKMEKQEARGKKDTRQSSGGKRQASNSPASPNKRNSSNSIS 1861
            :.|.:|                  |:..|.:.:.:|.....|.|: :||...:|...........
Human   940 KPPKRD------------------EERGKTQGKHRKSFALDSEGE-EASQESSSEKDEEDDEEDE 985

  Fly  1862 EDVETPTSTNSAAAAAQRRNKKKRKVSRSLNNNTNGLGSGGGSNNKRRKSIVVESDGESHALTNS 1926
            ||.:...:.::        .||:.:||.         |....|::..:.|:..:||||:.:.::|
Human   986 EDEDREEAVDT--------TKKETEVSD---------GEDEESDSSSKCSLYADSDGENDSTSDS 1033

  Fly  1927 ESEDQGQHPQSHHSGSEDQAAGLLLALAHNNSSPNE---------PFKSPLSQSHSLPATPASVS 1982
            ||........|..|.|...::    :.:..:||.:|         |..||..:...:| |||.|.
Human  1034 ESSSSSSSSSSSSSSSSSSSS----SSSSESSSEDEEEEERPAALPSASPPPREVPVP-TPAPVE 1093

  Fly  1983 SACLLIEAAMG----PLQQQPA-------PASASPSLAEFK--YPPGGAKTKKSLMSSWFQQAEQ 2034
            ..  :.|...|    ||.:|.|       |...||..|..:  .||.|.....       .:.::
Human  1094 VP--VPERVAGSPVTPLPEQEASPARPAGPTEESPPSAPLRPPEPPAGPPAPA-------PRPDE 1149

  Fly  2035 QHASGLDSL---------VQAAMSEINGEREQLQRQPQGESLPAPALLKVEQFIHQAESTTAVPA 2090
            :.:|.:..|         |..:..|:....|.....|.....|.||..|..:.:.
Human  1150 RPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPPPATPPQAKFPGPASRKAPRGVE---------- 1204

  Fly  2091 REQLHLPLQNNSSVKKRWL---------------RQAISEETTPVDELQQSQNQSVTATPSPQPV 2140
            |...:||| :::|:.|.|.               |....||..|..|:..:....:..||:.:.:
Human  1205 RTIRNLPL-DHASLVKSWPEEVSRGGRSRAGGRGRLTEEEEAEPGTEVDLAVLADLALTPARRGL 1268

  Fly  2141 PTVSPLANGFSTPLKKRRLVVVSNGTNVESDETHIDVIGEPKDEAEENVAMTELKVEIENHHQEQ 2205
            |.:..:.:..:|                           |..||||.
Human  1269 PALPAVEDSEAT---------------------------ETSDEAER------------------ 1288

  Fly  2206 DDDVDILRSPSPGTHQIVAEDN-LVKIEPEDTSAA---ADDVKIDVEREESQACDKFEEMVKVKR 2266
                     |.|....|:.|.| .:.::|...:.|   .:.|........|.|.:..|....|..
Human  1289 ---------PRPLLSHILLEHNYALAVKPTPPAPALRPPEPVPAPAALFSSPADEVLEAPEVVVA 1344

  Fly  2267 EEEEQREKEIKQLQERQEHEQPKVEPAPVEPKLENTVAKAEPKVEPSQEIVSKKEPTKVEPKPGE 2331
            |.||.:.::::|.:|..|.|..:               :.|.:.|.|.:..|..:        ||
Human  1345 EAEEPKPQQLQQQREEGEEEGEE---------------EGEEEEEESSDSSSSSD--------GE 1386

  Fly  2332 SLLRSTATVTATPTAATIAATTLLDVSKVAFKTRPPLKLEDEPQKKKPKLESILPAPVATVPPVS 2396
            ..||..:                               |....::::|             ||..
Human  1387 GALRRRS-------------------------------LRSHARRRRP-------------PPPP 1407

  Fly  2397 VPPIPAASNATTSAVTNTAAASLTTTTAPS---STKNLTEHDIQERLLSFHAANISYLQSRNKKA 2458
            .||.|.|....:.....|....:..:...|   |...||    .||||. ..:...:|...:...
Human  1408 PPPPPRAYEPRSEFEQMTILYDIWNSGLDSEDMSYLRLT----YERLLQ-QTSGADWLNDTHWVH 1467

  Fly  2459 TAALTSASPSQKSNSSSG--GSGTESKKSSKDKDEKRDKEKQLKKSKKEKKKSKD----KEKQKA 2517
            .......:|.:|.....|  ...|.|.:|          |.....|||||.|..|    ..:|..
Human  1468 HTITNLTTPKRKRRPQDGPREHQTGSARS----------EGYYPISKKEKDKYLDVCPVSARQLE 1522

  Fly  2518 AVNVNSTSQIVDTKK 2532
            .|:...|::::..::
Human  1523 GVDTQGTNRVLSERR 1537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
upSET	NP_001261819.1	PHD_MLL5	856..899	CDD:277025	2/9 (22%)
upSET	NP_001261819.1	SET	<1221..1273	CDD:214614	3/51 (6%)
SETD1A	NP_055527.1	RRM_Set1A	92..186	CDD:240992	13/82 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	194..308		29/144 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	331..363		9/45 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	381..486		23/195 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	506..655		38/165 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	834..854		3/36 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	891..1251		86/433 (20%)
		DNA_pol3_delta2	<1070..>1130	CDD:331068	17/62 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1264..1293		9/82 (11%)
		HCFC1-binding motif (HBM)	1299..1303		2/3 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1307..1417		30/176 (17%)
		Interaction with CFP1	1415..1450		6/38 (16%)
		N-SET	1425..1562	CDD:314603	27/128 (21%)
		Interaction with ASH2L, RBBP5 and WDR5. /evidence=ECO:0000269\|PubMed:17998332	1450..1537		20/97 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1472..1499		7/36 (19%)
		WDR5 interaction motif (WIN). /evidence=ECO:0000269\|PubMed:22266653, ECO:0000269\|PubMed:22665483	1492..1497		2/14 (14%)
		SET	1568..1691	CDD:214614
		PostSET	1691..1707	CDD:214703
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030