Protein Alignment upSET and SET1

DIOPT Version :9

• Sequence 1: NP_001261819.1
• Gene: upSET / 39551
• FlyBaseID: FBgn0036398
• Length: 3146
• Species: Drosophila melanogaster
• Sequence 2: NP_011987.1
• Gene: SET1 / 856519
• SGDID: S000001161
• Length: 1080
• Species: Saccharomyces cerevisiae
• Alignment Length: 1229
• Identity: 234/1229 - (19%)
• Similarity: 390/1229 - (31%)
• Gaps: 376/1229 - (30%)

  Fly  1837 SSGGKRQASNSPASPNKRNSSNSISEDVETPTSTNSAAAAAQRRNKKKRKVSRSLNNNTNGLGSG 1901
            |||..||....|......:...|.....:..:|..:     |||.......:|...|:..    .
Yeast    11 SSGSYRQPQEQPQYSRSGHYQYSNGHSHQQYSSQYN-----QRRRYNHNDGTRRRYNDDR----P 66

  Fly  1902 GGSNNKRRKSIVVESDGESHALTNSESEDQGQH--PQSHHSGSEDQAAGLLLALAHNNSSPNEPF 1964
            ..|||...:.....::.:|....|.:|:...:.  .||.:|.|.          .||..:
Yeast    67 HSSNNASTRQYYATNNSQSGPYVNKKSDISSRRGMSQSRYSNSN----------VHNTLA----- 116

  Fly  1965 KSPLSQSHSLPATPASVSSACLLIEAAMGPLQQQPAPASASPSL---------AEFKY--PPGGA 2018
                |.|.|||     ..||.|        |||:|      ||:         ::|.|  |..|.
Yeast   117 ----SSSGSLP-----TESALL--------LQQRP------PSVLRYNTDNLKSKFHYFDPIKGE 158

  Fly  2019 KTKKSLMSSWFQQAEQQHASGLDSLVQAAMSEINGEREQLQRQPQGESLPAPALLKVEQFIHQAE 2083
            ...|..|.||  :|..:..|.....|...:.:...:.:...|.|:           ::....:.|
Yeast   159 FFNKDKMLSW--KATDKEFSETGYYVVKELQDGQFKFKIKHRHPE-----------IKASDPRNE 210

  Fly  2084 STTAVPAREQLHLPLQNNSSVKKRWLRQAISEETTPVDELQQSQNQSVTATPSPQPVPTVSPLAN 2148
            :......:...|...:|:..:..|     ||.:           ..|:...||.:.|  |.|..:
Yeast   211 NGIMTSGKVATHRKCRNSLILLPR-----ISYD-----------RYSLGPPPSCEIV--VYPAQD 257

  Fly  2149 GFSTPLKKRRLVVVSNGTNVESDETHIDVIGEPKDEAEENVAMTELKVEIENHHQEQDDDVDILR 2213
            ..:|.::.   :.:.|......:.:|.:...:|......:|.:.:        :...|..::
Yeast   258 STTTNIQD---ISIKNYFKKYGEISHFEAFNDPNSALPLHVYLIK--------YASSDGKIN--- 308

  Fly  2214 SPSPGTHQIVAEDNLVKIEPEDTSAAADDVKIDVEREESQAC----DKFEEMVK----VKREEEE 2270
                                 |.:.||...   |.:.||..|    .|||.::.    :.....:
Yeast   309 ---------------------DAAKAAFSA---VRKHESSGCFIMGFKFEVILNKHSILNNIISK 349

  Fly  2271 QREKEIKQLQERQEH-EQPKVEPAPVEPKLENTVAKAEPKVEPSQEIVSKKEPTKVEPKPGESLL 2334
            ..|..:|:||:.||: ::.|      |.:.||         |.::|:..|......|||. ::|.
Yeast   350 FVEINVKKLQKLQENLKKAK------EKEAEN---------EKAKELQGKDITLPKEPKV-DTLS 398

  Fly  2335 RSTATVTATP--TAATIAATTLLDVSKVAFKTRPPLKLEDEPQKKKPKLESILPAPVATVPPVSV 2397
            .|:.:....|  ....:....:|.|||: |..:....:||    .|.||.....|.....|
Yeast   399 HSSGSEKRIPYDLLGVVNNRPVLHVSKI-FVAKHRFCVED----FKYKLRGYRCAKFIDHP---- 454

  Fly  2398 PPIPAASNATTSAVTNTAAASLTTTTAPSSTKNLTEHDIQER---LLSFHAANISYLQSRNKKAT 2459
                    .....:.|..|.:.|.:.|.|.  |||......|   |:.||.. :...|:|.:
Yeast   455 --------TGIYIIFNDIAHAQTCSNAESG--NLTIMSRSRRIPILIKFHLI-LPRFQNRTR--- 505

  Fly  2460 AALTSASPSQKSNSSSGGSGTESKKSSKDKDEKRDKEKQLKKSKKEKKKSKDKEKQKAAVNVNST 2524
                    ..||:|||..:....|..|        ||:.::.:.|:..|..:|...
Yeast   506 --------FNKSSSSSNSTNVPIKYES--------KEEFIEATAKQILKDLEKTLH--------- 545

  Fly  2525 SQIVDTKKKTTQPSKPDSKSSIAPVLVPPSLPVATANGKTKHTAYNN-------VDQQQQQQMRR 2582
               ||.||:...|:..|:       |...:.|...|..:.|......       .|:.::::..:
Yeast   546 ---VDIKKRLIGPTVFDA-------LDHANFPELLAKRELKEKEKRQQIASKIAEDELKRKEEAK 600

  Fly  2583 RTMSMCITPVTPTPVVTPSPLHGTPPSTKKRQTNFEQELTKPNSQILSSSILLNSSKGLGL-PLA 2646
            |...:             ..|:|....:.||      .|.:.||..|..:.|.......|: |:|
Yeast   601 RDFDL-------------FGLYGGYAKSNKR------NLKRHNSLALDHTSLKRKKLSNGIKPMA 646

  Fly  2647 APTVVSVPTAVQQQQH--RKENNHQEATPASGGPMSLAAAIASGKLNAISRRRESMCGSRQQQAL 2709
                           |  .:|.:.:|.||                ||
Yeast   647 ---------------HLLNEETDSKETTP----------------LN------------------ 662

  Fly  2710 IAAALKKEKKEKKKSKKKDREKQKHDKQKGKEKEREKDKEKDNKQKTNHIQKPAHPTTVPANSMP 2774
                   ::...:.||:.|.|.:.......:|:|.|...:|        .:..:.|||..::.:.
Yeast   663 -------DEGITRVSKEHDEEDENMTSSSSEEEEEEAPDKK--------FKSESEPTTPESDHLH 712

  Fly  2775 ISAPAPVP-------VLVPTPVTTPKAAPIPVLITQPTPSPIHVTQPLVNNCSTKVASLPFYNTI 2832
            ...|. ||       ||..:.:..|.|..||..:..|....:..:|.|        :|:...|.|
Yeast   713 GIKPL-VPDQNGSSDVLDASSMYKPTATEIPEPVYPPEEYDLKYSQTL--------SSMDLQNAI 768

  Fly  2833 YGKLQDPSTPTSSPIPVTNTMPSLAEYLESTKSKTTALSAVKPIGIAAVTPLSSAITPAKVAPSS 2897
            ..:               ..|..|.:.| ||.:.|             |||.:||....|:..|.
Yeast   769 KDE---------------EDMLILKQLL-STYTPT-------------VTPETSAALEYKIWQSR 804

  Fly  2898 ---LEMPPPATTPLKLYTRTASHDPRLNP--------MLTVPDPTPMPKRKLSISEYRMR-HRPS 2950
               ||....:...::|  .....|..|.|        ...:.|     |.|::...:|.| |:|.
Yeast   805 RKVLEEEKASDWQIEL--NGTLFDSELQPGSSFKAEGFRKIAD-----KLKINYLPHRRRVHQPL 862

  Fly  2951 VDTAPTTPTTPTTPTTPTTPPGSNKDRSFAKPQTI--NKCSLQSPERFQAAIRERRNSI 3007
            ............||........|||:.|.:.||.:  ::.:..|..|||..|..::.:|
Yeast   863 NTVNIHNERNEYTPELCQREESSNKEPSDSVPQEVSSSRDNRASNRRFQQDIEAQKAAI 921

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
upSET	NP_001261819.1	PHD_MLL5	856..899	CDD:277025
		SET	<1221..1273	CDD:214614
SET1	NP_011987.1	RRM_scSet1p_like	246..360	CDD:409743	24/153 (16%)
		SET_assoc	422..486	CDD:403081	19/82 (23%)
		SET	612..1080	CDD:225491	83/425 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030