DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment upSET and CTI6

DIOPT Version :9

Sequence 1:	NP_001261819.1	Gene:	upSET / 39551	FlyBaseID:	FBgn0036398	Length:	3146	Species:	Drosophila melanogaster
Sequence 2:	NP_015144.1	Gene:	CTI6 / 855920	SGDID:	S000006102	Length:	506	Species:	Saccharomyces cerevisiae

Alignment Length:	389	Identity:	93/389 - (23%)
Similarity:	153/389 - (39%)	Gaps:	67/389 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   820 SAISSSSRMGLASTDIDPGEETETAPEAEAEDDSVTRCIC---ELTHDDGYMICCDKCSAWQHVD 881
            :||.|.....:...|: |.|..|...|   |::..|||||   :...|.|:.|.|::||:|||..
Yeast    42 AAIGSVQEESVKQEDV-PMEGGEGEVE---EEEGETRCICGELDTPDDSGFFIQCEQCSSWQHGY 102

  Fly   882 CMGIDRQNIPEEYMCELCQPR-----AVDKARARAL-------QRQKRKEHMLLVATQ--AANGA 932
            |:.|.:.|.|::|.||.|:|.     ..|...||::       :||.|::.....|::  |||.|
Yeast   103 CVSITQDNAPDKYWCEQCRPELHQLFTTDTGEARSIYKPVQEKRRQSRRKARSAAASKSHAANEA 167

  Fly   933 AAVAAGTTLSGGLGSGLPMSEELQHRLASGLNGGFATGTGMSKKSKKTKENS------------- 984
            ......|:.:......:...|:.....||.:   .....|.::.|::.:.||
Yeast   168 EKSPRNTSNTDDNVDDIGDEEDEVEDEASAV---ALAKDGNTRSSRRRRRNSMDDASTDQYSLDP 229

  Fly   985 GSTSTLKKTKKSAVGMGGEKNASGSGTPTG--SSGKTSKKSSKRKSKSGGDGSSGGGSSPALTAA 1047
            |.:......:|.|..|..|:..........  .|.:||.:......::..|...|.        .
Yeast   230 GDSDKKLLDRKRATFMAREEKQYQRMLEKALKESRRTSHQEDPESYENDADIYQGD--------T 286

  Fly  1048 EKHAANLR-----QWIENYEYAVTNHYSPELRARLHAIQKQPSLLQSIQNTENKALRQIQQQLST 1107
            :.|....|     ...|....:|||   .:::..|     :||..||::.|.:......|::.|:
Yeast   287 DNHNGTTRLQTDVMLTEGKPDSVTN---DDMKESL-----RPSKEQSMEKTNDVEKEASQEKESS 343

  Fly  1108 AGSAEQLEQRAQ-LIPYAGAKVLISSVDLSPHAPIHELRGKYMLTTQFRTQNPTVNMNTPPPSN 1170
            .|||:..|:..: ::|...   :.||.|.|..|   ..||...::...|..|.|...||...:|
Yeast   344 TGSAQDTEKTDEPILPLTS---ISSSEDDSRKA---SSRGSKRVSKPARKGNRTRRSNTSSDTN 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
upSET	NP_001261819.1	PHD_MLL5	856..899	CDD:277025	20/45 (44%)
upSET	NP_001261819.1	SET	<1221..1273	CDD:214614
CTI6	NP_015144.1	PHD_MLL5	74..120	CDD:277025	20/45 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1844
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.930