DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment upSET and SET4

DIOPT Version :9

Sequence 1:	NP_001261819.1	Gene:	upSET / 39551	FlyBaseID:	FBgn0036398	Length:	3146	Species:	Drosophila melanogaster
Sequence 2:	NP_012430.1	Gene:	SET4 / 853339	SGDID:	S000003641	Length:	560	Species:	Saccharomyces cerevisiae

Alignment Length:	547	Identity:	104/547 - (19%)
Similarity:	171/547 - (31%)	Gaps:	195/547 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   811 RSQADDDAHSAISSSSRMGLASTDIDPGEETETAPEAEAEDDSVTR-CICELTHD-DGYMICCDK 873
            :.|..|| :|.:|        .|..:..:|.:..|...|||:.... |||..:.. |...|.|:|
Yeast   125 KKQNQDD-NSKVS--------VTHNESSKENKITPSMRAEDNKPKNGCICGSSDSKDELFIQCNK 180

  Fly   874 CSAWQHVDCMGIDRQN-IPEEYMCELCQPRA---VDKARARALQRQKRKEHML----LVATQAAN 930
            |..|||..|....:.: |..:::|:.|....   |::.:.....|:...|.:.    :|.|.|:|
Yeast   181 CKTWQHKLCYAFKKSDPIKRDFVCKRCDSDTKVQVNQVKPMIFPRKMGDERLFQFSSIVTTSASN 245

  Fly   931 GAAAVAAGTTLSGGLGSGLPMSEELQHRLASGLNGGFATGTGMSKKSKK--------TKENSGST 987
                                   ..||:  ..:|       .:.::.||        |.|||.|.
Yeast   246 -----------------------TNQHQ--QSVN-------NIEEQPKKRQLHYTAPTTENSNSI 278

  Fly   988 STLKKTKKSAVGMGGEKNASGSGTPTGSSGKTSKKSSKRKSKSGGDGSSGGGSSPALTAAEKHAA 1052
            ....:.:|..|.....|.....   ..||..|..|                    |:|.:|....
Yeast   279 RKKLRQEKLVVSSHFLKPLLNE---VSSSNDTEFK--------------------AITISEYKDK 320

  Fly  1053 NLRQWIENY---EYAVTNHYSPELRARLHAIQKQPSLLQSIQNTENKALRQIQQQLSTAGSAEQL 1114
            .::.:|:|:   ::.|.:::.....|.:..               .|:..:....:..|.|..:.
Yeast   321 YVKMFIDNHYDDDWVVCSNWESSRSADIEV---------------RKSSNERDFGVFAADSCVKG 370

  Fly  1115 EQRAQLIPYAGAKVLISSVDLSPHAPIHELRGKYMLTTQFRTQNPTVNMNTPPPSNYLNSFKAHK 1179
            |.                        |.|..||......::|.          |:|
Yeast   371 EL------------------------IQEYLGKIDFQKNYQTD----------PNN--------- 392

  Fly  1180 TPGQFVFFYQLPGVEAPMQTLRPDGSVPQVAQQPPSYLKGPEVCVDTRTYGNDARFVRRSCRPNA 1244
                   .|:|.|...|.....|..         |.|       :|:|..|...|::||||.||.
Yeast   393 -------DYRLMGTTKPKVLFHPHW---------PLY-------IDSRETGGLTRYIRRSCEPNV 434

  Fly  1245 EL---QHYFEKG------TLHLYIVALTHIRAQTEITIRHEPHDL-----TAVEQKKSHAAVIQP 1295
            ||   :...||.      .:...:.|:..||...||::..: .||     ..:...|...::..|
Yeast   435 ELVTVRPLDEKPRGDNDCRVKFVLRAIRDIRKGEEISVEWQ-WDLRNPIWEIINASKDLDSLPDP 498

  Fly  1296 -------------TSTRCACD-MGSDC 1308
                         |:..|||. :|.:|
Yeast   499 DKFWLMGSIKTILTNCDCACGYLGHNC 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
upSET	NP_001261819.1	PHD_MLL5	856..899	CDD:277025	14/45 (31%)
upSET	NP_001261819.1	SET	<1221..1273	CDD:214614	19/60 (32%)
SET4	NP_012430.1	SET	16..526	CDD:225491	104/547 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346293
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1844
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46856
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.860