Protein Alignment upSET and SET2

DIOPT Version :9

• Sequence 1: NP_001261819.1
• Gene: upSET / 39551
• FlyBaseID: FBgn0036398
• Length: 3146
• Species: Drosophila melanogaster
• Sequence 2: NP_012367.2
• Gene: SET2 / 853271
• SGDID: S000003704
• Length: 733
• Species: Saccharomyces cerevisiae
• Alignment Length: 873
• Identity: 167/873 - (19%)
• Similarity: 290/873 - (33%)
• Gaps: 289/873 - (33%)

  Fly  1883 KKRKVSRS------LNNNTNGLGSGGGSNNKRRKSIVVESDGESHALTNSESEDQGQHPQS---- 1937
            |.:.||.|      ||||..|        :|.::....|.|....|||..|:.|...:...
Yeast     3 KNQSVSASEDEKEILNNNAEG--------HKPQRLFDQEPDLTEEALTKFENLDDCIYANKRIGT 59

  Fly  1938 -------------------HHSGSEDQAAGLLLALAH---------NNSSPNEPFKSPLSQSHSL 1974
                               :|:..||......|.|..         .|...|:.|:
Yeast    60 FKNNDFMECDCYEEFSDGVNHACDEDSDCINRLTLIECVNDLCSSCGNDCQNQRFQ--------- 115

  Fly  1975 PATPASVSSACLLIEAAMGPLQQQPAPASASPSLAEFKYPPGGAKTKKSLMSSWFQQAEQQHASG 2039
                                 ::|.||.    ::.:.|:...|.:.::.:.::.|
Yeast   116 ---------------------KKQYAPI----AIFKTKHKGYGVRAEQDIEANQF---------- 145

  Fly  2040 LDSLVQAAMSEINGE-------REQL----QRQ---------PQGESLPAPALLKVEQFIHQAES 2084
                    :.|..||       |::|    ||.         ..||.:.|.....:.:|.:.:.|
Yeast   146 --------IYEYKGEVIEEMEFRDRLIDYDQRHFKHFYFMMLQNGEFIDATIKGSLARFCNHSCS 202

  Fly  2085 TTAVPAREQLHLPLQNNSSVKKRWLRQAI--------SEETT---PVDEL-QQSQ---------- 2127
            ..|..           |..|.|..||..|        .||.|   .||.. .|:|
Yeast   203 PNAYV-----------NKWVVKDKLRMGIFAQRKILKGEEITFDYNVDRYGAQAQKCYCEEPNCI 256

  Fly  2128 ------NQSVTATPSPQPVPTVSPLANGFSTPLKKRRLVVVSNGTNVESDETHIDVIGEP--KDE 2184
                  .|:..|:..||.:..    |.|.:..::|:.|.:..             :.|||  |:|
Yeast   257 GFLGGKTQTDAASLLPQNIAD----ALGVTVSMEKKWLKLKK-------------LSGEPIIKNE 304

  Fly  2185 AEENVAMTELK-VEIENHHQEQDDDVDILRSPS---PGTHQIVAEDNLVKI-EPEDTSAAADDVK 2244
             .||:.:..|: :|:    |..|..||:.:..|   ...::|:|...|.:: ..:|.|.....:|
Yeast   305 -NENINIEFLQSLEV----QPIDSPVDVTKIMSVLLQQDNKIIASKLLKRLFTIDDDSLRHQAIK 364

  Fly  2245 IDVEREESQACDKFEEMVKVKREEE--------EQREKEIKQLQERQEH--EQPKVEPAPVEPKL 2299
            :     ....|  |.:|:|:...|:        |..|.:||.::...:.  |.||.....:|...
Yeast   365 L-----HGYTC--FSKMLKLFITEQPQVDGKGNETEEDDIKFIKGILDFLLELPKTTRNGIESSQ 422

  Fly  2300 ENTVAKAEPKVEPSQEIVSKKEPTKVEPKPGESLLRSTATVT---ATPTAATIAATTLLDVSKVA 2361
            .:.|.|..|...|.           ::|...|.|.:.:...|   .|.....:||:.::|:.:|.
Yeast   423 IDNVVKTLPAKFPF-----------LKPNCDELLEKWSKFETYKRITKKDINVAASKMIDLRRVR 476

  Fly  2362 FKTRPP----LKLEDEPQKKKPKLESILPAPVATVPPVSVPPIPAASNATTSAVTNTAAASLTTT 2422
            .   ||    :.....|.....:.::.|..|            |:.|:...|:.:||...|.:::
Yeast   477 L---PPGWEIIHENGRPLYYNAEQKTKLHYP------------PSGSSKVFSSRSNTQVNSPSSS 526

  Fly  2423 TAP-------SSTKNLTEHDI----QERL----LSFHAANISYLQSRNKKATAALTSASPSQ--- 2469
            ..|       |....|::.:.    |:||    ::...|....|:|..:|........|..:
Yeast   527 GIPKTPGALDSKKHKLSDEEYERKKQKRLEYERIALERAKQEELESLKQKLKLENERKSVLEDII 591

  Fly  2470 -KSNSSSGGSGTESKKSSKDKDEKRDKEKQLKKSKKEKK--------------KSKDKEKQKAAV 2519
             ::|........|:||..:.|:.||.|.|.:.:|::.:.              |...:.||....
Yeast   592 AEANKQKELQKEEAKKLVEAKEAKRLKRKTVSQSQRLEHNWNKFFASFVPNLIKKNPQSKQFDHE 656

  Fly  2520 NVNSTSQIVDTKKKTTQPSKPDSKSSIAPVLVPPSLPVATANGKTKHTAYNNVDQ--QQQQQMRR 2582
            |:...::.: .|..||:..|.||..:      ||.........|.|....:.:|:  .:::|.:.
Yeast   657 NIKQCAKDI-VKILTTKELKKDSSRA------PPDDLTKGKRHKVKEFINSYMDKIILKKKQKKA 714

  Fly  2583 RTMSMCITPVTPTPVVTPSPLHGTPPST 2610
            ..:|...|.::       ||    ||||
Yeast   715 LALSSASTRMS-------SP----PPST 731

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
upSET	NP_001261819.1	PHD_MLL5	856..899	CDD:277025
		SET	<1221..1273	CDD:214614
SET2	NP_012367.2	AWS	64..119	CDD:197795	8/84 (10%)
		SET_SETD2	119..260	CDD:380949	31/173 (18%)
		SET	215..695	CDD:225491	109/541 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030