DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment upSET and KMT2D

DIOPT Version :9

Sequence 1:NP_001261819.1 Gene:upSET / 39551 FlyBaseID:FBgn0036398 Length:3146 Species:Drosophila melanogaster
Sequence 2:XP_011537072.1 Gene:KMT2D / 8085 HGNCID:7133 Length:5556 Species:Homo sapiens


Alignment Length:3301 Identity:667/3301 - (20%)
Similarity:1003/3301 - (30%) Gaps:1126/3301 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 SHDSVFVEPAVSSSGGGSTSSINRIGVASGPQP---PPPHIVIDGSSLSTQAQLRIMQRRMSIST 66
            |.|::.| |.....|||..|           :|   |||.    |.|                  
Human  2254 SLDNLAV-PESPGVGGGKAS-----------EPLLSPPPF----GES------------------ 2284

  Fly    67 RQILSASQSQSINQSQKYAVRTAAGTGALAAGAASSGSSGQ-----ELINPQIYKIVTTDGSTSN 126
            |:.|...:.:....|..|        |....|...|.|||.     ||..|.::|          
Human  2285 RKALEVKKEELGASSPSY--------GPPNLGFVDSPSSGTHLGGLELKTPDVFK---------- 2331

  Fly   127 VIIDASAAAPPHNSKLLLSNLTVLSKQAPVQGAAGQQQQQLNYL-------------GAKSLPYV 178
                    ||      |....:.:..|:|..|...|:......|             |:.:.|| 
Human  2332 --------AP------LTPRASQVEPQSPGLGLRPQEPPPAQALAPSPPSHPDIFRPGSYTDPY- 2381

  Fly   179 SASPAKTQQQPQKFGSISAFKAQHQQQQQHPHATLQKVTLGSRVATRLQSYVPASP-SQIMVQ-P 241
            :..|...:.||....|..|.          |..:|.....         |.||||| ||...| |
Human  2382 AQPPLTPRPQPPPPESCCAL----------PPRSLPSDPF---------SRVPASPQSQSSSQSP 2427

  Fly   242 AQPKYVNATATTIGGNAALLKKANQKITVKSVSNMSQQQQQQQQQQQQQLLQAQQLKTFITQQQQ 306
            ..|:.::|.|.           ....:|.:..|.....:...:.|.:.......:..   ..|..
Human  2428 LTPRPLSAEAF-----------CPSPVTPRFQSPDPYSRPPSRPQSRDPFAPLHKPP---RPQPP 2478

  Fly   307 QQTYKAGAKAKFVKQTTALSI----AALPQQQQQTTYAK---------------QSMVTTSTPAK 352
            :..:|||:.|.     |:|..    ||||.......:||               .:.|.|.:|.:
Human  2479 EVAFKAGSLAH-----TSLGAGGFPAALPAGPAGELHAKVPSGQPPNFVRSPGTGAFVGTPSPMR 2538

  Fly   353 VT--------KLNSKYVQQQISLPQGTQLQHKASPNV-----------TG----GGYLLQQSQAA 394
            .|        .|.....|..:..|.|........|.:           ||    .|..|..|..:
Human  2539 FTFPQAVGEPSLKPPVPQPGLPPPHGINSHFGPGPTLGKPQSTNYTVATGNFHPSGSPLGPSSGS 2603

  Fly   395 VG--------------------GTIKFVNSHGTVIQQHPQQQQATKRTHYNSSGSSDNEQHAVAN 439
            .|                    |::.:: |||           |::|:...|......:......
Human  2604 TGESYGLSPLRPPSVLPPPAPDGSLPYL-SHG-----------ASQRSGITSPVEKREDPGTGMG 2656

  Fly   440 SSLITDDVMIVNGTQ----------------MTDELSARILQSMAQKSFSQQQRFHQVPATGSGN 488
            |||.|.:   :.|||                ....|...:::...|::..:|::  :..|..:|.
Human  2657 SSLATAE---LPGTQDPGMSGLSQTELEKQRQRQRLRELLIRQQIQRNTLRQEK--ETAAAAAGA 2716

  Fly   489 MPPPTQIIYSNSTSNGAAASSPGGNASGNMLLAHYQAAGTKPVSSASFITVTGTPPVTV------ 547
            :.||        .|.||..|||   |...:.......|||:..||     :.|.||..:      
Human  2717 VGPP--------GSWGAEPSSP---AFEQLSRGQTPFAGTQDKSS-----LVGLPPSKLSGPILG 2765

  Fly   548 ----------------ATTPSVSISSHGFASGSAAISSYMSSATAARRQSVSAPSSRAVSLERKQ 596
                            ||..|:.::|.....||.|.           .|....|.|..:..:::|
Human  2766 PGSFPSDDRLSRPPPPATPSSMDVNSRQLVGGSQAF-----------YQRAPYPGSLPLQQQQQQ 2819

  Fly   597 HHQQLQHDVIGGGRKAPTVIEYYNKHGVNSIVGSSNNLAQSNSMSNLAGP---RSNSGS---GFA 655
            ..||.|                       :...:|...|.|....:..||   |...||   |.:
Human  2820 LWQQQQ-----------------------ATAATSMRFAMSARFPSTPGPELGRQALGSPLAGIS 2861

  Fly   656 T-------TTPTPATPLHLTPVNVPVHVEAAPPSSPALVKGSSQPPAQPQ--QQQQQAHPLGPNQ 711
            |       ..|.||.|.....:...|.....|..:|...:|   ||.:|:  ...:..|.|.|..
Human  2862 TRLPGPGEPVPGPAGPAQFIELRHNVQKGLGPGGTPFPGQG---PPQRPRFYPVSEDPHRLAPEG 2923

  Fly   712 LNANDEELYIE-------EVRPVPVLTQDLRLQQLHAIMQDHTYASQQQQQQPQQAAGDTTNPGA 769
            |..    |.:.       ...|.|.|...|                     .|.......|.|..
Human  2924 LRG----LAVSGLPPQKPSAPPAPELNNSL---------------------HPTPHTKGPTLPTG 2963

  Fly   770 AQQVQQPQQWSLGGIGVTVSGSQGTPTAVGGYCSYFGQQIARSQADDDAHSAISSS---SRMGLA 831
            .:.|.:|..          |...|.|..:.........:......|.|||.|:...   :.:|| 
Human  2964 LELVNRPPS----------STELGRPNPLALEAGKLPCEDPELDDDFDAHKALEDDEELAHLGL- 3017

  Fly   832 STDIDPG-EETETAPEAEAEDDSVTRCICELTHDDGYMICCDKCSAWQHVDCMGIDRQNIPEEYM 895
            ..|:..| :|..|....|..|..:.    :|.:.|.:.:.     |:...:....|:::|..|::
Human  3018 GVDVAKGDDELGTLENLETNDPHLD----DLLNGDEFDLL-----AYTDPELDTGDKKDIFNEHL 3073

  Fly   896 CELCQPRAVDKARARALQRQKRKEHMLLVATQAANGAAAVAAGTTLSGGLG---SGLPMSEELQH 957
                  |.|:.|      .:|.:...||...:              .|.||   ...|.::..:.
Human  3074 ------RLVESA------NEKAEREALLRGVE--------------PGPLGPEERPPPAADASEP 3112

  Fly   958 RLASGL--------NGG-------FATGTGMSKKSKKTKENSGSTSTLKKTKKSAVGMGGEKNAS 1007
            ||||.|        .||       |...|      .|.:....:.|.....|.....||......
Human  3113 RLASVLPEVKPKVEEGGRHPSPCQFTIAT------PKVEPAPAANSLGLGLKPGQSMMGSRDTRM 3171

  Fly  1008 GSGTPTGSSGKTSKKSSKRKSKSGGDGSSGGGSSPALTAAEKHAANLRQWIENYEY---AVTNHY 1069
            |:| |..|||.|::|:|        .|::||..:..||.:..........:|.:|.   |:|...
Human  3172 GTG-PFSSSGHTAEKAS--------FGATGGPPAHLLTPSPLSGPGGSSLLEKFELESGALTLPG 3227

  Fly  1070 SP--------ELRARLHAIQKQPSLLQSIQNTENKALRQIQQ---QLSTAGSAEQLEQRAQLIPY 1123
            .|        ::.:.|.| .:.|.|::.:...|.|.|::.||   ||..|...:|.:|:..|:..
Human  3228 GPAASGDELDKMESSLVA-SELPLLIEDLLEHEKKELQKKQQLSAQLQPAQQQQQQQQQHSLLSA 3291

  Fly  1124 AGAKVLISSVDLSPH---APIHELRGKYM-----LTTQFRTQNPTVNMNTPPPSNYLN------- 1173
            .|....:|    .||   :|  .|.|...     |....:...|...|.|.||::.|.       
Human  3292 PGPAQAMS----LPHEGSSP--SLAGSQQQLSLGLAGARQPGLPQPLMPTQPPAHALQQRLAPSM 3350

  Fly  1174 ---SFKAHKTPGQFVFFYQLPGVEA---PMQTLRPDGSVPQVAQQPPSYLKGPEVCVDTRTYGND 1232
               |.:.|...||.       |.:|   |.|:.:|..|...:...|||....|:.....:...| 
Human  3351 AMVSNQGHMLSGQH-------GGQAGLVPQQSSQPVLSQKPMGTMPPSMCMKPQQLAMQQQLAN- 3407

  Fly  1233 ARFVRRSCRPNAELQHYFEKGTL----HLYIVALTHIR---AQTEITIRH--------------- 1275
                  |..|:.:|..:..:..:    ...:|||..|:   ||..|.:..               
Human  3408 ------SFFPDTDLDKFAAEDIIDPIAKAKMVALKGIKKVMAQGSIGVAPGMNRQQVSLLAQRLS 3466

  Fly  1276 -------EPHDLTAVEQKKSHAAVIQPTSTRCACDMG----------SDCLFALPLAVQQQLQAP 1323
                   :.|......|::|.....||.........|          .:.||.....:|.||:..
Human  3467 GGPSSDLQNHVAAGSGQERSAGDPSQPRPNPPTFAQGVINEADQRQYEEWLFHTQQLLQMQLKVL 3531

  Fly  1324 PTQPRSSHRNKAAAAAAAAAAANSA-------------------AAIQLTMGLGVGATVAAGASV 1369
            ..| ...||....|..|....|..|                   :.||..:. .|........::
Human  3532 EEQ-IGVHRKSRKALCAKQRTAKKAGREFPEADAEKLKLVTEQQSKIQKQLD-QVRKQQKEHTNL 3594

  Fly  1370 LPNSRNRSTSSSGESSQM------------------------------GLNSPQ---LGQLNLGF 1401
            :...||:......:..|.                              ||..||   .||.. |.
Human  3595 MAEYRNKQQQQQQQQQQQQQQHSAVLALSPSQSPRLLTKLPGQLLPGHGLQPPQGPPGGQAG-GL 3658

  Fly  1402 KTSVTATSLTAPVPGVHCN----------NSGGSSSSSNNSCSVSMSSVLHDSGICTSSSSPSVS 1456
            :.:....:|.....|...|          :|||:.|.:      ..|.......:...|..|...
Human  3659 RLTPGGMALPGQPGGPFLNTALAQQQQQQHSGGAGSLA------GPSGGFFPGNLALRSLGPDSR 3717

  Fly  1457 IPSPTPTQMQSPTLQ-----QHPQQIPQQQLSLLQRSPTQQHQQ--------QILAALPTPMLTP 1508
            :......|:|...:|     |..||..|||..||.:...||.||        |.|...|..::.|
Human  3718 LLQERQLQLQQQRMQLAQKLQQQQQQQQQQQHLLGQVAIQQQQQQGPGVQTNQALGPKPQGLMPP 3782

  Fly  1509 ---------MLSPQLPK-------PAQ----QQAH------------VVLPQSQQTS-------- 1533
                     .||||.|:       |||    ||.|            |::.||:..|        
Human  3783 SSHQGLLVQQLSPQPPQGPQGMLGPAQVAVLQQQHPGALGPQGPHRQVLMTQSRVLSSPQLAQQG 3847

  Fly  1534 ---------LLQQQQSQQSQEPLAVIAAAAAAQQPMATY-----FVRQP-----QQQQQQQSPKP 1579
                     ..||||.||..:....:|..:..||.:.::     ...||     |.|||||..:.
Human  3848 QGLMGHRLVTAQQQQQQQQHQQQGSMAGLSHLQQSLMSHSGQPKLSAQPMGSLQQLQQQQQLQQQ 3912

  Fly  1580 QALVAQQQHVVGAQQQQHFLQQQQKQQQQQMADEARMAVSALQTLHAAPTSHIVSPIKVAAVQQQ 1644
            |.|..|||..:   |||..|||||.|||||                                |||
Human  3913 QQLQQQQQQQL---QQQQQLQQQQLQQQQQ--------------------------------QQQ 3942

  Fly  1645 SQPQQQQQNTHQQPHNQQAVQQQSNQLQQQQSQQP----NYPQ---SPQRQQKPQPVQHQPQIVI 1702
            .|.|||||...||...||..|||..|.||||.||.    |..:   |||:||       |.|:.:
Human  3943 LQQQQQQQLQQQQQQLQQQQQQQQQQFQQQQQQQQMGLLNQSRTLLSPQQQQ-------QQQVAL 4000

  Fly  1703 STGAQAIPATMPTKLSSPTKSAAPVISNNNITVSAQSSVVGGKKTPAKHPQQQQQQQQQPVTPVS 1767
            ..|   :||......||| .:..|.:            ::.||:.....|....:..:.|.|...
Human  4001 GPG---MPAKPLQHFSSP-GALGPTL------------LLTGKEQNTVDPAVSSEATEGPSTHQG 4049

  Fly  1768 AATAPAATPSSSESKEDDVSASSTTTPTTRTPAKDKPKQSREDRKLEAILRAIEKMEKQ-----E 1827
            ...|...||.|..::..:|. .|.:..:.....:.:|:......:|:..||...:.::|     .
Human  4050 GPLAIGTTPESMATEPGEVK-PSLSGDSQLLLVQPQPQPQPSSLQLQPPLRLPGQQQQQVSLLHT 4113

  Fly  1828 ARGKKDTRQSSGGKRQASNSP---ASPNKR--NSSNSISEDVETPTSTNSAAAAAQRRNKKKRKV 1887
            |.|....:..||...:||:.|   |.|:..  :...|:::::..|               ::..:
Human  4114 AGGGSHGQLGSGSSSEASSVPHLLAQPSVSLGDQPGSMTQNLLGP---------------QQPML 4163

  Fly  1888 SRSLNNNTNG--------LGSGGG---------------------SNNKRRKSIVVESDGESHAL 1923
            .|.:.|||..        |.||.|                     :.|.:.:.:..:...:..||
Human  4164 ERPMQNNTGPQPPKPGPVLQSGQGLPGVGIMPTVGQLRAQLQGVLAKNPQLRHLSPQQQQQLQAL 4228

  Fly  1924 TN----SESEDQGQHPQSHHSGSE-DQAAGLLLALAHNNSSPNEPFKSPLSQSHS---------L 1974
            ..    .:|:...|.|.....|:: ....|||.........|. |...||.:..:         |
Human  4229 LMQRQLQQSQAVRQTPPYQEPGTQTSPLQGLLGCQPQLGGFPG-PQTGPLQELGAGPRPQGPPRL 4292

  Fly  1975 PATPASVSSACLLIEAAMGPLQQQPAPAS----------ASPSL---AEFKYPPGGAKTKKSLMS 2026
            ||.|.::|:..:|     ||:...|.|:|          .|||.   .|.:.||....|.|    
Human  4293 PAPPGALSTGPVL-----GPVHPTPPPSSPQEPKRPSQLPSPSSQLPTEAQLPPTHPGTPK---- 4348

  Fly  2027 SWFQQAEQQHASGLDSLVQAAMSEINGEREQLQRQPQGESL--------PAPALLKVEQF----- 2078
                                               |||.:|        ||.|.|....|     
Human  4349 -----------------------------------PQGPTLEPPPGRVSPAAAQLADTLFSKGLG 4378

  Fly  2079 ----------IHQAESTTAVPAREQLHLPLQNNSSVKKRWLRQAISEETTPVDELQQSQNQSVTA 2133
                      ..:.|.::.||.    ||. |.|..|.....:.:|.:|  |.:|......|||..
Human  4379 PWDPPDNLAETQKPEQSSLVPG----HLD-QVNGQVVPEASQLSIKQE--PREEPCALGAQSVKR 4436

  Fly  2134 TPSPQPVPTVSPLANGFSTPLKKRRLVVVSNGTNVESDETHIDVIGEPKDEA----------EEN 2188
            ..:.:|:          ..|           ||:     .|:.:.| |:.||          .:|
Human  4437 EANGEPI----------GAP-----------GTS-----NHLLLAG-PRSEAGHLLLQKLLRAKN 4474

  Fly  2189 VAMTE------LKVEIENHHQEQDDDVDILRSPSPGTHQIVAEDNLVKIEPEDTSAAADDVKIDV 2247
            |.::.      |:.||..|   .|..:..|.....||..          ..||  |||.......
Human  4475 VQLSTGRGSEGLRAEINGH---IDSKLAGLEQKLQGTPS----------NKED--AAARKPLTPK 4524

  Fly  2248 EREESQACDKFEEMVKVKREEEEQREKEIKQLQERQEHE-QPKVEPA---------------PV- 2295
            .:...:|.|:.....|..|:|:..|..|....|.:||.. .|..|||               || 
Human  4525 PKRVQKASDRLVSSRKKLRKEDGVRASEALLKQLKQELSLLPLTEPAITANFSLFAPFGSGCPVN 4589

  Fly  2296 -EPKLENTVAKAEPKVEPS--QEIVSKKE-------PTKVEPKPGESLLRSTATVTATPT----- 2345
             :.:|............|.  .::::|..       |:.:.|.|..|:.:.... ..||:     
Human  4590 GQSQLRGAFGSGALPTGPDYYSQLLTKNNLSNPPTPPSSLPPTPPPSVQQKMVN-GVTPSEELGE 4653

  Fly  2346 ------AATIAATTLLDVSKV-------AFKTRPPLKLED---EPQKKKPKLESILPAP------ 2388
                  :|..:...|.|.|:|       |..|.|..:.||   |..:.....:||:||.      
Human  4654 HPKDAASARDSERALRDTSEVKSLDLLAALPTPPHNQTEDVRMESDEDSDSPDSIVPASSPESIL 4718

  Fly  2389 -------------------------VATVPPVSVP-------------PIPAASNATTSAVTNTA 2415
                                     :..:|..|:|             .:|.....||......:
Human  4719 GEEAPRFPHLGSGRWEQEDRALSPVIPLIPRASIPVFPDTKPYGALGLEVPGKLPVTTWEKGKGS 4783

  Fly  2416 AASLTTTTAPSSTKNLTEHDIQ-ERLLSFHAANISYLQSRNKKATAALTSASPSQ-----KSNSS 2474
            ..|:..|.:.::.|||....:. ..|||....| ||         ..|...||::     |...:
Human  4784 EVSVMLTVSAAAAKNLNGVMVAVAELLSMKIPN-SY---------EVLFPESPARAGTEPKKGEA 4838

  Fly  2475 SGGSGTESKKSSKDKDEKRDKEKQ----------------LKKSKKEKKKSKDKEKQKAAVNVNS 2523
            .|..|.|.....|..|...|..||                |...|:|....:...:.....||::
Human  4839 EGPGGKEKGLEGKSPDTGPDWLKQFDAVLPGYTLKSQLDILSLLKQESPAPEPPTQHSYTYNVSN 4903

  Fly  2524 TSQIVDTKKKTT----QPSKPDSKSSIAPVLVPPSLPVATANGKTKHTAYNNVDQQQQQQMRRRT 2584
                :|.::.:.    :||.|.|..:.:|. .||:.|:                           
Human  4904 ----LDVRQLSAPPPEEPSPPPSPLAPSPA-SPPTEPL--------------------------- 4936

  Fly  2585 MSMCITPVTPTPVVTPSPLHGTPPSTK---KRQTNFEQELTKP-------NSQILSSSILLNSSK 2639
            :.:...|:...||.:|.||..:|.|.:   :.:...|.|.::|       ..:.....:||...|
Human  4937 VELPTEPLAEPPVPSPLPLASSPESARPKPRARPPEEGEDSRPPRLKKWKGVRWKRLRLLLTIQK 5001

  Fly  2640 GLGLPLAAPTVVSV---------PTAVQQQQHRKENNHQEATPASGGPMSL 2681
            |.|.......|...         |..|.:...|....|:|...|:.||..|
Human  5002 GSGRQEDEREVAEFMEQLGTALRPDKVPRDMRRCCFCHEEGDGATDGPARL 5052

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
upSETNP_001261819.1 PHD_MLL5 856..899 CDD:277025 6/42 (14%)
SET <1221..1273 CDD:214614 11/58 (19%)
KMT2DXP_011537072.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.030

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