DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment upSET and Setd5

DIOPT Version :9

Sequence 1:	NP_001261819.1	Gene:	upSET / 39551	FlyBaseID:	FBgn0036398	Length:	3146	Species:	Drosophila melanogaster
Sequence 2:	XP_006506740.1	Gene:	Setd5 / 72895	MGIID:	1920145	Length:	1467	Species:	Mus musculus

Alignment Length:	1676	Identity:	341/1676 - (20%)
Similarity:	557/1676 - (33%)	Gaps:	557/1676 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   769 AAQQVQQPQQWSLGGIGVTV-SGSQGTPTAVGGYCSYFGQQIARSQADDDAHSAISSSSRMGLAS 832
            |:..|.:...:|....|.|. .|.:|.|.|..   :|.........|.....:.|..|...||.|
Mouse    37 ASPAVNEKSVYSTHNYGTTQRHGCRGLPYADH---NYGAPPPPTPPASPPVQTIIPRSDLNGLPS 98

  Fly   833 -----TDIDPGEETETAPEAEAEDDSVTRCICELTHDDGYMICCDKCSAWQHVDCMGIDRQNIPE 892
                 ....|..|.||.|         |.|.|.|: .||:::.||||
Mouse    99 PVEERCGDSPNSEGETVP---------TWCPCGLS-QDGFLLNCDKC------------------ 135

  Fly   893 EYMCELCQPRAVDKARARALQRQKRKEHMLLVATQAANGAAAVAAGTTLSGGLGSGL-PMSEEL- 955
                     |.:.:.:...|.|:|:                     ..:|||..|.. ...|||
Mouse   136 ---------RGMSRGKVIRLHRRKQ---------------------DNISGGDSSATESWDEELS 170

  Fly   956 ---------QHRLASGLNGGFATGTGMSKKSKKTKENSGSTSTLKKTKKSAVGMGGEKNASGSGT 1011
                     ||           |.|.::...::||.        ||.|||.     ||   |...
Mouse   171 PSTVLYTATQH-----------TPTSITLTVRRTKP--------KKRKKSP-----EK---GRAA 208

  Fly  1012 PTGSSGKTSK-KSSKRKSKSGGDGSSGGGSSPALTAAEKHAANLRQWIENYEYAVTNHYSPE--- 1072
            |     ||.| |:|..::::..:.::.|..:           .:|.|.:.||.|.||.||.:
Mouse   209 P-----KTKKIKNSPSEAQNLDENTTEGWEN-----------RIRLWTDQYEEAFTNQYSADVQN 257

  Fly  1073 -LRARLHAIQK---QPSLLQSIQNTE---NKALRQIQQQLSTAGSAEQLEQRAQLIPYAGAKVLI 1130
             |...||:.::   :|::|.:|..||   |..:...|.||. .|...::::.        .|:|.
Mouse   258 ALEQHLHSNKEFVGKPAILDTINKTELACNNTVIGSQMQLQ-LGRVTRVQKH--------RKILR 313

  Fly  1131 SSVDLSPHAPIHELRGKYMLTTQFRTQNPTVNMNTPPPSNYLNSFKAH--KTPGQFVFFYQLPGV 1193
            ::.||:....|.|.|||.||..||.     ||              .|  |.|..||.||
Mouse   314 AARDLALDTLIIEYRGKVMLRQQFE-----VN--------------GHFFKKPYPFVLFY----- 354

  Fly  1194 EAPMQTLRPDGSVPQVAQQPPSYLKGPEVCVDTRTYGNDARFVRRSCRPNAELQHYFEKGTLHLY 1258
                                 |...|.|:|||.||:||||||:||||.||||::|....|.:||.
Mouse   355 ---------------------SKFNGVEMCVDARTFGNDARFIRRSCTPNAEVRHMIADGMIHLC 398

  Fly  1259 IVALTHIRAQTEITIRHEPHDLTAVEQKKSHAAVIQPTSTRCACDMGS-DCLFAL--PLAVQQQL 1320
            |.|::.|....|:||        |.:.:.|:...    ...|||..|: :|....  |.|.:..|
Mouse   399 IYAVSAITKDAEVTI--------AFDYEYSNCNY----KVDCACHKGNRNCPIQKRNPNAAELPL 451

  Fly  1321 QAPPTQP---RSSHRNKA----------------------------------------------- 1335
            ..||:.|   ..:.|.||
Mouse   452 PPPPSFPTIGAETRRRKARRKELELEQQNEVPEENPDPQPQEVPEKVTVSNEHEEVDNPEEKPEE 516

  Fly  1336 -AAAAAAAAAANSAAAIQLTMGLGVGATVAAGASVLPNSRNRSTSSSGESSQMGLNSPQLGQLNL 1399
             ....|.....|||.:.:......|.|.:.|..|:....:.|.......||.:.:
Mouse   517 EEKEEATDDQENSAHSRRTREDRKVEAIMHAFESLEKRKKRRDQPVEQSSSDIEI---------- 571

  Fly  1400 GFKTSVTATSLTAPVPGVHCNNSGGSSSSSNNSCSVSMSSVLHDSGICTSSSSPSVSIPSPTPTQ 1464
                   .||.:..|.|.....:...|..|:...:|::.|....:|:.|..||.:..:.:..|..
Mouse   572 -------TTSSSEIVVGEETKTAAPESEVSSPVSNVAIPSTPQSTGVNTRRSSHAGDVAAEKPIP 629

  Fly  1465 MQSPTLQQHPQQIPQQQLSLLQRSPTQ--QHQQQILAALPTPMLTPMLSPQLPKPAQQQA----H 1523
            ...|.....|:  |:.::|..:.|..|  :.|:|.:|.          ..:|.:.|.::.    .
Mouse   630 KPPPAKPSRPR--PKSRISRYRTSSAQRLKRQKQAIAQ----------QAELSQAALEEGGSNNS 682

  Fly  1524 VVLPQSQQTSLLQQQQSQQSQEPLAVIAAA-----AAAQQPMA-TYFVRQ--PQQQQQQQSP--- 1577
            |..|::..|....:.:.....:|..:....     ||::.|.. .|.|.:  ..:.::|:.|
Mouse   683 VTPPEAGNTDSSGENRQLTGSDPTVISVTGSHVNRAASKYPKTKKYLVTEWLNDKAEKQECPVEC 747

  Fly  1578 ------KPQALVAQQQHVVG-------AQQQQHFLQ-----QQQKQQQQQMADEARMAVSALQTL 1624
                  .|..|......:.|       ....:|:::     ..:::::..:.|         .|.
Mouse   748 PLRITTDPTVLATTLNMLPGLIHSPLICTTPKHYIRFGSPFMPERRRRPLLPD---------GTF 803

  Fly  1625 HAAPTSHIVSPIKVAAVQQQSQPQQ-QQQNTHQ--QPHNQQAV------------QQQSNQLQQQ 1674
            .:.....|...::....|..|.||: :.|:.:|  :..|..::            :.:|..|.:|
Mouse   804 SSCKKRWIKQALEEGMTQTSSVPQETRTQHLYQSNETSNSSSICKDNADLLSPLKKWKSRYLMEQ 868

  Fly  1675 QSQQPNYPQSPQRQQKPQPVQHQPQIVISTGAQAIPA------------TMPTKLSSPTKSAAP- 1726
            ...:...|.||.....|......||  ::|..|..|.            :..|.|::.::|..|
Mouse   869 NITKLLQPLSPVTPPPPSSGSKSPQ--LTTPGQTHPGEEECRNGYSLMFSPITSLTTASRSNTPL 931

  Fly  1727 ------------------------------VISNNNITVSAQSSVV------------GGKKTPA 1749
                                          :::.|:..:::..|||            .|.:|..
Mouse   932 QFELCHRKDLDLTKVGFPDSSTHSCADRPSLLNCNHPDLASHPSVVPTSEAGFPSRSGDGPQTLL 996

  Fly  1750 KHPQQQQQQQ---QQPVTPVSAATAPAA-----------------------TPSSSESKE----- 1783
            ::..|..:.:   ....:|::|  .|.|                       :|:...|..
Mouse   997 RNSDQAFRTEFNLMYAYSPLNA--MPRADGLYRGSPLVGDRKPLHLDGGYCSPAEGFSSRYEHGF 1059

  Fly  1784 -DDVSASSTTTPTTRT-----PAKDKPKQSREDRKLEAILRAIEKMEKQEAR----GKKDTRQ-- 1836
             .|:|..|.:....||     .|...|.|.::...||      .:..||||:    |..|:.|
Mouse  1060 MKDLSRGSMSPGGERTCEGVPSAPQNPPQRKKVSLLE------YRKRKQEAKENSGGGNDSSQSK 1118

  Fly  1837 --SSGGKRQASNS----------------PASPNKRNS-SNSISEDVETPTSTNSAAAAAQRRNK 1882
              |||..:.:|||                |:||:|:.| |:|.:..:|..:.::|...::.....
Mouse  1119 SKSSGAGQGSSNSVSDTGAHGVQGSSAGTPSSPHKKFSPSHSSASHLEAVSPSDSRGTSSSHCRP 1183

  Fly  1883 KKRKVSR-SLNNNTNGLGSGGGSNNKRRKSIVVESDGE-----SHALTNSESED-QGQHPQSHHS 1940
            ::...|| .:..:...|..||......|.|:.|...||     ...:|..||:. .|:.|
Mouse  1184 QENISSRWMVPTSVERLREGGSIPKVLRSSVRVAQKGEPSPTWESNITEKESDPADGEGP----- 1243

  Fly  1941 GSEDQAAGLLLALAHNNSSPNEPFKSPLSQSHSLPATPASVSSACLLIEA----AMGPLQQQPAP 2001
                                 ||..|.||:..:: .:|:..|...|..::    :...|||..:|
Mouse  1244 ---------------------EPLSSALSKGATV-YSPSRYSYQLLQCDSPRTESQSLLQQSSSP 1286

  Fly  2002 ASASPSLAE-FKY---------PPGGAKTKKSLMSSWFQQAEQQHASGLDSLVQAAMSEINGERE 2056
            ....|:.:. :.|         ||....::.||.|:.:  ....|....|||     :...|...
Mouse  1287 FRGHPTQSPGYSYRTTALRPGNPPSHGSSESSLSSTSY--PSPAHPVSTDSL-----APFTGTPG 1344

  Fly  2057 QLQRQPQGESLPAPALLKVEQFIHQAESTTAVPAREQLHLPLQNNSSVKKRWLRQAISEETTPVD 2121
            ....||                 |...||.:       :||.::.||.......|..|:..|. |
Mouse  1345 YYSSQP-----------------HSGNSTGS-------NLPRRSCSSSAASPTPQGPSDSPTS-D 1384

  Fly  2122 ELQQSQNQSVTATPSPQ--------PVPTVSPLANGFSTPLKKRRLVVVSN 2164
            .:.||...::::|..||        .:.|:|....|.|...:..|:..|||
Mouse  1385 SVSQSSTGTLSSTSFPQNSRSSLPSDLRTISLPNAGQSAAYQASRVSAVSN 1435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
upSET	NP_001261819.1	PHD_MLL5	856..899	CDD:277025	9/42 (21%)
upSET	NP_001261819.1	SET	<1221..1273	CDD:214614	28/51 (55%)
Setd5	XP_006506740.1	SET_SETD5	292..441	CDD:380958	65/214 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831200
Domainoid	1	1.000	115	1.000	Domainoid score	I6008
eggNOG	1	0.900	-	-		E1_KOG1844
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	321	1.000	Inparanoid score	I2502
Isobase	1	0.950	-	0	Normalized mean entropy	S7271
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004035
OrthoInspector	1	1.000	-	-		otm43703
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46462
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.960