DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment upSET and Spocd1

DIOPT Version :9

Sequence 1:	NP_001261819.1	Gene:	upSET / 39551	FlyBaseID:	FBgn0036398	Length:	3146	Species:	Drosophila melanogaster
Sequence 2:	XP_017175994.1	Gene:	Spocd1 / 622480	MGIID:	3652045	Length:	1015	Species:	Mus musculus

Alignment Length:	972	Identity:	196/972 - (20%)
Similarity:	311/972 - (31%)	Gaps:	319/972 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1769 ATAP----AATPSSSESKEDDVSASSTTTPTTRTPAKDKPKQSREDRKLEAILRAIEKMEKQEAR 1829
            |::|    |.|.....|.||...:....:.....|:...|...|:.||.....:..||
Mouse    59 ASSPSFRQATTVEGMVSPEDPTLSKEGLSAKGPPPSPVLPPFRRKCRKCGICPQEEEK------- 116

  Fly  1830 GKKDTRQSSG-----GKRQASNSP--ASPN-----KRNSSNSISEDVETPTSTNSAAAAAQRRN- 1881
                    ||     |:|...:.|  |||.     .|..|:..:|..|...|....|...:..|
Mouse   117 --------SGFSLRFGQRPDGDPPECASPEAFAGPPRLLSSKDTEPGEPGGSWVECAVETEVENM 173

  Fly  1882 --KKKRKVSRSLNNNTNGLGSGGGSNNKRRKSIVVESDGESHAL----TNSESEDQ--------- 1931
              .|......||::.....|..||    ...|:|.:...:|.||    ...:|.||
Mouse   174 LFSKDGVAPDSLDHLFEFPGLFGG----EPLSLVTQEPLQSPALYPEVLTEDSTDQQEVQPAFVV 234

  Fly  1932 ---GQHPQSHHSGSEDQA-AGLLLALAHNNSSPNEPFKSPLSQSHSLPATPASVSSACLLIEAAM 1992
               |..|..  .|.||:| :|..:.|....|:|          ::|..::|..:..    ::.|
Mouse   235 GSPGTPPDP--VGPEDKAQSGSRMELEQGLSAP----------ANSCASSPEPLGG----LDGA- 282

  Fly  1993 GPLQQQ----------PAPASASPSLAEFKYPPGGAKTKKSLMSSWFQQAEQQHASGLDS----- 2042
             ||:|:          .:|..:|...||      ||..|.      |.:.|.:...|:.:
Mouse   283 -PLEQRRPTHVKKRPWTSPDDSSQDHAE------GASKKD------FPRLEARVPRGVKTVYYVY 334

  Fly  2043 ------LVQAAMSEINGEREQLQRQPQGESLPAPALLKVEQFIHQAESTTAVPAREQLHLPLQNN 2101
                  ||.||.|...|:.|.|:.            |.......:...|||.|.      |.|::
Mouse   335 TGSGIRLVGAASSSQPGQIEPLEE------------LDTNSARRKRRPTTAHPT------PCQSD 381

  Fly  2102 SSVKKRWLRQAISEETTPVDELQQSQNQSVTATPSPQPVPTVSPLANGF-STPLKKRRLVVVSNG 2165
            .|            ||...:..||....     |..|   .::||..|. ||.::..:.|:.:..
Mouse   382 PS------------ETENAEPHQQRAED-----PGEQ---GMTPLDAGVRSTVVRAMQEVLWTRA 426

  Fly  2166 TNVES---DETHIDVIGEPKDEAEENVAMTELKVEIENHHQ------EQDDDVDILRSPSPGTHQ 2221
            ..:..   .|..::.|.|..:||..::.. :..:..:|.::      ....:||:....:   |.
Mouse   427 QELPDLALREDEVEAIAEGIEEALFHLTQ-DTNLRYKNKYRSLLFNLRDPRNVDLFLKVA---HC 487

  Fly  2222 IVAEDNLV-----KIEPEDTSAAADDVKIDVEREESQACDKFEEMVKVKREEEEQREKEI----- 2276
            .|..:|||     ::.|::.|...|       :||.:..|..           ||::||:
Mouse   488 DVTPNNLVQMSSIQLAPKELSRWRD-------QEERKGLDII-----------EQQQKELYRLPA 534

  Fly  2277 KQLQERQEHEQPK-----------VEP--------APVEPKLENTV------------------- 2303
            .:|..:.|.|.|:           :||        .|:...||:|.
Mouse   535 SKLTHKGEVEIPRDLDQMLTLEDLMEPIVPRECSLQPLSTPLEDTTNWHQHHQCDSNCQICTGGE 599

  Fly  2304 --AKAEPKVEPSQEI-----VSKKEPTKVEPKPGESLLRSTATVTATPTAATIAATTLLDVSKVA 2361
              .||:...:|..::     |.:|..||:....|..:.|....:...|..|..::..:|.|.:.
Mouse   600 EGRKADDGSQPELQVDISYNVDRKSSTKLPAFSGVIMNREENAIQKAPGPAPASSPEVLKVGET- 663

  Fly  2362 FKTRPPLKLEDEPQKKKPKLESILPAPVATVPPVSVPP--------------------------- 2399
                ||.:.:|..|         :||.:...|| |.||
Mouse   664 ----PPKEPQDRLQ---------MPAGLKNAPP-SPPPWEGSLDMFSIKHFRAKAQLISGHSCQL 714

  Fly  2400 IPAASNATTSA--VTNTAAASLTTTTAPSSTKNLT--------EHDIQE-RLLSFHAANISYLQS 2453
            :.|..:...||  :..:....|..:..||..|::.        ..|||. |||      .|||.:
Mouse   715 VQALPDVIRSAGRLPPSHVWDLLDSMGPSKAKDICVIRLCPHGSRDIQNYRLL------YSYLNN 773

  Fly  2454 RN----------KKATAALTSASPSQKSNSSSGGSGTESKKSSK------DKDEKRDKEKQLKKS 2502
            :.          |.....|.:..|........||.|.|...:|.      .||...|....:..|
Mouse   774 KQCHCLATVQQVKMVLLPLPAFEPLPARLRPLGGPGLEITHTSLLLAVLFPKDALPDTATSIPVS 838

  Fly  2503 KK-EKKKSKDKEKQKAAVNVNSTSQIVDTKKKTTQPSKPDSKSSIA-------PVLVPPSLP 2556
            .| .|..|..|..::...:....     ..:.|:.|.:.|.|.|:|       .|..|.|.|
Mouse   839 NKVPKTVSFSKRVERILYSPEDR-----RSEATSSPLEEDPKQSLARGSLAPRSVCAPQSFP 895

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
upSET	NP_001261819.1	PHD_MLL5	856..899	CDD:277025
upSET	NP_001261819.1	SET	<1221..1273	CDD:214614
Spocd1	XP_017175994.1	TFIIS_M	410..520	CDD:400056	21/120 (18%)
Spocd1	XP_017175994.1	SPOC	681..825	CDD:400205	29/150 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030