DRSC/TRiP Functional Genomics Resources

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Protein Alignment upSET and ash1l

DIOPT Version :9

Sequence 1:NP_001261819.1 Gene:upSET / 39551 FlyBaseID:FBgn0036398 Length:3146 Species:Drosophila melanogaster
Sequence 2:XP_005159540.1 Gene:ash1l / 563799 ZFINID:ZDB-GENE-030131-6101 Length:2988 Species:Danio rerio


Alignment Length:2214 Identity:392/2214 - (17%)
Similarity:683/2214 - (30%) Gaps:810/2214 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly  1372 NSRNRSTSSSGES----SQMGLNSPQLGQLNLGFKTSVTATSLTAPVP----------------- 1415
            |..:.:.|.:|:.    :|..:......:.|:..|..:.|..:..|..                 
Zfish    51 NEASGAESGTGDQPQQPTQFSVKETSYSEGNVKLKIGLQAKRMKKPPKILENYVCRPAFRATVRH 115

  Fly  1416 -----GVHCNNSGGSSSSSNNSCSVS-------MSSVLHDSGICTSSSSPSVSIPSP-------- 1460
                 |...|...|:|.:::||.|.|       ..||  :.|...|:::|:.|.|||        
Zfish   116 SGGRGGGRANRGAGASDANSNSTSTSNGKEGEKKPSV--NRGASQSAAAPAASTPSPSLPPASIN 178

  Fly  1461 --TPTQMQSPTLQQHPQQIPQQQLSLLQRSPTQQHQQQILAALPTPMLTPMLSPQLPKP-AQQQA 1522
              ||....:|..:..|:        |..:|..:...:.: |:...|:       .|.:| .:.::
Zfish   179 TVTPVNGNAPAKRGPPK--------LACKSEGKADVKSV-ASSEKPL-------NLHRPTTESKS 227

  Fly  1523 HVVLPQSQQTSLLQQQQSQQSQEPLAVIAAAAAAQQPMATYFVRQPQQQQQQQSPKPQALVAQQQ 1587
            |    .|.:.:.:.|..|..:..|.||..||.:.|.|.....::.|                   
Zfish   228 H----SSGKKNHVPQTNSAPAPSPPAVPPAATSQQDPKIDGILKTP------------------- 269

  Fly  1588 HVVGAQQQQHFLQQQQKQQQQQMADEARMAVSALQTLHAAPTSHIVSPIKVAAVQQQSQPQQQQQ 1652
                   |.:||:.|::|::         .:|:..|    ||                       
Zfish   270 -------QCNFLEGQKEQER---------GISSWGT----PT----------------------- 291

  Fly  1653 NTHQQPHNQQAVQQQSNQLQQQQSQQPNYPQSPQRQQKPQPVQHQPQIVISTGAQAIPATMPTKL 1717
                          .:.:|.|..:..|     |.:..||:..:..|              .|...
Zfish   292 --------------VTEKLAQLIATCP-----PSKCPKPKARKVSP--------------APAHS 323

  Fly  1718 SSPTKSAAPVISNNNITVSAQSSVVGGKKT--PAKHPQQQQQQQQQPVTPVSAATAPAAT---PS 1777
            |||     |:|||    :......:..:.|  .|.|..|.....:.|..|..:....:..   ..
Zfish   324 SSP-----PLISN----LQRPERAMANRNTYSRAVHLAQPPPVSRPPGRPYGSKNKDSILEKFSG 379

  Fly  1778 SSESKEDD-----VSASSTTTPTTRTPAKDKPKQSREDRKLEAILRAIEKMEKQEARGKKDTRQS 1837
            :|:.:|.|     ||.||:||.||.:.|     .|:...:|.......|..:.....|.|...:.
Zfish   380 TSKKEESDGLSKGVSGSSSTTTTTTSSA-----LSQNSSRLTTTTSTNESTDINNTDGMKSQSRL 439

  Fly  1838 SGGKRQASNSPASPNKRNSSN-----SISEDVETPTSTNSAAAAAQRR-----NKKKRKVSRSLN 1892
            ......:|::.|||...:||:     |.|.::..|.|..|...|:..|     .|.|.:......
Zfish   440 GHCPSHSSSAAASPPFSSSSSVERIGSTSCNIGLPGSLTSRPKASPSRIEDFSEKDKERDREKDT 504

  Fly  1893 NNTNGLGSGGGSNNKRRKSIVVESDGESHALTNSESEDQGQ--HPQSHHSGSEDQAAGLLLALAH 1955
            ::...|..|      ...:|..:.|.:.....::...|:|:  .|.......|.:.:|:      
Zfish   505 DSPRDLSKG------ITPAITGKQDAKERCSLSAPRNDRGKSSSPVKRSPNQESRVSGV------ 557

  Fly  1956 NNSSPNEPFKSPLSQSHSLPATPASVSSACLLIEAAMGPLQQQPAP--------ASASPSLAEFK 2012
              .||.|..|..:|     |:.|:..|              :.|.|        :.||||..:.|
Zfish   558 --PSPAESTKCTIS-----PSYPSGAS--------------RSPPPLCDDTGAISPASPSEQDSK 601

  Fly  2013 YPPGGAKTKKSLMSSWFQQAEQQHASGLDSLVQAAMSEINGEREQLQR-QPQGESLPAPALLKVE 2076
                ..|.::.....|.:...:.|.|         :.|.....:|:.. .|.|.|..:|....||
Zfish   602 ----PLKKRRGRRPRWTKAVSRTHKS---------LHESPSNHQQIPTPMPSGLSFSSPIRESVE 653

  Fly  2077 QFIHQAESTTAVPAREQLHLPLQNNSSVKKRWLRQ-------AISEETTPVDELQQSQN-QSVTA 2133
            |.:  ::|.|: |....:.     :||.|||...:       |.:...|| ::|..|:: .|:..
Zfish   654 QPL--SDSYTS-PEDSDIF-----DSSPKKRGRPKTKMPRLDAPAHGCTP-NKLAPSKSFSSLLK 709

  Fly  2134 TPSPQPVPTVSPLANGFSTP--LKKRRLVVVSNGTNVESDETHIDVIGEPKDEAEENVAMTELKV 2196
            :...|..|.:.|..: |:.|  :.::|                    |.||              
Zfish   710 SKEEQDPPVLHPEVD-FNPPKMMARKR--------------------GRPK-------------- 739

  Fly  2197 EIENHHQEQDDDVDILRSPSPGTHQIVAEDNLVKIEPEDTSAAADDVKIDVEREESQACDKFEEM 2261
                            ||| |...|   |.....:.||...|:..:...   |.:.......:.:
Zfish   740 ----------------RSP-PTLPQ---ETQPPTLAPESGEASVGEKPF---RNKGNGQLIMKTI 781

  Fly  2262 V-KVKREEEEQREKEIKQL---------QERQEHEQPKVEPAPVEPKLENTVA-----KAEPKVE 2311
            : |:.:.:..:|::.:.|:         ||......|...|...:|:...::|     |..|::.
Zfish   782 IGKINKMKTVKRKRLLSQILLGPKPAEEQECSRSSGPTGSPVATKPQSLTSLAATFGGKLGPQIN 846

  Fly  2312 PSQEIV-------SKKEPTKVEPKPG------ESLLRSTATVTATPTAATIAATTLLDVSKVAFK 2363
            .|::..       .:|..|...|.||      |..|...   |::|....:.|            
Zfish   847 VSKKGTIYMGKRRGRKPKTSTNPSPGAPTPPPEPFLSPN---TSSPHHHQVQA------------ 896

  Fly  2364 TRPPLKLEDEPQKKKPKLESILPAP--------------VATVPPVSV----------------- 2397
                  |:::|.:..|  ..:.|:|              .:.|.|.||                 
Zfish   897 ------LQNQPHQLPP--SEVFPSPSLSQSSGGQSPISDASFVEPGSVHFSSHPHCSHSHQVHHS 953

  Fly  2398 ---PPIPAASNATTSAVTNTAAASLTTTTAPSSTKNLT-------EHDIQER-----------LL 2441
               ||      .|.||.:..:.||..|:||..|.|..:       .|..::.           ||
Zfish   954 FSFPP------PTFSAPSARSVASAATSTAHPSQKKSSCRGYHHHHHHYRQHYHYRKFSPPRPLL 1012

  Fly  2442 SFHAANISYLQSRNKKATAALTSASPSQKSNSSSGGSGTESKKSSKDKDEKRDKEKQLK------ 2500
            ....|.:|.|    |:||.:..|.|.|:::..|..|.||:: .|:.|:.||......|.      
Zfish  1013 PTSPAPLSEL----KEATPSPVSESHSEETVPSDSGIGTDN-NSTSDRGEKAGSANGLPGVGVSQ 1072

  Fly  2501 ---------------------KSKKEKKKSKDKEKQKAAVNVNSTSQIVDTKKKTTQP----SKP 2540
                                 .|.:.:::             :|:|.:::....|..|    :.|
Zfish  1073 GMAGGLLMPGVIGPGIGTGIGLSSRGRRR-------------HSSSVLLERPSPTPSPLGVRASP 1124

  Fly  2541 DSKSSIAPVLVPPSLPVATANG-KTKH-----------TAYNNVDQQQQQ------QMRRRTM-- 2585
            |.:.|      .|:.|.:...| |.||           .:|:.:.:|:::      |:|.|..  
Zfish  1125 DPRRS------HPAAPSSALVGHKEKHKHKCKRRGHGCPSYDKLKRQKRKRKKKYLQLRSRRQDP 1183

  Fly  2586 -------SMCI----------TPV----------------------------------------- 2592
                   .:|:          ||.                                         
Zfish  1184 DFLADLDEICVQLSDIRISHRTPTLRLGSSIGLGAGAGPGRGSGLGSTRPSSSLGGGTNPPPHHY 1248

  Fly  2593 ------------------TPTPVVTPSPLH-----------GTPPSTKK--RQTNFEQELTKPNS 2626
                              :|.|......||           |.||..::  .:..|...|..|  
Zfish  1249 LHRDLLPTIFRINFSGYYSPHPAYPCDSLHYVRKPDLKKKRGRPPKLRESISEVPFVPGLGFP-- 1311

  Fly  2627 QILSSSILLNSSKGLGLPLAAPTV-------VSVPTAVQQQQHRK-------ENNHQEATPASGG 2677
              |||....:.|  .|:|.::..:       .:.|:|:....|.:       .:.|..:.|....
Zfish  1312 --LSSGGFYHPS--YGVPYSSTPLGLGYYRGYTPPSALYPHPHHQAPHSGPSHHVHSPSFPPPPP 1372

  Fly  2678 PMSLAAAIASGKLNAISR---------RRESMCGSRQQQALIAAALKKE------KKEKKKSKKK 2727
            |..:.....|..|...|:         |:|.:.|.|  .:::..|:..|      .|.|.:.|.:
Zfish  1373 PSYVHHHHPSHLLLNPSKFHKKKHKLLRQEYLGGGR--SSMLYPAMSSELSFGWHHKHKHRHKHR 1435

  Fly  2728 DR--EKQKHD----------------------KQKGKEKERE-----KDKEKDNKQKTNHIQKPA 2763
            ||  |::..|                      .::|..:..:     :|...|:  :||   |.:
Zfish  1436 DRCGEEEGDDGGGVLGGIGGRGVGGEGLGAGRGERGSVESLQHCRFGRDGSADS--RTN---KQS 1495

  Fly  2764 HPTTVPANSMPISA------PAPVPVLVPTPVTTPKAA----PI--------------------- 2797
            .....|::|...||      .|.:..|.|:.::...|:    |:                     
Zfish  1496 ASANSPSSSSTSSAERYKRKEASMSCLGPSRLSLGTASRGHHPVDSWFRMGSSDTDYSKLSRNQS 1560

  Fly  2798 --------------PVLIT----QPTPSPIHVTQPLVNNCSTKVASLPFYNTIYGKLQDPSTPTS 2844
                          ||..:    :...|||.  :|.:::.:...||.....::.|.......|..
Zfish  1561 FSGSGAFSEGHVQNPVDCSESDEEDAASPIE--EPEISHHTNLFASALSRTSLKGSRSKKGGPLE 1623

  Fly  2845 SPIPVTNTMPSLAEYLESTKSKTTALSAVK-----------PIGIAAVTPLSSAI---------T 2889
            |        |||:. |:.|..:..:.|:.|           .:|.::|..:|..:         .
Zfish  1624 S--------PSLSR-LDRTVRRDRSTSSEKREIGNVSSLQNRVGQSSVPDVSEGLHHRHHHHHHP 1679

  Fly  2890 PAKVAPSSLEMP------PPATTPLKLYTRTASHDP-RLNPMLTVPDP------TPMPKRKLSIS 2941
            |..::.::..:|      |..|.||:..:|.||... ...|...:..|      .|.||..|...
Zfish  1680 PLSLSHAASCLPHCTLDQPGNTAPLRPSSRQASPSTCSSQPACCLDSPPSHLSHRPPPKNNLLHV 1744

  Fly  2942 EYRMRHRPSVDTA-----------PTTPTTPTTPTTPTTPPGSNKDRSFAKPQTINKCSLQSPER 2995
            ...:|.:.....|           |..|.....|:.|.|||          |||..:.:...|||
Zfish  1745 NKILRAKKLQRQARTGNNMVKKRGPGRPRKNPLPSPPATPP----------PQTSEQDNHPLPER 1799

  Fly  2996 FQA-AIRERRNSISA--------HHPQQNAHHNLNNNKGGISNKSGSSSGNHLQQALGVAGGRLQ 3051
            .:| |:.|....:.|        ....:...|.....:||...:..:.....::..........:
Zfish  1800 HRATALWEADTVVDAIEAVVQNQRKKGRKRKHWERETEGGDEEEEDAEEERQVEDEEEEEDEEQE 1864

  Fly  3052 SKNAI-VDPAATTLSTVNS-ILSTAQKLHMF----DDKPKGGHFNAAPTLLE--------QQQEK 3102
            .::|. .|...:.:.|..| ...|.:::|.|    :.||.|......|...|        .|:||
Zfish  1865 QQSAAREDDVMSRVRTEGSRQWLTQEEVHCFRSALEGKPDGSPERPGPATSEPTPNPSVTSQREK 1929

  Fly  3103 MSER 3106
            ...|
Zfish  1930 RVAR 1933

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
upSETNP_001261819.1 PHD_MLL5 856..899 CDD:277025
SET <1221..1273 CDD:214614
ash1lXP_005159540.1 CytochromB561_N <529..>674 CDD:286826 38/192 (20%)
AWS 2037..2088 CDD:197795
SET 2091..2238 CDD:214614
COG5076 2281..>2500 CDD:227408
Bromo_ASH1 2408..2513 CDD:99955
PHD_ASH1L 2559..2601 CDD:277023
BAH_polybromo 2633..2772 CDD:240068
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.030

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