|
Fly 820 SAISSSSRMGLASTDIDPG-EETETAPEAEAEDD-----SVTRCICELTHDDGYMICCDKCSAWQ 878
|.:.|.:.:|:.:| |. :||.:|......:| .||||||..||||||||||||||.||
Human 81 SVLISKNEVGIFTT---PNFDETSSATTISTSEDGSYGTDVTRCICGFTHDDGYMICCDKCSVWQ 142
Fly 879 HVDCMGIDRQNIPEEYMCELCQPRAVDKARARALQRQKRKEHMLLVATQAANGAAAVAAGTTLSG 943
|:||||||||:||:.|:||.||||.:||.||..|||:||:. ::.|.|.:.
Human 143 HIDCMGIDRQHIPDTYLCERCQPRNLDKERAVLLQRRKREN---------------MSDGDTSAT 192
Fly 944 GLGSGLPMS--EELQHRLASGLNGGFATGTGMSKKSKKTKENSGSTST-LKKTKKSAVGMGGEKN 1005
..|..:|:. ...||...|.. .|.:.:||.:.|.::.||.... :.|.||
Human 193 ESGDEVPVELYTAFQHTPTSIT----LTASRVSKVNDKRRKKSGEKEQHISKCKK---------- 243
Fly 1006 ASGSGTPTGSSGKTSKKSSKRKSKS-----GGDGSSGGGSSPALTAAEKHAANLRQWIENYEYAV 1065
|...| |:|||:.|..: ..|||:.|..: .::.|::.||.|.
Human 244 AFREG---------SRKSSRVKGSAPEIDPSSDGSNFGWET-----------KIKAWMDRYEEAN 288
Fly 1066 TNHYS-------PELRARLHAIQKQPSLLQSIQNTENKALRQIQQQLSTAGSAEQLEQRAQLIPY 1123
.|.|| ..:..||.....:..:.:|..||.|...: ..:|...|
Human 289 NNQYSEGVQREAQRIALRLGNGNDKKEMNKSDLNTNNLLFK------------PPVESHIQ---- 337
Fly 1124 AGAKVLISSVDLSPHAPIHELRGKYMLTTQFRTQNPTVNMNTPPPSNYLNSFKAHKTPGQFVFFY 1188
...|:|.|:.||.|.|.|.|.|||:||..||.. :.|. .|.|..||.||
Human 338 KNKKILKSAKDLPPDALIIEYRGKFMLREQFEA------------NGYF-----FKRPYPFVLFY 385
Fly 1189 QLPGVEAPMQTLRPDGSVPQVAQQPPSYLKGPEVCVDTRTYGNDARFVRRSCRPNAELQHYFEKG 1253
|...|.|:|||.||:||:|||:||||.||||::|..:.|
Human 386 --------------------------SKFHGLEMCVDARTFGNEARFIRRSCTPNAEVRHEIQDG 424
Fly 1254 TLHLYIVALTHIRAQTEITIRHEPHDLTAVEQKKSHAAVIQPTSTRCACDMGSDCLFALPLAVQQ 1318
|:||||.::..|...|||||..: .|.| :|.:.:..|..:
Human 425 TIHLYIYSIHSIPKGTEITIAFD-------------------------FDYG-NCKYKVDCACLK 463
Fly 1319 QLQAPPTQPRSSHRNKAAAAAAAAAAANSAAAIQLTMGLGVGATVAAGASVLPNSRNRSTSSSGE 1383
:....|...||| |
Human 464 ENPECPVLKRSS----------------------------------------------------E 476
Fly 1384 SSQMGLNSPQLGQLNLGFKTSVTATSLTAPVPGVHCNNSGGSSSSSNNSCSVSMSSVLHDSGICT 1448
|.: .:|.|::|. .
Human 477 SME---------NINSGYETR-------------------------------------------R 489
Fly 1449 SSSSPSVSIPSPTPTQMQSPTLQQHPQQIPQQQLSLLQRSPTQQHQQQILAALPTPMLTPMLSPQ 1513
........|.....||.|:.||....
Human 490 KKGKKDKDISKEKDTQNQNITLDCEG--------------------------------------- 515
Fly 1514 LPKPAQQQAHVVLPQSQQTSLLQQQQSQQSQEPLAVIAAAAAAQQPMATYFVRQPQQQQQQQSPK 1578
.|..::.|:.:|::.||
Human 516 -----------------------------------------------TTNKMKSPETKQRKLSP- 532
Fly 1579 PQALVAQQQHVVGAQQQQHFLQQQQKQQQQQMADEARMAVSALQTLHAAPTSHIVSPIKVAAVQQ 1643
.|::||
Human 533 -----------------------------------LRLSVS------------------------ 538
Fly 1644 QSQPQQQQQNTHQQPHNQQAVQQQSNQLQQQQSQQPNYPQSPQRQQKPQPVQHQPQIVISTGAQA 1708
.:|:|::....:
Human 539 -------------------------------NNQEPDFIDDIE---------------------- 550
Fly 1709 IPATMPTKLSSPTKSAAPVISNNNITVSAQSSVVGGKKTPAKHPQQQQQQQQQPVTPVSAATAPA 1773
:|||..:..:.:.::|
Human 551 ------------------------------------EKTPISNEVEMESEEQ------------- 566
Fly 1774 ATPSSSESKEDDVSASSTTTPTTRTPAKDKPKQSREDRKLEAILRAIEKMEKQEARGKKDTRQSS 1838
.|:.|.|.:||:||:||||:|..::||:|.|.::...:.|
Human 567 -------------------------IAERKRKMTREERKMEAILQAFARLEKREKRREQALERIS 606
Fly 1839 GGKRQASNSPASPNKRNSSNSISEDVE-------TPTSTNSAAAAAQRRNKKKRKVSRSLNNNTN 1896
..|.:...........:.:..|.|..: ||...| |.|:::..|||..:.
Human 607 TAKTEVKTECKDTQIVSDAEVIQEQAKEENASKPTPAKVN--------RTKQRKSFSRSRTHI-- 661
Fly 1897 GLGSGGGSNNKRRKSIVVESDGESHALTNSESEDQGQHPQSHHSGSEDQAAGLLLALAHNNSSPN 1961
|...:|.:::.:.|| ..|:
Human 662 ------GQQRRRHRTVSMCSD----------------------------------------IQPS 680
Fly 1962 EPFKSPLSQSHSLPATPASV------SSACLLIEAAMGPLQQQPAPASASPSLAEFKYPPGGAKT 2020
.|.....||.:.:..|..:: :.|.::.|..:..|.:.|. ||| ||
Human 681 SPDIEVTSQQNDIENTVLTIEPETETALAEIITETEVPALNKCPT-----------KYP----KT 730
Fly 2021 KKSLMSSWFQQAEQQHASGLDSLVQAAMSEINGEREQLQRQPQGESLP----APALLKVEQFIHQ 2081
||.|::.|..:..::.....|.|.:..: .|..:.|.|..|. .||| :|.:....: |.
Human 731 KKHLVNEWLSEKNEKTGKPSDGLSERPL-RITTDPEVLATQL--NSLPGLTYSPHVYSTPK--HY 790
Fly 2082 AESTTA-VPAREQLHLPLQN-NSSVKKRWLRQAISEE---------------------------- 2116
...|:. :..:.:...|.:| :.|.|||||:||:.||
Human 791 IRFTSPFLSEKRRRKEPTENISGSCKKRWLKQALEEENSAILHRFNSPCQERSRSPAVNGENKSP 855
Fly 2117 ------------TTPVDE------LQQSQNQSVTATPSPQPVPT---VSPLANGFSTPLKKRR-- 2158
|||:.: |....:::.|.||||...|| ::|:...|:||.:.:.
Human 856 LLLNDSCSLPDLTTPLKKRRFYQLLDSVYSETSTPTPSPYATPTHTDITPMDPSFATPPRIKSDD 920
Fly 2159 -------------LVVVSNGTNVESDETHIDVIGEPKDEAEENVAMTELKVEIENHHQEQDDDVD 2210
:..|:.|| ..:..|.:.|..|:...| ::...:.||..|...
Human 921 ETCRNGYKPIYSPVTPVTPGT--PGNTMHFENISSPESSPE---------IKRRTYSQEGYDRSS 974
Fly 2211 ILRSPSPGTHQIVAEDNLVKIEPEDTSAAADDVKIDVEREESQACDKFEEMVKVKREEEEQREKE 2275
.:.:..|..:..:.|..|.:|:....::... :.:|.|: | ..|||
Human 975 TMLTLGPFRNSNLTELGLQEIKTIGYTSPRS--RTEVNRQ----C---------------PGEKE 1018
Fly 2276 -IKQLQERQEHEQPKVEPAPVEPKLENTVAKAEPKVEPSQEIVSK------------KEPTKV-- 2325
:..||...: .|||..:...|| ..|..:.||:.::.|. |.|.:.
Human 1019 PVSDLQLGLD----AVEPTALHKTLE---TPAHDRAEPNSQLDSTHSGRGTMYSSWVKSPDRTGV 1076
Fly 2326 ---------EPKPGESL-------LRSTATVTATPTAATIAATTLLDVSKVAFKT---------- 2364
:..|...| :..:..:....|......||:...|:....:
Human 1077 NFSVNSNLRDLTPSHQLEVGGGFRISESKCLMQDDTRGMFMETTVFCTSEDGLVSGFGRTVNDNL 1141
Fly 2365 --------RPP----------LKLEDEPQKKKPKLESILPAPVATVPP----------------- 2394
.|| .|.:.|.:|...|.|:. |:.:|.|
Human 1142 IDGNCTPQNPPQKKKVSLLEYRKRQREARKSGSKTENF---PLISVSPHASGSLSNNGDGCASSN 1203
Fly 2395 ---------VSVP-PIPA-ASNATTSAVTNTAAASLTTT----------TAPSSTKNLTEHDIQE 2438
.|:| |.|| ..|||:...:|.......|. ||.:|.:.:.|...|.
Human 1204 DNGEQVDHTASLPLPTPATVYNATSEETSNNCPVKDATASEKNEPEVQWTASTSVEQVRERSYQR 1268
Fly 2439 R-LLSFHAANISYLQSRNKKATAALTSASPSQKSNSSSGGSGTESKKSSKDKDEKRDKEKQLKKS 2502
. |||.|. :.::....:...|.|||...:|.|..|....:..:|.. ..|
Human 1269 ALLLSDHR------KDKDSGGESPCVSCSPSHVQSSPSSHSNHIPQLQAKGP----------VPS 1317
Fly 2503 KKEKKKSKDKEKQKAAVNVN----STSQIVDTKKKTTQPSKPDSKSSIAPVLVPPSLPVATANGK 2563
..|..:..|.|..:...... .||| :|.|...:.|||.|..|:.| |.|:||
Human 1318 FSELMEDPDPENPEPTTTNECPSPDTSQ--NTCKSPPKMSKPGSPGSVIP---------AQAHGK 1371
Fly 2564 TKHTAYNNVDQQQQQQMRRRTMSMCITPVTPTPVVTPSPLHGTPPSTKKRQTNFEQELTK---PN 2625
.:...|.|... |.:.....:.:|......:|:.:|..|.|:| |.
Human 1372 ----IFTKPDPQWDS--------------TVSASEAENGVHLKTELQQKQLSNNNQALSKNHPPQ 1418
Fly 2626 SQILSSSILLNSSKGLGLPLAAPTVVSVPTAVQQQQHRKENNHQEATPASGGPMSLAAAIASGKL 2690
:.:.:||..|:.. || ||||.: |...:.|.|..|.|..|.: .:..|.|
Human 1419 THVRNSSEQLSQK----LP-------SVPTKL----HCPPSPHLENPPKSSTPHT---PVQHGYL 1465
Fly 2691 NAISRRRESMCGSRQQQALIAAALKKEKKEKKKSKKKDREKQKHDKQKGKEKEREKDKEKD---- 2751
: .|..|::.....:.|..|..:....:::.:::
Human 1466 S----------------------------PKPPSQQLGSPYRPHHSQSPQVGTPQREPQRNFYPA 1502
Fly 2752 ------NKQK----TNHIQKPAHPTTVP-----ANSMPISAPAPVPVLVPTPVTTPKAAPIPVLI 2801
|.|: |...|.|:..::.. ..|:..:||.|.| |.|
Human 1503 AQNLPANTQQATSGTLFTQTPSGQSSATYSQFNQQSLNSTAPPPPP---PPP------------- 1551
Fly 2802 TQPTPSPIHVTQPLVNNCSTKVASLPFYNTIYGKLQDPSTPTSSP---IPVTNTMPSL------- 2856
|:.|.....||..| ...||.:.|.|...:..||.| :|.|.:..::
Human 1552 --PSSSYYQNQQPSAN--------FQNYNQLKGSLSQQTVFTSGPNQALPGTTSQQTVPGHHVTP 1606
Fly 2857 AEYLES---TKSKTTALSAVKPIGIAAVTPLSSAITPAKV-APSSLEM--------PPPATTP-L 2908
..:|.| |....||.:.|.| ..|...|..|..| .|:|.:. |..|.|| .
Human 1607 GHFLPSQNPTIHHQTAAAVVPP-----PPPPPPAPGPHLVQQPNSHQQHSVAHVVGPVHAVTPGS 1666
Fly 2909 KLYTRTASHDPRLNPMLTVPDPT----PMPKRKLSISEYRMRHRPSVDTAPTTPTTPTTPTTPTT 2969
.::::||.| .|.|....|.|. |.|.....:...:.:|:..|::|| |..|..
Human 1667 HIHSQTAGH--HLPPPPPPPGPAPHHHPPPHPSTGLQGLQAQHQHVVNSAP--------PPPPPP 1721
Fly 2970 PPGS--NKDRSFAKPQTINKCSLQSPERFQAAIRERRNSISAH-----HPQQNAHHNLNNNKGGI 3027
||.| .........|.::....|.|..|.: ||| :|.|..|| ...|..
Human 1722 PPSSVLASGHHTTSAQALHHPPHQGPPLFPS---------SAHPTVPPYPSQATHH---TTLGPG 1774
Fly 3028 SNKSGSSSGNHLQQALGVAGGRLQSK--NAIVDPAAT 3062
.....|.:|.|. .|.|.|..||.: |:|..|.|:
Human 1775 PQHQPSGTGPHC--PLPVTGPHLQPQGPNSIPTPTAS 1809
| 
