DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment upSET and ASH1L

DIOPT Version :9

Sequence 1:	NP_001261819.1	Gene:	upSET / 39551	FlyBaseID:	FBgn0036398	Length:	3146	Species:	Drosophila melanogaster
Sequence 2:	NP_001353106.1	Gene:	ASH1L / 55870	HGNCID:	19088	Length:	2969	Species:	Homo sapiens

Alignment Length:	2017	Identity:	360/2017 - (17%)
Similarity:	656/2017 - (32%)	Gaps:	694/2017 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1565 VRQPQQQQQQQSPKPQALV-AQQQHVVGAQQQQHFLQQQQKQQQQQMADEARMAVSALQTLHAAP 1628
            :|:..:::..::.|...|. ||||..|   ::.:|.:...|.:....|...:.....|:.....|
Human    49 LRKRNRERNIEAGKDDGLTDAQQQFSV---KETNFSEGNLKLKIGLQAKRTKKPPKNLENYVCRP 110

  Fly  1629 TSHIVSPIKVAAVQQQSQPQQQQQNTH-----------QQPHNQQAVQQQSNQLQQQQSQQPNYP 1682
            .  |.:.||......:|.....::|.|           ::..:..|::.||.::.:..||..|.|
Human   111 A--IKTTIKHPRKALKSGKMTDEKNEHCPSKRDPSKLYKKADDVAAIECQSEEVIRLHSQGENNP 173

  Fly  1683 ----QSPQRQQKPQPVQHQPQIVISTG--------------------AQAIPATMPTKLSSPTK- 1722
                .||...:....:...|..::.:.                    ||.| ||.|...||.||
Human   174 LSKKLSPVHSEMADYINATPSTLLGSRDPDLKDRALLNGGTSVTEKLAQLI-ATCPPSKSSKTKP 237

  Fly  1723 ------SAAPVISNNNITVSAQSSVVG-GKKTPAKHPQQQQQQQQQPVTPVSAATA-PAATPSSS 1779
                  :.|.::|.:.|..:...||.| ..|...|.|...        |.|...|. |...|..:
Human   238 KKLGTGTTAGLVSKDLIRKAGVGSVAGIIHKDLIKKPTIS--------TAVGLVTKDPGKKPVFN 294

  Fly  1780 ES----KEDDVSASSTTT------------PTTRTP----AKDKPKQ----------SRED---- 1810
            .:    .:|.|....|.|            |.|.|.    :||..|:          .:|.
Human   295 AAVGLVNKDSVKKLGTGTTAVFINKNLGKKPGTITTVGLLSKDSGKKLGIGIVPGLVHKESGKKL 359

  Fly  1811 --------------RKLEAILRAI-----EKMEKQEARG--KKDTRQSSGGKRQASNSPASPNKR 1854
                          :||.:.:..:     :|:....|.|  .||.     ||:..|...|....:
Human   360 GLGTVVGLVNKDLGKKLGSTVGLVAKDCAKKIVASSAMGLVNKDI-----GKKLMSCPLAGLISK 419

  Fly  1855 NSSNSISEDVETPTSTNSAAAAAQRRNKKKRKVSRSLNNNTNGLGSGGGSNN--KRRKSIVVESD 1917
            ::.|..:|.:........|:.:....|::.:::|.||.::..   |.....|  ::.|..::|..
Human   420 DAINLKAEALLPTQEPLKASCSTNINNQESQELSESLKDSAT---SKTFEKNVVRQNKESILEKF 481

  Fly  1918 GESHALTNSESE----------------DQGQHPQSHHSGSEDQ------AAGLLLALAHNNSSP 1960
            .....:.|.|.|                ::|.:..|.|   |.|      :....:..|.:.|:.
Human   482 SVRKEIINLEKEMFNEGTCIQQDSFSSSEKGSYETSKH---EKQPPVYCTSPDFKMGGASDVSTA 543

  Fly  1961 NEPFKSPLSQSHSLPATPASVSSACLLIEAAMGPLQQQPAPASASPSLAEFKYPPGGAKTKKSLM 2025
            ..|| |.:.:| :||:...:||         :.||.:  :|...|..||          ....|:
Human   544 KSPF-SAVGES-NLPSPSPTVS---------VNPLTR--SPPETSSQLA----------PNPLLL 585

  Fly  2026 SSWFQQAEQQHASGLDSLVQAAMSEINGEREQLQRQPQGESLPAPALLKVEQFIHQAESTTAVPA 2090
            ||..:..|:             :||..|:                     .||  .:|||
Human   586 SSTTELIEE-------------ISESVGK---------------------NQF--TSEST----- 609

  Fly  2091 REQLHLPLQNNS-----SVKKRWLRQAISE-ETTPVD--ELQQSQNQSVTATPSPQPVPTVSP-- 2145
                ||.:.:.|     |::.:.:.:.::: :||.:|  .:..|..:..:.| |...:.|::|
Human   610 ----HLNVGHRSVGHSISIECKGIDKEVNDSKTTHIDIPRISSSLGKKPSLT-SESSIHTITPSV 669

  Fly  2146 --------------------------LANGFST-----PLKKRR------LVVVSNGTNVESDET 2173
                                      :|...||     |||||:      ..||:..|.......
Human   670 VNFTSLFSNKPFLKLGAVSASDKHCQVAESLSTSLQSKPLKKRKGRKPRWTKVVARSTCRSPKGL 734

  Fly  2174 HIDVIGEPKDEAEENVAMTELKVEIENHHQEQDDDVDILRSPSPGTHQIVAEDNLVKIEPEDTSA 2238
            .::     :.|..:||:.:.|    .|.:.|....:..:..||     .|..|.|.:..|:.:.:
Human   735 ELE-----RSELFKNVSCSSL----SNSNSEPAKFMKNIGPPS-----FVDHDFLKRRLPKLSKS 785

  Fly  2239 AADDVKIDVEREE------------SQAC---DKFEEMVKVKREEEEQREKEIKQLQERQEHEQP 2288
            .|..:.:..:.|:            |..|   |...::.|.||  ...:.||:.|| |.......
Human   786 TAPSLALLADSEKPSHKSFATHKLSSSMCVSSDLLSDIYKPKR--GRPKSKEMPQL-EGPPKRTL 847

  Fly  2289 KVEPAPVEPKLENTVAKAEPKVEPSQEIVSKKEPTKVEPKPGESLLRSTATVTATPTAATIAATT 2353
            |: ||.....|::...:..|.::|..||.|.|:...|.|.|
Human   848 KI-PASKVFSLQSKEEQEPPILQPEIEIPSFKQGLSVSPFP------------------------ 887

  Fly  2354 LLDVSKVAFKTRPPLKLEDEPQKKKPKLESILPAPVATVPPV-SVPPIPAASNATTSAVTNTAAA 2417
                                  ||:.:.:..:.:||...||| ||.|..|
Human   888 ----------------------KKRGRPKRQMRSPVKMKPPVLSVAPFVA--------------- 915

  Fly  2418 SLTTTTAPSSTKNLTEHDIQERLLSFHAANISYLQSRNKKATAALTSASPSQKSNSSSGGSGTES 2482
                |.:||..::.:::         |.::..:.:|.::     |........|:..|..|.::.
Human   916 ----TESPSKLESESDN---------HRSSSDFFESEDQ-----LQDPDDLDDSHRPSVCSMSDL 962

  Fly  2483 KKSSKDKDEKRDKEKQLKKSKKEKKKSKDKEKQKAAVNVNSTSQIVDTKKKTTQPSKPDSKSSIA 2547
            :.....|..||:..:.:|...::..|.|.. |:|..:|...:|.:..:.|...|....::.||:|
Human   963 EMEPDKKITKRNNGQLMKTIIRKINKMKTL-KRKKLLNQILSSSVESSNKGKVQSKLHNTVSSLA 1026

  Fly  2548 P-----------VLVPPSLPVATANGKTKHTAYNN----------VDQQQQQQMRRRTMSMCITP 2591
            .           |....::.:....|:...|..|.          |.:|..||.....:...:.|
Human  1027 ATFGSKLGQQINVSKKGTIYIGKRRGRKPKTVLNGILSGSPTSLAVLEQTAQQAAGSALGQILPP 1091

  Fly  2592 VTPTPV----VTPSPLHGTPPSTKKRQTNFEQE--LTKPNS-----------QILSSSILLNSSK 2639
            :.|:..    :.|||:......|...|:....:  ..:|:|           .::.:..:..:||
Human  1092 LLPSSASSSEILPSPICSQSSGTSGGQSPVSSDAGFVEPSSVPYLHLHSRQGSMIQTLAMKKASK 1156

  Fly  2640 GLGLPLAAPTVV-SVPTAVQQQQHRKE-------NNHQEAT-PASGGPMSLAAAIASGKLNAISR 2695
            | ...|:.||:: :.|:.:.:....||       .:|.:.| |:..|       |.:.. |:.|.
Human  1157 G-RRRLSPPTLLPNSPSHLSELTSLKEATPSPISESHSDETIPSDSG-------IGTDN-NSTSD 1212

  Fly  2696 RRESMCGSRQQQ-------------ALIAAALKKEKKEKKKSKKKDREKQKHDKQK-GKEKEREK 2746
            |.|..||.::::             :.:.::||  :|.|.|.|:::.:...:||.| .|.|.::|
Human  1213 RAEKFCGQKKRRHSFEHVSLIPPETSTVLSSLK--EKHKHKCKRRNHDYLSYDKMKRQKRKRKKK 1275

  Fly  2747 DKEKDNKQ----------------------KTNH-IQKPAHPTTVPAN--------SMPISAPAP 2780
            ..:..|:|                      :::| |.:...||....|        |.|:.   |
Human  1276 YPQLRNRQDPDFIAELEELISRLSEIRITHRSHHFIPRDLLPTIFRINFNSFYTHPSFPLD---P 1337

  Fly  2781 VPVLVPTPVTTPKAAPIPVLITQPTPSPIHVTQPLVNNCSTKVASLPFYNTIYGKLQDPSTPTSS 2845
            :..:....:...:..|       |.........|.:::.|..::|..||.: ||....||..|::
Human  1338 LHYIRKPDLKKKRGRP-------PKMREAMAEMPFMHSLSFPLSSTGFYPS-YGMPYSPSPLTAA 1394

  Fly  2846 PIPVTNTMPSLAEYLESTKSKTTALSAVKPIGIAAVTPLSSAITPAKVAPS-SLEMPPPA----- 2904
                                         |||:.........:.|...:|| :..:|||:
Human  1395 -----------------------------PIGLGYYGRYPPTLYPPPPSPSFTTPLPPPSYMHAG 1430

  Fly  2905 ---TTPLKLYTR-----------TASHDPRLNPMLTVPDPTP----------------------- 2932
               ..|.|.:.:           |.|..|.|: |.|.|...|
Human  1431 HLLLNPAKYHKKKHKLLRQEAFLTTSRTPLLS-MSTYPSVPPEMAYGWMVEHKHRHRHKHREHRS 1494

  Fly  2933 --MPKRKL----------SISEYRM-------------RHR------------------------ 2948
              .|:..:          |:..||.             :||
Human  1495 SEQPQVSMDTGSSRSVLESLKRYRFGKDAVGERYKHKEKHRCHMSCPHLSPSKSLINREEQWVHR 1559

  Fly  2949 -PS--------------VDTAPTTPTTPTTPTTPTTPPGSNKDRSFAKPQTINKCSLQSPERF-Q 2997
             ||              :|.:.::|:......||.:.|.|:.:.:......|..|.:.:|... :
Human  1560 EPSESSPLALGLQTPLQIDCSESSPSLSLGGFTPNSEPASSDEHTNLFTSAIGSCRVSNPNSSGR 1624

  Fly  2998 AAIRERRNSISAHHPQQNAHH---NLNNNKGGISNKSGSSSGNHLQQALGVAGGRLQSKNAIVDP 3059
            ..:.:.....||.....|..|   :|.:|:..:...:||       |.......:..|::....|
Human  1625 KKLTDSPGLFSAQDTSLNRLHRKESLPSNERAVQTLAGS-------QPTSDKPSQRPSESTNCSP 1682

  Fly  3060 ------AATTLSTVNSILSTAQKLHMFDDKPKGGHFNAAPTLLE-----QQQEKMSE-------- 3105
                  :.:|.||||.:.|.:.:|....|       ::..:||:     :.||.|.:
Human  1683 TRKRSSSESTSSTVNGVPSRSPRLVASGD-------DSVDSLLQRMVQNEDQEPMEKSIDAVIAT 1740

  Fly  3106 ----------RSRCLQRTI--------------SCD---SRVIERLGTGAAAGALEKVTTASTRR 3143
                      ||....||:              ||:   |.:.|:|.:..:...:::....:.:|
Human  1741 ASAPPSSSPGRSHSKDRTLGKPDSLLVPAVTSDSCNNSISLLSEKLTSSCSPHHIKRSVVEAMQR 1805

  Fly  3144 DA 3145
            .|
Human  1806 QA 1807

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
upSET	NP_001261819.1	PHD_MLL5	856..899	CDD:277025
upSET	NP_001261819.1	SET	<1221..1273	CDD:214614
ASH1L	NP_001353106.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..70		3/20 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	118..143		3/24 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	501..525		5/26 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	537..583		16/68 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	824..845		8/23 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	878..966		24/166 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1100..1128		5/27 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1151..1231		20/88 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1243..1281		12/39 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1489..1508		1/18 (6%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1580..1711		26/137 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1741..1761		4/19 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1911..1991
		Catalytic domain	2069..2288
		AWS	2092..2143	CDD:197795
		SET	2146..2266	CDD:214614
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2288..2346
		Bromo_ASH1	2443..2548	CDD:99955
		PHD_ASH1L	2586..2628	CDD:277023
		BAH_polybromo	2665..2799	CDD:240068
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2825..2856
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2876..2919
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030