DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment upSET and phf3

DIOPT Version :9

Sequence 1:	NP_001261819.1	Gene:	upSET / 39551	FlyBaseID:	FBgn0036398	Length:	3146	Species:	Drosophila melanogaster
Sequence 2:	XP_005157087.1	Gene:	phf3 / 553518	ZFINID:	ZDB-GENE-090313-207	Length:	1691	Species:	Danio rerio

Alignment Length:	2106	Identity:	365/2106 - (17%)
Similarity:	616/2106 - (29%)	Gaps:	806/2106 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 APPHNSKLLLSNLTVLSKQAPVQGAAGQQQQQLN----YLGAKSLPYVSASPAKTQQQPQKFGSI 195
            |.|.:|   |.|:  ||.:.|:.|:|..|...|.    .||:.:......:.|..:|.|.
Zfish    37 AKPEDS---LKNM--LSDKDPMFGSASTQFHLLENEDFKLGSSADADHEMTGAGVRQSPS----- 91

  Fly   196 SAFKAQHQQ----QQQHPHATLQKVTLGSRVATRLQSYVPASPSQIMVQPAQPKYVNATATTIGG 256
               ..:|.|    |.:.....:|:....||...|.:...||
Zfish    92 ---DGEHNQSGFLQDRRQAGQMQRRQTASRGRVRGRRLGPA------------------------ 129

  Fly   257 NAALLKKANQKITVKSVSNMSQQQQQQQQQQQQQLLQAQQLKTFITQQQQQQTYKAGAKAKFVKQ 321
                 :||.:....:|..:....:.....::::.||.    :.|...:............:....
Zfish   130 -----RKAAESYNRESTCSEEHDRDNSPDEKREALLS----RRFGVHEVDSSMNPVVVLRRLTVT 185

  Fly   322 TTALSIAALPQQQQQ----TTYAKQSM------------------------VTTSTPAKVTKLNS 358
            .....|..||...|.    :|.|.||:                        |..|||..|
Zfish   186 VGGYKIELLPGPSQSFGSFSTSALQSLGFQDDGIIADGLGLDLGQNQDEQVVDNSTPEAV----- 245

  Fly   359 KYVQQQISLPQGTQLQHKASPNVTGGGYLLQQSQAAVGGTIKFVNSHGTVIQQHPQQQQATKRTH 423
                .::|:.|.|  .|....:.  |.|:                        :|.:.|.|
Zfish   246 ----GEVSIDQST--SHDVPMDF--GPYV------------------------NPNEVQDT---- 274

  Fly   424 YNSSGSSDNEQHAVANSSLI---------TDDVMIVNGTQMTDELSARILQSMAQKSFSQQQRFH 479
                           ||:::         ::|....|....|.:|||
Zfish   275 ---------------NSTMVLKPKVENATSEDAKKKNNQIKTQKLSA------------------ 306

  Fly   480 QVPATGSGNMP-PPTQIIYSNSTSNGAAASSPGGNASGNMLLAHYQAAGTKPVSSASFITVTGTP 543
            |.|...:|... |..:.:..|..|..||.:.|.......:|....:....|.:.       ||.|
Zfish   307 QKPGNKNGTAARPAVKKLLKNKQSLSAAKNKPSSPTKPGLLQKESKHPQDKKIH-------TGQP 364

  Fly   544 PVTVATTPSVSISSHGFASG---SAAISSYMSSATAARRQSVSAPSSRAVSLERKQHHQQLQHDV 605
            .|.......|.:...|.|.|   .:.|.......:|::..|.|.|.|..::.:....
Zfish   365 EVHKGKPIKVGLKRPGAALGPKDGSKIQKIQDGHSASKTASPSGPLSPTITKKSSSE-------- 421

  Fly   606 IGGGRKAPTVIEYYNKHGVNSI-VGSSNNLAQSNSM----SNLAGPRSNS-----------GSGF 654
              .|..:||   ...|...:|: :..:|:...|||:    :|...|.|||           .|..
Zfish   422 --SGPLSPT---NSRKPSSDSVPLSPTNSRKPSNSVPLSSTNSRKPSSNSVPLSPSNSRKPSSNL 481

  Fly   655 ATTTPTPATPLH-----LTPVN--------VPVHVEAAPPSS--PALVKG-------SSQPPAQP 697
            ...:||.:..|.     |:|.|        ||:    :|.:|  |:...|       |..||.:|
Zfish   482 VPLSPTNSRKLSSDSGPLSPTNSRKPSSDSVPL----SPTNSRRPSSESGPGVKSVQSPHPPKKP 542

  Fly   698 QQQQQQAHPLGPNQLNA-NDEELYIEEVRPVPVLTQDLRLQQLHAIMQDHTYASQQQQQQPQQAA 761
            |......:...|...|: .|||                         ||...|.:.::.|.:..:
Zfish   543 QNPPTSGNKTNPPVANSQGDEE-------------------------QDKVKAKKIEKTQQRHKS 582

  Fly   762 GDTTNPGAAQQVQQPQQWSLGGIGVTVSGSQGTPTAVGGYCSYFGQQIARSQADDDAHSAISSSS 826
            .::    .:..:::||.:.          ....|             :.:.:|:.||
Zfish   583 RNS----RSISIEEPQLFI----------PDNAP-------------VVKKEAEGDA-------- 612

  Fly   827 RMGLASTDIDPGEETETAPEAEAEDDSVTRCI-CELTHDDGYMICCDKCSAWQHVDCMGIDRQNI 890
               ||              |:|...|....|: |:..|::.:|:.|.:|..|.|.||:|:|...:
Zfish   613 ---LA--------------ESETVWDPTKNCVLCKKPHNNRFMVGCGRCDDWFHGDCVGLDLAKV 660

  Fly   891 ------PEEYMCELCQPRAVDKARARALQ------RQKRKEHMLLVATQAANGAAAVAAGTTLSG 943
                  .:||:|..|..:..:|.:|..|.      :||::....|.|                 |
Zfish   661 QQMEKEDQEYVCLKCCAQEDEKTQASELSDDKSAAKQKQRPQQSLTA-----------------G 708

  Fly   944 GL-------GSGLPMSEELQHRLASGLNGGFATGTGMSKKSKKTK---ENSGSTST--------- 989
            |:       |...|..:..|            .|..:..::||.|   .:|...||
Zfish   709 GIRPFRKDAGERRPSEDSAQ------------KGPNVKHETKKVKISPVSSKKPSTGHIRRSVRD 761

  Fly   990 ------LKKTKKSAVGMGGEKNASGSGTPTGSSGKTSKK--------SSKRKSKSGG------DG 1034
                  ||::|:|.:.:..::       |...:.:|.|:        .||.|:|...      |.
Zfish   762 SLEEILLKRSKESDLKISSDR-------PAEVARRTEKELFALFQGVDSKYKNKYRSLTFNLKDA 819

  Fly  1035 SSG--------GGSSPA----LTAAEKHAANLRQWIENYEYAVTNHYSPELRARLHAIQKQPSLL 1087
            .:.        |..|||    :||.|..:..|..|.:.           |.|..:..|:|:.
Zfish   820 KNNVLFKRVLKGEVSPADLVRMTAEELASKELAAWRKR-----------ENRHTIEMIEKEQ--- 870

  Fly  1088 QSIQNTENKALRQIQQQLSTAGSAEQLEQRAQLIPYAGAKVLISSVDLSPHAPIHELRGKYMLTT 1152
               :..|.:.:.:|..:    |..|...|.....|.|        :::.|...:..:........
Zfish   871 ---REVERRPITKITHK----GEIEIENQEPAKAPEA--------IEVEPEPVLKVVEVPEEKPP 920

  Fly  1153 QFRTQNPTVNMNTPPPSNYLNSFKAHKTPGQFVFFYQL-----------PGVEAPMQTLR----- 1201
            :.:.::|..:::|      .|..|:|        .:.|           |..||..:.::
Zfish   921 EIKVESPKKSIDT------TNLHKSH--------LFDLNCKICTGRMAPPTEEASTKVVKVATTV 971

  Fly  1202 ------------PDGSVPQVAQQP---------------PSYLKGPEVC--VDTRTYGND----- 1232
                        |..:.|..|...               |...:...:|  .||.|:.:.
Zfish   972 VRRQSSATEESQPSTTTPTSALMDDLTLRAMEEGLLNFLPESSRADSLCSKEDTATFLSSLESLW 1036

  Fly  1233 ---------ARFVRRSCRPNAELQH----------------------YFEK----GTLHLYIVAL 1262
                     |||:.:|...:..|.|                      |.||    ||..:.::..
Zfish  1037 GGYVDMPAVARFLTKSYLVSGTLDHLTQDLPDNIQVGGRISPQIVWDYVEKIRASGTKEICVIRF 1101

  Fly  1263 THIRAQTEIT-------------------------------------IRHE--PHDLTAVEQKKS 1288
            :....:.||:                                     |.|:  |.|...:|..:.
Zfish  1102 SPDTEEDEISYTLLYAYFSSRRRYGVVANNRKQVKDMYLIPLGSTEKIPHQIVPFDGPGLETNRP 1166

  Fly  1289 H---AAVIQPTSTRCACDMGSDCLFALPLAVQQQLQAP----PTQPRSSHRNKAAAAAAAAAAAN 1346
            :   ..:|:....|   |.|    ..||..|.   :||    .::|:..:..|...|.
Zfish  1167 NLLLGLIIRQRPKR---DFG----VILPSDVS---EAPSFLAESKPQVDYPQKTPVAL------- 1214

  Fly  1347 SAAAIQLTMGLGVGATVAAGASVLPNSRNRSTSSSGES--SQMGLNSPQLGQLNLGFKTSVTATS 1409
                          .|..:..|.|.|:|.:.|:...:|  .:..|::.....::|.|...|
Zfish  1215 --------------DTEQSFISDLGNARKKDTTDLIKSVVEEPILDTETDENVSLRFLPGV---- 1261

  Fly  1410 LTAPVPGVHCNNSGGSSSSSNNSCSVSMSSVLHDSGICTSSSSPSV-----SIPSPTPTQMQSPT 1469
            |..|.....|:|....|.|:.                 |.:.:|||     :..||.|. ..:|.
Zfish  1262 LKLPEKAASCSNDNMKSDSTK-----------------TEAKTPSVDSGNNATVSPKPI-ASAPR 1308

  Fly  1470 L------QQHPQQIPQQQLSL---LQRSPTQQHQQQIL------AALPTPMLTPMLSPQLPKPAQ 1519
            |      ::.|:.:..:|..:   |:.|..::....:|      |.:.|......|:...||...
Zfish  1309 LDRFVIKKKEPKAVKTEQAPVSVSLEISSEKKETAVVLSLSDKPADVSTESFLSSLTNTKPKEES 1373

  Fly  1520 QQAHVVLPQSQQTSLLQQQQSQQSQE-------------------------PLAVIAAAAAAQQP 1559
            :......|.||:||  |...|..|::                         |..::..|::|.:|
Zfish  1374 ESCSTASPTSQETS--QTTSSGTSKDSVDEGSSSAPKNETISSPTATTKVSPAGILKRASSAPEP 1436

  Fly  1560 MATYFVRQPQQQQQQQSPKPQALVAQQQHVVGAQQQQHFLQQQQKQQQQQMADEARMAVSALQTL 1624
            ..:       :..:..|.||                      :||...|....|.:    |::.:
Zfish  1437 TES-------KLPESSSEKP----------------------EQKVTPQPSTQECK----AIEDI 1468

  Fly  1625 HAAPTSHIVSPIKVAAVQQQSQPQQQQQNTHQQP--HNQQAVQQQSNQLQQQQSQQPNYPQS--P 1685
            .|..|   :|.|......:||:........:..|  |:     ..|.....|....|..|..  |
Zfish  1469 QAITT---ISSIGKNEGLKQSRSSSFNPKVYNPPVFHS-----YLSGPPDPQFYPPPANPAHFLP 1525

  Fly  1686 QRQQKPQPVQHQPQIVISTGAQAIPATMPTKLSSPTKSAAPVISNNNITVSAQSSVVGGKKTPAK 1750
            .:...|.|.|..|.   ....|..|.:.|..|:.|.....|
Zfish  1526 LQAHLPPPFQFPPG---PPPLQMFPQSDPHMLAPPWPQTVP------------------------ 1563

  Fly  1751 HPQQQQQQQQQPVTPVS-AATAPAATPSSSESKEDDVSASSTTTPTTRTPAKDKPKQSRE----- 1809
                   .|..|..|:: .::.|.|.|.|.:.|..:.|.|......:|...:...|.||:
Zfish  1564 -------PQTLPPPPMAYESSLPTALPLSKDEKVSEKSYSDFVDKLSRRSEETHRKDSRDREHYD 1621

  Fly  1810 -----------DRKLEAILRAIEKMEKQEARGKKDTRQSSGGKRQASNSPASPNKRNSSNSISED 1863
                       ||:     :..|:....:.|..||.|.....:|:.|:.....:|..|.:|..|
Zfish  1622 KHHHKSRHYERDRE-----KHRERSHSHKERHSKDERYEKHRERRHSSHHRDRDKHRSRDSDHE- 1680

  Fly  1864 VETPTSTNSAAAAAQRRNKKKRKVSR 1889
                               |.||.||
Zfish  1681 -------------------KHRKDSR 1687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
upSET	NP_001261819.1	PHD_MLL5	856..899	CDD:277025	15/49 (31%)
upSET	NP_001261819.1	SET	<1221..1273	CDD:214614	17/130 (13%)
phf3	XP_005157087.1	DUF4045	<341..732	CDD:330572	97/520 (19%)
		PHD_PHF3	625..675	CDD:277108	15/49 (31%)
		TFIIS_M	755..863	CDD:311443	23/125 (18%)
		SPOC	1027..1176	CDD:311609	20/148 (14%)
		Endomucin	1271..>1449	CDD:330316	36/204 (18%)
		RRM	1605..>1690	CDD:330708	21/108 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.030