DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment upSET and SETD5

DIOPT Version :9

Sequence 1:NP_001261819.1 Gene:upSET / 39551 FlyBaseID:FBgn0036398 Length:3146 Species:Drosophila melanogaster
Sequence 2:XP_011532222.1 Gene:SETD5 / 55209 HGNCID:25566 Length:1500 Species:Homo sapiens


Alignment Length:2275 Identity:412/2275 - (18%)
Similarity:667/2275 - (29%) Gaps:942/2275 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly   769 AAQQVQQPQQWSLGGIGVTV-SGSQGTPTAVGGYCSYFGQQIARSQADDDAHSAISSSSRMGLAS 832
            |:..|.:...:|....|.|. .|.:|.|.|..   :|.........|.....:.|..|...||.|
Human    37 ASPAVNEKSVYSTHNYGTTQRHGCRGLPYADH---NYGAPPPPTPPASPPVQTIIPRSDLNGLPS 98

  Fly   833 -----TDIDPGEETETAPEAEAEDDSVTRCICELTHDDGYMICCDKCSAWQHVDCMGIDRQNIPE 892
                 ....|..|.||.|         |.|.|.|: .||:::.||||                  
Human    99 PVEERCGDSPNSEGETVP---------TWCPCGLS-QDGFLLNCDKC------------------ 135

  Fly   893 EYMCELCQPRAVDKARARALQRQKRKEHMLLVATQAANGAAAVAAGTTLSGGLGSGL-PMSEEL- 955
                     |.:.:.:...|.|:|:                     ..:|||..|.. ...||| 
Human   136 ---------RGMSRGKVIRLHRRKQ---------------------DNISGGDSSATESWDEELS 170

  Fly   956 ---------QHRLASGLNGGFATGTGMSKKSKKTKENSGSTSTLKKTKKS-AVGMGGEKNASGSG 1010
                     ||           |.|.::...::||.        ||.||| ..|....|......
Human   171 PSTVLYTATQH-----------TPTSITLTVRRTKP--------KKRKKSPEKGRAAPKTKKIKA 216

  Fly  1011 TPTGSSGKTSKKSSKRKSKSGGDGSSGGGSSPALTAAEKHAANLRQWIENYEYAVTNHYSPE--- 1072
            ...||......|:|..::::..:.::.|..:           .:|.|.:.||.|.||.||.:   
Human   217 FREGSRKSLRMKNSPSEAQNLDENTTEGWEN-----------RIRLWTDQYEEAFTNQYSADVQN 270

  Fly  1073 -LRARLHAIQK---QPSLLQSIQNTE---NKALRQIQQQLSTAGSAEQLEQRAQLIPYAGAKVLI 1130
             |...||:.::   :|::|.:|..||   |..:...|.||. .|...::::.        .|:|.
Human   271 ALEQHLHSSKEFVGKPTILDTINKTELACNNTVIGSQMQLQ-LGRVTRVQKH--------RKILR 326

  Fly  1131 SSVDLSPHAPIHELRGKYMLTTQFRTQNPTVNMNTPPPSNYLNSFKAH--KTPGQFVFFYQLPGV 1193
            ::.||:....|.|.|||.||..||.     ||              .|  |.|..||.||     
Human   327 AARDLALDTLIIEYRGKVMLRQQFE-----VN--------------GHFFKKPYPFVLFY----- 367

  Fly  1194 EAPMQTLRPDGSVPQVAQQPPSYLKGPEVCVDTRTYGNDARFVRRSCRPNAELQHYFEKGTLHLY 1258
                                 |...|.|:|||.||:||||||:||||.||||::|....|.:||.
Human   368 ---------------------SKFNGVEMCVDARTFGNDARFIRRSCTPNAEVRHMIADGMIHLC 411

  Fly  1259 IVALTHIRAQTEITIRHEPHDLTAVEQKKSHAAVIQPTSTRCACDMGSDCLFALPLAVQQQLQAP 1323
            |.|::.|....|:||        |.:.:.|:...    ...|||..|                  
Human   412 IYAVSAITKDAEVTI--------AFDYEYSNCNY----KVDCACHKG------------------ 446

  Fly  1324 PTQPRSSHRNKAAAAAAAAAAANSAAAIQLTMGLGVGATVAAGASVLPNSRNRSTSSSGESSQMG 1388
                                                                             
Human   447 ----------------------------------------------------------------- 446

  Fly  1389 LNSPQLGQLNLGFKTSVTATSLTAPVPGVHCNNSGGSSSSSNNSCSVSMSSVLHDSGICTSSSSP 1453
                                                     |.:|                    
Human   447 -----------------------------------------NRNC-------------------- 450

  Fly  1454 SVSIPSPTPTQMQSPTLQQHPQQIPQQQLSLLQRSPTQQHQQQILAALPTPMLTPMLSPQLPKPA 1518
                    |.|.::|...:.|                         .||.|...|.:..:..:..
Human   451 --------PIQKRNPNATELP-------------------------LLPPPPSLPTIGAETRRRK 482

  Fly  1519 QQQAHVVLPQSQQTSLLQQQQSQQSQEPLAVIAAAAAAQQPMATYFVRQPQQQQQQQSPKPQALV 1583
            .::..:.:.|..:.|  ::...|||||....:..::..::      |..|::       ||:   
Human   483 ARRKELEMEQQNEAS--EENNDQQSQEVPEKVTVSSDHEE------VDNPEE-------KPE--- 529

  Fly  1584 AQQQHVVGAQQQQHFLQQQQKQQQQQMADEARMAVSALQTLHAAPTSHIVSPIKVAAVQQQSQPQ 1648
                     ::::..:..|:.....:...|.|                     ||.|:....:..
Human   530 ---------EEKEEVIDDQENLAHSRRTREDR---------------------KVEAIMHAFENL 564

  Fly  1649 QQQQNTHQQPHNQQAVQQQSNQLQQQQSQQPNYPQSPQRQQKPQPVQHQPQIVISTGAQAIPATM 1713
            ::::....||            |:|..|                      .:.|:|.....|...
Human   565 EKRKKRRDQP------------LEQSNS----------------------DVEITTTTSETPVGE 595

  Fly  1714 PTKLSSPTKSAAPVISNNNITVSAQSSVVGGKKTPAKHPQQQQQQQQQPVTPVSAATAPAATPSS 1778
            .||..:|....:..:||..|..:.||..|..:::                               
Human   596 ETKTEAPESEVSNSVSNVTIPSTPQSVGVNTRRS------------------------------- 629

  Fly  1779 SESKEDDVSASS-TTTPTTRTPAKDKPKQSREDRKLEAILRAIEKMEKQEARGKKDTRQSSGGKR 1842
              |:..|::|.. ...|....|::.:|| ||           |.:.....|:..|  ||.....:
Human   630 --SQAGDIAAEKLVPKPPPAKPSRPRPK-SR-----------ISRYRTSSAQRLK--RQKQANAQ 678

  Fly  1843 QASNSPASPNKRNSSNSISEDVETPTSTNSAAAAAQRRNKKKRKVSRSLNNNTNGLGSGGGSNNK 1907
            ||..|.|:..:..|::.:     |||...|                                   
Human   679 QAELSQAALEEGGSNSLV-----TPTEAGS----------------------------------- 703

  Fly  1908 RRKSIVVESDGESHALTNSESEDQGQHPQSHHSGSEDQAAGLLLALAHNNSSPNEPFKSPLSQSH 1972
                  ::|.||:..||.|                                   :|....::.||
Human   704 ------LDSSGENRPLTGS-----------------------------------DPTVVSITGSH 727

  Fly  1973 SLPATPASVSSACLLIEAAMGPLQQQPAPASASPSLAEFKYPPGGAKTKKSLMSSWF-QQAEQQH 2036
                                             .:.|..|||    ||||.|::.|. .:||:|.
Human   728 ---------------------------------VNRAASKYP----KTKKYLVTEWLNDKAEKQE 755

  Fly  2037 ASGLDSLVQAAMSEINGEREQLQRQPQGESLPAPALLKVEQFIHQAESTTA-----------VPA 2090
            ..     |:..:        ::...|   ::.|..|..:...||.....|.           :|.
Human   756 CP-----VECPL--------RITTDP---TVLATTLNMLPGLIHSPLICTTPKHYIRFGSPFIPE 804

  Fly  2091 REQLH-LPLQNNSSVKKRWLRQAISE---------ETTPVDELQQSQNQSVTATPSPQPVPTVSP 2145
            |.:.. ||....||.||||::||:.|         :.|....|.||...|.:::........:||
Human   805 RRRRPLLPDGTFSSCKKRWIKQALEEGMTQTSSVPQETRTQHLYQSNENSSSSSICKDNADLLSP 869

  Fly  2146 LANGFSTPLKKRRLVVVSNGTNVESDETHIDVIGEPKDEAEENVAMTELKVEIENHHQEQD--DD 2208
            |...      |.|.::..|.|.:....:  .|...|.:...::   .:|.....:|..|::  :.
Human   870 LKKW------KSRYLMEQNVTKLLRPLS--PVTPPPPNSGSKS---PQLATPGSSHPGEEECRNG 923

  Fly  2209 VDILRSPSPGTHQIVAEDNLVKIEPEDTSAAADDVKIDVEREESQACDKFEEMVKVKREEEEQRE 2273
            ..::.||....                |:|:..:..:           :||.:...:.....:.|
Human   924 YSLMFSPVTSL----------------TTASRCNTPL-----------QFENISSPESSPAHRPE 961

  Fly  2274 KEIKQLQERQEHEQPKV-------EPAPVEPKLEN---TVAKAEPKVEPSQEIVSKKEPTKVEPK 2328
            ....:|..|::.:..||       ......|.|.|   :.....|.:.|:.|             
Human   962 SLSPELCHRKDLDLAKVGYLDSNTNSCADRPSLLNSGHSDLAPHPSLGPTSE------------- 1013

  Fly  2329 PGESLLRSTATVTATPTAATIAATTLLDVSKVAFKTRPPLKLEDEPQKKKPKLESILPAP--VAT 2391
                        |..|:.:.....||:..|..||:|...|.....|....|:.:.:....  |..
Human  1014 ------------TGFPSRSGDGHQTLVRNSDQAFRTEFNLMYAYSPLNAMPRADGLYRGSPLVGD 1066

  Fly  2392 VPPVSV------PPIPAASNATTSAVTNTAAASLT------TTTAPSSTKNLTEHDIQERLLSFH 2444
            ..|:.:      |....:|......:.:.:..||:      ....||:.:|..:.          
Human  1067 RKPLHLDGGYCSPAEGFSSRYEHGLMKDLSRGSLSPGGERACEGVPSAPQNPPQR---------- 1121

  Fly  2445 AANISYLQSRNKKATAALTSASPSQKSNSSSGGSGTESKKSSKDKDEKRDKEKQLKKSKKEKKKS 2509
             ..:|.|:.|.:|..|         |.||:.||..:...||                        
Human  1122 -KKVSLLEYRKRKQEA---------KENSAGGGGDSAQSKS------------------------ 1152

  Fly  2510 KDKEKQKAAVNVNSTSQIVDTKKKTTQ------PSKPDSKSSIAPVLVPPSLPVATANGKTKHTA 2568
                 :.|.....|::.:.||.....|      ||.|..|.|       ||           |::
Human  1153 -----KSAGAGQGSSNSVSDTGAHGVQGSSARTPSSPHKKFS-------PS-----------HSS 1194

  Fly  2569 YNNVDQQQQQQMRRRTMSMCITPVTPTPVVTPSPLHGTPPSTKKRQTNFEQELTKPNS------- 2626
            .::::                       .|:||...||..|..:.|.|.......|.|       
Human  1195 MSHLE-----------------------AVSPSDSRGTSSSHCRPQENISSRWMVPTSVERLREG 1236

  Fly  2627 ----QILSSSILLNSSKGLGLPLAAPTVVSVPTAVQQQQHRKENNHQEATPASG-GPMSLAAAIA 2686
                ::|.||:.: :.||    ..:||..|..|            .:::.||.| ||.:|::|::
Human  1237 GSIPKVLRSSVRV-AQKG----EPSPTWESNIT------------EKDSDPADGEGPETLSSALS 1284

  Fly  2687 SGKLNAISRRRES----MCGS--RQQQALIAAALKKEKKEKKKSKKKDREKQKHDKQKGKEKERE 2745
            .| ....|..|.|    .|.|  .:.|:|:              ::.....:.|..|......|.
Human  1285 KG-ATVYSPSRYSYQLLQCDSPRTESQSLL--------------QQSSSPFRGHPTQSPGYSYRT 1334

  Fly  2746 KDKEKDNKQKTNHIQKPAHPTTVPA-NSMPISAPAPVPVLVPTPVTTPKAAPIPVLITQPTPSPI 2809
            ......|        .|:|.::..: :|...|:||       .||:|...||.       |.:|.
Human  1335 TALRPGN--------PPSHGSSESSLSSTSYSSPA-------HPVSTDSLAPF-------TGTPG 1377

  Fly  2810 HV-TQPLVNN----------CSTKVASLPFYNTIYGKLQDPS-TPTSSPIPVTNTMPSLAEYLES 2862
            :. :||...|          |.:..||        ..||.|| :|||..:..::|     ..|.|
Human  1378 YFSSQPHSGNSTGSNLPRRSCPSSAAS--------PTLQGPSDSPTSDSVSQSST-----GTLSS 1429

  Fly  2863 TKSKTTALSAVKPIGIAAVTPLSSAITPAKVAPSSLEMPPPATTPLKLYTRTAS---HDPRLNPM 2924
            |.....:.|:: |..:..:: |.||...|....|.:.    |.:..:.|....|   |..||.|:
Human  1430 TSFPQNSRSSL-PSDLRTIS-LPSAGQSAVYQASRVS----AVSNSQHYPHRGSGGVHQYRLQPL 1488

  Fly  2925  2924
            Human  1489  1488

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
upSETNP_001261819.1 PHD_MLL5 856..899 CDD:277025 9/42 (21%)
SET <1221..1273 CDD:214614 28/51 (55%)
SETD5XP_011532222.1 SET_SETD5 305..454 CDD:380958 67/366 (18%)
COG5644 <473..>693 CDD:227931 52/348 (15%)
PLN02217 <1360..1467 CDD:215130 34/139 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165141258
Domainoid 1 1.000 71 1.000 Domainoid score I9453
eggNOG 1 0.900 - - E1_KOG1844
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0004035
OrthoInspector 1 1.000 - - otm41658
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR46462
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
87.960

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