DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment upSET and phf20b

DIOPT Version :9

Sequence 1:	NP_001261819.1	Gene:	upSET / 39551	FlyBaseID:	FBgn0036398	Length:	3146	Species:	Drosophila melanogaster
Sequence 2:	XP_005162050.1	Gene:	phf20b / 445482	ZFINID:	ZDB-GENE-040822-33	Length:	1030	Species:	Danio rerio

Alignment Length:	1015	Identity:	192/1015 - (18%)
Similarity:	345/1015 - (33%)	Gaps:	283/1015 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 LQKVTLGSRVAT---RLQSYVPASPSQIMVQPAQ-----------PKYVNATATTIGGNAALLKK 263
            |:|..|..|...   ::...|.||.|.....||:           .|:.:....|:.|
Zfish    73 LRKQGLNERQCASGFQVNQKVLASWSDCRYYPAKILSRDKDDFYTVKFFDGIIKTVKG------- 130

  Fly   264 ANQKITVK-----SVSNMSQQQQQQQQQQQQQLLQAQQ--------LKTFITQQQQQQTYKAGAK 315
                |.||     |....|.||.:::..|.::.|:.::        .:..::....:...:|...
Zfish   131 ----IKVKPFRKQSSDGRSNQQARKRADQNEKELKPKENGNSRHNSSRHSVSDHDGESESEADED 191

  Fly   316 AKFVKQTTALSIAALPQQQQQTTYAKQSMVTTSTPAKVTKLNSKYVQQQISLPQGT---QLQHKA 377
            ...:.::|.|.... .::..:|.....|.|:::........|.....:..:|..|.   :::.:.
Zfish   192 TTVMDESTDLQNGG-EKESTETKMVNDSEVSSAEHQPSEDQNQPSEDKTENLENGNVEIKIEEEE 255

  Fly   378 SPNVTGGGYLLQQSQAAV--GGTIKFVNSHGTVIQQHPQQQQATKRTHYNSSGSSDNEQHAVANS 440
            ...:.||     |.:|.|  .|..|.....|....:.|   ...|||...::...:.|
Zfish   256 EEEMDGG-----QEEAKVLHNGIDKNDEHKGEASDESP---SLPKRTRSRTADGKEAE------- 305

  Fly   441 SLITDDVMIVNGTQMTDELSARILQSMAQKS--FSQQQRFHQVPATG-SGNMPPPTQIIYSNSTS 502
                    :|||.::....::....|.|::|  .|...|..|.|... ..:..|.|..|....|
Zfish   306 --------MVNGPELRKRRASTGQTSPAKRSRANSSTDRNTQTPIKPVKSDSVPDTLDIKDEKT- 361

  Fly   503 NGAAASSPGGNASGNMLLAHYQAAGTKPVSSASFITVTGTPPVTVATTPSVSISSHGFASGSAAI 567
                  ||.|                ||           .|.....:||.::
Zfish   362 ------SPAG----------------KP-----------APAEEAGSTPELA------------- 380

  Fly   568 SSYMSSATAARRQSVSAPSSRAVSLE---RKQHHQ-------QLQHD--------VIGGGRKAPT 614
                    ||.::.|..|::...|.|   |...:|       :|.|:        .:...||| :
Zfish   381 --------AALKRQVHLPTTNKYSREPLYRVIKNQPPPILSIELDHNPFKCKMAGCLKSFRKA-S 436

  Fly   615 VIEYYNKHGVNSIVGSSNNLAQSNSMSNLAGPRSNSGSGFATTTPTPATPLHLTPVNVPVHVEAA 679
            ::.|:.|:              .::.|:.:.||..........:|:..||.....|:...|..:
Zfish   437 LLHYHMKY--------------YHAQSDPSPPRCVQTRSSDKQSPSQETPRRRRTVSASHHTPS- 486

  Fly   680 PPSSPALVKGSSQPPAQPQQQQQQAHPLGPNQLNAN---------DEELYIEEVRPVPVLTQDLR 735
             |.|.:....|..|||...:.:|::..||..:...|         |.:...:|.    .|.:..|
Zfish   487 -PLSDSKSGHSLSPPAVGIKHRQRSATLGAERSKENQVFNRSLHDDRDWVAKET----ALKERER 546

  Fly   736 LQQLHAIMQDHTYASQQQQQQPQQAAGDTTNPGAAQQV-QQPQQWSLGGIGVTVSGSQGTPTAVG 799
            |::..   |...:..:.::::.::....:.:....:.: .:|       :...::.:...|.::
Zfish   547 LREKR---QREFFRIKLKKKKKKKRKSKSDSHSTEESIGPKP-------LPCNLNSAHKLPLSL- 600

  Fly   800 GYCSY--FGQQIARSQADDDAHSAISSSSRM---GLASTDID-------PGEETETAPEAEAEDD 852
            .:.||  .|.:...||.:|.: |.:||.|.:   ..:.|::|       .|.||.|      ...
Zfish   601 THRSYTGHGPEKMLSQGEDSS-SDLSSDSPVWSEDESDTELDLNVPLSEQGVETVT------HSS 658

  Fly   853 SVTRCICELTHDDGYMICCDKCSAWQHVDCMGIDRQNIPEEYMCELCQ-PRAVDKARARALQRQK 916
            .:.|||||:..::.:||.||:|..|||..|||:...::|:.|.|.:|: |.|         |||.
Zfish   659 EIVRCICEVQEENDFMIQCDECLCWQHGTCMGLYEDSVPDSYSCYICRDPPA---------QRQS 714

  Fly   917 RK----------EHM----LLVATQAANGAAAVAAGTTLSGGLGSGLPMSEELQHRLASGLNGGF 967
            ::          .||    .|....:...:..|.|...|.|.:           ||:...|||
Zfish   715 QRYWYDKDWLSSGHMYGLSFLEENYSHQNSKKVTAAHQLLGDV-----------HRVFEVLNG-- 766

  Fly   968 ATGTGMSKKSKKTKENSGSTSTLKKTKKSAVG----MGGEKNASGSGTPTGSS----GKTSKKSS 1024
                ...|.|....:........::..|.|.|    |.|:   ||..||...|    |:...::.
Zfish   767 ----LQLKMSILQTQAHPDLKLWRQPWKHADGLRRRMAGD---SGIATPLPPSPPEMGENEFETL 824

  Fly  1025 KRKSKSGGDGSSGGGSSPALTAAEKHAANLRQWIEN-YEYAVTNHYSPELRARL----------- 1077
            |               |.|.:..|.|.:....:|.: :.|.....|.|.:..||
Zfish   825 K---------------SEAPSPMETHCSFQDSYISSEHCYQKPRTYYPAVERRLVVETRGGSELE 874

  Fly  1078 HAIQKQPSLLQSIQNTENKALRQIQQQLSTAGSAEQLEQR 1117
            .:::....||:..:......|...|.:|:....:::||.|
Zfish   875 DSLRSTEDLLEMAEQRYGTQLDHDQHKLADRSFSKELESR 914

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
upSET	NP_001261819.1	PHD_MLL5	856..899	CDD:277025	19/42 (45%)
upSET	NP_001261819.1	SET	<1221..1273	CDD:214614
phf20b	XP_005162050.1	MBT	1..68	CDD:302657
		TUDOR	90..135	CDD:119391	11/55 (20%)
		PHD_PHF20	662..705	CDD:277104	19/42 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147824at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.040