DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment upSET and MBD-R2

DIOPT Version :9

Sequence 1:	NP_001261819.1	Gene:	upSET / 39551	FlyBaseID:	FBgn0036398	Length:	3146	Species:	Drosophila melanogaster
Sequence 2:	NP_731688.2	Gene:	MBD-R2 / 41498	FlyBaseID:	FBgn0038016	Length:	1169	Species:	Drosophila melanogaster

Alignment Length:	1046	Identity:	196/1046 - (18%)
Similarity:	337/1046 - (32%)	Gaps:	304/1046 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 SGQELINPQIYKIVTTDGSTSNVIIDASAAAPPHNSKLLLSNLTVLSKQAPVQGAA---GQQQQQ 166
            :|:.|:.|:::..|...|......|:|...|..|               |.|:|..   |..|..
  Fly    70 NGKYLLKPRVFPTVFPWGKMDTAEIEADQRALQH---------------ASVEGTTETPGNAQSS 119

  Fly   167 LNYLGAKS------LPYVSASPAKTQQQPQKFGSISAFKAQHQQQQQHPHATLQKVTLGSRVATR 225
            .|....|:      ...:|.|..:...:..|.|..:.......:..:..:....|...|:.||..
  Fly   120 TNDDVIKATVDQIVAQILSESAERKATEEGKTGKAADDVKNTPESGEDANKAAAKEPSGTPVAAS 184

  Fly   226 LQSYVP----ASPSQIMVQPAQPKYVNATATTIGGNAALLK------------------------ 262
            .::.||    ||.|...:....|||.|....|||.....|.
  Fly   185 SEATVPAPGSASSSNSPLPGTPPKYSNPHNLTIGARLEALSVEGNWLPARIVEVNETEQTLLVRF 249

  Fly   263 KANQKITVK-SVSNMSQQQQQQQQQQQQQLLQAQQLKTF-------------------ITQQQQQ 307
            :.|.|:.|. |.|...|:....:.::.:|.|..:.|..|                   |.:....
  Fly   250 ERNHKLKVSPSTSGSFQEWMAIKSERLRQRLSNRVLPVFELDEKCMARWSGPRKFPGTIRKLLGN 314

  Fly   308 QTYKAGAKAKFVKQTTALSIAALPQQQQQTTYAKQSMVTTSTPAKVTKLNSKYVQQQISLPQGTQ 372
            .||:......:||...|:.:..:|:|......|::....:.||.. |.::|..|..:
  Fly   315 DTYEVLFDDGYVKNVRAVHMNKMPKQLPPVQVAEEGASKSPTPVG-TPVSSAPVAPK-------- 370

  Fly   373 LQHKASPNVTGGGY------------------LLQQSQ---AAVG---------GTIKFVNSH-- 405
               :||....||..                  ||..:.   |::|         .|..:||..
  Fly   371 ---RASTGSLGGSSGSSGSKKSKCAPQRRDWPLLDMASLDIASLGLPEIPHDGEWTCHWVNDQPI 432

  Fly   406 GT----VIQQHPQQQQAT-------------KRTHYNSS----------GSSDNEQHAVANSSLI 443
            ||    ::.:|   |:.|             |..:..|:          ..|.....:.::..|.
  Fly   433 GTEGFLIVGEH---QKPTVIVQDWRLPPGWIKHMYQRSNVLGKWDVILVSPSGKRFRSKSDLKLF 494

  Fly   444 TDDVMIVNGTQMTD---------ELSARI-------------------LQSMAQKSFSQQQRFHQ 480
            .:...:|....:.|         :::|.:                   :.|...:|.:.|   |.
  Fly   495 LESQNLVYNPDVYDFSIHRRRAKDINAYVYTHGYNPQPPPKPRPMDVSMNSTLDQSITSQ---HS 556

  Fly   481 VPATGSGNMPPPTQIIYSNSTSNGAAASSPGGNASGNMLLAHYQAAG-TKPVSSASFITVT--GT 542
            :|:|       |..:..|.......|:..|    ...::....|.|. |||...|..:..:  ||
  Fly   557 LPST-------PMPVKESQYMEAPVASLMP----PAELMSPQTQPADETKPKIEAEILEASEGGT 610

  Fly   543 PPVTVATTPSVSISSHGFASG-------SAAISSYMSSATAARRQSVSAPSSRAVSLERKQHHQQ 600
            ..:.:| .|.|..:...|..|       :..:......|...|::..       :.:..:.:|::
  Fly   611 SQLMLA-DPHVVENGFAFIGGLKVKIQDNLYVCPREDCAKTYRKEDF-------LLIHIRHYHKE 667

  Fly   601 LQHDV--------IGGGRKAPTVIEYYNKHGVNSIVGS-------SNNLAQSNSMSNLAGPRSNS 650
            ....|        :...|..|:.|:.......|.|...       ..:|.||.|....:
  Fly   668 FAEHVSHCPKMQELAVKRTHPSSIDQVEAVPKNQIPNQQFFAKMHQQDLQQSRSFKRQS------ 726

  Fly   651 GSGFATTTPTPATPLHLTPVNVPVHVEAAPPS-SPALVKGSSQPPAQPQQQQQQAHPLGPNQ--- 711
                .:.|.|.:||..:||....:..:..||| ||.:..|.        :|:..:...||.|
  Fly   727 ----VSATATSSTPSDITPTKALLSPKMEPPSVSPTVESGI--------KQEDVSLDAGPTQSFN 779

  Fly   712 --LNANDEELYIE-EVRPVPVLTQDLRLQQLHAIMQDHTYASQQQQQQPQQAAGDTTNPGAAQQV 773
              |:.:.:...:. ..||......:.:..|...|:.|:.......:|..::.......|....::
  Fly   780 PSLSRSCKRARLSPSKRPSGSRKSNRQRSQRRPILSDNPAGHGLTEQDVEETRQSFNTPTPDTRI 844

  Fly   774 QQPQQWSLGGIGVTVSGSQGTPTAVGGYCSYFGQQIARSQADDDAHSAISSSSRMGLASTDID-- 836
            ...::.|  |...|...|..:| |:|                 |:.|..||:.:     |||:
  Fly   845 DSKKRRS--GAATTPISSIDSP-AMG-----------------DSVSTPSSNDQ-----TDINAA 884

  Fly   837 ----PGEETETAPEAEAED-----------DSVTRCICELTHDDGYMICCDKCSAWQHVDCMGID 886
                |.|....||:...|:           :.:..||||...:||.||.|:.|..|||..|.||.
  Fly   885 LAPPPAETLSKAPQYIKENGELIRIVRMRQEEIINCICEYGEEDGLMIQCELCLCWQHGACNGIV 949

  Fly   887 RQ-NIPEEYMCELCQPRAVDKARARALQRQKRKEHML------LVATQAANGAAA-----VAAGT 939
            :: ::|::|:|.:|:    :..|.|...|.|..:..|      :.|...||..|.     :....
  Fly   950 KEADVPDKYVCYICR----NPQRGRDSMRFKHDQDWLFEGKLPVAAYHTANPQATKQFELLKRSH 1010

  Fly   940 TLSGGL 945
            ||:|.|
  Fly  1011 TLTGNL 1016

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
upSET	NP_001261819.1	PHD_MLL5	856..899	CDD:277025	19/43 (44%)
upSET	NP_001261819.1	SET	<1221..1273	CDD:214614
MBD-R2	NP_731688.2	THAP	4..86	CDD:283206	4/15 (27%)
		TUDOR	292..329	CDD:119391	5/36 (14%)
		MeCP2_MBD	449..522	CDD:238690	6/72 (8%)
		PHD_SF	919..963	CDD:304600	19/43 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1844
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147824at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940