DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment upSET and Phf20l1

DIOPT Version :9

Sequence 1:	NP_001261819.1	Gene:	upSET / 39551	FlyBaseID:	FBgn0036398	Length:	3146	Species:	Drosophila melanogaster
Sequence 2:	XP_038935114.1	Gene:	Phf20l1 / 314964	RGDID:	1560141	Length:	1021	Species:	Rattus norvegicus

Alignment Length:	880	Identity:	171/880 - (19%)
Similarity:	300/880 - (34%)	Gaps:	274/880 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   401 FVNSHGTVIQQ--HPQQQQATKRTHYNSSGSSDNEQHAVAN--SSLITDDVMIVNGTQMTDELSA 461
            ||..|...:.:  .||.:........|:.|:|...:.|..|  :.|:....:.|:|.:..::.||
  Rat   244 FVGLHIDSVPKIVFPQPESTLTNKRKNNQGNSFQAKRARLNKITGLLASKAVGVDGAEKKEDCSA 308

  Fly   462 R---ILQSMAQKSFSQQQRFHQVPATGSGNMPPPTQIIYSNSTSNGAAASS----PGGNASGNML 519
            .   :.|:::.|  .|.|:.::...:.|.|...|.  :.|::.|:|.|.|.    ..|.:||.:.
  Rat   309 TAPVLEQAISPK--PQSQKKNEAVISSSANTQKPA--LLSSTLSSGKARSKKCKHESGESSGCIK 369

  Fly   520 LAH-------YQAAGTKPVSS-ASFITVTGTP-PVT----------------VATTPSVSISSHG 559
            ...       .||.....||. :|.|..|.:| ||.                :||.|....|...
  Rat   370 APKSPLAPELIQAKDLTLVSQLSSVINKTSSPQPVNPPRPCKHSERRRRSQRLATLPMPDDSLEK 434

  Fly   560 FASGSAAISSYMSSATAARRQSVSAPSSRAVSLERKQHHQQLQHDVIGGGRKAPTVIEYYNKHGV 624
            .:|.|:|....:.|.::..:|..|.|...|::      :..||       :..|.:
  Rat   435 LSSSSSATDGKVFSISSQNQQESSVPEVPAIA------YVPLQ-------KLGPCL--------- 477

  Fly   625 NSIVGSSNNLAQSNSMSNLAGPRSNSGSGFATTTPTPATPLHLTPVN-VPVHVEAAPPSSPALVK 688
                  ..:|:..:.::....|.|:...|.........|||...|.: |...|:.|     |...
  Rat   478 ------PLDLSCGSEVTGSQAPDSSYPGGECPREEKEETPLFANPTSKVVSDVKGA-----AAAT 531

  Fly   689 GSSQPPAQPQQQQQQAHPLGPNQLNANDEELYIEEVRPVPVLTQDLRLQQLHAIMQDHTYASQQQ 753
            |..:...:.:.:::.:...|..:  ..|:|.  :|.|.                 :||....|::
  Rat   532 GILKTEKKVKLEEKTSTAFGKRK--EKDKER--KEKRD-----------------KDHYKPKQKK 575

  Fly   754 QQQPQQAAG-------DTTNPGAAQQVQQPQQWSLGGIGVTVSGSQGTP-------TAVGGY--- 801
            :::.::.:.       :.::....::...|...|        |||...|       |....|
  Rat   576 KKKKKKKSKQHDYSDYEDSSLDFLERCSSPLTRS--------SGSSLAPRSTFTEKTTTYQYPRA 632

  Fly   802 ---CSYFGQQIARSQADDDAHSAISSSSRMGLASTDIDPGEETETAPEAEAEDDS---VTRCICE 860
               ....|:.::..:..||     ||:..:.|:..:.:...::....|::.|||:   :.|||||
  Rat   633 ILSVDLSGENLSDVEFLDD-----SSTESLLLSGDEYNQDFDSTNFEESQDEDDALNEIVRCICE 692

  Fly   861 LTHDDGYMICCDKCSAWQHVDCMGIDRQNIPEEYMCELCQPRAVDKARARALQRQKRKEHMLLVA 925
            |..::|:||.|::|..|||..|||:...:|||:|:|.:|  |.....|..|..|..::
  Rat   693 LDEENGFMIQCEECLCWQHSVCMGLLEDSIPEQYICYIC--RDPPGQRWNAKYRYDKE------- 748

  Fly   926 TQAANGAAAVAAGTTLSGGLGSGLPMSEE-----------LQHRLASGLNG------GFATGTGM 973
                          .|:.|...||...:|           ..|.|.:.:.|      |.....|:
  Rat   749 --------------WLNNGRMYGLSFVKENYSHLNAKKIVSTHHLLADVYGITEVLHGLQLKIGI 799

  Fly   974 SKKSKKTKENSGSTSTLKKTKKSAVGMGGEK--------NASG---------------------- 1008
            .|..........:.|..:|.:...|. |.|:        |:.|
  Rat   800 LKNKHHPDLRLWAYSGKRKDQDQVVA-GAERKVILQDTANSEGRKYVQNHKEPPLKMEETYITSE 863

  Fly  1009 --------------SGTPTGSS-----------------------------GKTSKKSSKRKSK- 1029
                          |.|..|||                             |.:.||:...::|
  Rat   864 HSYQKPQSFSQDCHSLTDPGSSDDDDVSSFEEDGELHVADNSHLLYSVKERGVSEKKNPASENKV 928

  Fly  1030 ---SGGDGSSGGGSSPALTAAEKHAANLRQWIENYEYAVTNHYSPELRARLHAIQKQPSLLQS-- 1089
               :...|..|.|.     |..:...||...|||.:..||        :|:..|:|:..:|:|
  Rat   929 FVYNDKKGMEGPGD-----AHLQWQLNLLTHIENVQNEVT--------SRMDLIEKEVDVLESWL 980

  Fly  1090 -----IQNTENKA-----LRQIQQQLSTAGSAEQL 1114
                 ::..:..|     .|.|:|.|...|..:|:
  Rat   981 DFTGELEPPDPLARLPQLKRHIKQLLLDMGKVQQI 1015

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
upSET	NP_001261819.1	PHD_MLL5	856..899	CDD:277025	22/42 (52%)
upSET	NP_001261819.1	SET	<1221..1273	CDD:214614
Phf20l1	XP_038935114.1	MBT	3..68	CDD:418456
		Tudor_PHF20L1	86..143	CDD:410525
		PTZ00449	<320..524	CDD:185628	48/235 (20%)
		PHD20L1_u1	323..388	CDD:374703	14/66 (21%)
		PHD_PHF20L1	688..733	CDD:277103	23/46 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147824at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010