DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment upSET and Kmt2e

DIOPT Version :9

Sequence 1:	NP_001261819.1	Gene:	upSET / 39551	FlyBaseID:	FBgn0036398	Length:	3146	Species:	Drosophila melanogaster
Sequence 2:	NP_001094321.2	Gene:	Kmt2e / 311968	RGDID:	1309641	Length:	1856	Species:	Rattus norvegicus

Alignment Length:	2495	Identity:	491/2495 - (19%)
Similarity:	760/2495 - (30%)	Gaps:	1022/2495 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   820 SAISSSSRMGLASTDIDPG-EETETAPEAEAEDD-----SVTRCICELTHDDGYMICCDKCSAWQ 878
            |.:.|.:.:|:.:|   |. :||.:|......:|     .||||||..||||||||||||||.||
  Rat    81 SGLISKNEVGIFTT---PHFDETSSATTISTSEDGSYGTDVTRCICGFTHDDGYMICCDKCSVWQ 142

  Fly   879 HVDCMGIDRQNIPEEYMCELCQPRAVDKARARALQRQKRKEHMLLVATQAANGAAAVAAGTTLSG 943
            |:||||||||:||:.|:||.||||::||.||..|||:||:.               ::.|.|.:.
  Rat   143 HIDCMGIDRQHIPDTYLCERCQPRSLDKERAVLLQRRKREN---------------MSDGDTSAT 192

  Fly   944 GLGSGLPMS--EELQHRLASGLNGGFATGTGMSKKSKKTKENSGSTSTLKKTKKSAVGMGGEKNA 1006
            ..|..:|:.  ...||           |.|.::..:.:..:     .|.|:.|||     |||..
  Rat   193 ESGDEVPVELYTAFQH-----------TPTSITLAASRAPK-----VTDKRRKKS-----GEKEQ 236

  Fly  1007 SGSGTPTGSSGKTSKKSSKRKSKSGG-----DGSSGGGSSPALTAAEKHAANLRQWIENYEYAVT 1066
            :     .....|..::.|::.|:..|     |.||.|.:....|       .::.|::.||.|..
  Rat   237 N-----FPKCKKAFREGSRKSSRVKGSAPEIDPSSDGSNFVWET-------KIKAWMDRYEEANN 289

  Fly  1067 NHYSPELRARLHAIQKQPS-LLQSI-QNTENKALRQIQQQLSTAGSAEQLEQRAQLIPYAGAKVL 1129
            |.||       ..:|::.. |.|.: ..:::|.:.:.:..::::.....:|...|    ...|:|
  Rat   290 NQYS-------EGVQREAQRLAQRLGSGSDSKDMSKPELSVNSSLFRPPVESHIQ----KNKKIL 343

  Fly  1130 ISSVDLSPHAPIHELRGKYMLTTQFRTQNPTVNMNTPPPSNYLNSFKAHKTPGQFVFFYQLPGVE 1194
            .|:.||.|.|.|.|.|||:||..||..            :.|.     .|.|..||.||
  Rat   344 KSAKDLPPDALIIEYRGKFMLREQFEA------------NGYF-----FKRPYPFVLFY------ 385

  Fly  1195 APMQTLRPDGSVPQVAQQPPSYLKGPEVCVDTRTYGNDARFVRRSCRPNAELQHYFEKGTLHLYI 1259
                                |...|.|:|||.||:||:|||:||||.||||::|..|:||:||||
  Rat   386 --------------------SKFHGLEMCVDARTFGNEARFIRRSCTPNAEVRHEIEEGTIHLYI 430

  Fly  1260 VALTHIRAQTEITIRHEPHDLTAVEQKKSHAAVIQPTSTRCACDMGSDCLFALPLAVQQQLQAPP 1324
            .:...|...|||||..:                         .|.| :|.:.:..|..::....|
  Rat   431 YSTQSIPKGTEITIAFD-------------------------FDYG-NCKYKVDCACLKENPECP 469

  Fly  1325 TQPRSSHRNKAAAAAAAAAAANSAAAIQLTMGLGVGATVAAGASVLPNSRNRSTSSSGESSQMGL 1389
            ...|||                                                    ||::
  Rat   470 VLKRSS----------------------------------------------------ESTE--- 479

  Fly  1390 NSPQLGQLNLGFKTSVTATSLTAPVPGVHCNNSGGSSSSSNNSCSVSMSSVLHDSGICTSSSSPS 1454
                  .:|.|::|.               ...|......:....:...::..|   |..:::.
  Rat   480 ------NINSGYETR---------------RKKGKKEKDISKEKDIQNQNITLD---CEGTNNK- 519

  Fly  1455 VSIPSPTPTQMQSPTLQQHPQQIPQQQLSLLQRSPTQQHQQQILAALPTPMLTPMLSPQLPKPAQ 1519

  Rat   520 ----------------------------------------------------------------- 519

  Fly  1520 QQAHVVLPQSQQTSLLQQQQSQQSQEPLAVIAAAAAAQQPMATYFVRQPQQQQQQQSPKPQALVA 1584
                                                         :|.|:.:|::.||
  Rat   520 ---------------------------------------------IRSPETKQRKLSP------- 532

  Fly  1585 QQQHVVGAQQQQHFLQQQQKQQQQQMADEARMAVSALQTLHAAPTSHIVSPIKVAAVQQQSQPQQ 1649
                                         .|::||
  Rat   533 -----------------------------LRLSVS------------------------------ 538

  Fly  1650 QQQNTHQQPHNQQAVQQQSNQLQQQQSQQPNYPQSPQRQQKPQPVQHQPQIVISTGAQAIPATMP 1714
                                     .:|:|::....:.:
  Rat   539 -------------------------NNQEPDFIDDMEEK-------------------------- 552

  Fly  1715 TKLSSPTKSAAPVISNNNITVSAQSSVVGGKKTPAKHPQQQQQQQQQPVTPVSAATAPAATPSSS 1779
                                                             ||:|       |....
  Rat   553 -------------------------------------------------TPIS-------TEVEM 561

  Fly  1780 ESKEDDVSASSTTTPTTRTPAKDKPKQSREDRKLEAILRAIEKMEKQEARGKKDTRQSSGGKRQA 1844
            ||:|.              .|:.:.|.:||:||:||||:|..::||:|.|.::...:.|..|.:.
  Rat   562 ESEEQ--------------IAERRRKMTREERKMEAILQAFARLEKREKRREQALERISTAKTEV 612

  Fly  1845 SNSPASPNKRNSSNSISEDVETPTSTNSAAAAAQRRNKKKRKVSRSLNNNTNGLGSGGGSNNKRR 1909
            ..........:.::.:.|.|:..|:....||.. .|.|:::..|||..:.        |...:|.
  Rat   613 RPECKESQVISDADVVQEQVKEETAIKPTAAKV-NRTKQRKSFSRSRTHI--------GQQRRRH 668

  Fly  1910 KSIVVESDGESHALTNSESEDQGQHPQSHHSGSEDQAAGLLLALAHNNSSPNEPFKSPLSQSHSL 1974
            :::.:.||                                        ..|:.|....:||.:.:
  Rat   669 RTVSMCSD----------------------------------------IQPSSPDVEVMSQQNDI 693

  Fly  1975 --------PATPASVSSACLLIEAAMGPLQQQPAPASASPSLAEFKYPPGGAKTKKSLMSSWFQQ 2031
                    |.|.|:|:.....:||        || .:..|:    |||    ||||.|::.|..:
  Rat   694 ENTVLAIEPETEAAVAEIITEVEA--------PA-LNKCPT----KYP----KTKKHLVNEWLSE 741

  Fly  2032 AEQQHASGLDSLVQAAMSEINGEREQLQRQPQGESLP----APALLKVEQFIHQAESTTAVPARE 2092
            ..::.....|||.:..: .|..:.|.|..|.  .|||    :|.:....:  |....|:...:.:
  Rat   742 KNEKTGKPSDSLSERPL-RITTDPEVLATQL--NSLPGLTYSPHVYSTPK--HYIRFTSPFLSEK 801

  Fly  2093 QLHLPLQNN--SSVKKRWLRQAISEETTPVDELQQSQNQSVTATPSPQPVPTVSPLANG------ 2149
            :.......|  .|.|||||:||:.||.:.|.....|..|.     .|:     ||..||
  Rat   802 KRRKETTENISGSCKKRWLKQALEEENSTVLHRYHSPCQE-----RPR-----SPTVNGESKSPL 856

  Fly  2150 ----------FSTPLKKRRLVVVSNGTNVESD---------ETHIDVIGEPKDEAEENVAMTELK 2195
                      .:||||||||..:.:....||.         .||.|:  .|.|.|  ......:|
  Rat   857 LLSDSCSLPDLTTPLKKRRLYQLLDSAYSESSTPTPSPYATPTHTDI--TPTDPA--FATPPRIK 917

  Fly  2196 VEIENHHQEQDDDVDILRSPSPGTHQIVAEDNLVKIEPEDTSAAADDVKIDVEREESQACDKFEE 2260
            .:.|.:..........:...:|||     ..|.:..|...:..::.::|.....:|..  |:...
  Rat   918 SDDETYRNSYKPIYSPVTPVTPGT-----PGNTMHFENISSPESSPEIKRCTYNQEGY--DRPST 975

  Fly  2261 MVKV----KREEEEQREKEIKQL-----QERQEHEQP----------------KVEPAPVEPKLE 2300
            |:.:    .....|...:|||.:     :.|.|..:|                .||||.::..:|
  Rat   976 MLTLGPFRNSNLNELGLQEIKTIGYTSPRSRTEVNRPCPGEKESVSDLQLGLDAVEPAALQKTME 1040

  Fly  2301 NTVAKAEPKVEPSQEIVSK------------KEPTKV---------------------------- 2325
               ..|..:.|||.::.|.            |.|.:.
  Rat  1041 ---TPAHDRTEPSSQLDSTHSGRGTMYSSWVKSPDRTGVNFSVNSNLRDLTPSHQLEIGGGFRIS 1102

  Fly  2326 EPK-----PGESLLRSTATVTATPTAATIAATTLLDVSKVAFKTRPPLKLEDEPQKK-------- 2377
            |.|     ....:...||....:...........::.|.:.....|    ::.||||
  Rat  1103 ESKCLTQDDARGMFMETAVFCPSEDGLVSGFGRTVNDSLIDGSCTP----QNPPQKKKVSLLEYR 1163

  Fly  2378 -----------KPK---LESILPAPVATVPP------------------VSVPPIPAASNATTSA 2410
                       ||:   |.|:.|.|..|:..                  .|:|..|.|:..|.|.
  Rat  1164 KRQREARKSGSKPENLALISVSPHPSGTLSSSGDGCVHSSENGEQPENRASLPLAPPAAACTASC 1228

  Fly  2411 VTNTA-----AASLTTTTAPSS--TKNLTEHDIQER------LLSFHAANISYLQSRNKKATAAL 2462
            ...::     .|:.|..|.|..  |.:.:...::||      |||.|.      :.::....:..
  Rat  1229 EEGSSDCPVRDANPTEKTDPEVQWTASTSVEQVRERSYQRALLLSDHR------KDKDGGGESPC 1287

  Fly  2463 TSASPSQKSNSSSGGSGTESKKSSKDKDEKRDKEKQLKKSKKEKKKSKDKEKQKAAVNVNSTSQI 2527
            .|.|||.          .:|..||......:...:.|.....|.....|.|..:|    .|||:.
  Rat  1288 VSCSPSH----------VQSSPSSHSNHIPQVPAQSLAPPLTEPMADLDPEGTEA----TSTSEC 1338

  Fly  2528 --VDTKKKTTQPSKPDSKSSIAP-------VLVPPSLPVATANGKTKHTAYNNVDQQQQQQMRRR 2583
              .||.:..::.|||.|...|.|       :..|.|...|||......::.:...:.||:|:...
  Rat  1339 PSPDTSQSPSKTSKPGSPGPINPAQSHGKMLTKPDSHWEATATVSEAESSVHLKPELQQKQLSSN 1403

  Fly  2584 TMSMCIT------------------PVTPTPV-VTPSPLHGTPPSTKKRQTNFEQELTKPNSQIL 2629
            |.::...                  |..||.: ..|||....||.:....|..:.....|..
  Rat  1404 TPALSKNHPPQAHVRNANDQLPQKLPSAPTKLHCPPSPHTENPPQSSTPHTPVQHGYLSPKP--- 1465

  Fly  2630 SSSILLNSSKGLGLPLAAPTVVSVPTAVQQQQHRKENNHQEATPASGGPMSLAAAIASGKLNAIS 2694
                   .|:.||.|.              :.|..: :.|..||....|.||..|..:.:.||
  Rat  1466 -------PSQHLGSPF--------------RPHHSQ-SPQVGTPQRETPRSLYPAAQNLQANA-- 1506

  Fly  2695 RRRESMCGSRQQQALIAAALKKEKKEKKKSKKKDREKQKHDKQKGKEKEREKDKEKDNKQKTNHI 2759
              :::.||     ||..
  Rat  1507 --QQAPCG-----ALFT------------------------------------------------ 1516

  Fly  2760 QKPAHPTTV---PANSMPISAPAPVPVLVPTPVTTPKAAPIPVLITQPTPSPIHVTQPLVNNCST 2821
            |.|:..::.   |.|...:|:|||.|   |.|               |.||..:..|       .
  Rat  1517 QTPSGQSSAAYSPFNQQALSSPAPPP---PPP---------------PPPSAYYQNQ-------Q 1556

  Fly  2822 KVASLPFYNTIYGKLQDPSTPTSSP---IPVTNTMPSL-------AEYLES---TKSKTTALSAV 2873
            ..|:...||.:.|.|...:..||.|   :|.|.:.||:       ..:|.|   |....||.:.|
  Rat  1557 PSANFQNYNQLKGSLSQQTVFTSGPNQALPGTTSQPSVPGHHVTPGHFLPSQNPTIHHQTAAAVV 1621

  Fly  2874 KP---------------------IGIAAVTPLSSAITPAKVAPSSL---EMPPPATTPLKLYTRT 2914
            .|                     ..:|.|.....|:||.....|..   .:|||...|
  Rat  1622 PPPPPPPPAPGPHLVQQPNSHQQHSVAHVVGTVHAVTPGSHIHSQTVGHHLPPPPPPP------- 1679

  Fly  2915 ASHDPRLNPMLTVPDPTPMPKRKLSISEYRMRHRPSVDTAPTTPTTPTTPTTPTTPPGSNKDRSF 2979
                   .|   .|...|.|.....:...:.:|:..|::||..|..|..|.:...     .....
  Rat  1680 -------GP---APHHHPPPHPSTGLQSLQAQHQHVVNSAPPPPPPPPPPASVLV-----SGHHS 1729

  Fly  2980 AKPQTINKCSLQSPERFQAAIRERRNSISAH-----HPQQNAHHNLNNNKGGISNKSGSSSGNHL 3039
            |..|.::....|.|..|         .:|.|     :|.|..||   ...|.......|.:|.|.
  Rat  1730 ASGQALHHPPHQGPPLF---------PVSVHPAVPPYPSQATHH---TTLGPGPQHQPSGTGPHC 1782

  Fly  3040 QQALGVAGGRLQSK--NAIVDPAAT 3062
              .|.|.|..||.:  |:|..|.|:
  Rat  1783 --PLPVPGPHLQPQGPNSIPTPTAS 1805

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
upSET	NP_001261819.1	PHD_MLL5	856..899	CDD:277025	34/42 (81%)
upSET	NP_001261819.1	SET	<1221..1273	CDD:214614	31/51 (61%)
Kmt2e	NP_001094321.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334925
Domainoid	1	1.000	111	1.000	Domainoid score	I6109
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	208	1.000	Inparanoid score	I3613
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004035
OrthoInspector	1	1.000	-	-		otm45780
orthoMCL	1	0.900	-	-		OOG6_106934
Panther	1	1.100	-	-	LDO	PTHR46462
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.980