Protein Alignment upSET and Kmt2e

DIOPT Version :10

• Sequence 1: NP_648681.1
• Gene: upSET / 39551
• FlyBaseID: FBgn0036398
• Length: 3146
• Species: Drosophila melanogaster
• Sequence 2: NP_001094321.2
• Gene: Kmt2e / 311968
• RGDID: 1309641
• Length: 1856
• Species: Rattus norvegicus
• Alignment Length: 2495
• Identity: 491/2495 - (19%)
• Similarity: 760/2495 - (30%)
• Gaps: 1022/2495 - (40%)

  Fly   820 SAISSSSRMGLASTDIDPG-EETETAPEAEAEDD-----SVTRCICELTHDDGYMICCDKCSAWQ 878
            |.:.|.:.:|:.:|   |. :||.:|......:|     .||||||..||||||||||||||.||
  Rat    81 SGLISKNEVGIFTT---PHFDETSSATTISTSEDGSYGTDVTRCICGFTHDDGYMICCDKCSVWQ 142

  Fly   879 HVDCMGIDRQNIPEEYMCELCQPRAVDKARARALQRQKRKEHMLLVATQAANGAAAVAAGTTLSG 943
            |:||||||||:||:.|:||.||||::||.||..|||:||:.               ::.|.|.:.
  Rat   143 HIDCMGIDRQHIPDTYLCERCQPRSLDKERAVLLQRRKREN---------------MSDGDTSAT 192

  Fly   944 GLGSGLPMS--EELQHRLASGLNGGFATGTGMSKKSKKTKENSGSTSTLKKTKKSAVGMGGEKNA 1006
            ..|..:|:.  ...||           |.|.::..:.:..:     .|.|:.|||     |||..
  Rat   193 ESGDEVPVELYTAFQH-----------TPTSITLAASRAPK-----VTDKRRKKS-----GEKEQ 236

  Fly  1007 SGSGTPTGSSGKTSKKSSKRKSKSGG-----DGSSGGGSSPALTAAEKHAANLRQWIENYEYAVT 1066
            :     .....|..::.|::.|:..|     |.||.|.:....|       .::.|::.||.|..
  Rat   237 N-----FPKCKKAFREGSRKSSRVKGSAPEIDPSSDGSNFVWET-------KIKAWMDRYEEANN 289

  Fly  1067 NHYSPELRARLHAIQKQPS-LLQSI-QNTENKALRQIQQQLSTAGSAEQLEQRAQLIPYAGAKVL 1129
            |.||       ..:|::.. |.|.: ..:::|.:.:.:..::::.....:|...|    ...|:|
  Rat   290 NQYS-------EGVQREAQRLAQRLGSGSDSKDMSKPELSVNSSLFRPPVESHIQ----KNKKIL 343

  Fly  1130 ISSVDLSPHAPIHELRGKYMLTTQFRTQNPTVNMNTPPPSNYLNSFKAHKTPGQFVFFYQLPGVE 1194
            .|:.||.|.|.|.|.|||:||..||..            :.|.     .|.|..||.||
  Rat   344 KSAKDLPPDALIIEYRGKFMLREQFEA------------NGYF-----FKRPYPFVLFY------ 385

  Fly  1195 APMQTLRPDGSVPQVAQQPPSYLKGPEVCVDTRTYGNDARFVRRSCRPNAELQHYFEKGTLHLYI 1259
                                |...|.|:|||.||:||:|||:||||.||||::|..|:||:||||
  Rat   386 --------------------SKFHGLEMCVDARTFGNEARFIRRSCTPNAEVRHEIEEGTIHLYI 430

  Fly  1260 VALTHIRAQTEITIRHEPHDLTAVEQKKSHAAVIQPTSTRCACDMGSDCLFALPLAVQQQLQAPP 1324
            .:...|...|||||..:                         .|.| :|.:.:..|..::....|
  Rat   431 YSTQSIPKGTEITIAFD-------------------------FDYG-NCKYKVDCACLKENPECP 469

  Fly  1325 TQPRSSHRNKAAAAAAAAAAANSAAAIQLTMGLGVGATVAAGASVLPNSRNRSTSSSGESSQMGL 1389
            ...|||                                                    ||::
  Rat   470 VLKRSS----------------------------------------------------ESTE--- 479

  Fly  1390 NSPQLGQLNLGFKTSVTATSLTAPVPGVHCNNSGGSSSSSNNSCSVSMSSVLHDSGICTSSSSPS 1454
                  .:|.|::|.               ...|......:....:...::..|   |..:::.
  Rat   480 ------NINSGYETR---------------RKKGKKEKDISKEKDIQNQNITLD---CEGTNNK- 519

  Fly  1455 VSIPSPTPTQMQSPTLQQHPQQIPQQQLSLLQRSPTQQHQQQILAALPTPMLTPMLSPQLPKPAQ 1519
                                                                             
  Rat   520 ----------------------------------------------------------------- 519

  Fly  1520 QQAHVVLPQSQQTSLLQQQQSQQSQEPLAVIAAAAAAQQPMATYFVRQPQQQQQQQSPKPQALVA 1584
                                                         :|.|:.:|::.||
  Rat   520 ---------------------------------------------IRSPETKQRKLSP------- 532

  Fly  1585 QQQHVVGAQQQQHFLQQQQKQQQQQMADEARMAVSALQTLHAAPTSHIVSPIKVAAVQQQSQPQQ 1649
                                         .|::||
  Rat   533 -----------------------------LRLSVS------------------------------ 538

  Fly  1650 QQQNTHQQPHNQQAVQQQSNQLQQQQSQQPNYPQSPQRQQKPQPVQHQPQIVISTGAQAIPATMP 1714
                                     .:|:|::....:.:
  Rat   539 -------------------------NNQEPDFIDDMEEK-------------------------- 552

  Fly  1715 TKLSSPTKSAAPVISNNNITVSAQSSVVGGKKTPAKHPQQQQQQQQQPVTPVSAATAPAATPSSS 1779
                                                             ||:|       |....
  Rat   553 -------------------------------------------------TPIS-------TEVEM 561

  Fly  1780 ESKEDDVSASSTTTPTTRTPAKDKPKQSREDRKLEAILRAIEKMEKQEARGKKDTRQSSGGKRQA 1844
            ||:|.              .|:.:.|.:||:||:||||:|..::||:|.|.::...:.|..|.:.
  Rat   562 ESEEQ--------------IAERRRKMTREERKMEAILQAFARLEKREKRREQALERISTAKTEV 612

  Fly  1845 SNSPASPNKRNSSNSISEDVETPTSTNSAAAAAQRRNKKKRKVSRSLNNNTNGLGSGGGSNNKRR 1909
            ..........:.::.:.|.|:..|:....||.. .|.|:::..|||..:.        |...:|.
  Rat   613 RPECKESQVISDADVVQEQVKEETAIKPTAAKV-NRTKQRKSFSRSRTHI--------GQQRRRH 668

  Fly  1910 KSIVVESDGESHALTNSESEDQGQHPQSHHSGSEDQAAGLLLALAHNNSSPNEPFKSPLSQSHSL 1974
            :::.:.||                                        ..|:.|....:||.:.:
  Rat   669 RTVSMCSD----------------------------------------IQPSSPDVEVMSQQNDI 693

  Fly  1975 --------PATPASVSSACLLIEAAMGPLQQQPAPASASPSLAEFKYPPGGAKTKKSLMSSWFQQ 2031
                    |.|.|:|:.....:||        || .:..|:    |||    ||||.|::.|..:
  Rat   694 ENTVLAIEPETEAAVAEIITEVEA--------PA-LNKCPT----KYP----KTKKHLVNEWLSE 741

  Fly  2032 AEQQHASGLDSLVQAAMSEINGEREQLQRQPQGESLP----APALLKVEQFIHQAESTTAVPARE 2092
            ..::.....|||.:..: .|..:.|.|..|.  .|||    :|.:....:  |....|:...:.:
  Rat   742 KNEKTGKPSDSLSERPL-RITTDPEVLATQL--NSLPGLTYSPHVYSTPK--HYIRFTSPFLSEK 801

  Fly  2093 QLHLPLQNN--SSVKKRWLRQAISEETTPVDELQQSQNQSVTATPSPQPVPTVSPLANG------ 2149
            :.......|  .|.|||||:||:.||.:.|.....|..|.     .|:     ||..||
  Rat   802 KRRKETTENISGSCKKRWLKQALEEENSTVLHRYHSPCQE-----RPR-----SPTVNGESKSPL 856

  Fly  2150 ----------FSTPLKKRRLVVVSNGTNVESD---------ETHIDVIGEPKDEAEENVAMTELK 2195
                      .:||||||||..:.:....||.         .||.|:  .|.|.|  ......:|
  Rat   857 LLSDSCSLPDLTTPLKKRRLYQLLDSAYSESSTPTPSPYATPTHTDI--TPTDPA--FATPPRIK 917

  Fly  2196 VEIENHHQEQDDDVDILRSPSPGTHQIVAEDNLVKIEPEDTSAAADDVKIDVEREESQACDKFEE 2260
            .:.|.:..........:...:|||     ..|.:..|...:..::.::|.....:|..  |:...
  Rat   918 SDDETYRNSYKPIYSPVTPVTPGT-----PGNTMHFENISSPESSPEIKRCTYNQEGY--DRPST 975

  Fly  2261 MVKV----KREEEEQREKEIKQL-----QERQEHEQP----------------KVEPAPVEPKLE 2300
            |:.:    .....|...:|||.:     :.|.|..:|                .||||.::..:|
  Rat   976 MLTLGPFRNSNLNELGLQEIKTIGYTSPRSRTEVNRPCPGEKESVSDLQLGLDAVEPAALQKTME 1040

  Fly  2301 NTVAKAEPKVEPSQEIVSK------------KEPTKV---------------------------- 2325
               ..|..:.|||.::.|.            |.|.:.
  Rat  1041 ---TPAHDRTEPSSQLDSTHSGRGTMYSSWVKSPDRTGVNFSVNSNLRDLTPSHQLEIGGGFRIS 1102

  Fly  2326 EPK-----PGESLLRSTATVTATPTAATIAATTLLDVSKVAFKTRPPLKLEDEPQKK-------- 2377
            |.|     ....:...||....:...........::.|.:.....|    ::.||||
  Rat  1103 ESKCLTQDDARGMFMETAVFCPSEDGLVSGFGRTVNDSLIDGSCTP----QNPPQKKKVSLLEYR 1163

  Fly  2378 -----------KPK---LESILPAPVATVPP------------------VSVPPIPAASNATTSA 2410
                       ||:   |.|:.|.|..|:..                  .|:|..|.|:..|.|.
  Rat  1164 KRQREARKSGSKPENLALISVSPHPSGTLSSSGDGCVHSSENGEQPENRASLPLAPPAAACTASC 1228

  Fly  2411 VTNTA-----AASLTTTTAPSS--TKNLTEHDIQER------LLSFHAANISYLQSRNKKATAAL 2462
            ...::     .|:.|..|.|..  |.:.:...::||      |||.|.      :.::....:..
  Rat  1229 EEGSSDCPVRDANPTEKTDPEVQWTASTSVEQVRERSYQRALLLSDHR------KDKDGGGESPC 1287

  Fly  2463 TSASPSQKSNSSSGGSGTESKKSSKDKDEKRDKEKQLKKSKKEKKKSKDKEKQKAAVNVNSTSQI 2527
            .|.|||.          .:|..||......:...:.|.....|.....|.|..:|    .|||:.
  Rat  1288 VSCSPSH----------VQSSPSSHSNHIPQVPAQSLAPPLTEPMADLDPEGTEA----TSTSEC 1338

  Fly  2528 --VDTKKKTTQPSKPDSKSSIAP-------VLVPPSLPVATANGKTKHTAYNNVDQQQQQQMRRR 2583
              .||.:..::.|||.|...|.|       :..|.|...|||......::.:...:.||:|:...
  Rat  1339 PSPDTSQSPSKTSKPGSPGPINPAQSHGKMLTKPDSHWEATATVSEAESSVHLKPELQQKQLSSN 1403

  Fly  2584 TMSMCIT------------------PVTPTPV-VTPSPLHGTPPSTKKRQTNFEQELTKPNSQIL 2629
            |.::...                  |..||.: ..|||....||.:....|..:.....|..
  Rat  1404 TPALSKNHPPQAHVRNANDQLPQKLPSAPTKLHCPPSPHTENPPQSSTPHTPVQHGYLSPKP--- 1465

  Fly  2630 SSSILLNSSKGLGLPLAAPTVVSVPTAVQQQQHRKENNHQEATPASGGPMSLAAAIASGKLNAIS 2694
                   .|:.||.|.              :.|..: :.|..||....|.||..|..:.:.||
  Rat  1466 -------PSQHLGSPF--------------RPHHSQ-SPQVGTPQRETPRSLYPAAQNLQANA-- 1506

  Fly  2695 RRRESMCGSRQQQALIAAALKKEKKEKKKSKKKDREKQKHDKQKGKEKEREKDKEKDNKQKTNHI 2759
              :::.||     ||..
  Rat  1507 --QQAPCG-----ALFT------------------------------------------------ 1516

  Fly  2760 QKPAHPTTV---PANSMPISAPAPVPVLVPTPVTTPKAAPIPVLITQPTPSPIHVTQPLVNNCST 2821
            |.|:..::.   |.|...:|:|||.|   |.|               |.||..:..|       .
  Rat  1517 QTPSGQSSAAYSPFNQQALSSPAPPP---PPP---------------PPPSAYYQNQ-------Q 1556

  Fly  2822 KVASLPFYNTIYGKLQDPSTPTSSP---IPVTNTMPSL-------AEYLES---TKSKTTALSAV 2873
            ..|:...||.:.|.|...:..||.|   :|.|.:.||:       ..:|.|   |....||.:.|
  Rat  1557 PSANFQNYNQLKGSLSQQTVFTSGPNQALPGTTSQPSVPGHHVTPGHFLPSQNPTIHHQTAAAVV 1621

  Fly  2874 KP---------------------IGIAAVTPLSSAITPAKVAPSSL---EMPPPATTPLKLYTRT 2914
            .|                     ..:|.|.....|:||.....|..   .:|||...|
  Rat  1622 PPPPPPPPAPGPHLVQQPNSHQQHSVAHVVGTVHAVTPGSHIHSQTVGHHLPPPPPPP------- 1679

  Fly  2915 ASHDPRLNPMLTVPDPTPMPKRKLSISEYRMRHRPSVDTAPTTPTTPTTPTTPTTPPGSNKDRSF 2979
                   .|   .|...|.|.....:...:.:|:..|::||..|..|..|.:...     .....
  Rat  1680 -------GP---APHHHPPPHPSTGLQSLQAQHQHVVNSAPPPPPPPPPPASVLV-----SGHHS 1729

  Fly  2980 AKPQTINKCSLQSPERFQAAIRERRNSISAH-----HPQQNAHHNLNNNKGGISNKSGSSSGNHL 3039
            |..|.::....|.|..|         .:|.|     :|.|..||   ...|.......|.:|.|.
  Rat  1730 ASGQALHHPPHQGPPLF---------PVSVHPAVPPYPSQATHH---TTLGPGPQHQPSGTGPHC 1782

  Fly  3040 QQALGVAGGRLQSK--NAIVDPAAT 3062
              .|.|.|..||.:  |:|..|.|:
  Rat  1783 --PLPVPGPHLQPQGPNSIPTPTAS 1805

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
upSET	NP_648681.1	PHD_MLL5	856..899	CDD:277025	34/42 (81%)
		SET_SETD5-like	1112..1276	CDD:380927	60/163 (37%)
Kmt2e	NP_001094321.2	PHD_MLL5	120..163	CDD:277025	34/42 (81%)
		SET_KMT2E	324..451	CDD:380959	61/198 (31%)
		TPH	<561..>669	CDD:464007	32/130 (25%)
		Atrophin-1	1163..>1678	CDD:460830	127/641 (20%)
		PAT1	1291..>1508	CDD:401645	55/259 (21%)