DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment upSET and trr

DIOPT Version :9

Sequence 1:	NP_001261819.1	Gene:	upSET / 39551	FlyBaseID:	FBgn0036398	Length:	3146	Species:	Drosophila melanogaster
Sequence 2:	NP_726773.2	Gene:	trr / 31149	FlyBaseID:	FBgn0023518	Length:	2431	Species:	Drosophila melanogaster

Alignment Length:	2544	Identity:	480/2544 - (18%)
Similarity:	782/2544 - (30%)	Gaps:	901/2544 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 SLPYVSAS-PAKTQQQPQKFGSI--SAFKAQHQQQQQHPHATLQKVTLGSRVATRLQSYVPASPS 235
            ::|.|:.| .|..:.:|::..|:  :||.|          .:|||.: |...||      ||.
  Fly     2 NIPKVTTSLGAAEKAKPERVASVAAAAFNA----------VSLQKRS-GDDTAT------PAE-- 47

  Fly   236 QIMVQPAQPKYVNATATTIG-GNAALLKKANQKITVKSVSNMSQQQQQQQQQQQQQLLQAQQLKT 299
                .|.:.|  ..|...:| |.||      ..:..|:.|...||...|:..||.
  Fly    48 ----DPTRKK--AKTELLLGTGTAA------PSLPAKASSTAPQQLLYQRSGQQA---------- 90

  Fly   300 FITQQQQQQTYKAGAKAKFVKQTTALSIAALPQQQQQTTYAKQSMVTTSTPAKVTKLNSKYVQQQ 364
                       ||..||....|....:......:.||.........|.....|....: |..:.:
  Fly    91 -----------KAQVKAASEPQDVETADGVWDARDQQIIVCNFGSGTEMGAIKAEDAD-KQSEYR 143

  Fly   365 ISLPQGTQLQHKASPNVTGGGYLLQQSQAAVGGTIK--------FVNSHGTVIQQHPQQQQATKR 421
            ||.|:.:|    ::|       ||.::.|....|.|        ..:|..:||...|   ..:.:
  Fly   144 ISTPRNSQ----SNP-------LLHRNTAFTSFTKKEGASSSASSSSSTASVISIEP---SGSGQ 194

  Fly   422 THYNSSGSSDNEQHAVANSSLITDDVMIVNGTQMTDELSARILQSMAQKSFSQQQRFHQVPATGS 486
            .|..:||.|::..:.:                                           :||:|:
  Fly   195 DHAENSGKSEDLDYVL-------------------------------------------MPASGA 216

  Fly   487 GNMPPPTQIIYSNSTSNGAAASSPGGNASGNMLL-AHYQAAGTKPVSSASFI------------- 537
            .:   .|.:  .|||..|..|.:|.|..:..::| |:...||.....:.:.:
  Fly   217 DS---STSV--GNSTGTGTPAGTPIGATTSTIILNANNGTAGVSGAGTTTILTQKSGHTNYNIFN 276

  Fly   538 -TVTG--TPPVTV-------------------------ATTPSVSISSHGFASGSAAISSYMSSA 574
             |.||  ||..|:                         .||..|||   |..:.|..:...:.||
  Fly   277 TTATGSQTPTTTLLNRVNLHPKMKTQLMVNAKKLSEVTQTTAKVSI---GNKTISVPLLKPLMSA 338

  Fly   575 TAARRQSVSAPSSRAVSLERKQHHQQLQHDVIGGGRKAPTVIEYYNKHGVNSIVGSSNNLAQSNS 639
            :.|      |.:..|..:|.||        ::..|.:..||:....:.|...:....::.|..|.
  Fly   339 SGA------ATAGGATIVESKQ--------LLQPGGQVTTVMSAAQQSGGQQVHPHVHSHAHHNF 389

  Fly   640 MSNL-AGPRSNSGSGFATTTPTPATPLHLTPVNVPVHVEAAPPSSPALVKGSSQPPAQPQQQQQQ 703
            ...: .||: |||      |....:.|.:.|.|..:          ...|..|:...|.||.|||
  Fly   390 TKLIKRGPK-NSG------TIVSFSGLQIKPANTKI----------VATKVVSKKMLQLQQHQQQ 437

  Fly   704 AHPLGPNQLNANDEELYIEEVRPVPVLTQDLRLQQLHAIMQDHTYASQQQQQQPQQAAG------ 762
                                            :||            |||.||.|..:|
  Fly   438 --------------------------------IQQ------------QQQLQQLQVTSGGGLAPP 458

  Fly   763 -------DTTNPGAAQQVQQPQQWSLGGIGVTVSGSQGTPTAVGGYCSYFGQQIARSQADDDAHS 820
                   .||||.        |.:::.....||..:                  |.|:.|..|..
  Fly   459 TGSIVTITTTNPS--------QTYAMVQDSATVGPA------------------AHSEDDAPAPR 497

  Fly   821 AISSSSRMGLASTDIDPGEETETAPEAEAEDDSVTRCICELTHDDGYMICCDKCSAWQHVDCMGI 885
            .|::.|.......:....:|:...||             |.|:.:..:|             ..:
  Fly   498 KITAYSENLQKILNKSKSQESTGGPE-------------EFTNINSVVI-------------KPL 536

  Fly   886 DRQNIPEEYMCELCQPRAVDKARARALQRQKRKEHMLLVATQAANGAAAVAAGTTLSGGLGSGLP 950
            |:..:.       |.|         :....|:::|     :|||...:..|.|:      |:|.|
  Fly   537 DKNTLN-------CPP---------SFNIFKQQQH-----SQAAQSQSISAVGS------GAGTP 574

  Fly   951 MSEELQHRLASGLNGGFATGTGMSKKSKKTKENSGSTST--------------LKKTKKSAVGMG 1001
            ::    ..:|||.....||.:.:|..:.....||....|              |.||.     |.
  Fly   575 VT----FTMASGNASDLATTSTVSVSAGTICINSPMMGTRPIISIQNKNISLVLSKTT-----MA 630

  Fly  1002 GEKNASGSGTPTGSSG---------KTSKKSSKRKSKSGGDGSSGGGSSPALTAAE---KHAANL 1054
            .:|....:.|...|..         :.|.......|.:.|..:||......||.|.   |.:.:|
  Fly   631 QQKPKMITTTTLSSQAALQMHHALIQDSSADKAGSSANSGSATSGASMQLKLTTANTPTKLSVSL 695

  Fly  1055 RQWIENYEYAVTNHYSPELRARLHAIQKQPSLLQSIQNTENKALRQIQQQLSTAGSAEQLEQRAQ 1119
            ...:...|     ....|.:|:|  :.||.::::....|...                  |:||:
  Fly   696 APDVVKLE-----EVGSESKAKL--LVKQEAVVKDSTGTPTS------------------EERAE 735

  Fly  1120 LIPYAGAKVLISSVDLSPHAPIHELRGKYMLTTQFRTQNPTVNMNTPPPSNYLNSFKAHKTPGQF 1184
            .|                ..|...|.....:|...:.||.:.|
  Fly   736 EI----------------GTPEKRLNANATMTAINQVQNQSAN---------------------- 762

  Fly  1185 VFFYQLPGVEAPMQTLRPDGSVPQVAQQPPSYLKGPEVCVDTRTYGNDARFVRRSCRPNAELQHY 1249
                     :..|.|.....|.|..          |...|:.....|.    |.:...||.|:..
  Fly   763 ---------QIQMATSTSTASNPST----------PNPTVNATPMNNQ----RSAAEDNALLKQL 804

  Fly  1250 FEKGTLHLYIVALTHIRAQTEITIRHEPHDLTAVEQKKSHAAVIQPTSTRCACDMGSDCLFALPL 1314
            .:..       :.:|...|..||..|           ...|:...|.|.|...::.:..:..: .
  Fly   805 LQNN-------SSSHSLNQISITSAH-----------VGSASASAPLSARKVINVRAPSMGKV-R 850

  Fly  1315 AVQQQLQAPPTQPRSSHRNKAAAAAAAAAAANSAAAIQLTMGLGVGATVAAGASVLPNSRNRSTS 1379
            :::.||..|...|..:    |..||.:::::.|.|....|      .|||:|.|    |:..:|:
  Fly   851 SLEDQLARPVIPPVPT----ATQAAGSSSSSGSVATSTTT------TTVASGGS----SQQVATA 901

  Fly  1380 SSGESSQMGLNSPQLGQLNLGFKTSVTATSLTAPVPGVHCNNSGGSSSSSNNSCSVSMSSVLHDS 1444
            |:                     |::..:::....|||     ||.:.....|.        ..:
  Fly   902 SA---------------------TALPVSAVAITTPGV-----GGEAKLEQKSD--------QPA 932

  Fly  1445 GICTSSSSPSVSIPSPTPTQMQSPTLQQHPQQIPQQQLSLLQRSPTQQHQQQILAALPTPMLTPM 1509
            .|..:.|......|.|.|.|.|...|.|     |||    ||.||.|..|...:.:..|..::
  Fly   933 AIMQNQSQNQAPPPPPPPQQQQQQQLHQ-----PQQ----LQPSPHQVKQTVQIVSKETSFIS-- 986

  Fly  1510 LSPQLPKPAQQQAHVVLPQSQQTSLLQQQQSQQSQEPLAVIAAAAAAQQPMATYFVRQPQQQQQQ 1574
                  .|...:..|....|:...||.....:.:..|::.:..:.:.:|       ..|::.|.
  Fly   987 ------GPVAAKTLVTEATSKPAELLPPPPYEMATAPISNVTISISTKQ-------AAPKELQM- 1037

  Fly  1575 QSPKPQALVAQQQHVVGAQQQQHFLQQQQKQ--QQQQMADEARMA-------VSALQTLHAAPTS 1630
               ||:|:...    :..:|....|.:|.:.  ..:|.|..|.:|       |||..|     .:
  Fly  1038 ---KPKAVAMS----LPMEQGDESLPEQAEPPLHSEQGATAAGVAPHSGGPLVSAQWT-----NN 1090

  Fly  1631 HIVSPIKVAAVQ-QQSQPQQQQQNTHQQPHNQQAVQQQSNQLQQQQSQQP---NYPQSPQRQQKP 1691
            |:...:....:. :..:||:::...|.|...:|.         |||::.|   :.|.:|..|..|
  Fly  1091 HLEGGVATTKIPFKPGEPQKRKLPMHPQLDEKQI---------QQQAEIPISTSLPTTPTGQGTP 1146

  Fly  1692 ----------------------QPVQHQPQIVISTGAQAIPATMPTKLSSPTK------SAAPVI 1728
                                  ||:|:|.|..:...|| :.|||...||....      :|..:.
  Fly  1147 DKVQLISAIATYVKKSGVPNEAQPIQNQSQGQVQMQAQ-MQATMQGHLSGQMSGQISGHAAGQIP 1210

  Fly  1729 SNNNITVSAQSSVVGGKKTPAKHPQQQQQQ--QQQPVTPVSAATAPAATPSSSESKEDDVSASST 1791
            :..::.|..|..:       |.||||||||  |.||    ..||.|  .|.:.:      .|...
  Fly  1211 AQMHLQVQHQLHM-------AVHPQQQQQQLHQNQP----QNATIP--LPVTGQ------GAVPI 1256

  Fly  1792 TTPTTRTPAKDKPKQSREDRKLEAILRAIEKMEKQEARGKKDTRQSSGGKRQASNSPASPNKRNS 1856
            ..||..:.|.|:.|:              .|.|.|:.|........:||..:....|.      .
  Fly  1257 PVPTMESKAGDQRKR--------------RKREVQKPRRTNLNAGQAGGALKDLTGPL------P 1301

  Fly  1857 SNSISEDVETPTSTNSAAAAAQRRNKKKRKVSRSLNNNTNGLGSGGGSN---NKR-RKSIVVESD 1917
            :.::.:....|..|.....||...........:.:.....|..:|..|:   .|| ||...||.|
  Fly  1302 AGAMVQLAGMPPGTQYIQGAASGTGHVITSTGQGVTLGGVGASTGASSSPMLKKRVRKFSKVEED 1366

  Fly  1918 GESHA---LTNSESEDQGQHPQSHHS-------GSEDQAAGLLLALAHNNSSPNEPFKSPLSQSH 1972
            .::..   ||:.......|..:.|.:       ||.:.:.|
  Fly  1367 HDAFTEKLLTHIRQMQPLQVLEPHLNRNFHFLIGSNETSGG------------------------ 1407

  Fly  1973 SLPATPASVSSACLLIEAAMGPLQQQPAPASASPSLAEFKYPPGGAKTKKSLMSSWFQQAEQQHA 2037
               .:|||:|||                 |||..|.|      ||.|.|.. ...|   ...:|.
  Fly  1408 ---GSPASMSSA-----------------ASAGSSSA------GGGKLKGG-SRGW---PLSRHL 1442

  Fly  2038 SGL---DSLVQAAMSEINGEREQLQRQPQGESLPA-PALLKVEQF-----------IHQAESTTA 2087
            .||   |..|......:|              ||. |:|...|:|           ..::.|...
  Fly  1443 EGLEDCDGTVLGRYGRVN--------------LPGIPSLYDSERFGGSRGLVGGSARTRSPSPAE 1493

  Fly  2088 VPAREQLHLP---LQNN-----------SSVKKRWLRQ--AISEETTPVDELQQSQNQSVTAT-- 2134
            .|..|:: ||   :||:           .:.::|.:|.  |:.:......:|.:|:..:..||
  Fly  1494 SPGAEKM-LPMSSIQNDFYDQEFSTHMERNPRERLVRHIGAVKDCNLETVDLVESEGVAAWATLP 1557

  Fly  2135 --------------------PSPQPVP--------TVSPLANGFSTPLKKRRLVVVSNGTNVESD 2171
                                .||..:|        .||||.......|:|.:
  Fly  1558 RLTRYPGLILLNGNSRCHGRMSPVALPEDPLTMRFPVSPLLRSCGEELRKTQ------------- 1609

  Fly  2172 ETHIDVIGEPKDEAEENVAMTELKVEIENHHQEQDDDVDILRSPSPGTHQI--VAED--NLVKIE 2232
                          :..:.|..|.....|::|:::.:| ||..|:..:..|  |..|  ||:.:.
  Fly  1610 --------------QMELGMGPLGNNNNNNYQQKNQNV-ILALPASASENIAGVLRDLANLLHLA 1659

  Fly  2233 PEDTSAAADDVKIDVEREESQACDKFEEMVKVKREEEEQREKEIKQ-LQERQE---------HEQ 2287
            |..|....:| ||..:.|:.......|:.|..||...:.....::: |..|::         |..
  Fly  1660 PALTCKIIED-KIGNKLEDQFMNQDDEKHVDFKRPLSQVSHGHLRKILNGRRKLCRSCGNVVHAT 1723

  Fly  2288 PKVEPAPVEPKLENTVAKAEPKVEPSQEIVSKKEPTKVEPKP----------------GESLLRS 2336
            ....|....|.||..:    |::....:::    |.|..|.|                |:.....
  Fly  1724 GLRVPRHSVPALEEQL----PRLAQLMDML----PRKSVPPPFVYFCDRACFARFKWNGKDGQAE 1780

  Fly  2337 TATVTATPTAATIAATTLLDV--SKVAFKTRP-PLKLEDEPQKKKPKLESILPAPVATVPP---- 2394
            .|::...|...:...::..|.  |..|..|.| .:.::.||:.:..|..|: |.....:|.
  Fly  1781 AASLLLQPAGGSAVKSSNGDSPGSFCASSTAPAEMVVKQEPEDEDEKTPSV-PGNPTNIPAQRKC 1844

  Fly  2395 ---------VSVPPIPAASNATTSAVTNTAAASLTTTTAPSSTKNLTEHDIQE------------ 2438
                     .:....|:......:|...|.|..:..|...:.|..|...|.::
  Fly  1845 IVKCFSADCFTTDSAPSGLELDGTAGAGTGAGPVNNTVWETETSGLQLEDTRQCVFCNQRGDGQA 1909

  Fly  2439 ----RLLSF 2443
                |||:|
  Fly  1910 DGPSRLLNF 1918

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
upSET	NP_001261819.1	PHD_MLL5	856..899	CDD:277025	4/42 (10%)
upSET	NP_001261819.1	SET	<1221..1273	CDD:214614	9/51 (18%)
trr	NP_726773.2	PHA03255	184..>320	CDD:165513	30/186 (16%)
		ePHD2_KMT2C_like	1898..2002	CDD:277136	4/21 (19%)
		FYRN	2068..2118	CDD:283589
		FYRC	2126..2215	CDD:197781
		SET	<2266..2431	CDD:225491
		SET	2291..2413	CDD:214614
		PostSET	2415..2431	CDD:214703
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.030