DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment upSET and Setd5

DIOPT Version :9

Sequence 1:	NP_001261819.1	Gene:	upSET / 39551	FlyBaseID:	FBgn0036398	Length:	3146	Species:	Drosophila melanogaster
Sequence 2:	XP_017448059.1	Gene:	Setd5 / 297514	RGDID:	1310433	Length:	1478	Species:	Rattus norvegicus

Alignment Length:	1666	Identity:	343/1666 - (20%)
Similarity:	545/1666 - (32%)	Gaps:	526/1666 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   769 AAQQVQQPQQWSLGGIGVTV-SGSQGTPTAVGGYCSYFGQQIARSQADDDAHSAISSSSRMGLAS 832
            |:..|.:...:|....|.|. .|.:|.|.|..   :|.........|.....:.|..|...||.|
  Rat    37 ASPAVNEKSLYSTHNYGTTQRHGCRGLPYADH---NYGAPPPPTPPASPPVQTIIPRSDLNGLPS 98

  Fly   833 -----TDIDPGEETETAPEAEAEDDSVTRCICELTHDDGYMICCDKCSAWQHVDCMGIDRQNIPE 892
                 ....|..|.||.|         |.|.|.|: .||:::.||||
  Rat    99 PVEERCGDSPNSEGETVP---------TWCPCGLS-QDGFLLNCDKC------------------ 135

  Fly   893 EYMCELCQPRAVDKARARALQRQKRKEHMLLVATQAANGAAAVAAGTTLSGGLGSGL-PMSEEL- 955
                     |.:.:.:...|.|:|:                     ..:|||..|.. ...|||
  Rat   136 ---------RGMSRGKVIRLHRRKQ---------------------DNISGGDSSATESWDEELS 170

  Fly   956 ---------QHRLASGLNGGFATGTGMSKKSKKTKENSGSTSTLKKTKKS-AVGMGGEKNASGSG 1010
                     ||           |.|.::...::||.        ||.||| ..|....|......
  Rat   171 PSTVLYTATQH-----------TPTSITLTVRRTKP--------KKRKKSPEKGRAAPKTKKIKA 216

  Fly  1011 TPTGSSGKTSKKSSKRKSKSGGDGSSGGGSSPALTAAEKHAANLRQWIENYEYAVTNHYSPE--- 1072
            ...||......|:|..::::..:.::.|..:           .:|.|.:.||.|.||.||.:
  Rat   217 FREGSRKSLRMKNSPSEAQNLDENTTEGWEN-----------RIRLWTDQYEEAFTNQYSADVQN 270

  Fly  1073 -LRARLHAIQK---QPSLLQSIQNTE---NKALRQIQQQLSTAGSAEQLEQRAQLIPYAGAKVLI 1130
             |...||:.::   :|::|.:|..||   |..:...|.||. .|...::::.        .|:|.
  Rat   271 ALEQHLHSNKEFVGKPAILDTINKTELACNNTVIGSQMQLQ-LGRVTRVQKH--------RKILR 326

  Fly  1131 SSVDLSPHAPIHELRGKYMLTTQFRTQNPTVNMNTPPPSNYLNSFKAH--KTPGQFVFFYQLPGV 1193
            ::.||:....|.|.|||.||..||.     ||              .|  |.|..||.||
  Rat   327 AARDLALDTLIIEYRGKVMLRQQFE-----VN--------------GHFFKKPYPFVLFY----- 367

  Fly  1194 EAPMQTLRPDGSVPQVAQQPPSYLKGPEVCVDTRTYGNDARFVRRSCRPNAELQHYFEKGTLHLY 1258
                                 |...|.|:|||.||:||||||:||||.||||::|....|.:||.
  Rat   368 ---------------------SKFNGVEMCVDARTFGNDARFIRRSCTPNAEVRHMIADGMIHLC 411

  Fly  1259 IVALTHIRAQTEITIRHEPHDLTAVEQKKSHAAVIQPTSTRCACDMGS-DCLFAL--PLAVQQQL 1320
            |.|::.|....|:||        |.:.:.|:...    ...|||..|: :|....  |.|.:..|
  Rat   412 IYAVSAITKDAEVTI--------AFDYEYSNCNY----KVDCACHKGNRNCPIQKRNPNAAELPL 464

  Fly  1321 QAP--PTQPRSSHRNKAAAAAAAAAAANSAAAIQ---LTMGLGVGATVAAGASVLPNSRNRSTSS 1380
            ..|  ||....:.|.||..........|......   ....:....||::....:.|...:....
  Rat   465 PPPSFPTIGAETRRRKARRKELEMEQQNEVPEENHDPQPQEVPEKVTVSSEHEEVDNPEEKPEEE 529

  Fly  1381 SGESSQMGLNSPQLGQLNLGFKTSVTATSLTA----------PVPGVHCNNSGGSSSSSNNSCSV 1435
            ..|::....||....:.....|......:...          ||            ..||:...:
  Rat   530 KEEATDDQENSAHSRRTREDRKVEAIMHAFETLEKRKKRRDQPV------------EQSNSDVEI 582

  Fly  1436 SMSSVLHDSGICTSSSSPSVSIPSPTPTQMQSPTLQQHPQQIPQQQLSLLQRSPTQQHQQQILAA 1500
            :.||.....|..|.:::|...:.:|. |.:..|:       |||......:||   .|...:.|.
  Rat   583 TTSSSEIGVGEETKTAAPESEVNNPV-TNIAIPS-------IPQSTGVNTRRS---SHAGDVAAE 636

  Fly  1501 LPTPMLTPMLSPQLPKPAQQQAHVVLPQSQQTSLLQQQQSQQSQEPLAVIAAAAAAQQPMATYFV 1565
            .|.|. .|...|..|:|..:.:......:|:....:|..:||::      .|.||.::..:...|
  Rat   637 KPVPK-PPPAKPSRPRPKSRISRYRTSSAQRLKRQKQANAQQAE------LAQAALEEGGSNNSV 694

  Fly  1566 RQPQQQQQQQSPKPQALVAQQQHVVGA-------------QQQQHFLQQ--QQKQQQQQMADEAR 1615
            ..|:......|.:.:.|......||..             :.:::.:.:  ..|.::|:...|..
  Rat   695 TLPEAGNIDSSGESRPLTGSDPTVVSVTGSHVNRAASKYPKTKKYLVTEWLNDKAEKQECPVECP 759

  Fly  1616 MAVSA-----LQTLHAAP-----------TSHIV---SP-----------------------IKV 1638
            :.::.     ..||:..|           ..|.:   ||                       ||.
  Rat   760 LRITTDPTVLATTLNMLPGLIHSPLICTTPKHYIRFGSPFMPERRRRPLLPDGTFSSCKKRWIKQ 824

  Fly  1639 A----AVQQQSQPQQ-QQQNTHQQPHNQQA--------------VQQQSNQLQQQQSQQPNYPQS 1684
            |    ..|..|.||: :.|:.:|...|..:              .:.:|..|.:|...:...|.|
  Rat   825 ALEEGMTQTSSVPQETRTQHLYQSNENSNSSSICKDNADLLSPLKKWKSRYLMEQNITKLLRPLS 889

  Fly  1685 PQRQQKPQPVQHQPQIVISTGAQAIPA------------TMPTKLSSPTKSAAPV---------- 1727
            |.....|......||  ::|..|..|.            :..|.|::.::|..|:
  Rat   890 PVTPPPPSSGSKSPQ--LTTPGQTHPGEEECRNGYSLMFSPITSLTTASRSNTPLQFELCHRKDL 952

  Fly  1728 -----------------------ISNNNITVS---AQSSVVGGKKTPAKHPQQQQQQQQQ----- 1761
                                   .|:.::|..   |.:|..|........||...:...|
  Rat   953 DLTKVGYPDSSTHSCGDRPSLLNCSHPDLTSHPSVAPTSEAGFPSRSGDGPQTLLRNSDQAFRTE 1017

  Fly  1762 -----PVTPVSAATAPAA-----------------------TPSSSESKE------DDVSASSTT 1792
                 ..:|::|  .|.|                       :|:...|..      .|:|..|.:
  Rat  1018 FNLMYAYSPLNA--MPRADGLYRGSPLVGDRKPLHLDGGYCSPAEGFSSRYEHGFMKDLSRGSMS 1080

  Fly  1793 TPTTRT-----PAKDKPKQSREDRKLEAILRAIEKMEKQEAR----GKKDTRQ----SSGGKRQA 1844
            ....||     .|...|.|.::...||      .:..||||:    |..|:.|    |||..:.:
  Rat  1081 PGGERTCEGVPSAPQNPPQRKKVSLLE------YRKRKQEAKENSGGGSDSSQSKSKSSGAGQGS 1139

  Fly  1845 SNS----------------PASPNKRNS-SNSISEDVETPTSTNSAAAAAQRRNKKKRKVSR-SL 1891
            |||                |:||:|:.| |:|.:..:|..:.::|...::.....::...|| .:
  Rat  1140 SNSVSDTGAHGVQGSSARTPSSPHKKFSPSHSSTSHLEAVSPSDSRGTSSSHCRPQENISSRWMV 1204

  Fly  1892 NNNTNGLGSGGGSNNKRRKSIVVESDGE-----SHALTNSESED-QGQHPQSHHSGSEDQAAGLL 1950
            ..:...|..||......|.|:.|...||     ...:|..||:. .|:.|
  Rat  1205 PTSVERLREGGSIPKVLRSSVRVAQKGEPSPTWESNITEKESDPADGEGP--------------- 1254

  Fly  1951 LALAHNNSSPNEPFKSPLSQSHSLPATPASVSSACLLIEA----AMGPLQQQPAPASASPSLAE- 2010
                       ||..|.||:..:: .:|:..|...|..::    :...|||..:|....|:.:.
  Rat  1255 -----------EPLSSALSKGATV-YSPSRYSYQLLQCDSPRTESQSLLQQSSSPFRGHPTQSPG 1307

  Fly  2011 FKY---------PPGGAKTKKSLMSSWFQQAEQQHASGLDSLVQAAMSEINGEREQLQRQPQGES 2066
            :.|         ||....::.||.|:.:  ....|....|||     :...|.......||
  Rat  1308 YSYRTTALRPGNPPSHGSSESSLSSTSY--PSPAHPVSTDSL-----APFTGTPGYYSSQP---- 1361

  Fly  2067 LPAPALLKVEQFIHQAESTTAVPAREQLHLPLQNNSSVKKRWLRQAISEETTPVDELQQSQNQSV 2131
                         |...||.:       :||.::.||.......|..|:..|. |.:.||...::
  Rat  1362 -------------HSGNSTGS-------NLPRRSCSSSAASPTPQGPSDSPTS-DSVSQSSTGTL 1405

  Fly  2132 TATPSPQ--------PVPTVSPLANGFSTPLKKRRLVVVSN 2164
            ::|..||        .:.|:|..:.|.|...:..|:..||:
  Rat  1406 SSTSFPQNSRSSLPSDLRTISLPSAGQSAAYQASRVSAVSS 1446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
upSET	NP_001261819.1	PHD_MLL5	856..899	CDD:277025	9/42 (21%)
upSET	NP_001261819.1	SET	<1221..1273	CDD:214614	28/51 (55%)
Setd5	XP_017448059.1	SET_SETD5	305..454	CDD:380958	65/214 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334924
Domainoid	1	1.000	111	1.000	Domainoid score	I6109
eggNOG	1	0.900	-	-		E1_KOG1844
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	208	1.000	Inparanoid score	I3613
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004035
OrthoInspector	1	1.000	-	-		otm45780
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46462
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.980