Protein Alignment upSET and lin-59

DIOPT Version :9

• Sequence 1: NP_001261819.1
• Gene: upSET / 39551
• FlyBaseID: FBgn0036398
• Length: 3146
• Species: Drosophila melanogaster
• Sequence 2: NP_491206.1
• Gene: lin-59 / 266825
• WormBaseID: WBGene00003040
• Length: 1312
• Species: Caenorhabditis elegans
• Alignment Length: 1179
• Identity: 245/1179 - (20%)
• Similarity: 378/1179 - (32%)
• Gaps: 380/1179 - (32%)

  Fly   414 QQQQATKRTHYNSSGSSDNEQHAVANSSLITDDVMIVNGTQMTDELSARILQSMAQKSFSQQQRF 478
            :|||   |..||:  .||.:.|..:.||                       ....|:...|..:.
 Worm     6 EQQQ---RYRYNA--RSDEQHHHPSTSS-----------------------HQYQQQGARQMHQM 42

  Fly   479 HQVPATGSGNMPPPTQIIYSNSTSNGAAASSPGGNA----SGNML------------------LA 521
            |.:.||   .|..||....:.|||:...::|.||:.    .||:|                  |.
 Worm    43 HPIQAT---LMCTPTTTSAAASTSSSGGSNSSGGSGGHRQQGNILRIGNSIKIGDNILEPAGTLV 104

  Fly   522 HYQAAG-------------TKPVSSASFITVTGTPPVTVATTPSVSISSH-----GFASGSAAIS 568
            ..||.|             |..|..|:...:..||||       :::.|:     ...||:..:|
 Worm   105 FSQADGTPWTGQRIVVNGSTHAVVKANLFPIGTTPPV-------LNMQSNQNWYMNQPSGTVPMS 162

  Fly   569 SYMSSATAARRQSVSAPSSRAVSLERKQHHQQLQHDVIGGGRKAPTVIEYYNKHGVNSIVGS--S 631
            |...:.|     |.:.|.|                                   |:.|:..|  |
 Worm   163 SNAPATT-----SSATPDS-----------------------------------GIQSVPTSPPS 187

  Fly   632 NNLAQSNSMSNLAGPRSNSGSGFATTTPTPATPLHLTPV-------NVPVHVEAAPP--SSPAL- 686
            .:.|..|.:............|.|..|..|.    |.||       :||...|..||  |:||:
 Worm   188 PSYAMMNDVDIGDHDDEEDDDGPADFTDMPL----LKPVDEDDDCYDVPCTSEGPPPNNSNPAIT 248

  Fly   687 -VKGSSQPPAQPQQQQQQAHPLGPN---------QLNANDEELYIEEVRPVPVLTQDLRLQQLHA 741
             :..|...||.|    :::.|.|.|         ..|.:.||:    ||  .::..|..:.:..|
 Worm   249 TIPSSCSTPAPP----KESLPTGMNVEEWGSFLIASNMDREEI----VR--RLMAHDPEMAKAIA 303

  Fly   742 IMQDHTYASQQQQQQPQQAAGDTTNPGAAQQVQQPQQWSLGGIGVTVSGSQGTPTAVGGYCSYFG 806
            :......|.:.::::..:|...:|.|                   |...::||.|.  ..|:
 Worm   304 MRIRELSAEESKKKKDMEAEVSSTTP-------------------TTPRARGTRTR--NKCA--- 344

  Fly   807 QQIARSQADDDAHSA----ISSSSRMGLASTDID----PGEETETAPE------AEAEDDSVTRC 857
               .||....|..::    ..|:|.|||...:.|    .|:.....|:      .|:.:|
 Worm   345 ---TRSTNSPDVTTSNLPEEPSTSTMGLVKENEDVEKVEGKRRGRKPKKRRGFHKESFED----- 401

  Fly   858 ICELTHDDGYMICCDKCSAWQHVDCMGIDRQNIPEEYMC----ELCQPRAVDKARARALQRQKRK 918
               |..|      ..|..|.||.|       ::||. .|    |...|..||..:.| |:.::..
 Worm   402 ---LESD------AKKSKAEQHED-------HLPEA-SCSSRPESVIPPPVDPIQFR-LKVREMM 448

  Fly   919 EHMLLVATQAANGAAAVAAGTTLSGGLGSGLPMSEE-----LQHRLASGLNGGFATGTGMSKKSK 978
            |..|...||                      .|||:     |.|..:|.:..|   ..|..::|.
 Worm   449 ERKLEQLTQ----------------------KMSEDMTELRLSHLTSSKMVNG---ERGKRRESF 488

  Fly   979 KTKENSGSTSTLKKTKKSAVGMGGEKNASGSGTPTGSSGKTSKKSSKR-KSKSGGDGSSGGGSSP 1042
            ..:.|..|    ||.:|.  ||.|.|......|.:....:......|. |.:|....:...|..|
 Worm   489 LRQLNEQS----KKLRKG--GMLGRKRLRMFMTESDILEENKDNIKKEVKEESTPPPTKLRGRLP 547

  Fly  1043 ALTAAEKHAANLRQWIE---NYEYAVTNHYSPELRARLHAIQKQPSL--------LQSIQNTENK 1096
            :....|.......:.:|   |.||.......|. ...:..:...|||        ..|..:..|:
 Worm   548 SRRTREPSEIVNPEPVEKKFNGEYFEITKSVPS-SDDIIPLWMAPSLTCGCTKGACTSDMDCLNR 611

  Fly  1097 ALRQIQQQLSTAGSAEQLEQRAQLIPYAGAKVLISSVDLSPHAPIHELRGKYMLTTQFRTQNPTV 1161
            |||   .|.|:..|......|.......|.|:.:|      :.|    |.|.:|.|
 Worm   612 ALR---VQCSSDCSVPYCSNRRFWKEDCGNKLCVS------NGP----RSKRVLKT--------- 654

  Fly  1162 NMNTPPPSNYLNSFKAHKTPGQFVFFYQLPGVEAPMQTLRPDGSV--PQVAQQPPSYLKGPEVC- 1223
                          |..:..|:|:..|.              |.|  .:.||:..:..:.|.:.
 Worm   655 --------------KIARRAGEFLCEYA--------------GEVITREQAQEKFAQDRDPRIIA 691

  Fly  1224 ------VDTRTYGNDARFVRRSCRPNAELQHYFEKGTLHLYIVALTHIRAQTEITIRHE---PHD 1279
                  ||.....|.|||::.||:||:.|:.:...|.....:.||:.:....|||:...   |.|
 Worm   692 IAAHLFVDATKRSNIARFIKHSCKPNSRLEVWSVNGFYRAGVFALSDLNPNAEITVDKSDLLPFD 756

  Fly  1280 LT----AVEQKKSHAAVIQPTSTRCACDMGSDCLFALPLAVQQQLQAPPTQPRSSHRNKAAAAAA 1340
            :.    |.|.|:    ||:....|||..  ::.:......::.:.:   |..||||   :...|.
 Worm   757 MACNCGATECKR----VIRGVRWRCADP--NEKIVTRRFVIRNRRK---TIERSSH---SGLPAI 809

  Fly  1341 AAAAANSAAAIQLTMGLGVGATVAAGASVLPNSRNRSTSSSGESSQMGLNSPQLGQLNLGFKTSV 1405
            .....:..::|:|.|           ..||.....|.....|..|:     ..|....|..|...
 Worm   810 LQTPMDENSSIRLKM-----------KQVLAAFAFRVRKIDGSMSR-----TMLPHYTLIIKFLK 858

  Fly  1406 TATSLTAPVPGVHCNNSGGSSSSSNN--SCSVSMSSVLHDSGICTSS--------SSP-----SV 1455
            |..:...||..|........:...::  ...|::.|....|.|.:||        ::|     |.
 Worm   859 TKGNNPNPVEFVSLFRKWLEAIDDDDLERAFVAIESHYMSSSILSSSLQSKKAKDNAPRARALST 923

  Fly  1456 SIPSPTPTQ 1464
            |.|||.|::
 Worm   924 SCPSPVPSK 932

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
upSET	NP_001261819.1	PHD_MLL5	856..899	CDD:277025	11/46 (24%)
		SET	<1221..1273	CDD:214614	16/58 (28%)
lin-59	NP_491206.1	AWS	591..636	CDD:197795	12/47 (26%)
		SET	638..748	CDD:214614	33/156 (21%)
		PHD	970..1027	CDD:279022
		BAH_polybromo	1118..1222	CDD:240068

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030