Protein Alignment upSET and set3

DIOPT Version :10

• Sequence 1: NP_648681.1
• Gene: upSET / 39551
• FlyBaseID: FBgn0036398
• Length: 3146
• Species: Drosophila melanogaster
• Sequence 2: NP_594837.1
• Gene: set3 / 2541899
• PomBaseID: SPAC22E12.11C
• Length: 859
• Species: Schizosaccharomyces pombe
• Alignment Length: 1127
• Identity: 202/1127 - (17%)
• Similarity: 381/1127 - (33%)
• Gaps: 377/1127 - (33%)

  Fly   856 RCICELTHDDGYMICCDKCSAWQHVDCMGIDRQNIPEEYMCELCQPRAVDKARARALQ--RQKRK 918
            ||:|....|||:.|.|:.|..|||..|:.||..|:||:|.||.||||.:|..:|..:|  |.:|:
pombe     5 RCVCPFEDDDGFTIQCESCEVWQHAVCVNIDANNVPEKYFCEQCQPRPIDADKAHKIQLARLQRE 69

  Fly   919 EHM--LLVATQAANGAAAVAAGTTLSGGLGSGLPMSEELQHRLASGLNGGFATGTGMSKKSKKTK 981
            |..  :|..::::|.                        :.|.:.|.||...|.:...::...|.
pombe    70 EEQSRILSRSRSSNN------------------------KRRTSFGKNGASPTHSASPRQGNNTG 110

  Fly   982 ENSG--STSTLKKTKKSAVGMGGEKNASGSGTPTGS-SGKTSKKSSKRKSKSGGDGSSGGGSSPA 1043
            .|..  |.||               |:|.||:...| :|.|...:....|::....|:...:.|.
pombe   111 ANGALFSQST---------------NSSNSGSYRNSVTGATLPNAHAPHSQNRRRRSNHLNNPPE 160

  Fly  1044 LTAAEKHAANLRQWIENYEYAVTNHYSPELRARLHAIQKQPSLLQSIQNTENKALRQIQQQLSTA 1108
            ....|  |:|      .|.|:....|.|        ::.......:::.::|..|:.:.:
pombe   161 APITE--ASN------EYVYSFHLEYVP--------LESNTFSASALEYSKNLDLKNLDE----- 204

  Fly  1109 GSAEQLEQRAQLIPYAGAKV------LISSVDLSPHAPIHELRGKYMLTTQFRTQNPTVNMNTPP 1167
              :|.|....|::|.:.:|.      |:|:.::.|:.||.|::|:.....::::.
pombe   205 --SEVLMDGCQVVPISSSKFCCSRFGLVSTCEIPPNTPIMEVKGRVCTQNEYKSD---------- 257

  Fly  1168 PSNYLNSFKAHKTPGQFVFFYQLPGVEAPMQTLRPDGSVPQVAQQPPSYLKGPEVCVDTRTYGND 1232
            |.|..|...|   |...|||               |.:              .::.||:|..|:.
pombe   258 PKNQYNILGA---PKPHVFF---------------DSN--------------SQLVVDSRVAGSK 290

  Fly  1233 ARFVRRSCRPNAELQHYFEKGT---LHLYIVALTHIRAQTEI------TIRHEPHDLTA------ 1282
            |||.|:.|:.|:.:...:..|:   ....:.:.|||..:|||      .|.|.......
pombe   291 ARFARKGCQSNSVVSSVYMNGSNSVPRFILYSTTHIAPETEIIGDWTLDISHPFRQFAPGMSRPS 355

  Fly  1283 --VEQKKSHAAVIQP--TSTRCACDMGSDCLFALPLAVQQQLQAPPTQPRSSHRNKAAAAAAAAA 1343
              :|:.:..:.|:..  :...||.....:|:|                   |...|...||..|:
pombe   356 FNMEELELLSEVLSTFLSFNECASQDKKNCVF-------------------SRVTKYIKAARRAS 401

  Fly  1344 AANSAAAIQLTMGLGVGATVAAGASVLPNSRNRSTSSSGESSQMGLNSPQLGQLNLGFKTSVTAT 1408
            .||..:..                                                  |..::.|
pombe   402 TANRVSVA--------------------------------------------------KDRLSLT 416

  Fly  1409 SLTAPVPGVHCNNSGGSSSSSNNSCSVSMSSVLHDSGICTSSSSPSVSIPSPT-PTQMQSPTLQQ 1472
            ..:.|                                   |:.||:.|:|.|: ||.:.:.:|::
pombe   417 PSSTP-----------------------------------STPSPAESLPQPSNPTSVYAKSLKE 446

  Fly  1473 HPQQIPQQQLSLLQRSPTQQHQQQILAALPTP------MLTPMLSPQL-PKPAQQQAHVVLPQSQ 1530
            .  .:.:.:||:||:.|.       :.:|||.      ::.|.|.|.: .|...:.....||..:
pombe   447 F--WLDKYRLSILQKWPA-------VKSLPTESVGIDVVMEPKLQPSVKEKKPTKDLQSPLPSVE 502

  Fly  1531 QTSLLQQQQSQQSQ----------EPLAVIAAAAAAQQPMATYFVRQPQQQQQQQSPKPQALVAQ 1585
            :.|..:.:::..:.          :.|:.|:..||.|........::|::.....:..|...|.:
pombe   503 EDSSNRDKKTDIADLHTDSKVGIADVLSPISPDAALQSDGPLKKAKEPEESSITPTTPPSFNVGE 567

  Fly  1586 QQHVVGAQQQQHFLQQQQKQQQQQMADEARMAVSALQTLHAAPTSHIVSPIKVAAVQQQSQPQQQ 1650
                                              :|....|:|..|   |.....:..::.|.::
pombe   568 ----------------------------------SLSRRSASPLQH---PRTSPDMLDKTSPCKR 595

  Fly  1651 QQNTHQQPHNQQAVQQQSNQLQQQQSQQPNYPQSPQRQQKPQPVQHQPQIVISTGAQ------AI 1709
            ...|....|.:.........:::::|...::...|...::...::.:|:...:.|.:      :.
pombe   596 GLGTITTVHKKHGSVDHLPSVKRRRSIANDFHGKPDYNKRSLSIERKPEAFKTKGDRPHKVHPSF 660

  Fly  1710 PATMPTKL----SSPTKSAAPVISNNNITVSAQSSVVGGKKTPAKHPQQQQQQQ----------- 1759
            .....:||    ||..||.: :..|...||..:|.|...:::...:..:|...:
pombe   661 HRNSDSKLKLEPSSKEKSGS-MFFNTLRTVKDKSHVHDTQRSSDVNFSRQNGTRSHSPSVSPVGF 724

  Fly  1760 ---QQPVTPVSAATAPAATPSSSESKEDDVSASSTTTPTTRTPAKDKPKQSREDRKLEAILRAIE 1821
               :.|||.....||||...:|..      :..:...||......|....:.:|..
pombe   725 SFDKSPVTTPPLPTAPAPVITSRH------ALVNNQFPTNNPNILDHKANNGDDIS--------- 774

  Fly  1822 KMEKQEARGKKDTRQSSGGKRQASNSPASPNKRNSSNSISEDVETPTSTNSAA---------AAA 1877
                                 .|.|:..|.||.| ||.:...|..|::|:::|         :.:
pombe   775 ---------------------NALNTSRSENKPN-SNLVQGSVVKPSNTSASALPTSAPKKLSLS 817

  Fly  1878 QRRNKKKRKV--SRSLNNNTNG 1897
            :.|.::::.:  .:|.:|..:|
pombe   818 EYRQRRQQNILHQQSKDNQAHG 839

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
upSET	NP_648681.1	PHD_MLL5	856..899	CDD:277025	21/42 (50%)
		SET_SETD5-like	1112..1276	CDD:380927	39/178 (22%)
set3	NP_594837.1	PHD_MLL5	5..48	CDD:277025	21/42 (50%)
		SET_SpSET3-like	215..387	CDD:380960	42/213 (20%)