DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment upSET and cti6

DIOPT Version :9

Sequence 1:	NP_001261819.1	Gene:	upSET / 39551	FlyBaseID:	FBgn0036398	Length:	3146	Species:	Drosophila melanogaster
Sequence 2:	NP_595212.1	Gene:	cti6 / 2539769	PomBaseID:	SPBC1685.08	Length:	424	Species:	Schizosaccharomyces pombe

Alignment Length:	401	Identity:	91/401 - (22%)
Similarity:	130/401 - (32%)	Gaps:	126/401 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   835 IDPGEETETAPEAEAEDDSVTRCICELTHDD------GYMICCDKCSAWQHVDCMGI-DRQNIPE 892
            :...||.||:...|     ||||:|.:...|      |..|.||:||.|||.:|:|. |...:||
pombe    34 VSDNEENETSSTGE-----VTRCVCGIVESDDEASDGGLYIQCDQCSVWQHGNCVGFADESEVPE 93

  Fly   893 EYMCELCQPR--------------------------------------AVDKARARALQRQKRK- 918
            .|.||:|.|.                                      |..|:..:.|....|.
pombe    94 VYYCEICHPEFHKVYQRGRGAKQSKYLGNGKPIEASQTEESSSTPPSPATKKSSKQRLTMNSRDA 158

  Fly   919 ----EHMLLVATQAANGAAAVAAGTTLSGGLGSGLPMSEELQHRLASGLNGGFATGTGM------ 973
                |..|.:|.:.:. ....:.|.|.|..|....|..|              :.||.:
pombe   159 ALDYEEYLAIAKEKSL-IPRRSRGRTSSKSLSPPAPQDE--------------SQGTEINLKQKI 208

  Fly   974 ----------SKKSKKTKENSGSTSTL---------KKTKKSAVGMGGE-----KNASGSGTPTG 1014
                      ||:||...|.:..|||.         ::|..:...:..|     |..||..:|..
pombe   209 EEENDEILEDSKESKDENEENKETSTTNVAETDAPEEETVDTVEEIADEEKHSVKEESGEASPQS 273

  Fly  1015 SSGKT---------SKKSSKRKSKSGGDGSSGGGSSPALTAAEKHAANLRQWIENYEYAVTNHYS 1070
            |...|         |.:.:||::.:..........:|..:...|......:...|     .||..
pombe   274 SQQSTITSISTTTRSTRKAKREAAAEDKADLPAAVAPKPSKTRKVGGRRGKSSSN-----DNHRI 333

  Fly  1071 PELR---ARLHAIQKQPSLLQSIQNTENKALRQIQQQLSTAGSAEQLEQRAQLIPYAGAKVLISS 1132
            |:|.   ..:..|.|...|...|..||.:  |::...|...|.. |:|..||   .||.:   ||
pombe   334 PQLHPDGTFVETITKPKGLHSRITMTEMR--RRVASMLEYIGHI-QVEMAAQ---SAGNQ---SS 389

  Fly  1133 VDLSPHAPIHE 1143
            ...|...|..|
pombe   390 TKSSKEGPEEE 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
upSET	NP_001261819.1	PHD_MLL5	856..899	CDD:277025	21/49 (43%)
upSET	NP_001261819.1	SET	<1221..1273	CDD:214614
cti6	NP_595212.1	PHD_SF	50..100	CDD:304600	21/49 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1844
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.930