DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment upSET and set1

DIOPT Version :9

Sequence 1:	NP_001261819.1	Gene:	upSET / 39551	FlyBaseID:	FBgn0036398	Length:	3146	Species:	Drosophila melanogaster
Sequence 2:	NP_587812.1	Gene:	set1 / 2538762	PomBaseID:	SPCC306.04c	Length:	920	Species:	Schizosaccharomyces pombe

Alignment Length:	963	Identity:	177/963 - (18%)
Similarity:	319/963 - (33%)	Gaps:	289/963 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1375 NRSTSSSGESSQMG----LNSPQLG-QLNLGFKTSVTATSLTAPVPGVHCNNSGGSSSSSNNSCS 1434
            |.||.|..:..|..    |..|:|| :.|||.|.
pombe     4 NTSTRSKSQPVQRNNYKVLYDPELGIKENLGRKI------------------------------- 37

  Fly  1435 VSMSSVLHDSGICTSSSSPSVSIPSPTPTQMQSPTLQQHPQQIPQQQ---LSLLQRSPTQQHQQQ 1496
                 :...:|:    |.|.:.:..|   ::::|.   :.:.||:..   |..||......::..
pombe    38 -----IYRFNGV----SKPPLVVRDP---RLKNPI---YARGIPKSGRPFLKSLQTINYDYNENS 87

  Fly  1497 ILAALPTPMLTPMLSPQLPKPAQQQAH-----------VVLPQSQQTSLLQQQQSQQSQEPLAVI 1550
            :....||.:....:|| |....|.:.|           :.|.....|||.....|...:..::|.
pombe    88 LGPEPPTQVFVSNISP-LVTSEQLRYHFKSFGEVFDLDLKLNPYTGTSLGLCCISFDKRSSISVA 151

  Fly  1551 AAAA--AAQQPMATYFVRQPQQQQQQQSPKPQALVAQQQ------------HVVGAQQQQHFLQQ 1601
            |.:|  |.||.....|           |.||.::|..:.            :.|..|.|:..||:
pombe   152 AHSAKIAVQQANGLRF-----------SGKPLSVVLDRDGSLCEEAFKKALNAVEKQFQEETLQK 205

  Fly  1602 QQKQQQQQMADEARMAVSALQTLHAAPTSHIVSPIKVAAVQQQSQPQQQQQNTHQQPHNQQAVQQ 1666
            |:.:::.:         |:.|.|.||....|      ...:|.|:..|...|...|....|.|.|
pombe   206 QRFEREDE---------SSRQKLSAAMNEDI------PPWRQPSKNSQTLSNGDLQHSKVQNVDQ 255

  Fly  1667 QSNQLQQQQSQQPN------YPQSPQRQQKPQPVQH-----------QPQIVISTGAQAIPATMP 1714
            :|..|...::..|.      |.....|...|..|.:           ..:|.::.....|.....
pombe   256 KSGFLTSSETDVPKNINDYIYLLIDDRFVPPDRVYYTDIKHHFRKFLYEKIYMNKDGFYITFNNY 320

  Fly  1715 TKLSSPTKSA-APVISNNNITVS----AQSSVVGGKKTPAKHPQQQQQQQQQPVTPV-------- 1766
            .:.|:..::. ...:.|..|.:.    ...:...|||:..:......::.....|.|
pombe   321 REASNCYRALDRTYVQNCRIKLKFHDIPSRTKEDGKKSAVRRVVLPPEEAYAEATSVVLRDLEAA 385

  Fly  1767 ------SAATAPA--------ATPSSSESKEDDVSASSTTTPTTRTPAKDKPKQSREDRKLEAIL 1817
                  |....||        ..||..|..::::..|||:.|       |.|      .|:|
pombe   386 LLRDVKSKIIGPAIFKYLHSMPKPSVKEELQENLLVSSTSVP-------DVP------LKIE--- 434

  Fly  1818 RAIEKMEKQEARGKKDTRQSSGGKRQASNSPASPNKRNSSNSISEDVETPTSTNSAAAAAQRRNK 1882
                               |:.||     .|:.|..:...:|...::...:.|.|.....:||..
pombe   435 -------------------STVGK-----LPSLPKFKKRVDSSKMNLSAGSKTKSKLQRRRRRRH 475

  Fly  1883 KKRKVSRSLNNNTNG-----------LGSGGGSNNKRRK--SI-VVESDGESHALTNSESEDQGQ 1933
            :.|.:...||...|.           |.|.|....:|.|  || .|:||..:...:::..|:...
pombe   476 EARPLHYQLNQMYNSSASEAESDQELLLSSGDERVERGKIGSIKSVKSDEATPVFSDTSDENDKF 540

  Fly  1934 H---PQSHHSGSEDQAAGLLLALAHNNSSPNEPFKSPLSQSHSLPATPASVSSACLLIEAAMGPL 1995
            |   .:|..|..:.:.    :.:.:.:||..|...|.||.|.::|.:.:::.      :..:.|.
pombe   541 HRFRTKSKISKKKYEK----MEVDYTSSSETESDASILSPSAAIPKSGSAIK------DELISPK 595

  Fly  1996 QQQPAPASASPSLAEFKYPPGGAKTKKSLMSSWFQQAEQQHASGLDSLVQAAMSEINGE-----R 2055
            ::.....:.:|.....::...|:....:|..::.:........||..||:      |.|     :
pombe   596 KEIDEVLALAPKWRINEFDETGSVYYGALPYNYPEDDVLLDLDGLQYLVK------NDEDYSYLQ 654

  Fly  2056 EQLQRQP-------------------------QGES--LPAPALLKVEQFIHQAESTTA------ 2087
            |.|:.:|                         .|::  ||.|     :.:.....|.:|
pombe   655 EALKDEPLMDINDPNFWAYERKSCKFKNGDVKYGDTAILPEP-----KGYFRSNTSGSAKSEGYY 714

  Fly  2088 -VPAREQ-LHLPLQNNSSVKKRWLRQAISEETTPV-DELQQSQNQSVTATPSPQPVPTVSPLANG 2149
             :|..|: |:|||:|.|::      ..||..|:.: ..:.:..|:.:.|......:|..:.|...
pombe   715 IIPTTEKSLYLPLRNRSTI------DTISHSTSRITSRMNRVNNRRLAAGVEKSQLPAEADLLRF 773

  Fly  2150 FSTPLKKRRL---------VVVSNGTNVESDETHIDVIGE-----PKDEAEEN 2188
            .:...:|::|         :.:....|::.::..|:.|||     ..|..|:|
pombe   774 NALKARKKQLHFGPSRIHTLGLFAMENIDKNDMVIEYIGEIIRQRVADNREKN 826

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
upSET	NP_001261819.1	PHD_MLL5	856..899	CDD:277025
upSET	NP_001261819.1	SET	<1221..1273	CDD:214614
set1	NP_587812.1	RRM	<90..>226	CDD:223796	34/156 (22%)
		RRM_spSet1p_like	96..180	CDD:240749	21/95 (22%)
		SET_assoc	279..342	CDD:288600	8/62 (13%)
		SET	457..920	CDD:225491	74/397 (19%)
		N-SET	641..771	CDD:288597	27/146 (18%)
		SET	783..899	CDD:214614	9/44 (20%)
		PostSET	904..920	CDD:214703
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030