DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment upSET and SPCC645.13

DIOPT Version :9

Sequence 1:	NP_001261819.1	Gene:	upSET / 39551	FlyBaseID:	FBgn0036398	Length:	3146	Species:	Drosophila melanogaster
Sequence 2:	NP_001342882.1	Gene:	SPCC645.13 / 2538700	PomBaseID:	SPCC645.13	Length:	721	Species:	Schizosaccharomyces pombe

Alignment Length:	797	Identity:	153/797 - (19%)
Similarity:	266/797 - (33%)	Gaps:	231/797 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   843 TAPEAEAEDDSVTRCICELTHDDG-YMICCDKCSAWQHVDCMGIDRQNIPEEYMCELCQPRAVDK 906
            ||..:|...::|.||:|:...|.| ..:.||.|..|||..|:|:..::|||.|.||:|..|: |.
pombe     9 TAKASEKPPETVVRCVCKSQEDIGDTWVQCDGCDCWQHASCVGLADKDIPESYYCEVCHSRS-DV 72

  Fly   907 ARARALQRQKRKEHM---LLVATQA------ANGAAAVAAGTTLSGGLGSGLPMSEELQHRLASG 962
            :........|.:||.   ||.:.:.      .|...:..:...::...|:.|..||.    .::.
pombe    73 SSQVQNSPNKDEEHQTADLLASNEGNEKNNEENNVVSSDSKEAITKESGAELESSEP----ASTN 133

  Fly   963 LNGGFATGTGMSKKSKKTKENSGSTSTLKKTKKSAVGMGGEKNASGSGTPTGSSGKTSKKSSKRK 1027
            .|.|..|.:|  ::|.:|.  .|||     |.||:......:...||...|.:..|.||.:.|..
pombe   134 SNVGMTTRSG--RQSPRTP--IGST-----TPKSSHSPPSTRKRRGSVGTTATHTKRSKNAPKTS 189

  Fly  1028 SKSGGDGSSGGGSSPALTAAEKHAAN------LRQWIENYEYAV--------------------- 1065
            .|...:.::......:|..:.....|      .:.|:..:|..:
pombe   190 PKDASNETADQEKELSLHTSIDEIQNPVRKSVAKAWVSVFEKIIEKAKLEGVQGLEDLNSTSLAL 254

  Fly  1066 --------------------TNHYSPELRA-RLHAI-QKQPSL------------------LQSI 1090
                                .|.|..:.|| |.:.: .|.|:.                  .:.:
pombe   255 QLEHIMFMVLSYTTDHSLTPNNKYREKFRALRFNLVDDKNPAFRARVLKNEISFNDLVNLSSEEM 319

  Fly  1091 QNTENKALRQIQQQLSTAGSA---------------EQLEQRAQLIPYAGAKVLISSVDLSPHAP 1140
            .|.:.|.|.:..:|.||..:.               ::|.|:.:|      .:..:...:.|..|
pombe   320 ANPDLKNLAEEIRQQSTENTVIKQHLIAPRDRLLDEDKLTQQDEL------GIAENDDAMFPKPP 378

  Fly  1141 IHELRGKYMLTTQFRTQNPTVNMNTP--PPSNYL------NSFKAHKTPGQFVFFYQLPGVEAPM 1197
                 |:.:.......:.||::..:|  |..|.|      |..||.|..|.  |....|.|..|.
pombe   379 -----GELVAPISIAEEEPTIDSKSPTLPEHNPLSEDDTSNGDKAAKRKGS--FNDTKPIVNVPS 436

  Fly  1198 QTLRPDGSVPQVAQQPP---------SYLKGPEVCVDTRTYGNDARF----VRRSC----RPNAE 1245
            .....|.::..:.::.|         .|....::..::..:|...:.    |:.:.    ..||
pombe   437 IVEIDDPTILDIVEEEPLARNDSFSSPYSPAEDMAEESEFFGMKEKIWTGKVKMATVSEFHANA- 500

  Fly  1246 LQHYFEKGTLHLYIV----ALTHIRAQTEITIRHEPHDLTAVEQKKSHAAVIQPTSTRCACDMGS 1306
            |..:.:....||:.:    ||...|......:::. |.|.....|:..|.:..||...   ..|.
pombe   501 LNLFGDVSASHLFEILSATALIEGRISVSSVLQYF-HALRKTPSKEIIAVLFVPTEQN---SQGF 561

  Fly  1307 DCLFALPLAVQQQLQAPPTQPRSSHRNKAAAAAAAAAAANSAAAIQLTMGLGVGATVAAGASV-L 1370
            |.|:...:                .||:.....:.:.:...|..|.:..|..|...:.....| |
pombe   562 DILYDYFV----------------KRNRYGVLHSKSNSVKDAYIIPMPSGNSVPELLDLLPKVDL 610

  Fly  1371 PNSRN----------RSTSSSGESSQMGLNSPQLGQLNLGFKTSVTATSLTAPVPGVHCNNSGGS 1425
            |..||          ..:||..||.:                   .||.:|....|:
pombe   611 PKDRNFQYFMGLFVLNKSSSRHESVE-------------------RATPITTSTNGI-------- 648

  Fly  1426 SSSSNNSCSVSMSSVLHDSGICTSSSSPSVS--IPSPTPTQM--------QSPTLQQHPQ----- 1475
             .|:..|.|.:.::.:|        |.||:.  |.:.||:.|        .:|.::.:|.
pombe   649 -PSTYQSASGTPTNPVH--------SYPSLESIINALTPSDMLLIKDVVENNPQIRANPSLAINP 704

  Fly  1476 QIPQQQLSLLQRSPTQQ 1492
            |..|..:|..|:..::|
pombe   705 QFMQNAISAAQKKASKQ 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
upSET	NP_001261819.1	PHD_MLL5	856..899	CDD:277025	19/43 (44%)
upSET	NP_001261819.1	SET	<1221..1273	CDD:214614	10/63 (16%)
SPCC645.13	NP_001342882.1	PHD_SF	22..66	CDD:328929	19/43 (44%)
		TFS2M	215..330	CDD:128786	13/114 (11%)
		SPOC	474..624	CDD:311609	30/170 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030