DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment upSET and Phf20l1

DIOPT Version :9

Sequence 1:	NP_001261819.1	Gene:	upSET / 39551	FlyBaseID:	FBgn0036398	Length:	3146	Species:	Drosophila melanogaster
Sequence 2:	XP_006520979.1	Gene:	Phf20l1 / 239510	MGIID:	2444412	Length:	1018	Species:	Mus musculus

Alignment Length:	1020	Identity:	192/1020 - (18%)
Similarity:	316/1020 - (30%)	Gaps:	365/1020 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   401 FVNSHGTVIQQ--HPQQQQATKRTHYNSSGSSDNEQHAVAN--SSLITDDVMIVNGTQMTDELSA 461
            ||..|...:.:  .||.:........|:.|:|...:.|..|  :.|:....:.|:|.:..::.||
Mouse   244 FVGLHIDTVPKIVFPQPESTLTNKRKNNQGNSFQAKRARLNKITGLLASKAVGVDGAERKEDCSA 308

  Fly   462 R---ILQSMAQKSFSQQQRFHQVPATGSGNMPPPTQIIYSNSTSNGAAASS----PGGNASGNML 519
            .   :.|:::.|  .|.|:.::...:.|.|...|.  :.|::.|:|.|.|.    ..|.:||.:.
Mouse   309 TAPVLEQAISPK--PQSQKKNEAVISSSANTQKPA--LLSSTLSSGKARSKKCKHESGESSGCIK 369

  Fly   520 LAH-------YQAAGTKPVSS-ASFITVTGTP-PVT----------------VATTPSVSISSHG 559
            ...       .||.....||. :|.|..|.:| ||.                :||.|....|...
Mouse   370 TPKSPLAPELIQAKDLTLVSQLSSVINKTSSPQPVNPPRPCKHSERRRRSQRLATLPMPDDSLEK 434

  Fly   560 FASGSAAISSYMSSATAARRQSVSAPSSRAVSLERKQHHQQLQHDVIGGGRKAPTVIEYYNKHGV 624
            .:|.|:|......|.::..:|..|.|...|::      :..||       :..|.:
Mouse   435 LSSSSSATDGKAFSISSQNQQQSSVPEVPAIA------YVPLQ-------KLGPCL--------- 477

  Fly   625 NSIVGSSNNLAQSNSMSNLAGPRSNSGSGFATTTPTPATPLHLTPVN-VPVHVEAAPPSSPALVK 688
                  ..:|:..:.::....|..:...|.........|||...|.: |...|:.|     |...
Mouse   478 ------PLDLSCGSEVTGSRTPHPSYHGGECPREEKEETPLFANPTSKVVSDVKGA-----AAAT 531

  Fly   689 GSSQPPAQPQQQQQQAHPLGPNQLNANDEELYIEEVRPVPVLTQDLRLQQLHAIMQDHTYASQQQ 753
            |.|:...:.:.:::.:...|..:  ..|:|.  :|.|.                 :||....|::
Mouse   532 GISKTEKKVKLEEKTSTAFGKRK--EKDKEK--KEKRD-----------------KDHYKPKQKK 575

  Fly   754 QQQPQQAAG-------DTTNPGAAQQVQQPQQWSLGGIGVTVSGSQGTP-------TAVGGY--- 801
            :::.::.:.       :.::....::...|...|        |||...|       |....|
Mouse   576 KKKKKKKSKQHDYSDYEDSSLDFLERCSSPLTRS--------SGSSLAPRSTFTEKTTTYQYPRA 632

  Fly   802 ---CSYFGQQIARSQADDDAHSAISSSSRMGLASTDIDPGEETETAPEAEAEDDS---VTRCICE 860
               ....|:.::..:..||     ||:..:.|:..:.:...::....|::.|||:   :.|||||
Mouse   633 ILSVDLSGENLSDVEFLDD-----SSTESLLLSGDEYNQDFDSTNFEESQDEDDALNEIVRCICE 692

  Fly   861 LTHDDGYMICCDKCSAWQHVDCMGIDRQNIPEEYMCELCQPRAVDKARARALQRQKRKEHMLLVA 925
            |..::|:||.|::|..|||..|||:...:|||:|:|.:|  |.....|..|..|..::
Mouse   693 LDEENGFMIQCEECLCWQHSVCMGLLEDSIPEQYICYIC--RDPPGQRWSAKYRYDKE------- 748

  Fly   926 TQAANGAAAVAAGTTLSGGLGSGLPMSEE-----------LQHRLASGLNG------GFATGTGM 973
                          .|:.|...||...:|           ..|.|.:.:.|      |.....|:
Mouse   749 --------------WLNNGRMYGLSFLKENYSHLNAKKIVSTHHLLADVYGVTEVLHGLQLKIGI 799

  Fly   974 SKKSKKTKENSGSTSTLKKTKKSAVGMGGEKNASGSGTPTGSSGKTSKKSSKRKSKSGGDGSSGG 1038
            .|.......:..:.|..:|.:..||.     .|....||...:....|:
Mouse   800 LKNKHHPDLHLWAYSGKRKDQDQAVA-----EAERKITPQDRANSEGKE---------------- 843

  Fly  1039 GSSPALTAAEKHAANLRQWIENYEYAVTNHYSPELR------ARLHAIQKQPSLLQSIQNTENKA 1097
                                     .|.||..|.||      ...|:.||..|..|..|:
Mouse   844 -------------------------CVQNHKEPALRMEETYITSEHSYQKPQSFSQDCQS----- 878

  Fly  1098 LRQIQQQLSTAGSAEQLEQRAQLIPYAGAKVLISSVDLSPHAPIHELRGKYMLTTQFRTQNPTVN 1162
                   |:..||::                   ..|.|......|||
Mouse   879 -------LTDPGSSD-------------------DDDASSFEEDGELR----------------- 900

  Fly  1163 MNTPPPSN--YLNSFKAHKTP--GQFVFFY-QLPGVEAPMQTLRPDGSVPQVAQQPPSYLKGPEV 1222
              .|..|:  |.|...:.|.|  |..||.| ...|.|.|
Mouse   901 --VPDKSHLLYKNRGVSEKNPASGNKVFVYNDKKGTEGP-------------------------- 937

  Fly  1223 CVDTRTYGNDARFVRRSCRPNAELQHYFEKGTLHL--YIVALTHI-RAQTEITIRHE-------- 1276
                                          |..||  .:..|||| ..|.|:|.|.:
Mouse   938 ------------------------------GDSHLQWQLNLLTHIENVQNEVTSRMDLIEKEVDV 972

  Fly  1277 -------------PHDLTAVEQKKSH-------AAVIQPTSTRCA 1301
                         |..|..:.|.|.|       ...:|..:|.|:
Mouse   973 LESWLDFTGELEPPDPLARLPQLKRHLKQLLLDVGKVQQIATLCS 1017

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
upSET	NP_001261819.1	PHD_MLL5	856..899	CDD:277025	22/42 (52%)
upSET	NP_001261819.1	SET	<1221..1273	CDD:214614	9/54 (17%)
Phf20l1	XP_006520979.1	MBT	3..68	CDD:388438
		TUDOR	90..135	CDD:119391
		PTZ00449	<320..511	CDD:185628	42/222 (19%)
		PHD20L1_u1	323..388	CDD:374703	14/66 (21%)
		PHD_PHF20L1	688..733	CDD:277103	23/46 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1844
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147824at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.940