DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment upSET and Dido1

DIOPT Version :9

Sequence 1:NP_001261819.1 Gene:upSET / 39551 FlyBaseID:FBgn0036398 Length:3146 Species:Drosophila melanogaster
Sequence 2:NP_780760.2 Gene:Dido1 / 23856 MGIID:1344352 Length:2256 Species:Mus musculus


Alignment Length:2498 Identity:449/2498 - (17%)
Similarity:780/2498 - (31%) Gaps:824/2498 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   671 NVPVHVE-AAPPSSPAL----------VKGSSQPPAQP-QQQQQQAHPLGPNQLNANDEE----- 718
            ||||.:| ::.|:|..:          |:.||:..:.| .....:.||....:....:||     
Mouse    86 NVPVSLEDSSEPTSSTVTDVETASEGSVESSSEIRSGPVSDSLGKEHPASSEKAKGGEEEEDTSD 150

  Fly   719 -----LYIEEVRPVPVLTQDLRLQQLHAIMQDHTYASQ----QQQQQPQQAAGDTTNPGAAQQ-- 772
                 |.::|      |...||.::....::.....||    :::::...|...:...|:|:|  
Mouse   151 SDSDGLTLKE------LQNRLRRKREQEPVERSLRGSQNRLRKKRREEDSAETGSVQIGSAEQDR 209

  Fly   773 ---VQQPQQWSLGGIGVTVSGSQGTPTAVGGYCSYFGQQIARSQADDDAHSAISSSSRMGLASTD 834
               .|:|:            .|||              .:::|:. ||..:.:...:..|  :|:
Mouse   210 PLCKQEPE------------ASQG--------------PVSQSET-DDIENQLEGKATQG--NTE 245

  Fly   835 IDPGEETETAPEAEAEDDSVTRCICELTHDDGYMICCDKCSAWQHVDCMGIDR------QNIPEE 893
            .:|.|..:..||.|..|.:...|||...|::.:|||||:|..|.|.||:||..      :...|:
Mouse   246 ENPREAGKPKPECEVYDPNALYCICRQPHNNRFMICCDRCEEWFHGDCVGISEARGRLLERNGED 310

  Fly   894 YMCELCQPRAV-DKARARALQRQKRKEHMLLVATQAANGAAAVAAGTTLSGGLGSGLPMSEELQH 957
            |:|..|....| |:....|...|.             :|..:|.|..|....:|:....|.|.| 
Mouse   311 YICPNCTILQVQDETNGSATDEQD-------------SGCRSVGADGTDCTSIGTVEQKSGEDQ- 361

  Fly   958 RLASGLNGGFATGTGMSKKSKKTKENSGSTSTLKKTK--KSAVGMGGEKNASGSGTPTG------ 1014
                |:.|..              |.:.:.|..||.|  :..|...|.....|.|..:.      
Mouse   362 ----GIKGRI--------------EKAANPSGKKKLKIFQPVVEAPGAPKCIGPGCSSVAQPDSV 408

  Fly  1015 ------------------SSGKTSKKSSKRKSKSGGDGSSGGGSSPAL----------TAAEKHA 1051
                              ||||..|...|.|.|:..:..|....|..:          .|:||..
Mouse   409 YCSNDCILKHAAATMRFLSSGKEQKTKPKEKVKTKPEKFSLPKCSVQVGIKISSVHKRLASEKRE 473

  Fly  1052 ANLRQ----------------------WIENYEYAVTNHYSPELRARLHAIQKQPSLL----QSI 1090
            ..:::                      |..::.|.......||....|     .|:||    :..
Mouse   474 NPVKKVMLASRSETSGKEAACESSTPSWASDHNYNAVKPEKPEKPTAL-----SPTLLSKSMKDD 533

  Fly  1091 QNTENKALRQI---QQQLSTAGSAEQLEQRAQLIP--------YAGAKVLISSVDLSPHAPIHEL 1144
            :..|::.:..:   ::.|.:|....:......|:|        .||||..|..            
Mouse   534 RRVEDRTMAAVTIPKKALPSASLVGRQTSPRNLVPKKLPPYSNMAGAKPAIKK------------ 586

  Fly  1145 RGKYMLTTQFRTQNPTVNMNTPPPSNYLNSFKAHK---TPGQFVFFYQLPGVEAPMQTLRPDGSV 1206
                 |.:.|:...|    ..|.||..|:...|.:   || ......:|||..|.:...|...|.
Mouse   587 -----LPSGFKGTIP----KRPWPSATLSGTSARQAGPTP-MTAASKKLPGSAAVVGVTRKPMSA 641

  Fly  1207 PQVAQQPPSYLKGPEVCVDTRTYGNDARFVRRSC------RPN------------AELQHYFEKG 1253
            ...|..|.....||.....::......:.:|||.      |.|            .::..:.||.
Mouse   642 NVPAASPAPGRLGPVSPAPSQPNSQIRQNIRRSLKEILWKRVNDSDDLIMTENEVGKIALHIEKE 706

  Fly  1254 TLHLYIV----------------------ALTHIRAQTEIT----IRHEPHDLTAVE----QKKS 1288
            ..:|:.|                      .|.|...:.||:    :|.:|.:|.:.|    .:|.
Mouse   707 MFNLFQVTDNRYKSKYRSIMFNLKDPKNQGLFHRVLREEISLAKLVRMKPEELVSKELSMWTEKP 771

  Fly  1289 HAAVIQPTSTRCACDMGSDCLFALPLAVQQQLQAPPTQPRSSHRNKAAAAAAAAAA--------- 1344
            ..:||: :.|:...:...:.  ..|..:.....:||.......:....||...:||         
Mouse   772 TKSVIE-SRTKLLNESKKNT--TKPETIPDMEDSPPVSDSEEQQESVRAAPEKSAAPLLDVFSSM 833

  Fly  1345 ----------------------------------------------------ANSAAAIQLTMGL 1357
                                                                ::...|:..|...
Mouse   834 LKDTTSQHRAHLFDLNCKICTGQVPSSEDEPAPKKQKLSASSKKEDFKPRHDSSPPNAVPNTADE 898

  Fly  1358 GVGATVAAGASVLPNSRNRST---------SSSGES----SQMGLNSPQLGQLNLGFKTSVT--- 1406
            |:..|:...||. |:..:.|:         .|.|:|    |.:|..||.......|..|:||   
Mouse   899 GIADTLPENASE-PDPESTSSLNQERKCFPESPGDSHPEPSSLGGLSPSSASGGSGVVTTVTMSG 962

  Fly  1407 ---------ATSLTAPVPGVHCNNSGGSSSSSNNSCSVSMSSVLHDSGICTSSSSPS---VSI-P 1458
                     :.::||.: ..|.:||..|.:..:.......|:|:..|.:...||||.   :|: |
Mouse   963 RDPRTALSGSCTVTASM-AAHLDNSQASETKLDMIKPALTSAVVPKSILAKPSSSPDPRYLSVPP 1026

  Fly  1459 SPTPTQMQSPTLQQHPQQIPQQQLSL-LQRSPT--------QQHQQQILAALPTPMLTPMLSPQL 1514
            ||:.::.:||         |:...:| |.|..|        |...:.:..|.|.......||..|
Mouse  1027 SPSISESRSP---------PEGDTTLFLSRLNTIWKGFINMQSVAKFVTKAYPVSGCLDYLSEDL 1082

  Fly  1515 PKPAQQQAHV---VLPQ-------------SQQTSLLQQQQSQQSQEPLAVIAAAAAAQQPMATY 1563
            |    ...|:   :.|:             |::..|::...:.:.:| :|.|:        :.:|
Mouse  1083 P----DTIHIGGRIAPKTVWDYVGKLKSSVSKELCLIRFHPATEEEE-VAYIS--------LYSY 1134

  Fly  1564 FVRQPQQQQQQQSPKPQALVAQQQHVVGAQQQQHFLQQQQKQQQQQMADEARMAVSALQTLHA-- 1626
            |                  .::.:..|.|...:|            :.|...:.:||...:.:  
Mouse  1135 F------------------SSRGRFGVVANNNRH------------VKDLYLIPLSAKDPVPSKL 1169

  Fly  1627 ---------APTSHIVSPIKVAAVQQQSQPQQQQQNTHQQPHNQQAVQQQSNQLQQQQSQQPNYP 1682
                     :|..:|:  :.:...|:..:|....:        .....::..:|||::.:...||
Mouse  1170 LPFEGPGLESPRPNII--LGLVICQKVKRPSSAGE--------LDKTDEKRTRLQQEELETSVYP 1224

  Fly  1683 QSPQRQQKPQPVQHQPQIVISTGAQAIPATMPTKLSSPTKSAAPVISNNNITVSAQSSVVGGKKT 1747
            :                         :.|.:|::...|..|.      ::|..:|.|:      |
Mouse  1225 K-------------------------VTAALPSEKKPPKYSV------HSIDTAATST------T 1252

  Fly  1748 PAKHPQQQQQQQQQPVTPVSAATAPAATPSSSESKEDDVSASSTTTPTTRTPAKDKPKQSREDRK 1812
            |...|.......:.||..:.::..|.:|.:.:.    ..:|:.|||.:..|.|..|...     .
Mouse  1253 PPGSPPPPPPLPEPPVLKILSSLKPGSTSTVTA----PTTAAITTTASPVTAATSKTAS-----P 1308

  Fly  1813 LEAILRAIEKMEKQEARGKKDTRQSSGGKRQASNSPASPNKRNSSNSISEDVETPTSTNSAAAAA 1877
            ||.||        |...|||.:.:.||  :::..|..||::  .|.:..||      |.|||...
Mouse  1309 LEHIL--------QTLFGKKKSFEPSG--KESVGSTLSPHQ--DSKAKGED------TMSAAPLL 1355

  Fly  1878 QRRNKKKRKVSRSLNNNTNGLGSGGGSNNKRRKSIVVESDGE---SHALTNSESEDQGQHPQSHH 1939
            ..                                 :|:..|:   ..||...|.:|:...|:..:
Mouse  1356 DP---------------------------------IVQQFGQFSKDKALEEEEEDDRPYDPEEEY 1387

  Fly  1940 SGSEDQAAGLLLALAHNNSSPNEPFK----SPLSQSHSLPATPASVSSACLLIEAAMGPLQQQP- 1999
              :.|:|...|||      .|..|..    |..::...:...|...:    ::|.|...:...| 
Mouse  1388 --NPDRAFHTLLA------EPGRPHDVQSVSETAEREEVAYDPEDET----ILEEAKVTIDDLPN 1440

  Fly  2000 ---APASASPSLAEFKYPPGGAKTKKSLMSSWFQQAEQQHASGLDSLVQAAMSEINGEREQL--Q 2059
               ...||:...|:|......|    ||:.      :|:....|:..::....::..:.|.|  |
Mouse  1441 RMCMKVSATERPADFTTDASSA----SLVE------QQKMLEELNKQIEEQKRQLEEQEEALRQQ 1495

  Fly  2060 RQPQGESL-------------PAPALLKVEQFIHQAESTTAVPAREQLHLPLQNNSSVKKRWLRQ 2111
            |...|.|:             |..:|.|.|.|..:.::..........:..|.:..|...|..|:
Mouse  1496 RAAVGVSMAHFSVSDALMSPPPKSSLGKTELFSQEQQAPDPSQGAPNTNHNLDSRQSRDPRQARR 1560

  Fly  2112 AISEETTPVDELQQSQNQSVT-----ATPSPQ--------PVPTVSPLANGFSTPLKKRRLVVVS 2163
            ..:|.|         :|:|:.     :||.||        |..|......|.:...|:...|..:
Mouse  1561 LAAENT---------ENESLPRAPTGSTPGPQGTLPARETPAGTAVVQGPGLAAEAKESMAVPWA 1616

  Fly  2164 NGTNV----ESDETHIDVIGEPKDEAEENVAMTELKVEIENHHQEQDDDVDILRSPSPGTHQIVA 2224
            .|.|.    |.|....:..|.|            :.:.::..|.....|.  ...|:|....   
Mouse  1617 PGENAVLRPEHDIQKCEHPGNP------------VSLPLDTSHLPTAGDG--AARPAPPRRV--- 1664

  Fly  2225 EDNLVKIEPEDTSAAADDVKIDVEREESQACDKFEEMVKVKREEEEQREKEIKQLQERQEHEQPK 2289
               |:...|..|...:..::...:...|.:.:.|.....:.:|..          ....::|.|:
Mouse  1665 ---LLPTPPSTTFPPSFPLQPKAQNFSSGSREPFSGPTFMSQETS----------LGSSQYEDPR 1716

  Fly  2290 VEPAPVEPKLENTVAKAEPKVEPSQEIVSKKEPTKVEPKPGESLLRSTATVTATPTAATIAATTL 2354
              .|....|.::.||..|...||             :|:||||                  .|:.
Mouse  1717 --GAQSAGKNDSPVADMEDSREP-------------QPRPGES------------------TTSF 1748

  Fly  2355 LDVSKVAFKTRPPLKLEDEPQKKKPKLES----ILPAPVATVPPVS----VP-------PIPAAS 2404
            ....:.....:|....:.||..:...:..    ..|.|...|||.|    ||       |.||..
Mouse  1749 PQPGQRGGGPQPQFPGQREPAPRTFGMSGHHGPSFPGPRGPVPPYSEENLVPNSDGPRGPPPARF 1813

  Fly  2405 NATTSAVTNTAAASLTTTTAPSSTKNLTEHDIQERLLSFHAANISYLQSRNKKATAALTSASPSQ 2469
            .|....:             ||             |.|.......|..:|         ..|||.
Mouse  1814 GAQKPPI-------------PS-------------LFSGQHGPPPYGDNR---------GLSPSY 1843

  Fly  2470 KSNSSSGGSG--TESKKSSKDKDEKRDKEKQLKKSKKEKKKSKDKEK---QKAAVNVNSTSQIVD 2529
            ......|...  .:.|....:|.|.:|...........:.:..|:.:   .:|........:.:.
Mouse  1844 LGGPRGGAPAQFEDRKDPHGEKREFQDTPYNEMTGAPAQCEGPDQAQFMGNRAPFQFGGQRRPLL 1908

  Fly  2530 TKKKTTQPSKPDSK--SSIAPVLVPPS--------LPVATANGKTKHTAY--------------- 2569
            |:.|..:...|.|:  :...|   ||.        .|....|.:..|...               
Mouse  1909 TQMKGPRGGPPPSQFGAQRGP---PPGHFVGPRGPHPSQFENSRGTHPGQFEGARGQAPGFMPGP 1970

  Fly  2570 NNVDQQQQQQMRRRTMSMCITPVTPTPVVTPSPLHGTPPSTKKRQTNFEQELTKPNSQILSSSIL 2634
            ..:..||.::.|..:...........|:....|....|...|..|.........|:||       
Mouse  1971 RGIQPQQFEEQRVNSPPRFAGQRASAPLPYGGPRGPAPFPEKNEQPPSRFHFQGPSSQ------- 2028

  Fly  2635 LNSSKGLGLPLAAP--TVVSVPTAVQQQQHRK----ENNHQEATPASGGP--------MSLAAAI 2685
                     |:..|  .::.:|:  ...||||    |.....|.|:|.||        ....:..
Mouse  2029 ---------PVKPPPRPLLELPS--HPPQHRKDRWDEAGPATALPSSAGPGQGHEADGQWATSEF 2082

  Fly  2686 ASGKLNAI------SRRRESM-CGSRQQ----------QALIAAALKKEKKEKKK----SKKKDR 2729
            ..||.:..      .|:||.. .||:::          ::....|.:..::|:::    |:::|.
Mouse  2083 REGKGHEYRSPAFEGRQRERFEAGSKEKPLDEPEAQGLESRQGRAFEDRRRERERGRNWSRERDW 2147

  Fly  2730 EKQK-----HDKQKGKEKEREKDKEKDN 2752
            |:.:     .:..||:::...:|:|:||
Mouse  2148 ERSRDWDRHREWDKGRDRSSNRDRERDN 2175

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
upSETNP_001261819.1 PHD_MLL5 856..899 CDD:277025 19/48 (40%)
SET <1221..1273 CDD:214614 13/95 (14%)
Dido1NP_780760.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..256 38/204 (19%)
TNG2 <157..299 CDD:227367 42/176 (24%)
Nuclear localization signal. /evidence=ECO:0000255 162..170 2/7 (29%)
Nuclear localization signal. /evidence=ECO:0000255 182..190 1/7 (14%)
PHD_DIDO1_like 263..316 CDD:277109 19/52 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 481..535 8/58 (14%)
PHA03247 <483..663 CDD:223021 38/206 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 598..624 7/26 (27%)
PRK14954 <600..>665 CDD:184918 16/65 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 641..668 4/26 (15%)
TFS2M 669..770 CDD:128786 17/100 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 778..822 6/45 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 856..970 19/114 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1011..1039 11/36 (31%)
SPOC 1045..1190 CDD:369497 27/189 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1197..1218 4/28 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1245..1288 9/52 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1320..1347 7/30 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1362..1421 14/66 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1509..1609 20/108 (19%)
PHA03247 <1571..2083 CDD:223021 105/630 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1630..2256 110/665 (17%)
SF-CC1 2142..>2180 CDD:273721 9/34 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.030

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