DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment upSET and Setd2

DIOPT Version :9

Sequence 1:NP_001261819.1 Gene:upSET / 39551 FlyBaseID:FBgn0036398 Length:3146 Species:Drosophila melanogaster
Sequence 2:XP_036010808.1 Gene:Setd2 / 235626 MGIID:1918177 Length:2551 Species:Mus musculus


Alignment Length:3091 Identity:560/3091 - (18%)
Similarity:917/3091 - (29%) Gaps:1139/3091 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   413 PQQQQATKRTHY--------------NSSGSSDNE-QHAVANSSLITDDVMIVNGTQMTDELSAR 462
            |.||...|...:              |.|...:|| .|..|.          :...|.|..:...
Mouse     5 PSQQPPPKMGDFYDPEHPTPDMFSWLNGSREEENETYHKQAK----------IENVQKTGFIKGP 59

  Fly   463 ILQSMAQKSFSQQQRFHQVPATGSGNMPPPTQIIYSNST---------SNGAAASSPGGNASGNM 518
            :.:.:|...|..:....:|.....|.........::..|         ||...:.||...|    
Mouse    60 VFKGVASSRFLPKGTKTKVNLEEQGRQKVSFSFSFTKKTLQNRFLTALSNEKQSDSPNSPA---- 120

  Fly   519 LLAHYQAAGTKPVSSASFITVTGTPPVTVATTPSVSISSHGFASGSAAISSYMSSATAARRQSVS 583
                                    ||:.|.:.|.|.:.               :..|....:..|
Mouse   121 ------------------------PPLQVDSNPKVKMD---------------AGDTFPATEESS 146

  Fly   584 APSSRAVSLERKQHHQQLQHDVIGGGRKAPTVIEYYNKHGVNSIVGSSNNLAQSNSMSNLAGPRS 648
            .|.|| |.|.|....:.|.|                        |.|...||.|.:.::...|  
Mouse   147 PPKSR-VELGRIHFKKHLLH------------------------VTSRPQLAASTTAASPLPP-- 184

  Fly   649 NSGSGFATTTPTPATPLH-------LTPVNVPVHVEAAPPSSPALVKGSSQPPA--QPQQQQQQA 704
                    ||..||....       .:|...|...:|:.||.||.:   |:|.|  ||.......
Mouse   185 --------TTQLPAVLAESMIDSPPSSPPPPPPPPQASSPSPPAQI---SEPVALPQPPATALMT 238

  Fly   705 HPLGPNQLNANDEELYIEEVRPV----PVLTQDLRLQQLHAIMQDHTYASQQQQQQPQQAAGDTT 765
            .|.||   ...|..:..::..||    .||..|.:...:...:::||..:.::|           
Mouse   239 SPPGP---LPGDVAVRAQKESPVKSGPEVLEVDTKQDIVSNSLEEHTVQTLKEQ----------- 289

  Fly   766 NPGAAQQVQQPQQWSLG-------GIGVTVSGSQGTPTAVGGYCSYFGQQIARSQADDDAHSAIS 823
                |..:.|.:...:|       |..:::|..:.:.....   |.|......|::|:|:....|
Mouse   290 ----ADHLLQKEDSHIGKEEEVSDGSKISLSSKKASSKKKS---SQFEGTFLGSESDEDSVRTSS 347

  Fly   824 SSSRMGL-ASTDIDPGEETETAPEAEAEDDSVTRCICELTHDDGYMICCDKCSAWQHVDCMGIDR 887
            |.....| :||.||...:.:.:......:|.......:...||.|      ||..:      ::|
Mouse   348 SQRSHDLKSSTSIDKERDFKKSSAPSKSEDLGKSSRSKTERDDRY------CSYSK------LER 400

  Fly   888 QNIPEEYMCELCQPRAVDKARARALQRQKRKEHMLLVATQAANGAAAVAAGTTLSGGLG--SGLP 950
            ..   .|:...|:... |:.|:|:..|..|                  |:.|:||....  |...
Mouse   401 DT---RYVSSRCRSER-DRRRSRSRSRSDR------------------ASRTSLSYSRSERSHYY 443

  Fly   951 MSEELQHRLA-------------------------------------------------SGLNGG 966
            .||...||.:                                                 |..:..
Mouse   444 DSERRYHRSSPYRERTRYSRPYTDNRARESSDSEDEYKKTYPRRTSAHSYRDLRTSSSYSKFDRD 508

  Fly   967 FATGTG-------------MSKKSKKTKE------------------------NSGSTSTLKKTK 994
            ..|.|.             :.::||:|.|                        :..|||..|...
Mouse   509 CKTETSYLEMERRGKYTSKLERESKRTSEHETIKRCCSPPNELGFRRGSSYSKHDNSTSRYKSAL 573

  Fly   995 KSAVGMG------------GEKNASGSG----TP--TGSSGKTSKKSSKRKSKSGGDGSSGGGSS 1041
            ..::...            .|:|.....    ||  .||..:|..|.|:|:.......|:....|
Mouse   574 SKSISKNDKFKNSFCCTELNEENKQSHSFSLQTPCSKGSELRTINKISEREKTGSPTPSNQLNDS 638

  Fly  1042 PALTAAEKHAANLRQWIENYEYAVTNHYSPELRARLHAIQKQPSLLQ-SIQNTENKALRQI-QQQ 1104
            |.....::                    ||.|:........:.|:.: .:...:|..||.. ..:
Mouse   639 PTFKKLDE--------------------SPVLKPEFIGHDGRESIKELELSKVKNDQLRNFCSIE 683

  Fly  1105 LSTAGSAEQLEQRAQLIPYAGAK---VLISSVDLSPHAPIHELRGKYMLTTQFRTQNPTVNMNTP 1166
            |:..||.   |..|.:..:..:|   :.::|.|....:.:..|....||::     |...|:...
Mouse   684 LNVNGSP---ETEADVATFCTSKTDAISMTSDDSVTGSEVSPLIKACMLSS-----NGFQNVGRC 740

  Fly  1167 PPSNYLNSFKAHKTPGQFVFFYQLPGVEAPMQTLRP------DG--SVP-QVAQQPPSYLKGPEV 1222
            ...:..::.:.|.|.            ::|.:.:.|      |.  |:| :....|.:.:|.|  
Mouse   741 RERDSDDTCRQHNTS------------KSPFREMEPLLSPHHDKLMSLPVKTIDYPKTLIKEP-- 791

  Fly  1223 CVDTR-----TYGNDARFVRRSCRP--NAELQHYFEKG-TLHLYIVALTHIRAQTEITIRHEPHD 1279
             ||.|     |..:|.     .|.|  |.|.::..... |:..:.....|:.::|.|....||.|
Mouse   792 -VDKRHSCCKTKDSDI-----YCSPNENPEAENAEPSAMTISSHSFVNVHLESKTVICDNREPTD 850

  Fly  1280 L----TAVEQKKSHAAVIQPTSTRCACDMGSDCLFALPLAVQ--QQLQAPPTQPRSSHRNKAAAA 1338
            .    |..|.|:|..      ||..|.....|.|:. |:...  ..||:||:..|....      
Mouse   851 RHSENTCDEYKQSIG------STSSASHNHFDGLYE-PIGSSGISSLQSPPSGIRCEEN------ 902

  Fly  1339 AAAAAAANSAAAIQLTMGL----------GVGATVAAGASVLPNS------RNRSTS-SSGESSQ 1386
                 .:.:..|::...|:          .||       |.||:|      .||..: .||:|.|
Mouse   903 -----TSPTLDAVESKKGIDFLKYARKETDVG-------SALPDSGKGFSWENRHNNVLSGQSLQ 955

  Fly  1387 ------------------MGLNSPQLG--------------QLNLGFKTS--VTAT-----SLTA 1412
                              :.|:..|.|              .|||..:.|  :|.|     |..|
Mouse   956 EAQEEGNSILHERRGRPEIPLDEEQRGHTHISDDSEVVFPYDLNLTMEDSDGITYTLKCDSSGNA 1020

  Fly  1413 P--VPGVHCNNSGGSSSSSNNSCSVSMSSVLHDSGICTSSSSPSVSIP--SPTPTQMQSPTLQQH 1473
            |  |..||.:.||.|:|||:.|.|....|  .||.|..:.....|.:|  |..|.:..||...:.
Mouse  1021 PEIVSTVHEDYSGSSASSSDESDSEDTES--DDSSIPRNRLQSVVVVPKNSTLPMEETSPCSSRS 1083

  Fly  1474 PQQIPQQQLSLLQRSPTQQH-------------QQQILAALPTPMLTPMLSPQLPKPAQQQ---- 1521
            .|..............|::|             .::......|.........|..:.|...    
Mouse  1084 SQSYKHYSDRWEDGLETRRHAYEEEYESKGCSQTEKYFLHKGTERSAESCYSQFGRKADNHLPDI 1148

  Fly  1522 AHVVLPQSQQTSLLQQQQSQQSQ----EPLAVIAAAAAAQQPMATY---FVRQPQQQQQQQ--SP 1577
            ||.   ||.......|..|:...    .|...:.|..:..|.:..|   |...|.:.:||.  |.
Mouse  1149 AHA---QSDGVDSTSQTDSRSDHLGHLNPEDTLRAKTSRPQELPVYSDDFEDLPNKSRQQMIFSN 1210

  Fly  1578 KPQALVAQQQHVVGAQQQQHFLQQQQKQQQQQMADEARMAVSALQTLHAAPTSHIVSPIKVAAVQ 1642
            :|.:                     .:..:.:::..:...:|.:..||::.        ::..:.
Mouse  1211 RPDS---------------------SRLGKTELSFSSSCDISRMDGLHSSE--------ELRNLG 1246

  Fly  1643 QQSQPQQQQQNTHQQPHNQQAV-----QQQSNQLQQQQSQQPNYPQ-----SPQRQQKPQPVQHQ 1697
            .....|::...|:|||.:....     .|||.   :......||.|     .|:...:|.     
Mouse  1247 WDFSQQERPTTTYQQPDSSYGTCGTHKYQQST---EHYGGTHNYWQGNGYWDPRSAGRPP----- 1303

  Fly  1698 PQIVISTGA--QAIPATMPTKL------------------SSPTKS-----------AAPVISNN 1731
                 .||.  ..|...:|..|                  |||:..           .||.||:|
Mouse  1304 -----GTGLAYDRIQGQVPDSLTDDREEEEHWDQRSGSHFSSPSNKFFFHQKDKGSVQAPEISSN 1363

  Fly  1732 NITVSAQSSVVGGKKTPAKH-----------PQQQQQQ-----------QQQPVTPVSAATAPAA 1774
            :|   ..:.|:..:|..:|:           |::::|:           |.:....|......::
Mouse  1364 SI---KDALVMNERKDFSKNFEKNDIKERGPPKKRRQELESDSESDGELQARKKVRVEMEQGESS 1425

  Fly  1775 TPSSSESKEDDVSASSTTTPTTRTPA--KDKPKQSREDRKLEAILRAIEKMEKQEARGKKDTRQS 1837
            .|..||     :...|......|.|.  |:..|..:.....:.|...:...|:::.:..:|.:  
Mouse  1426 VPQHSE-----LMGPSCAMDDFRDPQRWKEFAKLGKMPCYFDLIEENVYLTERKKNKSHRDIK-- 1483

  Fly  1838 SGGKRQASNSPASPNKRNSSN-SISED-------VETPTSTNSAAAAAQRRNKKKR--------- 1885
               :.|...:|.|.::|.... :..||       :|..:...:....:.||.::|:         
Mouse  1484 ---RMQCECTPLSKDERAQGEVACGEDCLNRLLMIECSSRCPNGDYCSNRRFQRKQHADVEVILT 1545

  Fly  1886 -------KVSRSLNNNTNGLG-SGGGSNNKRRKSIVVESDGESH------ALTNSESEDQGQHPQ 1936
                   :.::.|.:||..|. .|...::|..|:.|.|.....:      ||.|.|..|..|   
Mouse  1546 EKKGWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYARNKNIHYYFMALKNDEIIDATQ--- 1607

  Fly  1937 SHHSGSEDQAAGLLLALAHNNSSPN---------------------EPFKSPLS-----QSHSLP 1975
                      .|......:::..||                     .|..|.|:     |.:...
Mouse  1608 ----------KGNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVPSGSELTFDYQFQRYGKE 1662

  Fly  1976 ATPASVSSA-C---------LLIEAAMGPLQQQPA--PASASPSLAEFKYPPGGAKTKKSLMS-- 2026
            |......|| |         :.|.||.|.::::.:  ..|....|........|...|..::|  
Mouse  1663 AQKCFCGSANCRGYLGGENRVSIRAAGGKMKKERSRKKDSVDGELEALMENGEGLSDKNQVLSLS 1727

  Fly  2027 -------------SWFQQAEQQHAS----------GLDSLVQAAMSEINGEREQLQRQPQG---- 2064
                         :..:..:..|:.          || ||:...|:|:...||..|:..:.    
Mouse  1728 RLMVRIETLEQKLTCLKLIQNTHSQSCLKSFLERHGL-SLLWIWMAELGDGRESNQKLQEEIIKT 1791

  Fly  2065 -ESLPAPALLKVEQFIHQAESTTAVPAREQLHLPLQNNSSVKKRWLRQAISEETTPVDELQQ--- 2125
             |.||.|....:|               |...||      :.:||     |:..|.|.:|.:   
Mouse  1792 LEHLPIPTKNMLE---------------ESKVLP------IIQRW-----SQTKTAVPQLSEGDG 1830

  Fly  2126 --SQNQSVTATPSPQPVPTVSPLANGFSTPLKKRRLVVVSNGTNVESDETHIDVIGEPKDEAEEN 2188
              |:|.|...||...|.|:..|                   .|.:::|        .||     .
Mouse  1831 YSSENTSRAHTPLNTPDPSAKP-------------------STEMDTD--------TPK-----K 1863

  Fly  2189 VAMTELKVEIENHHQEQDDDVDILRSPSPGTHQIVAEDNLVKIEPEDTSAAADDVKIDVER-EES 2252
            :....||:..||.......||         |.::..:|....::..:|....:|.::..:: ...
Mouse  1864 LIFRRLKIISENSMDSAVSDV---------TSELECKDGKEDLDQLETVTVEEDEELQSQQLLPQ 1919

  Fly  2253 QACDKFEEMVKVKREEEEQREKEIKQLQERQEHEQPKVEPAPVE-PKLENTVAKAEPKVEPSQEI 2316
            |.|:.     ||    |.:...|:.:|...:.....:.||.... .|||.|:|:..|. :..:|.
Mouse  1920 QLCES-----KV----ESEATIEVSKLPTSEPEADTETEPKDSNGTKLEETIAEETPS-QDEEEG 1974

  Fly  2317 VSKKEPTKVEPKPGESLLRSTATVTATPTAATIAATTLLDVSKVAFKTRPPLKLEDE----PQKK 2377
            ||..|..:.:..|.::                      :|:|.:|.|.....|...|    |:|.
Mouse  1975 VSDVESERSQEPPDKT----------------------VDISDLATKLLDSWKDLKEVYRIPKKS 2017

  Fly  2378 KPKLESILPAPVATVPPVSVPPIPAASNATTSAVTNTAAASLTTTTAPSSTKNLTEHDIQERLLS 2442
            :.:.||                        |.|.....||:....|||.:.....|.|..:    
Mouse  2018 QTEKES------------------------TVAERGRDAAAFRDQTAPKTPNRSRERDPDK---- 2054

  Fly  2443 FHAANISYLQSRNKKATAALTSASPSQKSNSSSGGSGTE----------SKKSSKDKD-EKRDKE 2496
                     ||:||:......|.||.    ||:...||:          |||..:.|| .|...|
Mouse  2055 ---------QSQNKEKRKRRGSLSPP----SSAYERGTKRPDDRYDTPTSKKKVRIKDRNKLSTE 2106

  Fly  2497 KQLKKSKKEKKKSKDKEKQKAAVNVNSTSQIVDTKKKTTQPSKPDS---KSSIAPVL-VPPSLPV 2557
            ::.|..::|..:.:.:::|:...|:..||           |...||   .:|..|.. .||..|:
Mouse  2107 ERRKLFEQEVAQREAQKQQQQMQNLGMTS-----------PLPFDSLGYNASHHPFAGYPPGYPM 2160

  Fly  2558 ATANGKTKHTAYNNVDQQQQQQMRRRTMSMCITPVTPTPVVTPSPL-HGTPPSTKKRQTNFEQEL 2621
                     .||.:.......::...|.||       .||.:|:|. |..|              
Mouse  2161 ---------QAYVDPSNPNAGKVLLPTPSM-------DPVCSPAPYDHAQP-------------- 2195

  Fly  2622 TKPNSQILSSSILLNSSKGLGLPLAAPTV--VSVPTAVQQQQHRKENN---HQEATPASGGPMSL 2681
                       ::.:|::.|..|.:.|.|  |:....|...|:..:|.   ||:           
Mouse  2196 -----------LVGHSTESLAAPPSVPVVPHVAASVEVSSSQYVAQNESVVHQD----------- 2238

  Fly  2682 AAAIASGKLNAISRRRESMCGSRQQQALIAAALKKEKKEKKKSKKKDREKQKHDKQKGKEKEREK 2746
                                                                             
Mouse  2239 ----------------------------------------------------------------- 2238

  Fly  2747 DKEKDNKQKTNHIQKPAHPTTVPANSMPISAPAPV-------------PVLVPTPVTTPKAAPIP 2798
                               :.||.  ||:.||.||             .|.|             
Mouse  2239 -------------------SNVPV--MPVQAPGPVQGQNYNVWESNQQSVSV------------- 2269

  Fly  2799 VLITQPTPSPIHVTQPLV----NNCSTKVASLPFYNTIYGKLQDPSTPTSSPIPVTNTMPSLAEY 2859
                |...||.. :|..:    ..||          |:| .:..|.:.|:.||..:...||| :|
Mouse  2270 ----QQQYSPAQ-SQTTIYYQGQTCS----------TVY-SVTSPYSQTTPPIVQSYAQPSL-QY 2317

  Fly  2860 LESTKSKTTALSAVKPIGIAAVTPLSSAITPAKVAPSSLEMPPPATTPLKLYTRTASHDPRLNPM 2924
            ::..:..|.....|.....||||   |.:.|.:  |.||:.|....|               |.:
Mouse  2318 IQGQQIFTAHPQGVVVQPTAAVT---SIVAPGQ--PQSLQPPEMVVT---------------NNL 2362

  Fly  2925 LTVPDPTPMPKRKLSI--SEYRMRHRPS-------VDTAPTTPTTPT------------------ 2962
            |.:|.|:| ||.|..:  ..::....|.       |.|..|....||                  
Mouse  2363 LDLPPPSP-PKPKTIVLPPNWKTARDPEGKIYYYHVITRQTQWDPPTWESPGDDASLEHEAEMDL 2426

  Fly  2963 -TPTTPTTPPGSNKDRSFAKPQTINKCSLQSPERFQ 2997
             |||....|..::|....|:..|.::.:.:|.|.|:
Mouse  2427 GTPTYDENPMKTSKKPKTAEADTSSELAKKSKEVFR 2462

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
upSETNP_001261819.1 PHD_MLL5 856..899 CDD:277025 7/42 (17%)
SET <1221..1273 CDD:214614 13/59 (22%)
Setd2XP_036010808.1 AWS 1483..1537 CDD:197795 10/58 (17%)
SET_SETD2 1537..1678 CDD:380949 26/153 (17%)
WW 2378..2407 CDD:395320 4/28 (14%)
SRI 2454..2542 CDD:400510 3/9 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.030

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