DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment upSET and Nsd3

DIOPT Version :9

Sequence 1:	NP_001261819.1	Gene:	upSET / 39551	FlyBaseID:	FBgn0036398	Length:	3146	Species:	Drosophila melanogaster
Sequence 2:	NP_001074738.1	Gene:	Nsd3 / 234135	MGIID:	2142581	Length:	1446	Species:	Mus musculus

Alignment Length:	1539	Identity:	248/1539 - (16%)
Similarity:	443/1539 - (28%)	Gaps:	658/1539 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 PQPPPPHI---VIDGSSLSTQAQLRIMQ-----RRMSIST------RQILSASQSQSINQSQKYA 85
            |.||||.:   ||...:.|.:.:|:|.:     |.:..|:      .::.::..::|.::|:|..
Mouse   142 PPPPPPSVPQTVIPKKTGSPEIKLKITKTIQNGRELFESSLCGDLLNEVQASEHTKSKHESRKEK 206

  Fly    86 VRTAAGTGALAAGAASSGSSGQELINPQIYKIVTTDGSTSNVIIDASAAAPPHNSKLLLSNLTVL 150
            .:.:         .....|..:|..:.:|.|:.....:..|..:|.:...|...        .||
Mouse   207 RKKS---------NRHESSRSEERRSHKIPKLEPEGQNRPNERVDTAPEKPREE--------PVL 254

  Fly   151 SKQAPVQGAAGQQQQQLNYLGAKSLPYVSASPAKTQQQPQKFGSISAFKAQHQQQQQHPHATLQK 215
            .:..|||                  |.:|:.|........||
Mouse   255 KEAIPVQ------------------PILSSVPTTETSTGVKF----------------------- 278

  Fly   216 VTLGSRVATRLQSYVPASPSQIMVQPAQPKYVNATATTIGGNAALLKKANQKITVKSVSNMSQQ- 279
             .:|..|.:::.:| |..|..:...|...  |::...|.|.         ::..|:..||..::
Mouse   279 -QVGDLVWSKVGTY-PWWPCMVSSDPQLE--VHSKINTRGA---------REYHVQFFSNQPERA 330

  Fly   280 -------QQQQQQQQQQQLLQAQQLKTFITQQQQQQTYKAGAKAKFVKQTTALSIAALPQQQQQ- 336
                   ::.:..:|.::|| |:..|......::|:..|                   |:.|::
Mouse   331 WVHEKRVREYKGHEQYEELL-AEAAKQASNHSEKQKIRK-------------------PRPQRER 375

  Fly   337 ------TTYAKQSMVTTSTPAKVTKLNSKYVQQQISLPQGTQLQHKASPNVTGGGYLLQQSQAAV 395
                  ..:|::::..| ...:|.:....|:.:|   |:  :...:|..|||        |:..|
Mouse   376 AQWDIGIAHAEKALKMT-REERVEQYTFIYIDKQ---PE--EASSQAKKNVT--------SKTEV 426

  Fly   396 GGTIKFVNSHGTVIQQHPQQQQATKRTHYNSSGSSDNEQHAVANSSLITDDVMIVNGTQMTDELS 460
                |......:|:...|:|..|.:                ||:|...||
Mouse   427 ----KKPRRPRSVLNSQPEQTNAGE----------------VASSQSSTD--------------- 456

  Fly   461 ARILQSMAQK---SFSQQQRFHQVPATGSGNMPPPTQIIYSNSTSNGAAASS----PGG------ 512
               |:..:|:   |..:::             |||.:|.:..:.:..:..:|    .|.
Mouse   457 ---LRRQSQRRHTSLEEEE-------------PPPVKIAWKTAAARKSLPASITMHKGSLDLQKC 505

  Fly   513 ---------------NASGNMLLAHYQAAGTKPVSSASFITVTG------TPPVTVATTPSVSIS 556
                           ||:|:..........||.:.:.:.|:|.|      :.|...:..|:.|.|
Mouse   506 NMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIGNKTEISVRGQDRLIISSPSQRSEKPAQSAS 570

  Fly   557 SHGFASGSAAISSYMSSATAARRQSVSAPSSRAVSLERKQHHQQLQHDVIGGGRKAPTVIEYYNK 621
            |....||||..........:.|.:|.|..|:..|..::.:..|
Mouse   571 SPEATSGSAGPVEKKQQRRSIRTRSESEKSAEVVPKKKIKKEQ---------------------- 613

  Fly   622 HGVNSIVGSSNNLAQSNSMSNLAGPRSNSGSGFATTTPTPATPLHLTPVNVPVHVEAAPPSS--P 684
                                                                  ||.||.:|  .
Mouse   614 ------------------------------------------------------VETAPQASLKT 624

  Fly   685 ALVKGSSQ--PPAQPQQQQQQAHPLGPNQLNANDEELYIEEVRPVPVLTQDLRLQQLHAIMQDHT 747
            .|.||:|:  ...:|.:::.:|         :.|.|                        ....|
Mouse   625 GLQKGASEISDSCKPLKKRSRA---------STDVE------------------------TASCT 656

  Fly   748 YASQQQQQQPQQAAGDTTNPGAAQQVQQPQQWSLGGIGVTVSGSQGTPTAVGGYCSYFGQQI--- 809
            |.             ||::                      |.|:|......|    ||:|:
Mouse   657 YR-------------DTSD----------------------SDSRGLSDGQVG----FGKQVDSP 682

  Fly   810 -ARSQAD-DDAHSAISSSSRMGLASTDIDPGEETETAPEAEAEDDSVTRC-ICELTHDDGYMICC 871
             |.:.|| .||.|..||.||.|:.::..|                  |.| :||...|  .::.|
Mouse   683 SATADADASDAQSVDSSLSRRGVGTSKKD------------------TVCQVCEKAGD--CLVAC 727

  Fly   872 D-KCSAWQHVDCMGIDRQNIPE-EYMCELCQ---------------------------------- 900
            : :|....||:|:|:..  :|| .:.||.|:
Mouse   728 EGECCRHFHVECLGLTA--VPEGHFTCEECETGQHPCFSCKVSGKDVKRCSVSVCGKFYHEACVR 790

  Fly   901 --PRAVDKARA--------------RALQRQKRKEHMLLVATQAAN--GAAAVAAGTTLSGGLGS 947
              |.|:.:::.              :.:.:..:...|..:....|.  |.|.||||   |..:.|
Mouse   791 KFPTAIFESKGFRCPQHCCSSCSMEKDIHKASKGRMMRCLRCPVAYHVGDACVAAG---SVSVSS 852

  Fly   948 GLPMSEELQHR--LASGLNGGF----ATG-----------TGMSKKSKKTKENSGSTSTLKKTKK 995
            .:.:......|  .::.:|.||    |.|           :..:.||......|.....:|...
Mouse   853 HILICSNHSKRSSQSAAINVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLSESNRAELMKLPM- 916

  Fly   996 SAVGMGGEKNASGSGTPTGSSGKTSKKSSKRKSKSGG-------------------DGSSGGGSS 1041
                           .|:.|       :||::.:.||                   |...|..:.
Mouse   917 ---------------IPSSS-------ASKKRCEKGGRLLCCESCPASFHPECLSIDMPEGCWNC 959

  Fly  1042 PALTAAEK---------HAANLRQW------------------------------IENYEYAVTN 1067
            ....|.:|         ...|.|.|                              ..:|.:....
Mouse   960 NDCKAGKKLHYKQIVWVKLGNYRWWPAEICSPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQG 1024

  Fly  1068 HYSPELRARLHAIQKQPSLLQSIQNTENKALRQIQQQLSTAGSAEQLEQR---AQLIPYAGAKVL 1129
            ...|.:....|..:.|.|:.::.:....:|.::.|:..:...|.|.||..   .:..||
Mouse  1025 RVFPYVEGDKHFAEGQTSINKTFKKALEEAAKRFQELKAQRESKEALEMERTSRKPPPY------ 1083

  Fly  1130 ISSVDLSPHAPIHELRGKYMLTTQFRTQNPTVNMNTPPPS---------NYLNSFKAHKTPGQFV 1185
                   .|...:::.||..:.....::.|..|......:         |.::.::.|
Mouse  1084 -------KHIKANKVIGKVQVQVADLSEIPRCNCKPGDENPCGLESQCLNRMSQYECH------- 1134

  Fly  1186 FFYQLPGV---------EAPMQTLRPDGSVPQVAQQ------PPSYLKG------------PEVC 1223
                 |.|         :...:.|.||..|.:..::      ..|..||            .|.|
Mouse  1135 -----PQVCPAGDRCQNQCFTKRLYPDAEVIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEEC 1194

  Fly  1224 -------------------------VDTRTYGNDARFVRRSCRPNAELQHYFEKGTLHLYIVALT 1263
                                     :|....||.:||:..||.||.|.|.:...|.:.:.:.||.
Mouse  1195 RLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALC 1259

  Fly  1264 HIRAQTEITIRHEPHDLTAVEQKKSHAAVIQPTSTRCACDMGSD 1307
            .|.|..|:|..:....|               .:.|..|..|:|
Mouse  1260 DIPAGMELTFNYNLDCL---------------GNGRTVCHCGAD 1288

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
upSET	NP_001261819.1	PHD_MLL5	856..899	CDD:277025	14/45 (31%)
upSET	NP_001261819.1	SET	<1221..1273	CDD:214614	19/76 (25%)
Nsd3	NP_001074738.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	191..257		12/82 (15%)
		MSH6_like	277..393	CDD:99898	25/172 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	354..377		5/41 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	411..476		21/123 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	550..705		49/302 (16%)
		PHD_SF	713..755	CDD:304600	14/45 (31%)
		PHD2_NSD3	761..807	CDD:277122	2/45 (4%)
		PHD_SF	808..860	CDD:304600	10/54 (19%)
		PHD4_NSD3	927..962	CDD:277128	4/34 (12%)
		WHSC1_related	968..1061	CDD:99899	10/92 (11%)
		AWS	1104..1154	CDD:197795	6/61 (10%)
		SET	1155..1278	CDD:214614	27/137 (20%)
		PHD5_NSD3	1332..1374	CDD:277131
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030