DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment upSET and Setd1a

DIOPT Version :9

Sequence 1:	NP_001261819.1	Gene:	upSET / 39551	FlyBaseID:	FBgn0036398	Length:	3146	Species:	Drosophila melanogaster
Sequence 2:	NP_821172.2	Gene:	Setd1a / 233904	MGIID:	2446244	Length:	1716	Species:	Mus musculus

Alignment Length:	1748	Identity:	311/1748 - (17%)
Similarity:	523/1748 - (29%)	Gaps:	601/1748 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   927 QAANGAAAVAAGTTLSGGLGSGLPMSEELQHRLA-------------SGLNGGFATGTGMSKKSK 978
            ::::..||..||||:.|..|:|.|.|::.....:             ....|...|..|.:..|:
Mouse   219 RSSSDTAAYPAGTTVGGTPGNGTPCSQDTNFSSSRQDTPSSFGQFTPQSSQGTPYTSRGSTPYSQ 283

  Fly   979 KTKENSGSTSTLKKTKKSAVGMG---GEKNASGSGTPTGSSGKTSKKSSKRKSKSGGDGSSGGGS 1040
            .:..:|.:|||..|.::|.....   ..::.|.|..|..::..||..::...:.|....||...|
Mouse   284 DSAYSSSTTSTSFKPRRSENSYQDSFSRRHFSTSSAPATTATATSATAAATAASSSSSSSSSSSS 348

  Fly  1041 SPALTAAEKHAANLRQWIENYE--YAVTNHYSPELRARLHAIQKQPSLLQSIQNTENKALRQIQQ 1103
            |   :::...|:..|....:|.  |...|.|.                    ::|.....|..::
Mouse   349 S---SSSSSSASQFRGSDSSYPAYYESWNRYQ--------------------RHTSYPPRRATRE 390

  Fly  1104 QLSTAGSAEQLEQRAQLIPYAGAKVLISSVDLSPHAPIHELRGKYMLTTQFRTQNPTVNMNTPPP 1168
            ..|.|..||...:|.                                                ||
Mouse   391 DPSGASFAENTAERF------------------------------------------------PP 407

  Fly  1169 S--NYLNSFKAHKTPGQFVFFYQLPGVEAPMQTLRPD----------------------GSVP-- 1207
            |  :||.......|...    |:.|..|||    .|:                      |..|
Mouse   408 SYTSYLAPEPNRSTDQD----YRPPASEAP----PPEPPEPGGGGGGSGGGGGGGGGGGGGAPSP 464

  Fly  1208 --QVAQQPP-------SYLKGPEVCVDTRTYGNDARFVRRSCRPNAELQHYFEKGTLHLYIVALT 1263
              :.|:.||       |....||...::..:.                ||              :
Mouse   465 EREEARTPPRPASPARSGSPAPETTNESVPFA----------------QH--------------S 499

  Fly  1264 HIRAQTEITIRHEPHDLTAVEQKKSHAAVIQPTSTRCACDMGSDCLFALPLAVQQQLQAPPTQPR 1328
            .:.::.|:.::         ||:...:.:...|                               .
Mouse   500 SLDSRIEMLLK---------EQRSKFSFLASDT-------------------------------E 524

  Fly  1329 SSHRNKAAAAAAAAAAANSAAAIQLTMGLGVGATVAAGASVLPNSRNRSTSSSGESSQMGLNSPQ 1393
            ....|.:|...|..|.|      ::..|.|.|......|..  |..:.:.:.|||
Mouse   525 EEEENSSAGPGARDAGA------EVPSGAGHGPCTPPPAPA--NFEDVAPTGSGE---------- 571

  Fly  1394 LGQLNLGFKTSVTATSLTAPVPGVHCNNSGGSSSSSNNSCSVSMSSVLHDSGICTSSSSPSVSIP 1458
                                 ||....:...:..:..:.||......:.|.   ....||.   |
Mouse   572 ---------------------PGAARESPKANGQNQASPCSSGEDMEISDD---DRGGSPP---P 609

  Fly  1459 SPTPTQMQSPTLQQHPQQIPQQQLSLLQRSPTQQHQQQILAALPTPMLTPMLSPQL-PKPAQQQA 1522
            :|||.|...|.....|...|....||....|  .||...|.. |.|...|  .|:. |.|.....
Mouse   610 APTPPQQPPPPPPPPPPPPPPYLASLPLGYP--PHQPAYLLP-PRPDGPP--PPEYPPPPPPPPP 669

  Fly  1523 HVV------------------LPQS--QQTSLLQQQQSQQSQEPLAVIAAAAAAQQPMATY---F 1564
            |:.                  :|.|  .||.:|.:....:..:.|    .||:|..|...:   |
Mouse   670 HIYDFVNSLELMDRLGAQWGGMPMSFQMQTQMLTRLHQLRQGKGL----TAASAGPPGGAFGEAF 730

  Fly  1565 VRQPQQQQQQQSPKPQALVAQQQHVVGAQQQQHF-----LQQQQKQQQQQMADEARM---AVSAL 1621
            :..|..|:.... .|.||..|.|...|:..::.:     :..:.........:|||:   ..:.:
Mouse   731 LPFPPPQEAAYG-LPYALYTQGQEGRGSYSREAYHLPLPMAAEPLPSSSVSGEEARLPHREEAEI 794

  Fly  1622 QTLHAAPTSHIVSPIKVAAVQQQSQPQQQQQNTHQQPHNQQAVQQQS----NQLQQQQSQQPNYP 1682
            ......|::..|..:....|       |:.::..|:..|::.|:..:    :|..:.:.::....
Mouse   795 AESKVLPSAGTVGRVLATLV-------QEMKSIMQRDLNRKMVENVAFGAFDQWWESKEEKAKPF 852

  Fly  1683 QSPQRQQKPQPVQHQPQIVISTGAQAIPATMPTKLSSP--------TKSAAPVISNNNITVSAQS 1739
            |:..:||..:..:.:                 .||..|        .||.    ....|...|..
Mouse   853 QNAAKQQAKEEDKEK-----------------MKLKEPGMLSLVDWAKSG----GITGIEAFAFG 896

  Fly  1740 SVVGG----------KKTPAKHPQQQQQQQQQPVTPVSAATAPAATPSSSESKEDD----VSASS 1790
            |.:.|          :|.|::..:..::::.:|.||             :|..|||    ..|..
Mouse   897 SGLRGALRLPSFKVKRKEPSEISEASEEKRPRPSTP-------------AEEDEDDPEREKEAGE 948

  Fly  1791 TTTPTTRTPAKDKPKQSREDRKLEAILRAIEKMEKQEARGKKDTRQSSGGKRQASNSPASPNKRN 1855
            ...|.|:.|.:|:                 |:.:.|....|..|..|.|  .:||...:|....:
Mouse   949 PGRPGTKPPKRDE-----------------ERGKTQGKHRKSFTLDSEG--EEASQESSSEKDED 994

  Fly  1856 SSNSISEDVETPTSTNSAAAAAQRRNKKKRKVSRSLNNNTNGLGSGGGSNNKRRKSIVVESDGES 1920
            ..:...||.|...:.::        .||:.:.|.         |....|::..:.|:..:||||:
Mouse   995 DDDEDEEDEEQEEAVDA--------TKKEAEASD---------GEDEDSDSSSQCSLYADSDGEN 1042

  Fly  1921 HALTNSE---------SEDQGQHPQSHHSGSEDQAAGLLLALAHNNSSPNEPFKS---------- 1966
            .:.::||         |........|..|.||::....::..|.......||..:
Mouse  1043 GSTSDSESGSSSSSSSSSSSSSSSSSSESSSEEEEQSAVIPSASPPREVPEPLPAPDEKPETDGL 1107

  Fly  1967 ------PLSQSHSLPATPASVSSACLLIEAAMGPLQQQP------------APASASPSLAE--- 2010
                  |||:..:||..||             ||.::.|            .|..|:|.|.|
Mouse  1108 VDSPVMPLSEKETLPTQPA-------------GPAEEPPPSVPQPPAEPPAGPPDAAPRLDERPS 1159

  Fly  2011 --FKYPPGGAKTKKSLMSSWFQQAEQQHASGLDSLVQAAMSEINGEREQLQRQPQGESLPAPALL 2073
              ....|...|.:|::..|..::|.....|      .||         .||.:..|     |...
Mouse  1160 SPIPLLPPPKKRRKTVSFSAAEEAPVPEPS------TAA---------PLQAKSSG-----PVSR 1204

  Fly  2074 KVEQFIHQAESTTAVPAREQLHLPLQNNSSVKKRWLRQ-AISEETTPVDELQQSQNQSVTATPSP 2137
            ||.:.:.          |...:||| :::|:.|.|..: |..........::.::.:..|.:.:.
Mouse  1205 KVPRVVE----------RTIRNLPL-DHASLVKSWPEEVARGGRNRAGGRVRSTEEEEATESGTE 1258

  Fly  2138 QPVPTVSPLANGFSTPLKKRRLVVVSNGTNVESDETHIDVIGEPKDEAEENVAMTELKVEIENHH 2202
            ..:..::.||   .|| .:|.|..:..|.:.|:.||        .||||.
Mouse  1259 VDLAVLADLA---LTP-ARRGLATLPTGDDSEATET--------SDEAER--------------- 1296

  Fly  2203 QEQDDDVDILRSPSPGTHQIVAEDN-LVKIEPEDT-----------------SAAADD------- 2242
                        |||....|:.|.| .:.|:|..|                 |:.||:
Mouse  1297 ------------PSPLLSHILLEHNYALAIKPPPTTPAPRPLEPAPALAALFSSPADEVLEAPEV 1349

  Fly  2243 VKIDVEREESQACDKFEEMVKVKREEEEQREKEI-----------------KQLQERQEHEQPKV 2290
            |..:.|..:.|...:..|....:.||:|:.|.|.                 :.|:......:|.:
Mouse  1350 VVAEAEEPKQQLQQQHPEQEGEEEEEDEEEESESSESSSSSSSDEEGAIRRRSLRSHTRRRRPPL 1414

  Fly  2291 EPAPVEPKLENTVAKAEPKVEPSQEIVSK-------KEPTKVEPKPGESLLRST--ATVTATPTA 2346
            .|.|..|          |..||..|....       .....:|..   |.||.|  ..:..|..|
Mouse  1415 PPPPPPP----------PSFEPRSEFEQMTILYDIWNSGLDLEDM---SYLRLTYERLLQQTSGA 1466

  Fly  2347 ATIAAT-----TLLDVSKVAFKTRPPLKLEDEP---QKKKPKLESILPA------PVATVPPVSV 2397
            ..:..|     |:.::|....|.||    :|.|   |....:.|...|.      ....|.|||.
Mouse  1467 DWLNDTHWVQHTITNLSTPKRKRRP----QDGPREHQTGSARSEGYYPISKKEKDKYLDVCPVSA 1527

  Fly  2398 PPIPAASNATTSAVTNTAAASLTTTTAPSSTKNLTEHDIQE-RLLSFHAANISYLQSR 2454
            ..:.......|:.|.:...:......:...|..:.:.|:.: ..|.|....:.:.:||
Mouse  1528 RQLEGGDTQGTNRVLSERRSEQRRLLSAIGTSAIMDSDLLKLNQLKFRKKKLRFGRSR 1585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
upSET	NP_001261819.1	PHD_MLL5	856..899	CDD:277025
upSET	NP_001261819.1	SET	<1221..1273	CDD:214614	4/51 (8%)
Setd1a	NP_821172.2	RRM_Set1A	92..186	CDD:240992
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	194..367		33/150 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	380..499		29/204 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	516..670		41/234 (18%)
		Topoisomer_IB_N	<835..>883	CDD:322080	7/64 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	849..869		3/36 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	911..1206		73/376 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1230..1259		2/28 (7%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1275..1297		9/56 (16%)
		HCFC1-binding motif (HBM). /evidence=ECO:0000250\|UniProtKB:O15047	1307..1311		2/3 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1355..1427		15/81 (19%)
		Interaction with CFP1. /evidence=ECO:0000250\|UniProtKB:O15047	1424..1459		8/37 (22%)
		N-SET	1434..1571	CDD:314603	26/143 (18%)
		Interaction with ASH2L, RBBP5 and WDR5. /evidence=ECO:0000250\|UniProtKB:O15047	1459..1546		19/90 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1480..1508		8/31 (26%)
		WDR5 interaction motif (WIN). /evidence=ECO:0000250\|UniProtKB:O15047	1501..1506		0/4 (0%)
		SET	1577..1700	CDD:214614	2/9 (22%)
		PostSET	1700..1716	CDD:214703
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030