DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment upSET and Phf13

DIOPT Version :9

Sequence 1:	NP_001261819.1	Gene:	upSET / 39551	FlyBaseID:	FBgn0036398	Length:	3146	Species:	Drosophila melanogaster
Sequence 2:	NP_766293.2	Gene:	Phf13 / 230936	MGIID:	2446217	Length:	296	Species:	Mus musculus

Alignment Length:	301	Identity:	66/301 - (21%)
Similarity:	112/301 - (37%)	Gaps:	75/301 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   634 LAQSNSMSN-LAGPRSNSG--SGFATTTPTPATP----LHLTPVNVPVHVEAAPPSSPALVKGSS 691
            |..|.|.:| .||...:.|  :||:..  ||:.|    .||.    |..::.|.||:..|.:.::
Mouse    51 LRSSPSPANSTAGTIDSDGWDTGFSDI--TPSVPDRCFSHLQ----PSLLQRAKPSNYLLDRKTT 109

  Fly   692 QPPAQPQQQQQQAHPLGPNQLNANDEELYIEEVRPVPVLTQDLRLQQLHAIMQDHTYASQQQQQQ 756
            ....:.::::::...: |.:....:..|.:|...|..                 .|.:|...|..
Mouse   110 DKLKKKKRRKRRDSDI-PVKEGFRESLLKLEAADPYV-----------------ETPSSPTMQDI 156

  Fly   757 PQQAA-------GDTTNPGAAQQVQQPQQWSLGGIGVTVSGSQGTPTAVGGYCSYFGQQIARSQA 814
            ||.:|       .||.:.|:...|...|        ||...::|..|.|..     |:|:.....
Mouse   157 PQASADPCSGWDSDTPSSGSCATVSPDQ--------VTEIKTEGKRTIVRQ-----GKQVVFRDE 208

  Fly   815 DDDAHSAISSSSRMGLASTDIDPGEETETAPEAEAEDDS--VTRCICELTHDDGYMICCDKCSAW 877
            |...:            ..||          ..:::|||  :..|.|........||.|::|..|
Mouse   209 DSTGN------------DEDI----------MVDSDDDSWDLVTCFCMKPFAGRPMIECNECHTW 251

  Fly   878 QHVDCMGIDRQNIPEEYMCELCQPRAVDKARARALQRQKRK 918
            .|:.|..|.:.|:||.::|:.|:....|..|:...:...||
Mouse   252 IHLSCAKIRKSNVPEVFVCQKCRDSKFDIRRSNRSRMGSRK 292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
upSET	NP_001261819.1	PHD_MLL5	856..899	CDD:277025	14/42 (33%)
upSET	NP_001261819.1	SET	<1221..1273	CDD:214614
Phf13	NP_766293.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	51..73		7/21 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	97..126		4/29 (14%)
		Nuclear localization signal. /evidence=ECO:0000250	106..123		0/16 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	145..183		10/54 (19%)
		PHD_PHF13	228..274	CDD:277102	14/45 (31%)
		Interaction with trimethylated histone H3 (H3K4). /evidence=ECO:0000250	237..244		1/6 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1844
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900