DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment upSET and SETD1B

DIOPT Version :9

Sequence 1:NP_001261819.1 Gene:upSET / 39551 FlyBaseID:FBgn0036398 Length:3146 Species:Drosophila melanogaster
Sequence 2:NP_001340274.1 Gene:SETD1B / 23067 HGNCID:29187 Length:1966 Species:Homo sapiens


Alignment Length:2352 Identity:433/2352 - (18%)
Similarity:654/2352 - (27%) Gaps:932/2352 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   889 NIPEEYMCELCQPRAVDKARARALQRQKRKEHM-----LLVATQAANGAAAVAAGTTLSGG---- 944
            ||.|.::.::|: :..:......|...|.|:|:     :....:.|..|......|::.|.    
Human   113 NIRENFLRDMCK-KYGEVEEVEILYNPKTKKHLGIAKVVFATVRGAKDAVQHLHSTSVMGNIIHV 176

  Fly   945 ---------------LGSG------LPMSE------------ELQHRLASGLNGGFATGTGMSKK 976
                           |.:|      ||:.|            :|...|....:||.:.|.|..  
Human   177 ELDTKGETRMRFYELLVTGRYTPQTLPVGELDAVSPIVNETLQLSDALKRLKDGGLSAGCGSG-- 239

  Fly   977 SKKTKENSGSTSTLKKTKKSAVGMGGEKNASGSGTP-TGSSGKTSKKSSKRKSKSGGDGSSGGGS 1040
            |.....|||.|...:.|..|:..: ...|:.|.||| |...|....:.|...|:.         .
Human   240 SSSVTPNSGGTPFSQDTAYSSCRL-DTPNSYGQGTPLTPRLGTPFSQDSSYSSRQ---------P 294

  Fly  1041 SPALTAAEKHAANLRQWIENYEYAVTNHYSPELRARLHAIQKQPSLLQSIQNTENKALRQIQQQL 1105
            :|:...::..|...:  ...:|...|:.|:  .|...|.:...|::                   
Human   295 TPSYLFSQDPAVTFK--ARRHESKFTDAYN--RRHEHHYVHNSPAV------------------- 336

  Fly  1106 STAGSAEQLEQRAQLIPYAGAKVLI-SSVDLSPHAPIHELRGKYMLTTQFRTQNPTVNMNTPPPS 1169
             ||              .|||.... .|.|| |...:....|......:.:.|:.....:|||| 
Human   337 -TA--------------VAGATAAFRGSSDL-PFGAVGGTGGSSGPPFKAQPQDSATFAHTPPP- 384

  Fly  1170 NYLNSFKAHKTPGQFVFFYQLPGVE---APMQTLRPDGSVPQVAQQPPSYLKGPEVCVDTRTYGN 1231
                   |..||.        ||.:   :|.||        .||..||.    ||....|..:| 
Human   385 -------AQATPA--------PGFKSAFSPYQT--------PVAHFPPP----PEEPTATAAFG- 421

  Fly  1232 DARFVRRSCRPNAELQHYFEKGTLHLYIVALTHIRAQTEITIRHEPHDLTAVEQKKSHAAVIQPT 1296
                    .|.:.|.:                  ||..       |..|...|            
Human   422 --------ARDSGEFR------------------RAPA-------PPPLPPAE------------ 441

  Fly  1297 STRCACDMGSDCLFALPLAVQQQLQAPPTQPRSSHRNKAAAAAAAAAAANSAAAIQLTMGLGVGA 1361
                            ||| :::...||..|...                       |..:.:|.
Human   442 ----------------PLA-KEKPGTPPGPPPPD-----------------------TNSMELGG 466

  Fly  1362 TVAAGASVLPNSRNRSTSSSGESSQMGLNSPQ---LGQLNLGFKTSVT-ATSLTAPVPGVHCNNS 1422
            ....|.|  |...:...:.:.|||..|...|.   ..::.:..|...| ...|..|.........
Human   467 RPTFGWS--PEPCDSPGTPTLESSPAGPEKPHDSLDSRIEMLLKEQRTKLLFLREPDSDTELQME 529

  Fly  1423 GGSSSSSNNSCSVSMSSVLHDSGICTSSSSPSVSIPSPTPTQMQSPTLQQ-HPQQIPQQQLSLLQ 1486
            |...|||:     |..|.|...|   ::|.|....|:|..::..|..|:. .|..:|.       
Human   530 GSPISSSS-----SQLSPLAPFG---TNSQPGFRGPTPPSSRPSSTGLEDISPTPLPD------- 579

  Fly  1487 RSPTQQHQQQILAALPTPMLTPMLSPQLPKPA---QQQAHVVL-------PQSQQTSLLQQQQSQ 1541
             |...:.....|...|.|      .|..|.||   .|.|.|.|       |.|::....||...:
Human   580 -SDEDEELDLGLGPRPPP------EPGPPDPAGLLSQTAEVALDLVGDRTPTSEKMDEGQQSSGE 637

  Fly  1542 -----QSQEPLAVIAAAAAAQQPMATYFVRQPQQQQQQQSPKPQALVAQQQHVVGAQQQQHFLQQ 1601
                 ..:.|.|.|.:|                     ..|||..:..      ||         
Human   638 DMEISDDEMPSAPITSA---------------------DCPKPMVVTP------GA--------- 666

  Fly  1602 QQKQQQQQMADEARMAVSALQTLHAAPTSHIVSPIKVAAVQQQSQPQQQQQNTHQQPHNQQAVQQ 1666
                          .||:|...|  |||..:..|.....:.....|                   
Human   667 --------------AAVAAPSVL--APTLPLPPPPGFPPLPPPPPP------------------- 696

  Fly  1667 QSNQLQQQQSQQPNYPQSP--QRQQKPQPVQHQPQIVISTGAQAIPATMPTKLSSPTKSAAPVIS 1729
                    ...||.:|..|  .....|.|..|....|......|.|...|..:..|.....|.:.
Human   697 --------PPPQPGFPMPPPLPPPPPPPPPAHPAVTVPPPPLPAPPGVPPPPILPPLPPFPPGLF 753

  Fly  1730 NNNITVSAQSSVVGGK--KTPAKHPQQQQ-------QQQQQPVTPVSAATAPAAT---------- 1775
              .:.....|.|:||:  ..|.....|.|       .|...|..|..||.|.||:          
Human   754 --PVMQVDMSHVLGGQWGGMPMSFQMQTQVLSRLMTGQGACPYPPFMAAAAAAASAGLQFVNLPP 816

  Fly  1776 -----------PSSSESKEDDVSASSTTTPTTRTPAKDKPKQSREDRKLEAILRAIEKMEKQEAR 1829
                       |...:..........:..|....|.::.|.::..|..|..:|:.::.:.|::..
Human   817 YRGPFSLSNSGPGRGQHWPPLPKFDPSVPPPGYMPRQEDPHKATVDGVLLVVLKELKAIMKRDLN 881

  Fly  1830 GK---------------KDTRQSSGGKRQASNSPASPNKRNSSNSISEDVETPTSTNSAAAAAQR 1879
            .|               |..|.:     :||.:|.     .|.....||                
Human   882 RKMVEVVAFRAFDEWWDKKERMA-----KASLTPV-----KSGEHKDED---------------- 920

  Fly  1880 RNKKKRKVSRSLNNN--------TNGLGSGGGSNN---------KRRKSIVVESDGESHALTNSE 1927
            |.|.|.:::..|..:        ..|||.|.|...         ||::.....|.|:...|..|.
Human   921 RPKPKDRIASCLLESWGKGEGLGYEGLGLGIGLRGAIRLPSFKVKRKEPPDTTSSGDQKRLRPST 985

  Fly  1928 SEDQGQHPQSHHSGSEDQAAGLLLALAHNNSSPNEPFKSPLSQSHSLPATPASVSSACLLIEAAM 1992
            |.|:           ||:                   :|...:...:..||..::          
Human   986 SVDE-----------EDE-------------------ESERERDRDMADTPCELA---------- 1010

  Fly  1993 GPLQQQPAPASASPSLAEFKYPPGGAKTKKSLMSSWFQQAEQQHASGLDSLVQAAMSEINGEREQ 2057
                               |..|.|...::          .......|||         .||.: 
Human  1011 -------------------KRDPKGVGVRR----------RPARPLELDS---------GGEED- 1036

  Fly  2058 LQRQPQGESLPAPALLKVEQFIHQAESTTAVPAREQLHLPLQNNSSVKKRWLRQAISEETTPVDE 2122
                 :.|||.|.:......   .:.|:|..|:         :::|.|:        ||....:|
Human  1037 -----EKESLSASSSSSASS---SSGSSTTSPS---------SSASDKE--------EEQESTEE 1076

  Fly  2123 LQQSQNQSVTATPSPQPVPTVSPLANGFSTPLKKRRLVVVSNGTNVESDETHIDVIGEPKDEAE- 2186
            .::::.:.....|..|                      :.|:.|:..||:...|...:.:||:| 
Human  1077 EEEAEEEEEEEVPRSQ----------------------LSSSSTSSTSDKDDDDDDSDDRDESEN 1119

  Fly  2187 --ENVAMTELKVEIENHHQEQDDDVDILRSPSPGTHQIVAEDNLVKIEPEDTSAAADDVKIDVER 2249
              |:.|::|.. |.:....::::.|.|:.|               |.|...:|.:::..:.:...
Human  1120 DDEDTALSEAS-EKDEGDSDEEETVSIVTS---------------KAEATSSSESSESSEFESSS 1168

  Fly  2250 EESQACDKFEEMVKVKREEEEQREKEIKQLQE----------RQEHEQ-------PKVEPAPVEP 2297
            |.|.:..:.||.| |.|||||:.|:|....:|          .|:.|:       |.|:...:|.
Human  1169 ESSPSSSEDEEEV-VAREEEEEEEEEEMVAEESMASAGPEDFEQDGEEAALAPGAPAVDSLGMEE 1232

  Fly  2298 KLENTVAKAEPKVEPS-----------QEIVSKKEPTKVEPKPGESLLRSTATVTATPTAATIAA 2351
            :::.......|:..||           :|....:||.:   :||.| ......::..|.|..:.|
Human  1233 EVDIETEAVAPEERPSMLDEPPLPVGVEEPADSREPPE---EPGLS-QEGAMLLSPEPPAKEVEA 1293

  Fly  2352 TTLLDVSKVAFKTRPP----------LKLEDEPQKKKP-KLESILPAPVATVPP----------- 2394
                         |||          |::|.||....| .|:..||.|....||           
Human  1294 -------------RPPLSPERAPEHDLEVEPEPPMMLPLPLQPPLPPPRPPRPPSPPPEPETTDA 1345

  Fly  2395 --VSVPPIPAASN--ATTSAVTNTAAASLTTTTAPSSTKNLTEHDIQERLLSFHAANISYLQSRN 2455
              .||||.|.|.:  ..|..:..:.|.|.:|.|.|::...       |..||..::.:|....:.
Human  1346 SHPSVPPEPLAEDHPPHTPGLCGSLAKSQSTETVPATPGG-------EPPLSGGSSGLSLSSPQV 1403

  Fly  2456 KKATAALTSASPSQKSNSSSGGSGTESKKSSKDKDEKRDKEKQLKKSKKEKKKSKDKEKQKAAVN 2520
            ..:..:..:.|||    .||||                                           
Human  1404 PGSPFSYPAPSPS----LSSGG------------------------------------------- 1421

  Fly  2521 VNSTSQIVDTKKKTTQPSKPDSKSSIAPVLVPPSLPVATANGKTKHTAYNNVDQQQQQQMRRRTM 2585
                           .|..|....|..|....||.|:                            
Human  1422 ---------------LPRTPGRDFSFTPTFSEPSGPL---------------------------- 1443

  Fly  2586 SMCITPVTPTPVVTPSPLHGTPPSTKKRQTNFEQELTKPNSQILSSSILLNSSKGLGLPLAAPTV 2650
               :.||.|.|                  |....|.:.|    |:|.:||.:...|.|||..|..
Human  1444 ---LLPVCPLP------------------TGRRDERSGP----LASPVLLETGLPLPLPLPLPLP 1483

  Fly  2651 VSVPTAVQQQQHRKENNHQEATPASGGPMSLAAAIAS---------GKLNAISRRRESMCGSRQQ 2706
            :::|..::.|.       :..||.   |..|.|.:||         |:.........|:.|...:
Human  1484 LALPAVLRAQA-------RAPTPL---PPLLPAPLASCPPPMKRKPGRPRRSPPSMLSLDGPLVR 1538

  Fly  2707 QALIAAALKKEKKEKKKSKKKDREKQKHDKQKGKEKEREKDKEKDNKQKTNHIQKPAHPTTVPAN 2771
            .. ..|||.:|........:.......||                             |.||..:
Human  1539 PP-AGAALGRELLLLPGQPQTPVFPSTHD-----------------------------PRTVTLD 1573

  Fly  2772 SMPISAPAPVPVLVPTPVTTPKAAPIPVLITQPTPSPIHVTQPLVNNCSTKVASLPFYNTIYGKL 2836
            ......|||.|.|.|.|       |.|     |.|.|:..|:            |||      |.
Human  1574 FRNAGIPAPPPPLPPQP-------PPP-----PPPPPVEPTK------------LPF------KE 1608

  Fly  2837 QDPSTPTSSPIP--------VTNTMPSLAEYLESTKS--------KTTALSAVKPIGIAAVTPLS 2885
            .|...| |..||        ||.      ||:|..||        |......|.|.|...::|  
Human  1609 LDNQWP-SEAIPPGPRGRDEVTE------EYMELAKSRGPWRRPPKKRHEDLVPPAGSPELSP-- 1664

  Fly  2886 SAITPAKVAPSSLEMPPPATTPLKL--------------------YTRTASHD---PRLNPMLTV 2927
                     |..|..|......:.:                    |.|....|   ..||..|.|
Human  1665 ---------PQPLFRPRSEFEEMTILYDIWNGGIDEEDIRFLCVTYERLLQQDNGMDWLNDTLWV 1720

  Fly  2928 PDPT------PMPKRKLSISEY-----------------RMRH----RPSVDTAPTTPTTPTTPT 2965
            ..|:      ...||...|.|:                 ::|:    |.|.|..|......:.|.
Human  1721 YHPSTSLSSAKKKKRDDGIREHVTGCARSEGFYTIDKKDKLRYLNSSRASTDEPPADTQGMSIPA 1785

  Fly  2966 TP--TTPPGSNK 2975
            .|  :|..||.:
Human  1786 QPHASTRAGSER 1797

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
upSETNP_001261819.1 PHD_MLL5 856..899 CDD:277025 3/9 (33%)
SET <1221..1273 CDD:214614 7/51 (14%)
SETD1BNP_001340274.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26
RRM_Set1B 101..193 CDD:240993 12/80 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 235..302 19/78 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 357..660 87/461 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 675..719 12/72 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 963..1462 135/780 (17%)
Trypan_PARP <1237..1308 CDD:330686 15/87 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1501..1541 8/40 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1555..1606 19/103 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1636..1668 8/42 (19%)
N-SET 1679..1821 CDD:314603 22/119 (18%)
WDR5 interaction motif (WIN). /evidence=ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:22665483 1745..1750 0/4 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1767..1800 9/31 (29%)
SET 1834..1949 CDD:214614
PostSET 1950..1966 CDD:214703
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.030

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