DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment upSET and Phf3

DIOPT Version :9

Sequence 1:	NP_001261819.1	Gene:	upSET / 39551	FlyBaseID:	FBgn0036398	Length:	3146	Species:	Drosophila melanogaster
Sequence 2:	NP_001074549.1	Gene:	Phf3 / 213109	MGIID:	2446126	Length:	2025	Species:	Mus musculus

Alignment Length:	2049	Identity:	358/2049 - (17%)
Similarity:	635/2049 - (30%)	Gaps:	670/2049 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1195 APMQTLRPDG---SVPQVAQQPPSYLKGPEVCVDTRTYGNDARFVRRSCR--PNAELQHYFEKGT 1254
            |.:.|.:|.|   |..:|..:|....:|.|. |.........:..|||.|  ...::.......:
Mouse   153 ATLSTKKPSGKTLSTSKVGVKPAERCQGKEE-VYASLKSEHPKESRRSGRHAEQMDVAPEVSASS 216

  Fly  1255 LHLYIVALTHIRAQTEITIRHEPHD-------------------LTAVEQKKSHAAVIQPTSTRC 1300
            :...:.:...::.:.|...:|..::                   ..:||:|...|.:      .|
Mouse   217 VDSSVSSCAGMKEEAEFDPKHACNNQGEVNVPSPELDCPLLSETSASVEEKNIEALM------EC 275

  Fly  1301 ACDMGSDCLFALPLAVQQQ---------------------------LQAPPTQPRSSHRNKAAAA 1338
            .....|..||..|:...:|                           ::.|....:::...:::..
Mouse   276 KAKTNSSPLFKFPVREDEQSDLVSGELNDTIEGKDAGGKPDQESEEVKFPCEGDQTAEEPESSDV 340

  Fly  1339 AAAAAAANSAAAIQLTMGLGVGATVAAGASVLPNSRNRSTSSSGESSQMGL-----------NSP 1392
            ::.:|.||                           :|::..:.|....:.|           |||
Mouse   341 SSDSACAN---------------------------KNKAEKNEGAECHLELKNTVDIVDKPENSP 378

  Fly  1393 QLGQL-NLGFKTSVTATSLTAPVPGVHCNNSGGSSSSSNNS-------CSVSMSSVLHDSGICTS 1449
            |..:| .||:.....:            |::...|:..|.|       |:....:...::.||..
Mouse   379 QRNELETLGYGEDTES------------NDARLQSTEFNKSDLEEVDACAFEPEASTLENTICDV 431

  Fly  1450 SSSPSVSIPSPTPTQMQSPTLQQ-----HPQQIPQQQLSLLQRSPTQQHQQQILAALPTPMLTPM 1509
            ....|..:......:|::..||.     .|:.|..:.:    :|.|  |.:|.:.. .||..|..
Mouse   432 LDQNSKQLNITQSIKMETANLQDDRSGLEPKNIKPKHI----KSVT--HSKQSMTT-ETPRKTVA 489

  Fly  1510 LSPQL------------------PKPAQQQAHVVLPQSQQTSLLQQQQSQQSQEPLAVIAAAAAA 1556
            ...::                  |:|.        |.||:...::::|..:..:..:..:...:.
Mouse   490 AKHEVGHSKTKSNVKAVKRNSGEPEPQ--------PDSQRPVKVRKKQGDKVWKSQSCNSGVKSV 546

  Fly  1557 QQPMATYFVRQPQQQQQQQSPKP------------QALVAQQQHVVGAQQQQHFLQQQQKQQQQQ 1609
            :....:...|.||.|...|..||            .....:..|.|......|..|:|.::.|||
Mouse   547 KSQAHSVLKRMPQDQNTMQISKPLTHPHSDKLHGHSGFSKEPPHPVQTGHLVHSSQKQSQKPQQQ 611

  Fly  1610 MADEARMAVSALQTLHAAPTS-HIV--SPIKVAAVQQQSQPQQQQQNTHQQ--------PHNQQA 1663
            .|  .....|.::..|..|.| |:.  ..:|.....:..||:|::.:....        |.|...
Mouse   612 AA--VGKGSSHVKDEHDHPVSEHLKEDDKLKPRKPDRNLQPRQRRSSRSFSLDEPPLFIPDNIAT 674

  Fly  1664 VQQQSNQLQQQQSQQPNYPQSPQRQ----QKPQPVQHQPQIVISTG---------AQAIPATMPT 1715
            |:::.:  .|..|.:..|..:|.:|    :||    |..:.::..|         ...:..:...
Mouse   675 VKKEGS--DQTTSIESKYMWTPSKQCGFCKKP----HGNRFMVGCGRCDDWFHGDCVGLSLSQAQ 733

  Fly  1716 KLSSPTK------------------------SAAPVISNNNITVSAQSSVVGGKKTPAKH--PQQ 1754
            ::....|                        :.||:.::     |....:..||.|.:||  ...
Mouse   734 QMGEEDKEYVCVRCCAEEDKKTDILDTEIFEAQAPIEAH-----SEDKRMECGKLTSSKHAVTDD 793

  Fly  1755 QQQQQQQP------------------------------VTPVSAATAPAATPSSSESKEDDVSAS 1789
            :.:....|                              :.|:...:.|.....|||.|.:.::..
Mouse   794 KHRHSDDPGKHKVKILKRESGEGKTSSDSRDNEIKKWQLAPLRKLSQPHLPRRSSEEKSEKIAKE 858

  Fly  1790 STTTPTTRTPAKDKPKQSREDRKLEAILRAIEKMEKQEARGKKDTRQSSGGKR----QASNSPAS 1850
            ||...:|.                |.:.|: ...||||.:.||   ...||..    .|::.|::
Mouse   859 STALASTG----------------ERVARS-GTHEKQETKKKK---MEKGGPNVHPPAATSKPSA 903

  Fly  1851 PNKRNSSNSISEDVETPTSTNS--------AAAAAQRRNK-----------KKRKVSRSLNNNTN 1896
            ...|.|.....:|:.....|:|        ||..|.:..|           |.:...|||..|..
Mouse   904 DQIRQSVRHSLKDILMKRLTDSNLKIPEEKAAKVATKIEKELFSFFRDTDAKYKNKYRSLMFNLK 968

  Fly  1897 GLGSGGGSNNKRRKSIVVESDGESHALTNSESE-----------DQGQH---------------- 1934
                 ...||...|.::.......|.:..|..|           .:.:|
Mouse   969 -----DPKNNILFKKVLKGEVTPDHLIRMSPEELASKELAAWRRRENRHTIEMIEKEQREVERRP 1028

  Fly  1935 -PQSHHSGS---------EDQAAGLLLALAHNNSSPNEPFKSPLSQSHSLPATPASVSSA----- 1984
             .:..|.|.         ::|.|.:.:.....|.|..:|..|. .|...:.:|....:|.
Mouse  1029 ITKITHKGEIEIESDAPMKEQEAAIEIQEPSANKSMEKPDVSE-KQKEEVDSTSKDTTSQHRQHL 1092

  Fly  1985 ----CLLIEAAMGPLQQQPAPASASPSLAEFKYPPGGAKTKKSLMSSWFQQAEQQHASGLDSLVQ 2045
                |.:....|.|.....:|.:.       |...|||:....      .:||.. |..|.|...
Mouse  1093 FDLNCKICIGRMAPPIDDLSPKTV-------KVVVGGARKHSD------NEAESL-ADALSSTTN 1143

  Fly  2046 AAMSEINGEREQLQRQPQGESLPAPA--------------------------LLKVEQFIHQAES 2084
            ...|::  ..|:.|..|:....|.|.                          :..|.:|:.:|..
Mouse  1144 ILTSDL--FEEEKQESPKSTFSPTPRPEMPGTVEVESTFLARLNFIWKGFINMPSVAKFVTKAYP 1206

  Fly  2085 TTAVPAREQLHLPLQNNSSVKKRWLRQAISEETT--PVDELQQSQNQSVTA---TP-SPQPVPTV 2143
            .:..|  |.|...|.::..|..|     ||.:|.  .|::::.|..:.:..   || :.:...:.
Mouse  1207 VSGSP--EYLTEDLPDSIQVGGR-----ISPQTVWDYVEKIKASGTKEICVVRFTPVTEEDQISY 1264

  Fly  2144 SPLANGFSTPLKKRRLVVVSNGTNVESDETHIDVIGEPKDEAEE------------------NVA 2190
            :.|...||:  :||..|..:|...|:      |:...|...|::                  |:.
Mouse  1265 TLLFAYFSS--RKRYGVAANNMKQVK------DMYLIPLGAADKIPHPLVPFDGPGLELHRPNLL 1321

  Fly  2191 M-TELKVEIENHHQEQDDDVDILRSPSPG-THQIVAEDNLVKIEPEDTSAAADDVKIDVEREESQ 2253
            : ..::.:::..|           |.|.| :|.....::...:.|.|.....:....:...|||.
Mouse  1322 LGLIIRQKLKRPH-----------SASAGPSHTGETPESAPIVLPPDKKGKMESCTEEAAEEESD 1375

  Fly  2254 ACDKFEEMVKVKREEEEQREKEIKQLQERQEHEQPKVEPAPVEPKLENTVAKAEP----KVEPSQ 2314
            ..:.|..::      .:||.|..:.|||..        |...||.:|  |.|.||    :..|..
Mouse  1376 FFNSFTTVL------HKQRNKPSQPLQEDL--------PTAAEPLME--VTKQEPPKPLRFLPGV 1424

  Fly  2315 EIVSKKEPTKVE----PKPGESLLRSTATVT------ATPTAATIAATTLLDVSKVAFKTRPPLK 2369
            .|....:|:.:|    |.|.:.:|:|....|      |.|   .:..:||.::..:..:..|.::
Mouse  1425 LIGWDNQPSTLELANKPLPVDDILQSLLGTTGQVYEQAQP---LVEQSTLKEIPFINDQANPKVE 1486

  Fly  2370 -------LEDEPQKKKPKLESILPA-------PVATVPPVSVPPIPAASNATTSAVTNTAA-ASL 2419
                   .|.:.::.|.|.|:|..:       ..::|...|:.|.|.||.:......:.:. |.|
Mouse  1487 KIDKVEVTEGDAKEIKVKAENISVSTSKNSGEETSSVGSSSISPGPLASLSLRGKPPDVSTEAFL 1551

  Fly  2420 TTTTAPSSTKNLTEHDIQERLLSFHAANISYLQSRNKKATAALTSASP-----------SQKSNS 2473
            |..:.||..:...|:  :||.|.    .:......|.......:|.||           ...|.|
Mouse  1552 TNLSIPSKQEESVEN--KERTLK----RLLLQDQENSLQDNRTSSDSPCWPGTGKGGMDGDGSGS 1610

  Fly  2474 SSG-GSGTESKKSSKDKDE----KRDKEKQLKKSKKEKKKSKDKE----------------KQKA 2517
            .|| |||:|...::....:    |||..:...:|::...:|||.|                |:..
Mouse  1611 GSGSGSGSEGPVANTRAPQFINLKRDPRQAAGRSQQTASESKDAESCRNGDKHAASAPPHNKEPL 1675

  Fly  2518 AVNVNSTSQIVDTKKKTTQPSKPDSK------------SSIAPVLVPPSLPVATANGKTKH---- 2566
            |..|....::...:|.:......||:            ||.|....|....|.|.|.:|.|
Mouse  1676 AEAVGGEGKLPSQEKSSCVEQNDDSEAAPNSSSVENLNSSQAEQANPSQEDVLTQNIETVHPFRR 1740

  Fly  2567 -----TAYNNVDQQQQQQMRRRTMSMCITPVTPTPVVTPSPLHGTPPSTKKRQTN---------- 2616
                 ::........|.:...:::|......:|......||:....|:.:..:::
Mouse  1741 GSAPTSSRFEGGNTCQSEFPSKSVSFTCRSSSPRASTNFSPMRPQQPNLQHLKSSPPGFPFPGPQ 1805

  Fly  2617 ---------FEQELTKPNSQILSSSILLNSSKGLGLPLAAPTVVSVPTAVQQQQHRKENNHQEAT 2672
                     |...|:.|          |....|.|.|...|.|...|..|..|..|..
Mouse  1806 NFPPQNMFGFPPHLSPP----------LLPPPGFGFPQNPPMVPWPPVHVPGQPQRMM------- 1853

  Fly  2673 PASGGPMSLAAAIASGK-------LNAISRRRESMCGSRQQQA----------------LIAAAL 2714
                ||:|.|:.....:       :....||.....|.:.||.                ..:..|
Mouse  1854 ----GPLSQASRYMGPQNFYQVKDIRRPERRHSDPWGRQDQQQPDRPFNRGKGDRQRFYSDSHHL 1914

  Fly  2715 KKEKKEK---------------------KKSKK-----KDREK---------------------- 2731
            |:|:.:|                     :|||:     ||:|:
Mouse  1915 KRERHDKDWEQESERHRHRDRSQERDRDRKSKEEAAAHKDKERPRLSHGDRAPDGKASRDGKSAD 1979

  Fly  2732 QKHDKQKG----KEKEREKDKEKDNKQKTNHIQK 2761
            :|.|:.||    |||||:|.|.|:.::......|
Mouse  1980 KKPDRPKGEDHEKEKERDKSKHKEGEKDRERYHK 2013

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
upSET	NP_001261819.1	PHD_MLL5	856..899	CDD:277025
upSET	NP_001261819.1	SET	<1221..1273	CDD:214614	7/53 (13%)
Phf3	NP_001074549.1	PHD_PHF3	697..747	CDD:277108	6/53 (11%)
		TFIIS_M	904..1017	CDD:369395	21/117 (18%)
		PHA03369	<983..1184	CDD:223061	34/217 (16%)
		SPOC	1181..1327	CDD:369497	28/160 (18%)
		SF-CC1	1916..>2025	CDD:273721	21/98 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030