Protein Alignment upSET and Setd1b

DIOPT Version :9

• Sequence 1: NP_001261819.1
• Gene: upSET / 39551
• FlyBaseID: FBgn0036398
• Length: 3146
• Species: Drosophila melanogaster
• Sequence 2: XP_006530300.1
• Gene: Setd1b / 208043
• MGIID: 2652820
• Length: 1986
• Species: Mus musculus
• Alignment Length: 2483
• Identity: 432/2483 - (17%)
• Similarity: 698/2483 - (28%)
• Gaps: 1005/2483 - (40%)

  Fly   889 NIPEEYMCELCQPRAVDKARARALQRQKRKEHM-----LLVATQAANGAAAVAAGTTLSGGL--- 945
            |:.|.::.::|: :..:......|...|.|:|:     :....:.|..|......|::.|.:
Mouse   112 NVRENFLRDMCK-KYGEVEEVEILYNPKTKKHLGIAKVVFATVRGAKEAVQHLHSTSVMGNIIHV 175

  Fly   946 ------------------GSGLP--------------MSEELQHRLASGL----NGGFATGTGMS 974
                              |...|              :||.||  |:..|    :|..:.|.|..
Mouse   176 ELDTKGETRMRFYELLVTGRYTPQTLPVGELDAISPIVSETLQ--LSDALKRLKDGSLSAGCGSG 238

  Fly   975 KKSKKTKENSGSTSTLKKTKKSAVGMGGEKNASGSGTP-TGSSGKTSKKSSKRKSKSGGDGSSGG 1038
              |.....|||.|...:.|..|:..: ...|:.|.||| |...|....:.|...|:.........
Mouse   239 --SSSVTPNSGGTPFSQDTAYSSCRL-DTPNSYGQGTPITPRLGTPFSQDSSYSSRQPTPSYLFS 300

  Fly  1039 GSSPALTAAEKHAANLRQWIENYEYAVTNHYSPELRARLHAIQKQPSLLQSIQNTENKALRQIQQ 1103
            ....|...|.:|.:   ::.:.|.....:||                    :.|:
Mouse   301 QDPTATFKARRHES---KFTDAYNRRHEHHY--------------------VHNS---------- 332

  Fly  1104 QLSTAGSAEQLEQRAQLIPYAGAKVLISSVDLSPHAPIHELRGKYMLTTQFRTQNPTVNMNTPPP 1168
              :.||:.         .|:.|:..|......|...|.           :.::|:.|...:||||
Mouse   333 --AVAGAT---------APFRGSSDLSFGTVGSSGTPF-----------KAQSQDATTFAHTPPP 375

  Fly  1169 ------SNYLNSFKAHKTP----------------------GQF---VFFYQLPGVEAPMQTL-- 1200
                  |.:.::|..::||                      |:|   .....||..|.|.:..
Mouse   376 AQTATASGFKSAFSPYQTPAPPFPPPPEEPTATAAFGSRDSGEFRRAPAPPPLPPAEPPAKEKPG 440

  Fly  1201 RPDGSVPQVAQQ-----PPSYLKGPEVC-------VDTRTYGNDARFVRRSCRPNAELQHYFEKG 1253
            .|.|..|..:..     .|::...||.|       :::...|.:        :|:..|....|.
Mouse   441 TPPGPPPPDSNSMELGGRPTFGWSPEPCDSPGTPTLESSPAGPE--------KPHDSLDSRIEM- 496

  Fly  1254 TLHLYIVALTHIRAQ---TEITIRHEPHDLTAVEQKKSHAAVIQPTSTRCACDMGSDCLFALPLA 1315
            .|......|..:|.|   |||.:...|        ..|.::.:.|.|     ..|::
Mouse   497 LLKEQRTKLPFLREQDSDTEIQMEGSP--------ISSSSSQLSPLS-----HFGTN-------- 540

  Fly  1316 VQQQLQAPPTQPRSSHRNKAAAAAAAAAAANSAAAIQLTMGLG---------------VGATVAA 1365
             .|.....|:.|.|...:......:.....:|.....|.:|||               :|.|...
Mouse   541 -SQPGFRGPSPPSSRPSSTGLEDISPTPLPDSDEDEDLGLGLGPRPPPEPGPPDPMGLLGQTAEV 604

  Fly  1366 GASV----LPNSRNRSTSSSGESSQMGLNSPQLGQLNLGFKTSVTATSLTAPVPGVHCNNSGGSS 1426
            ...:    .|.|.............|.::..::        .|...||...|.|.|....:|
Mouse   605 DLDLAGDRTPTSERMDEGQQSSGEDMEISDDEM--------PSAPITSADCPKPMVVTPGAG--- 658

  Fly  1427 SSSNNSCSVSMSSVLHDSGICTSSSSPSVSI---------------PSPTPTQMQSPTLQQHPQQ 1476
                   :|:..:||          :|::.:               |.|.|.....|.|...|..
Mouse   659 -------AVAAPNVL----------APNLPLPPPPGFPPLPPPPPPPPPQPGFPMPPPLPPPPPP 706

  Fly  1477 IPQQQLSLLQRSPTQQHQQQILAA---LPTPMLTPMLSPQLPK--PAQQ--QAHVV------LPQ 1528
            .|....::....|.       |.|   :|.|.:.|.|.|..|.  |..|  .:||:      :|.
Mouse   707 PPPAHPAVTVPPPP-------LPAPPGVPPPPILPPLPPFPPGLFPVMQVDMSHVLGGQWGGMPM 764

  Fly  1529 S--QQTSLLQQQQSQQSQEPLAVIAAAAAAQQPMATYFVRQP--------------QQQQQQQSP 1577
            |  .||.:|.:..:.|...|.....|||||.......||..|              :.|.....|
Mouse   765 SFQMQTQMLSRLMTGQGACPYPPFMAAAAAAASAGLQFVNLPPYRSPFSLSNSGPGRGQHWPPLP 829

  Fly  1578 K------PQALVAQQQH----------VVGAQQQQHFLQQQQKQQQQQMA-----DE-----ARM 1616
            |      |...:.:|:.          :|..::.:..:::...::..::.     ||     .||
Mouse   830 KFDPSVPPPGYIPRQEDPHKATVDGVLLVVLKELKAIMKRDLNRKMVEVVAFRAFDEWWDKKERM 894

  Fly  1617 AVSALQTLHAA---------PTSHIVS-------------------------PIKVAA--VQQQS 1645
            |.::|..:.:.         |...|.|                         .|::.:  |:::.
Mouse   895 AKASLTPVKSGEHKDEDRPKPKDRIASCLLESWGKGEGLGYEGLGLGIGLRGAIRLPSFKVKRKE 959

  Fly  1646 QPQQQQQNTHQQPHNQQAVQQQSNQLQQQQSQQPNYPQSPQRQQKPQPVQHQPQIVISTGAQAIP 1710
            .|........::.....:|.::..:.::::.:  :...:|....|..|.        |.|.:..|
Mouse   960 PPDTASSGDQKRLRPSTSVDEEDEESERERDR--DIADAPCELTKRDPK--------SVGVRRRP 1014

  Fly  1711 ATMPTKLSSPTKSAAPVISNNNITVSAQSSVVGGKKTPAKHPQQQQQQQQQPVTPVSAATAPAAT 1775
            . .|.:|.|                       ||           ::.:::.::..|:::|
Mouse  1015 G-RPLELDS-----------------------GG-----------EEDEKESLSASSSSSA---- 1040

  Fly  1776 PSSSESKEDDVSASSTTTPTTRTPAKDKPKQSREDRKLEAILRAIEKMEKQEARGKKDTRQSSGG 1840
             |||       |.||||:|:  :.|.||.::.||..:.|      |:.|::||..:::.     |
Mouse  1041 -SSS-------SGSSTTSPS--SSASDKEEEDRESTEEE------EEEEEEEAEEEEEE-----G 1084

  Fly  1841 KRQASNSPASPNKRNSSNSISEDVETPTSTNSAAAAAQRRNKKKRKVSRSLNNNTNGLGSGGGSN 1905
            .|...:||:|     ||:|..:|.:    .|.|
Mouse  1085 PRSRISSPSS-----SSSSDKDDED----DNEA-------------------------------- 1108

  Fly  1906 NKRRKSIVVESDGESHALTNSESEDQGQHPQSHHSGSEDQAAGLLLALAHNNSSPNEPFKSPLSQ 1970
                     :|||:    .:|:.:|||. |.|..|..:            |..|..|..:|
Mouse  1109 ---------DSDGQ----IDSDIDDQGA-PLSEASEKD------------NGDSEEEETES---- 1143

  Fly  1971 SHSLPATPASVSSACLLIEAAMGPLQQQPAPASASPSLAEFKYPPGGAKTKKSLMSSWFQQAEQQ 2035
                                    :....|||.:|.|.:|            |..||.|:.:.:.
Mouse  1144 ------------------------ITTSKAPAESSSSSSE------------SSGSSEFESSSES 1172

  Fly  2036 HASGLDSLVQAAMSEINGEREQLQRQPQGESLPAPALLKVEQFIHQAESTTAVPAREQLHLPLQN 2100
            .:|...|           |.|        |.:..|.:.:.|:...:.|..||:.|...:
Mouse  1173 ESSSSSS-----------EDE--------EEMTVPGVEEEEEEEEEEEKETAMAAATVV------ 1212

  Fly  2101 NSSVKKRWLRQAISEETTPVDELQQSQNQSVTATPSPQPVPTVSPLANGFSTPLKKRRLVVVSNG 2165
                       |::||:.|                                          .:.|
Mouse  1213 -----------AMAEESMP------------------------------------------PAGG 1224

  Fly  2166 TNVESDETHIDVIGEPKDEAEENVAMTELKVEIENHHQEQDDDVDILRSPSPGTHQIVAEDNLVK 2230
            .:.|.|...:.:  .|:....|::. ||.:|:|     |.:|:|..:::|              :
Mouse  1225 QDFEQDRAEVPL--GPRGPMRESLG-TEEEVDI-----EAEDEVPEMQAP--------------E 1267

  Fly  2231 IEPEDTSAAADDVKIDVEREESQACDKFEEMVKVKREEEEQREKEIKQLQERQEH---------- 2285
            :|.......|..::...|..|....:...:|  :...|...||.|..||....||
Mouse  1268 LEEPPLPMGARKLEGSPEPPEEPGPNTQGDM--LLSPELPARETEEAQLPSPPEHGPESDLDMEP 1330

  Fly  2286 EQPKVEPAPVEPKLENTVAKAEPKVEPSQEIVSKKEPTKVEPKPGESLLRSTATVTATPTAATIA 2350
            |.|.:...|::|.|........|...|        ||...||
Mouse  1331 EPPPMLSLPLQPPLPPPRLLRPPSPPP--------EPETPEP----------------------- 1364

  Fly  2351 ATTLLDVSKVAFKTRPPLKLEDEPQKKKPKLESILPA-----PVATVP--PVSVPPIPAASNATT 2408
                         .:||:.||..|:...|:...:..:     ...|||  |...||:..:|
Mouse  1365 -------------PKPPVPLEPPPEDHPPRTPGLCGSLAKSQSTETVPATPGGEPPLSGSS---- 1412

  Fly  2409 SAVTNTAAASLTTTTAPSSTKNLTEHDIQERLLSFHAANISYLQSRNKKATAALTSASPSQKSNS 2473
                  :..||::...|.|.                   .||                ||.....
Mouse  1413 ------SGLSLSSPQVPGSP-------------------FSY----------------PSPSPGL 1436

  Fly  2474 SSGGSGTESKKSSKDKDEKRDKEKQLKKSKKEKKKSKDKEKQKAAVNVNSTSQIVDTKKKTTQPS 2538
            ||||                                                          .|.
Mouse  1437 SSGG----------------------------------------------------------LPR 1443

  Fly  2539 KPDSKSSIAPVLVPPSLPVATANGKTKHTAYNNVDQQQQQQMRRRTMSMCITPVTPTPVVTPSPL 2603
            .|....|..|....||.|:                               :.||.|.|
Mouse  1444 TPGRDFSFTPTFPEPSGPL-------------------------------LLPVCPLP------- 1470

  Fly  2604 HGTPPSTKKRQTNFEQELTKPNSQILSSSILLNSSKGLGLPLAAPTVVSVPTAVQQQQHRKENNH 2668
                       |....|.|.|    |:|.:||.:...|.|||..|..:::|..|.:.|.|
Mouse  1471 -----------TGRRDERTGP----LASPVLLETGLPLPLPLPLPLPLALPVPVLRAQPR----- 1515

  Fly  2669 QEATPASGGPMSLAAAIASGKLNAISRRRESMCGSRQQQALIAAALKKEKKEKKKSKKKDREKQK 2733
                |....|..|.|.:|.             |         ...:|:
Mouse  1516 ----PPPQLPPLLPATLAP-------------C---------PTPIKR----------------- 1537

  Fly  2734 HDKQKGKEKEREKDKEKDNKQKTNHIQKPAHPTTVPANSM----PISAPAPVPVLVPTPVTTPKA 2794
                                       ||..|...|.:.:    |:..|.|.|.|....:..|..
Mouse  1538 ---------------------------KPGRPRRSPPSMLSLDGPLVRPPPGPALGRDLLLLPGQ 1575

  Fly  2795 APIPVLITQPTPSPIHVTQPLVNNCSTKVASLPFYNTIYGKLQDPSTPTSSPIPVTNTMPSLAEY 2859
            .|.|:..:...|               :..:|.|.||     ..|:.|  .|:|.....|.....
Mouse  1576 PPAPIFPSAHDP---------------RAVTLDFRNT-----GIPAPP--PPLPPQPPPPPPPPP 1618

  Fly  2860 LESTKSKTTALSAVKPIGIAAVTPLSSAITPAKVAPSSLEMPPPATTPLKLYTRTASHDPRLNPM 2924
            :||||.....|....|         |.||.|.          |......:.|...|.
Mouse  1619 VESTKLPFKELDNQWP---------SEAIPPG----------PRRDEVTEEYVDLAK-------- 1656

  Fly  2925 LTVPDPTPMPKRKLSISEYRMRHRPSVDTAPTTPTTPTTPTTPTTPPGSNKDRSFAKPQTI---- 2985
              |..|...|.:|        ||...|  ||:....|:.|.....|      ||..:..||
Mouse  1657 --VRGPWRRPPKK--------RHEDLV--APSASPEPSPPQPLFRP------RSEFEEMTILYDI 1703

  Fly  2986 -NKCSLQSPERFQAAIRERRNSISAHHPQQNAHHNLNNNKGGISNKSGSSSGNHLQQALGV---A 3046
             |....:...||.....||...      |.|....||:........:..||....::..|:   .
Mouse  1704 WNGGIDEEDIRFLCVTYERLLQ------QDNGMDWLNDTLWVYHPSTSLSSAKKKKREDGIREHV 1762

  Fly  3047 GGRLQSKNAIVDPAATTLSTVNSILSTAQKLHMFDDKPKGGHFNAAP-TLLEQQQEKMSERSRCL 3110
            .|..:|:..........|..:||..::..:..|  |..:|....|.| .......|:.||:.|.|
Mouse  1763 TGCARSEGFYTIDKKDKLRYLNSSRASTDEPPM--DTQQGMSIPAQPHASTRAGSERRSEQRRLL 1825

  Fly  3111 QR-TISCDSRVIE 3122
            .. |.||||.:::
Mouse  1826 SSFTGSCDSDLLK 1838

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
upSET	NP_001261819.1	PHD_MLL5	856..899	CDD:277025	2/9 (22%)
		SET	<1221..1273	CDD:214614	13/61 (21%)
Setd1b	XP_006530300.1	RRM_Set1B	100..192	CDD:240993	11/80 (14%)
		N-SET	1698..1841	CDD:371711	34/149 (23%)
		SET_SETD1	1835..1982	CDD:380946	0/4 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030