DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment upSET and Ash1l

DIOPT Version :9

Sequence 1:NP_001261819.1 Gene:upSET / 39551 FlyBaseID:FBgn0036398 Length:3146 Species:Drosophila melanogaster
Sequence 2:NP_619620.3 Gene:Ash1l / 192195 MGIID:2183158 Length:2958 Species:Mus musculus


Alignment Length:1971 Identity:370/1971 - (18%)
Similarity:625/1971 - (31%) Gaps:671/1971 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly  1548 AVIAAAAAAQQPMATYFVRQPQQQQQQQSPKPQALV-AQQQHVVGAQQQQHFLQQQQKQQQQQMA 1611
            |.|..|...:.|      |:..:::..::.|..... ||||..|   ::.:|.:...|.:....|
Mouse    37 AEIEGATEEEDP------RKRNRERGTEAGKEDGSTDAQQQFSV---KETNFSEGNLKLKIGLQA 92

  Fly  1612 DEARMAVSALQTLHAAPTSHIVSPIKVAAVQQQSQPQQQQQNTH-----------QQPHNQQAVQ 1665
            ...:.....|:.....|.  |.:.||.:....:|.....::|.|           ::..:..|:.
Mouse    93 KRTKKPPKNLENYVCRPA--IKTTIKHSRKALKSGKMTDEKNEHCPSKWDSSKLFKKAGDATAID 155

  Fly  1666 QQSNQLQQQQSQQPNYP----QSPQRQQKPQPVQHQPQIVISTG-------------------AQ 1707
            .|:.:.....||..:.|    .||...|....:...|.:|.|..                   ||
Mouse   156 CQAEESIHLHSQGESNPLSKKLSPVHSQMADYISAAPSLVGSRDPDIKDRALLNGGTSVTEKLAQ 220

  Fly  1708 AIPATMPTKLSSPTK------------------------SAAPVISNNNITVSAQSSVVG-GKKT 1747
            .| ||.|...||..|                        |.|.:|..:.|...|.|:.|| ..|.
Mouse   221 LI-ATCPPSKSSKAKPKKLGTGTTVGLVSKDLIRKPGVGSIAGIIHKDLIKKPALSTAVGLVTKD 284

  Fly  1748 PAKHPQQQQQQQQQPVTPVSAATAPAATPSSSESKEDDVSASSTTTPTTRTPAKDKPKQSREDRK 1812
            |.|.|.            .:||....        .:|.|....|.| |.....||..|:      
Mouse   285 PGKKPM------------FNAAVGLI--------NKDSVKKLGTGT-TAVFINKDLGKK------ 322

  Fly  1813 LEAILRAIEKMEKQEARGKK--------DTRQSSGGKRQASNSPASPNKR------NSSNSISED 1863
             ...:..:..:.|:.  |||        ...:.||.|..........||.      ::...:::|
Mouse   323 -PGAITTVGLLSKES--GKKLGIGIVPGLVNKESGKKLGLGTVVGLVNKELGKKLSSTVGLVAKD 384

  Fly  1864 VETPTSTNSAAAAAQRRNKKKRKVSRSLNNNTNG-LGSGGGSNNKRRKSIVVESDGESHALTNSE 1927
            |......:||.....:...||     .||....| |||....|.|....:..:...::....|..
Mouse   385 VTKKIVASSAMGLVNKDIGKK-----LLNCPMAGQLGSKDALNLKSEALLPTQEQLKASCSANIS 444

  Fly  1928 SEDQGQHPQSHHSGSEDQAAGLLL---ALAHNNSSPNEPFKSPLSQSHSLPATPASVSSACLLIE 1989
            :.|..:.|:|    .:|.|.|...   .:.|:..|..|.|               ||......:|
Mouse   445 NHDSQELPES----LKDSATGKAFEKSVMRHSKESMLEKF---------------SVRKEITNLE 490

  Fly  1990 AAM---GPLQQQPAPASASPSLAEF----KYPP----------GG---AKTKKSLMSSWFQQAEQ 2034
            ..|   |...||...:|:.....|.    |.||          ||   |.|.||..|        
Mouse   491 KEMFNEGTCIQQDNFSSSERGAFETSKHEKQPPVYCTSPDFQIGGASDASTAKSPFS-------- 547

  Fly  2035 QHASGLDSLVQAAMS-EINGEREQLQRQP---QGESLPAPALLK--VEQFIHQAEST-----TAV 2088
              |.|..:|..::.: .:|    .:.|.|   ..:.:|.|.||.  .||....:||.     || 
Mouse   548 --AVGESNLPSSSPTVSVN----PVTRSPPEASSQLVPNPLLLNSTAEQMEEISESIGKSQFTA- 605

  Fly  2089 PAREQLHLPLQNNSSVKKRWLRQAISEETTPVD-ELQQSQN---------------QSVTA---- 2133
               |..||      :|..|.|..::|.|...:| ||.:|:|               .|:|:    
Mouse   606 ---ESTHL------NVGHRSLGHSLSIECKGIDKELNESKNTHLDIPRISSSLGKKPSLTSDSGI 661

  Fly  2134 ---TPS----------------------PQPVPTVSPLANGF-STPLKKRR------LVVVSNGT 2166
               |||                      .:.......|::.| |.|||||:      ..||:..|
Mouse   662 HAITPSVVNFTSLFSNKPFLKLGAVTAPDKHCQVAESLSSSFQSKPLKKRKGRKPRWTKVVARST 726

  Fly  2167 NVESDETHIDVIGEPKDEAEENVAMTELKVEIENHHQEQDDDVDILRSPSP-------GTHQIVA 2224
            ........::     :.|..:||:.:.|.                 .|..|       |....|.
Mouse   727 CRSPKGLDLE-----RSELFKNVSCSSLS-----------------NSSEPAKFMKTIGASSFVD 769

  Fly  2225 EDNLVKIEPEDTSAAADDVKIDVEREE------------SQAC---DKFEEMVKVKREEEEQREK 2274
            .|.|.:..|:.:.::|..:.:..:.|:            |..|   |...::.|.||  ...:.|
Mouse   770 HDFLKRRLPKLSKSSAPSLALLTDSEKPSHKSFITHKLSSSMCVTSDLLSDIYKPKR--GRPKSK 832

  Fly  2275 EIKQLQERQEHEQPKVE---PAPVEPKLENTVAKAEPKVEPSQEIVSKKEPTKVEPKPGESLLRS 2336
            |:.||:     ..||..   ||.....|::...:..|.::|..||.|.|:...|.|.|       
Mouse   833 EMPQLE-----GPPKRTLKIPASKVFSLQSKEEQEPPILQPEIEIPSFKQSLSVSPFP------- 885

  Fly  2337 TATVTATPTAATIAATTLLDVSKVAFKTRPPLKLEDEPQKKKPKLESILPAPVATVPPV-SVPPI 2400
                                                   ||:.:.:..:.:||...||| ||.|.
Mouse   886 ---------------------------------------KKRGRPKRQMRSPVKMKPPVLSVAPF 911

  Fly  2401 PAASNATTSAVTNTAAASLTTTTAPSSTKNLTEHDIQERLLSFHAANISYLQSRNKKATAALTSA 2465
            .|                   |.:||..::.:|:         |.::..:.:|.::     |...
Mouse   912 VA-------------------TESPSKLESESEN---------HRSSSDFFESEDQ-----LQDT 943

  Fly  2466 SPSQKSNSSSGGSGTESKKSSKDKDEKRDKEKQLKKSKKEKKKSKDKEKQKAAVNVNSTSQIVDT 2530
            .....|:..|..|.::.:.....|..||:..:.:|...::..|.|.. |:|..:|...:|.:..:
Mouse   944 DDLDDSHRQSVCSMSDLEMEPDKKISKRNNGQLMKTIIRKINKMKTL-KRKKLLNQILSSSVESS 1007

  Fly  2531 KKKTTQPSKPDSKSSIAP-----------VLVPPSLPVATANGKTKHTAYNN----------VDQ 2574
            .|...|....::.||:|.           |....::.:....|:...|..|.          |.:
Mouse  1008 NKGKVQSKLHNTVSSLAATFGSKLGQQINVSKKGTIYIGKRRGRKPKTVLNGLLSGSPASLAVLE 1072

  Fly  2575 QQQQQMRRRTMSMCITPVTPTPV----VTPSPLHGTPPSTKKRQTNFEQE--LTKPNS------- 2626
            |..||.....:...:.|:.|:|.    :.|||:......|...|:....:  ..:|:|       
Mouse  1073 QTAQQAAGSALGQILPPLLPSPASSSEILPSPICSQSSGTSGGQSPVSSDAGFVEPSSVPYLHVH 1137

  Fly  2627 ----QILSSSILLNSSKGLGLPLAAPTVV-SVPTAVQQQQHRKE-------NNHQEAT-PASGGP 2678
                .::.:..:..:||| ...|:.||:: :.|:.:.:....||       .:|.:.| |:..| 
Mouse  1138 SRQGSMIQTLAMKKASKG-RRRLSPPTLLPNSPSHLSELTSLKEATPSPVSESHSDETIPSDSG- 1200

  Fly  2679 MSLAAAIASGKLNAISRRRESMCGSRQQQ-------------ALIAAALKKEKKEKKKSKKKDRE 2730
                  |.:.. |:.|.|.|..||.::::             :.:..:||  :|.|.|.|::..:
Mouse  1201 ------IGTDN-NSTSDRAEKFCGQKKRRHSFEHISLIPPETSTVLNSLK--EKHKHKCKRRSHD 1256

  Fly  2731 KQKHDKQK-GKEKEREKDKEKDNKQ----------------------KTNH-IQKPAHPTTVPAN 2771
            ...:||.| .|.|.::|..:..|:|                      :::| |.:...||....|
Mouse  1257 YLSYDKMKRQKRKRKKKYPQLRNRQDPDFIAELEELISRLSEIRITHRSHHFIPRDLLPTIFRIN 1321

  Fly  2772 --------SMPISAPAPVPVLVPTPVTTPKAAPIPVLITQPTPSPIHVTQPLVNNCSTKVASLPF 2828
                    |.|:.   |:..:....:...:..|       |.........|.:::.|..::|..|
Mouse  1322 FNSFYTHPSFPLD---PLHYIRKPDLKKKRGRP-------PKMREAMAEMPFMHSLSFPLSSTGF 1376

  Fly  2829 YNTIYGKLQDPSTPTSSPIPVTNTMPSLAEYLESTKSKTTALSAVKPIGIAAVTPLSSAITPAKV 2893
            |.: ||....||..|::                             |||:.........:.|...
Mouse  1377 YPS-YGMPYSPSPLTAA-----------------------------PIGLGYYGRYPPTLYPPPP 1411

  Fly  2894 APS-SLEMPPPA--------TTPLKLYTR-----------TASHDPRLNPMLTVPDPTP------ 2932
            :|| :..:|||:        ..|.|.:.:           |.|..|.|: |.|.|...|      
Mouse  1412 SPSFTTPLPPPSYMHAGHLLLNPTKYHKKKHKLLRQEAFLTTSRTPLLS-MSTYPSVPPEMAYGW 1475

  Fly  2933 ------------------MPKRKL----------SISEYRM-------------RHR-------- 2948
                              .|:..:          |:..||.             :||        
Mouse  1476 MVEHKHRHRHKHREHRSEQPQVSMDSGSSRSVLESLKRYRFGKDTVGDRYKHKEKHRCHMSCPHL 1540

  Fly  2949 -----------------PS--------------VDTAPTTPTTPTTPTTPTTPPGSNKDRSFAKP 2982
                             ||              :|.:.::|:......||.:.|.|:.:......
Mouse  1541 SPSKNLINREEQWVSREPSESSSLALGLQTPLQIDCSESSPSLSLGGFTPNSEPASSDEHMNLFT 1605

  Fly  2983 QTINKCSLQSPERFQAAIRERRNSISAHHPQQNAHHN-------LNNNKGGISNKSGSSSGN--- 3037
            ..|..|.:.:|   .::.|::........|.|:...|       |.:::..|.:.:||.|.:   
Mouse  1606 SAIGSCRVSNP---NSSCRKKLTDSPGLFPVQDTALNRPHRKEPLPSSERAIQSLAGSQSASDKP 1667

  Fly  3038 --HLQQALGVAGGRLQSKNAIVDPAATTLSTVNSILSTAQKL-HMFDDKPKGGHFNAAPTLLEQ- 3098
              ...::...:..|.:|.      :.:|.||||.:.|.:.:| ...||        :..:||:: 
Mouse  1668 SQRSSESTNCSPTRKRSS------SESTSSTVNGVPSRSPRLVASMDD--------SVDSLLQRI 1718

  Fly  3099 ----QQEKMSERSRCLQRTIS 3115
                :||.|.:.......|:|
Mouse  1719 VHHDEQESMEKNGDASITTVS 1739

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
upSETNP_001261819.1 PHD_MLL5 856..899 CDD:277025
SET <1221..1273 CDD:214614
Ash1lNP_619620.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..78 11/49 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 116..137 4/20 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 505..580 18/88 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 823..843 8/26 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 877..963 24/164 (15%)
motB <1061..1187 CDD:183756 23/126 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1094..1126 6/31 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1149..1219 20/78 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1243..1279 11/37 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1579..1599 5/19 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1613..1704 18/99 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1722..1754 5/18 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1921..1941
Catalytic domain. /evidence=ECO:0000250 2059..2278
AWS 2082..2133 CDD:197795
SET_ASH1L 2136..2276 CDD:380951
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2278..2334
Bromo_ASH1 2432..2537 CDD:99955
PHD_ASH1L 2575..2617 CDD:277023
BAH_polybromo 2654..2788 CDD:240068
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2814..2846
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2861..2909
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
22.030

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