DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment upSET and set-12

DIOPT Version :9

Sequence 1:	NP_001261819.1	Gene:	upSET / 39551	FlyBaseID:	FBgn0036398	Length:	3146	Species:	Drosophila melanogaster
Sequence 2:	NP_509306.2	Gene:	set-12 / 187229	WormBaseID:	WBGene00019584	Length:	389	Species:	Caenorhabditis elegans

Alignment Length:	514	Identity:	91/514 - (17%)
Similarity:	135/514 - (26%)	Gaps:	238/514 - (46%)

- Green bases have known domain annotations that are detailed below.

  Fly  2608 PSTKKRQTNFEQELTK---------------PNSQILSSSILLNSSKGLGLPLAAPTVVSVPTAV 2657
            |.| :..||.:.:|||               ||::.:..|.:.:..:..||    .||.|.....
Worm     2 PGT-RASTNKKTQLTKKNNSVFVYNTDPKFFPNTRRMDYSFICSPKRKTGL----LTVTSCKCGT 61

  Fly  2658 QQQQHRKEN--NHQEATPAS-------------------------GGPMSLAAAIASGKLNAISR 2695
            ........|  ||:|.....                         |..:.....||:||| .:..
Worm    62 DCTTEECSNFANHRECPRGCSNCENQRFRKRQFCGVETFLTDNGIGHGLRATEEIATGKL-ILEY 125

  Fly  2696 RRESMCGSRQQQALIAAALKKEKKEKKKSKKKDREKQKHDKQKGKEKEREKDKEKDNKQKTNHIQ 2760
            |.|             |..|.|..::.|..|||..|..:..:.|:....:..::.::.:..||..
Worm   126 RGE-------------AITKAEHNKRVKRYKKDGIKHSYSFEVGRNYYVDPTRKGNSARFINHSC 177

  Fly  2761 KPAHPTTVPANSMPISAPAPVPVLVPTPVTTPKAAPIPVLITQPTPSPIHVTQPLVNNCSTKVAS 2825
            .|                                                       |...||.:
Worm   178 NP-------------------------------------------------------NALVKVWT 187

  Fly  2826 LPFYNTIYGKLQDPSTPTSSPIPVTNTMPSLAEYLESTKSKTTALSAVKPIGIAAVTPLSSAIT- 2889
            :|                      ...|.||..:         |...:||         ...||
Worm   188 VP----------------------DRPMKSLGIF---------ASKVIKP---------GEEITF 212

  Fly  2890 ----------PAKVA----------PSSLEMPPPATTPLKLYTRTASHDPRLNPMLTVPDPT--- 2931
                      |.:..          ||:.|:|...:..||...|....||      |.|..|
Worm   213 DYGTSFRNDQPCQCGEAACRGWIGKPSTSEVPKDVSKELKKRGRKPKMDP------TAPISTTST 271

  Fly  2932 ------------PMPKRKLSISEYRMRHRPSVDTAPTTPTTPTTPTTPTTPPGSN--KDRSFAKP 2982
                        |:||.:      |.|.|   .|..|.|....|.|...:||..|  :|:...||
Worm   272 GGGDKGKLSGTIPVPKSR------RGRKR---KTDVTAPVPLATKTKRHSPPAENESEDKENVKP 327

  Fly  2983 QTINKCSLQSPERFQAAIRERRNSISAHHPQQNAHHNLNN----NKGGISNKSGSSSGN 3037
            .:....:                         ||.:||.|    |:.|:.::..|..||
Worm   328 PSEEDIT-------------------------NAMNNLLNKTYDNQNGVLDECRSIMGN 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
upSET	NP_001261819.1	PHD_MLL5	856..899	CDD:277025
upSET	NP_001261819.1	SET	<1221..1273	CDD:214614
set-12	NP_509306.2	AWS	53..94	CDD:197795	7/40 (18%)
set-12	NP_509306.2	SET	97..221	CDD:214614	32/232 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030