DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment upSET and Y73B3A.1

DIOPT Version :9

Sequence 1:	NP_001261819.1	Gene:	upSET / 39551	FlyBaseID:	FBgn0036398	Length:	3146	Species:	Drosophila melanogaster
Sequence 2:	NP_508081.2	Gene:	Y73B3A.1 / 180384	WormBaseID:	WBGene00022203	Length:	613	Species:	Caenorhabditis elegans

Alignment Length:	957	Identity:	180/957 - (18%)
Similarity:	273/957 - (28%)	Gaps:	398/957 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly  1583 VAQQQHVVGAQQQQHFLQQQQKQQQQQMADEARMAVSALQTLHAAPTSHIVSPIKVAAVQQQSQP 1647
            :|..:|.:.|.::. |.|...:|||.::|:...||...:|.:                    |:.
Worm     1 MADGEHTLPADEEL-FEQPPPQQQQPEIAEPIVMAQEPIQGV--------------------SED 44

  Fly  1648 QQQQQNTHQQPHNQQAVQQQSNQLQQQQSQQPNYPQSPQRQQKPQPVQHQPQIVISTGAQAIPAT 1712
            .|..:.||:.|.|.....|..||...|:      ||.|:.||.||....||...
Worm    45 PQASEATHEAPDNYPVDHQMENQEFYQE------PQIPEPQQIPQISVFQPAAY----------- 92

  Fly  1713 MPTKLSSPTKSAAPVISNNNITVSAQSSVVGGKKTPAKHPQQQQQQQQQPVTPVSAATAPAATPS 1777
                  :|:...||....||....|.:..         .|..:::|        .||..|.|..:
Worm    93 ------NPSNYVAPQQRANNFGEPAAADA---------RPLTEEEQ--------LAAEGPTADTA 134

  Fly  1778 SSESKED-DVSASSTTTPTTRTPAKDKPKQSREDRKLEAILRAIEKMEKQEARGKKDTRQSSGGK 1841
            ..:|.:| ||.                          ||||||...:...:
Worm   135 WIDSDDDTDVE--------------------------EAILRANFWLPYSD-------------- 159

  Fly  1842 RQASNSPASPNKRNSSNSISEDVETPTSTNSAAAAAQRRNKKKRKVSRSLNNNTNGLGSGGGSNN 1906
              .:..|..|..|         :..||.......|                    ||
Worm   160 --HNYDPPDPADR---------IILPTEGPFPCIA--------------------GL-------- 185

  Fly  1907 KRRKSIVVESDGESHALTNSESEDQGQHPQSHHSGSEDQAAGLLLALAHNNSSPNEPFKSPLSQS 1971
                      |.:.:.:.....||                       |....||...::......
Worm   186 ----------DEDCNIVKQWMPED-----------------------AVGPGSPGTQYRRNQQTG 217

  Fly  1972 HSLPATPASVSSACLLIEAAMGPLQQQPAPASAS----PSLAEFKYPPGGAKTKKSLMSSWFQQA 2032
            ..||:|             ::.| |||..|...:    |.:|...:..||            .|.
Worm   218 GGLPST-------------SVAP-QQQQLPVRHNIQNRPMVAAQPFSIGG------------NQV 256

  Fly  2033 EQQHASGLDSLVQAAMSEINGEREQLQRQPQ-------GESLPAPALLKVEQFIHQAESTTAVPA 2090
            |.....|:||.:|        :|..::..||       |..||...     |....:.:..|..|
Worm   257 EYGGIGGMDSRMQ--------QRGVVRDGPQYRVMNDFGNGLPMRG-----QLPRNSPAANATAA 308

  Fly  2091 REQLHLPLQNNSSVKKRWLRQAISEETTPVDELQQSQNQSVTATPSPQPVP---------TVSPL 2146
            ||                                   :....:.|:|.|.|         |..|.
Worm   309 RE-----------------------------------DAPEASIPAPAPSPPASRRSVSRTTQPS 338

  Fly  2147 ANGFSTPL-------KKRRLVVVSNGTNVESDETHIDVIGEPKDE---AEENVAMTELKVEI--- 2198
            .:.|:||.       :|||:|                   .||.|   :.:.|..||.|.:.
Worm   339 TSSFATPTEPPAKNQRKRRVV-------------------PPKSEPVLSAKRVRATEAKKKAVEK 384

  Fly  2199 --ENHHQEQDDDVDILRSPSPGTHQIVAEDNLVKIEPEDTSAAADDVKIDVEREESQACDKFEEM 2261
              |...:||       |.|:                                  ||....|.|:.
Worm   385 VKEKEKKEQ-------RKPN----------------------------------ESGPAPKSEKA 408

  Fly  2262 VKVKREEEEQREKEIKQLQERQEHEQPKVEPAPVEPKLENT--VAKAEPKVEPSQEIVSKKEPTK 2324
            |:   :.||:.||:.|..|      :|..:|...:|.|:.|  |...|.:...|....|...|.|
Worm   409 VE---KAEEKVEKKPKSPQ------KPPAKPTAQKPPLKKTEEVDGIEREASESSSKKSSVAPEK 464

  Fly  2325 VEPKP-------GESLLRSTATVTATPTAAT----IAATTLLDVSKVAFKTRPPLKLEDEPQKKK 2378
            ..||.       ..|..:..|...:||.|.|    |.:|...|:..|.....|   |:|.
Worm   465 KNPKKIAFVEYNSRSSRKRKAGECSTPPAVTRRGFIPSTEGEDLENVELSVIP---LDDH----- 521

  Fly  2379 PKLESILPAPVATVPPVSVPPIPAASNATTSAVTNTAAASLTTTTAPSSTKNL-TEH--DIQERL 2440
              |.|...||..|:    .|.:..|...|:..|.:.:..|.|...|..|..:. .||  .:|.|:
Worm   522 --LSSSNTAPTTTI----APSVGGAPKPTSVVVKSPSTRSRTRGAASQSVDDAPAEHSMSLQGRV 580

  Fly  2441 LSFHAANISYLQSRNKKATAALTSASPSQKSNSSSGGSGTESKKSSK 2487
            |:...:.:.                :|.....:|:..:...|::|::
Worm   581 LTMFGSTVD----------------APPPPPPASAETNSRRSRRSTR 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
upSET	NP_001261819.1	PHD_MLL5	856..899	CDD:277025
upSET	NP_001261819.1	SET	<1221..1273	CDD:214614
Y73B3A.1	NP_508081.2	PRK03427	<9..>132	CDD:235124	40/183 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1844
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900