DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment upSET and set-9

DIOPT Version :9

Sequence 1:	NP_001261819.1	Gene:	upSET / 39551	FlyBaseID:	FBgn0036398	Length:	3146	Species:	Drosophila melanogaster
Sequence 2:	NP_001379880.1	Gene:	set-9 / 177196	WormBaseID:	WBGene00017482	Length:	1623	Species:	Caenorhabditis elegans

Alignment Length:	2044	Identity:	373/2044 - (18%)
Similarity:	647/2044 - (31%)	Gaps:	735/2044 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   136 PPHNSKLLLSNLTVLSKQAPVQGAA------------------GQQQQQLNYLGAKSLP------ 176
            ||...:..::...|:: |.|:||.:                  ..|.:...:.....:|
Worm    19 PPQQQQPEIAEPIVMA-QEPIQGVSEDPQASEATHEAPDNYPVDHQMENQEFYHEPQIPEPQQIP 82

  Fly   177 ---------YVSASPAKTQQQPQKFGSISAFKAQ---HQQQQQHPHATLQKVTLGSRVATRLQ-- 227
                     |...:....||:...||..:|..|:   .|:|......|...|.:.|...|.::
Worm    83 QIPVFQPAAYNPPNYVAPQQRANNFGEPAAADARPLTEQEQLAAERPTEDTVWIDSDDDTDVEEA 147

  Fly   228 -------------SYVPASPSQIMVQPAQPKYVNATA--------------TTIG-GNAALLKKA 264
                         :|.|..|:..::.|.:..:.....              ..:| |:.....:.
Worm   148 ILRANFWLPYSDHNYDPPDPADRIILPTEGPFPCIAGLDEDCNIVKQWMPEDAVGPGSPGTQYRR 212

  Fly   265 NQKI--TVKSVSNMSQQQQ--QQQQQQQQQLLQAQQLKT---------FITQQQQQQTYKAGAKA 316
            ||:.  .:.|.|..|||||  .:...|.:.::.||....         ..::.||:...:.|.:.
Worm   213 NQQAGGGLPSTSVASQQQQLPVRHNIQNRPMVAAQPFSIGGNQVEYGGMDSRMQQRGVVRDGPQY 277

  Fly   317 KFV---------------KQTTALSIAALPQQQQQTTY----AKQSMVTTSTPAKVTKLNSKYVQ 362
            :.:               :.:.|.:.....::|||..|    |:.|:...:.||........|..
Worm   278 RVMNDFGNGLPMRGLLPPRNSPAANAINRAREQQQQMYHQAGARGSLQQRAAPAPADPTPGSYQH 342

  Fly   363 QQISLPQG-----TQLQHKASPNVTGGGYLLQQSQ--------------------AAVGGTIKFV 402
            ...::|.|     .::..:|.|.:.||.....:::                    ||....:..|
Worm   343 IVNAVPGGGANPMRRVPPQARPGMIGGAANNNRARPTHVTRPMDTQEFEHPVAPAAAPPHRVVDV 407

  Fly   403 NSHGTVIQQHPQQQQATKR---THYNSSGSSDN------EQHAVANS-----SLITDDVMIVNGT 453
            ..|....:|..:.||..::   ..:.::.:..:      :|...|:|     |:..:|::    .
Worm   408 APHRMTPEQRQELQQMNRQRAAPQFPAAAAQRSAEVIVIQQRPGASSRAPRPSMAQEDLL----R 468

  Fly   454 QMTDELSARILQSMAQKSFSQQQRFHQVPATGSGNMP-P------PTQIIYSNSTSNGAAASSP- 510
            ..|..||.|:.|. .|....:.:|| ||..|.:.:.| |      |.|:...:.....|||::|
Worm   469 SPTRRLSERVPQE-HQTPVLEPRRF-QVKVTDTYSTPIPKASDQLPAQLTEEDPPEESAAAAAPE 531

  Fly   511 -----GGNASGNMLL--------------AHYQAAGT---KPVSSASFITVTGTPPVTVATTPSV 553
                 .......::|              ||:....|   ||.||.|.:.....||......|.:
Worm   532 DVPDAAPEDPPKVILKPTPPHRMTQEEKNAHFARLTTDKEKPTSSTSILPQDAAPPHVPPPPPPL 596

  Fly   554 SISSHGFASGSAAISSYM----------------------------------SSATAARRQSVSA 584
            .:..|......|.:.|..                                  .|:.|||:::||.
Worm   597 VLRPHHQDETLAMVQSVFESKPRQPDTPKDKETISKIADLLRFSADEFTGQSGSSAAARQRTVSG 661

  Fly   585 PSSRAVSLERKQHHQQLQ--HDVIGGGRKAPTVIEYYNKHGVNSIVGSSNNLAQSNSMSNLAGPR 647
            .::||.:.:  .||||.|  |.:....||.|:...|      ::::|
Worm   662 SAARAQTYQ--MHHQQQQHHHQMPMDQRKRPSSGRY------DALMG------------------ 700

  Fly   648 SNSGSGFATTTPTPATPLHLTPVNVPVHVEAAPPSSPALVKGSSQPPAQPQQQQQQAH-PLGPNQ 711
                          |.||...|          ||           ||:|.|.....|| |.|
Worm   701 --------------AMPLQQQP----------PP-----------PPSQFQHTDSIAHRPRG--- 727

  Fly   712 LNANDEELYIEEVRPVPVLTQDLRLQQLHAIMQDHTYASQQQQQQPQQAAGDTTNPGAAQQVQQP 776
                         ||.......:.:                   |||::.|..|.|..||
Worm   728 -------------RPKGTRHPSVAV-------------------QPQRSGGARTLPPRAQ----- 755

  Fly   777 QQWSLGGIGVTVSGSQGTPTAVGGYCSYFGQQIARSQADDDAHSAISSSSRMGLASTDIDPGEET 841
                                                        .::.|:|.|..:.:.|  .|:
Worm   756 --------------------------------------------TVAMSARNGANAKNSD--SES 774

  Fly   842 ETAPEAEAEDDSVTRCICELTHDDGYMICCDKCSAWQHVDCMGIDRQNIPEEYMCELCQPRAVDK 906
            |...|| ||:....||.|.:.|.||..|.|:.|..|||:.|||:..::...:|.||:|.||.:..
Worm   775 EGIDEA-AEESWTMRCHCGMDHGDGDTIECEGCKTWQHMACMGLTLKSNTSKYKCEMCLPRRLPV 838

  Fly   907 ARARALQRQKRKEHMLLVATQAANGAAAVAAGTTLSGGLGSGLPMSEELQHRLASGLNGGFATGT 971
            ::|.|.:.|:|                                     :.:||.:.
Worm   839 SKAEAAREQER-------------------------------------ILNRLRAA--------- 857

  Fly   972 GMSKKSKKTKENSGSTSTLKKTKKSAVGMGGEKNASGSGTPTGSSGKTSKKSSKRKSKSGGDGSS 1036
              ::|.|:..|                             |.....|:|:.|:.|||
Worm   858 --ARKQKRKSE-----------------------------PVEQKQKSSQPSTSRKS-------- 883

  Fly  1037 GGGSSPAL-TAAEKHAANLRQWIENYEYAVTNHYSPELRARLHAIQKQ--PSLLQSIQNTENKAL 1098
               :..|| ..||...|.|            |.||.:..|.|..:::.  ...|.:......||.
Worm   884 ---APMALQQPAEPRVAQL------------NDYSKQASALLFGMEQTAGADTLLAESRLHKKAR 933

  Fly  1099 RQIQQQLSTAGSAEQLEQRAQLIPYAGAKVLISSVDLSPHAPIHELRGKYMLTTQFRTQNPTVNM 1163
            |...::...|.....|.|..|:                    |.|:.|...::::.:.|
Worm   934 RMFVEEAVEALVTTDLVQIRQV--------------------ILEVNGHVSMSSEVKRQ------ 972

  Fly  1164 NTPPPSNYLNSFKAHKTPGQFVFFYQLPGVEAPMQTLRPDGSVPQVAQQPPSYLKGPE-VCVDTR 1227
                |..           |..:|.|              ||.:...|.:...  .|.| ||:||:
Worm   973 ----PGG-----------GNCIFMY--------------DGLMKGTAGEDMG--DGQELVCIDTK 1006

  Fly  1228 TYGNDARFVRRSCRPNAELQHYF-EKGTLHLYIVALTHIRAQTEITIRHEPHDLTAVEQKKSHAA 1291
            ..|||.:|.||||.||..|:|.. ...||.:.|||...|...||:|:   |.|   .:.::|...
Worm  1007 RKGNDTKFTRRSCVPNCVLKHVLGSNATLGIMIVATKDITRNTEVTL---PFD---ADWRESEVE 1065

  Fly  1292 VIQPTSTRCACDMGSDCLFALPLAVQQQLQAPPTQPRSSHRNKAAAAA----------------- 1339
            :      .||..|..  |.|.|...:::..|........|:.:.|..|
Worm  1066 L------ECAEHMKE--LQACPFESERRRFAAERHRAMDHKKQEAEEARRADEERRRLEEEVRRE 1122

  Fly  1340 ----------AAAAAANSAAAIQLTMGLGVGATVAAGASVLPNSRNRSTSSS----GESSQMGLN 1390
                      |..|...:..|.:..........:.|.|:..|.|.|..|:..    .::.:|...
Worm  1123 RAAKTKQMDEAEKARLEAEKAAEKEKKAKERKKMEASAAAAPESTNSITAREERRIQQAEEMFRR 1187

  Fly  1391 SPQLGQLNLGFKTSVTATSLTAPVPGVHCNNSGGSSSSSNNSCSVSMSSVLHDSGICTSSSSPSV 1455
            ..:.|:.....:.|.:.|      ||                       ||..:|......:|..
Worm  1188 QEEEGKRKEARRRSKSVT------PG-----------------------VLEAAGTAAREDAPEA 1223

  Fly  1456 SIPSPTPTQMQSPTLQQHPQQIPQQQLSLLQRSPTQQHQQQILAALPTPMLTPMLSPQLPKPA-- 1518
            |||.|.|:...|                  :||.::..|         |..:...:|..| ||
Worm  1224 SIPVPAPSPPAS------------------RRSVSRTTQ---------PSTSSFATPTEP-PAKN 1260

  Fly  1519 QQQAHVVLPQSQQTSLLQQQQSQQSQEPLAVIA-------AAAAAQQPMA--------TYF---- 1564
            ::...||.|:|:..|..::.::.....|.|..|       |:|..:.|:|        |.|
Worm  1261 KRMRSVVPPKSEPASSAKRVRATTVATPKATTANDSRKRTASATGKTPVAKRSKNVAPTSFALAL 1325

  Fly  1565 VRQPQQQQQQQSP-----KPQALVAQQQHVVGAQQQQHFLQ-QQQKQQQQQMADEARMAVSALQT 1623
            :.:..::|.:.|.     .|..::.:::..:.|.|...|.: :.|.:::.:|.:.:|...:.
Worm  1326 IEKELREQARNSTVLEMILPDYIMNEERSGLLAGQSPDFSEVRAQIEEENRMKERSRKREAK--- 1387

  Fly  1624 LHAAPTSHIVSPIKVAAVQQQSQPQQQQQNTHQ---QPHNQQAVQQQSNQLQQQQSQQPNYPQSP 1685
                         |.|..:::.:.:::.:.|::   .|.:::||::...:::::       |:||
Worm  1388 -------------KKAVEKEKKEHRKEPKKTNEPGPAPKSEKAVEKAVEKVEKK-------PKSP 1432

  Fly  1686 QRQQKPQPVQHQPQIVISTGAQAIPATMPTKLSSPTKSAAPV--ISNNNITVSAQSSVVG--GKK 1746
            |:                      |...||..:.|.|....|  |.......|::.|.|.  .||
Worm  1433 QK----------------------PPAKPTAQNPPLKKTEEVDGIEREASESSSKESSVAPEEKK 1475

  Fly  1747 TP-----AKHPQQQQQQQQQPVTPVSAATAPAATP----SSSESKE-----------DDVSASST 1791
            .|     |::..::.|:::..    ..:|.||.|.    .|:|.::           ||..:||.
Worm  1476 NPKKITFAEYNSRRSQKREAG----ECSTPPAVTRRGFIPSTEGEDLVNVELSAIPLDDHPSSSN 1536

  Fly  1792 TTPTTRTPAKDKPKQSREDRKLEAILRAIEKMEKQEARGKKDTRQSSGGKRQASNSPASPNKRNS 1856
            |.|||..    .|......:....::::  ...:...||   ....|.....|.:|.:..::..|
Worm  1537 TAPTTTI----APSVGGAPKPTSVVVKS--PSTRSRTRG---AASESADDAPAEHSMSLQDRVFS 1592

  Fly  1857 SNSISEDVETPTSTNSAAAAAQRRNKKKR 1885
            ....:.|...|....::|....||::..|
Worm  1593 MFGSTVDAPAPPPPPASAETNSRRSRSTR 1621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
upSET	NP_001261819.1	PHD_MLL5	856..899	CDD:277025	18/42 (43%)
upSET	NP_001261819.1	SET	<1221..1273	CDD:214614	25/53 (47%)
set-9	NP_001379880.1	PRK03427	<9..>132	CDD:235124	19/113 (17%)
		Med15	196..>373	CDD:312941	33/176 (19%)
		PHD_Bye1p_SIZ1_like	788..831	CDD:277045	18/42 (43%)
		SET_SETD5-like	927..1059	CDD:380927	47/194 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166834
Domainoid	1	1.000	54	1.000	Domainoid score	I7506
eggNOG	1	0.900	-	-		E1_KOG1844
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto19508
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.860