DRSC/TRiP Functional Genomics Resources

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Protein Alignment upSET and set-16

DIOPT Version :9

Sequence 1:NP_001261819.1 Gene:upSET / 39551 FlyBaseID:FBgn0036398 Length:3146 Species:Drosophila melanogaster
Sequence 2:NP_499819.3 Gene:set-16 / 176802 WormBaseID:WBGene00011729 Length:2475 Species:Caenorhabditis elegans


Alignment Length:3118 Identity:511/3118 - (16%)
Similarity:853/3118 - (27%) Gaps:1291/3118 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly   315 KAKFVKQTTALSIAALPQQQQQ---TTYAKQSMVTTSTPAKVTKLNSKYVQQQISLPQGTQLQHK 376
            :::.:.....||.:|.|.:.|.   :.::..|:...|...:...|.|.|.:.|            
 Worm    87 RSQMLPDDVMLSASARPSRGQDAPLSPFSDPSVPQISLQMQPAPLPSSYPRSQ------------ 139

  Fly   377 ASPNVTGGGYLLQQSQAAVGGTIKFVNSHGTVIQQHPQQQQATKRTHYNSSGSSDNEQHAVANSS 441
               :..|..|    :|.|             .:||..||||            .:..|..:|..:
 Worm   140 ---DFNGDVY----TQIA-------------AMQQQRQQQQ------------QNQVQQMLATQA 172

  Fly   442 LITDDVMIVNGTQMTDELSARILQSMAQKSFSQQQRFHQVPATGSGNMPPPTQIIYSNSTSNGAA 506
            .:.|::....||..:|..|:    ...|::....:.|  |||:..|.            ...|.|
 Worm   173 QLMDEISDGGGTNDSDRNSS----PFYQEASDYDEDF--VPASTRGR------------GRGGGA 219

  Fly   507 ASSPGGNASGNMLLAHYQAAGTKPVSSASFITVTGTPPVTVATTPSVSISSHGFASGSAAISSYM 571
            ...||...|                        |||                             
 Worm   220 KKKPGRGGS------------------------TGT----------------------------- 231

  Fly   572 SSATAARRQSVSAPSSRAVSLERKQHHQQLQHDVIGGGRKAPTVIEYYNKHGVNSIVGSSNNLAQ 636
                  |||:...||.                              :::...:.::.|..::|.|
 Worm   232 ------RRQTNPGPSG------------------------------FFSATQLQAMSGDFSHLHQ 260

  Fly   637 SNSMSNLAGPRSNSGSGFATTTPTPATPLHLTPVNVPVHVEAAPPSSPALVKGSSQPPAQPQQQQ 701
            ....|:..|.|...|:|                .:||......|.......:||:...||..|.|
 Worm   261 PQQTSSTRGKRGKRGNG----------------TSVPRQPGKGPGRGRGRGRGSAAAIAQLAQLQ 309

  Fly   702 Q-----QAHPL--GPNQLNANDEELYIEEVRPVPVLTQDLRLQQLHAIMQDHTYASQQQQQQPQQ 759
            |     |..|:  |..||:.....:       .|.|...:            ||    |...|  
 Worm   310 QVQYGAQGAPMFNGAPQLHPTQPTV-------APTLPPSV------------TY----QNVAP-- 349

  Fly   760 AAGDTTNPGAAQQVQQPQQWSLGGIGVTVSGSQGTPTAVGGYCSYFGQQIARSQAD----DDAHS 820
                 |.|.|...:|.|....|..|   |...|..|           |.:|..:.|    :|..|
 Worm   350 -----TAPPAPPALQTPLPDPLPSI---VPSFQQAP-----------QAVAIREVDELMLEDESS 395

  Fly   821 AISSSSRMGLASTDIDPGEETETAPEAEAEDDSVTR-CICELTHD-----DGYMICCDKCS---- 875
            ..|..||.       |..|...||......|:.:.: |:|.:...     :|.|:.|..|:    
 Worm   396 RQSGGSRS-------DEPEYIRTAIVCRVNDEFLQKACMCLVCGSIGKGPEGSMVACSNCAQTYH 453

  Fly   876 -----------------AWQHVDC-------MGIDRQNIPEEYMCE--------LCQPRAVDKA- 907
                             .|:.:||       .|.|..|:   .:|:        .|....:||. 
 Worm   454 TYCVTLHDKLNSAVVGRGWRCLDCTVCEGCGTGGDEANL---LLCDECDVSYHIYCMKPLLDKIP 515

  Fly   908 ----RARALQRQKRKEHMLLVATQAANGAAAVAAG------------------------------ 938
                |.:...|.:|..|      :||:|....:.|                              
 Worm   516 QGPWRCQWCSRCRRCNH------KAASGNDLTSQGLCFPCASLRKCPRCERNYQLNEKLIRCSQC 574

  Fly   939 TTLSGGLGSGLPMSEELQHRLASGLN-----------GGFA-------TGTGMSKKSKKTKENSG 985
            :....|...||...|:|:......:.           .||:       ....:.|.:.:..::..
 Worm   575 SKWQHGACEGLYTDEQLEQAAIDRMRCSACRPKRVQPSGFSDVDTVWCDYVALDKDAHEILKSKY 639

  Fly   986 STSTLKKTKKSAVGMGGE-----------KNASGSGTPTGSSGKTSKKSSKRKSKSGGDGSSGGG 1039
            :.|.||.....:||....           :::|...||....|   ::...|.:.||..|.:..|
 Worm   640 TPSALKNHMMESVGYRESFDHYDDDYNPLEDSSDQVTPLPIPG---QRGRGRGNPSGRRGMNRIG 701

  Fly  1040 SSPALTAAEKHAANLRQWIENYEYAVTNHYSPELRARLHAIQKQPSLLQSIQNTENKALRQIQQQ 1104
                                     :...|:...|.|:.|:.::.:...:......:|.|..:.:
 Worm   702 -------------------------IGGFYAKLPRHRIQALTEEAAAAAASSEDSKQAKRPRKSR 741

  Fly  1105 LSTAGSA--EQLEQRAQLIPYAGAKVLISSVDLSPHAPIHELRGKYMLTTQFRTQNPTVNMNTPP 1167
            .|....|  .|:::....|.....|||:.:....|.  :.|..|.|..|                
 Worm   742 RSQLEDAYPPQIQEAFFGIKAVEGKVLVDTPVDEPF--LAEFNGWYKRT---------------- 788

  Fly  1168 PSNYLNSFKAHKTPGQFVFFYQLPGVEAPMQTLRPDGSVPQVAQQPPSYLKGPEVCVDT----RT 1228
                 .|.||.                                          |:|:..    ||
 Worm   789 -----RSTKAF------------------------------------------ELCMTASEMLRT 806

  Fly  1229 YGNDARFVRRSCRPNAELQHY--FEKGTLHLYIVALTHIRAQTEITIRHEPHDLTAVEQKKSHAA 1291
            ..::..|:.....||.|....  |:...|                    |..|:.....:..::.
 Worm   807 DIDENEFLDCVGLPNMETDALDDFDFNLL--------------------EDFDVDEENDELENSL 851

  Fly  1292 VIQPTSTRCACDMGSDCLFALPLAVQQQLQAPPTQPRSSHRNKAAAAAAAAAAANSAAAIQLTMG 1356
            :..|.:|    :|..|                                       :|..|:.:.|
 Worm   852 LGAPGNT----EMKED---------------------------------------AAEGIEGSYG 873

  Fly  1357 LGVGATVAAGASVLPNSRN----RSTSSSGESSQMGLNSPQLGQLNLGFKTSVTATSLTAPVPGV 1417
                          |.|.|    .||||:|.|  :|...|        |...:...:.....|||
 Worm   874 --------------PTSFNLDQRPSTSSAGGS--LGSQDP--------FHPGMNPANFAQHAPGV 914

  Fly  1418 HCNNSGGSSSSSNNSCSVSMSSVLHDSGICTSSSSPSVSIPSPTPTQMQSPTL------------ 1470
            . |....|.|.::||.....|:...:.                .|..:|:.|.            
 Worm   915 R-NAIARSGSQTDNSERYQFSARWEED----------------EPNGLQATTAAVLYSNEKHGYL 962

  Fly  1471 -QQHPQQIPQ-QQLSLLQRSPTQQHQQQI------------LAALPTPMLTPMLSPQLPKPAQQQ 1521
             ||.|..:.: :|:..|.|  |..|:.::            ....|.|..|.:.|...|.|.|..
 Worm   963 RQQFPNWVDRVKQIQKLWR--TLNHEVRLDYVNRARDNRTRSGNRPRPRRTNVQSTDSPPPPQMG 1025

  Fly  1522 AHVVLPQSQQTSLLQQQQSQQSQEPLAVIAAAAAAQQPMATYFVRQPQQQQQQQSPKPQALVAQQ 1586
            ..|  |.:..::::  ..|:||.:|..|.   .....||..|.|.|..::          :...:
 Worm  1026 FKV--PANPSSNMM--GSSEQSMQPKQVF---ITHHLPMDVYQVYQDLKR----------VKFDR 1073

  Fly  1587 QHVVGAQQQQHFLQQQQKQQQQQMADEARMAVSALQTLHAAP----------------TSHIVSP 1635
            :.:.|:.::|  |.:.:||::...|.:.:|    ::|..|||                .:.:...
 Worm  1074 ERLNGSLEEQ--LNKARKQKKNLAAKKRQM----VKTQTAAPDYDGRNIDLNESDQQTLATLTEQ 1132

  Fly  1636 IKV--AAVQQQSQPQQQQQNT-------HQQPHNQQAVQQQSNQL----QQQQSQQPNYPQSPQR 1687
            |||  |.::...:..::.::.       |....|:..|:::..||    .||.:...:...:.|.
 Worm  1133 IKVTQAEIELHRRDLKKHESNLSDFVMKHGILRNEHEVKREDVQLSAIRDQQYAAHADEMLAQQA 1197

  Fly  1688 QQKPQPVQHQPQIVISTGAQAIPATMPTKLSSPTKSAAPVISNNNITVSAQSSVVGGKKTPAKHP 1752
            |.:.....|.|.:|....|.::|..                                        
 Worm  1198 QNQGLGQVHPPVLVAPQAAISLPML---------------------------------------- 1222

  Fly  1753 QQQQQQQQQPVTPVSAATAPAATPSSSESKEDDVSASSTTTPTTRTPAKDKPKQSREDRKLEAIL 1817
             .||||..|.:..:.....|   |...               ..|.....:|:.:..:.::    
 Worm  1223 -NQQQQHHQRMMQMQMRGGP---PGQF---------------MMRAQPPQQPQINMHNHEI---- 1264

  Fly  1818 RAIEKMEKQEARGKKDTRQSSGGKRQAS-NSPASPNKRNSSNSISEDVETPTSTNSAAAAAQRRN 1881
              .::|..|:.|   :.....||.|... ..|...:..:...:|..||.|.....:..||.|:  
 Worm  1265 --AKRMLMQQFR---NAHPVMGGIRHDEITDPIMRDVYDCLEAIVFDVHTVAEREAMQAAGQQ-- 1322

  Fly  1882 KKKRKVSRSLNNNTNGLGSGGGSNNKRRKSIVVESDGESHALTNSESEDQGQHPQSHHSGSEDQA 1946
                                               ....|.:         |.....|.|.   .
 Worm  1323 -----------------------------------PPPPHIM---------QRMMQQHPGG---P 1340

  Fly  1947 AGLLLALAHNNSSPNEPFKSPLSQSHSLPATPASVSSACLLIEAAMGPLQQQPAP-----ASASP 2006
            .|..|.:         |.:.|..|...:|                     |||.|     ....|
 Worm  1341 GGPRLIM---------PGQFPQLQGRRIP---------------------QQPPPVQLPQVDVDP 1375

  Fly  2007 SLAEFKYPPGGAKTKKSLMS--------SWFQQAEQQHASGLDSLVQAAMSEINGEREQLQRQPQ 2063
            .....|...||...||:..|        :|.:|...:.             .:..:..:.|::|:
 Worm  1376 PKTAAKRKKGGGNPKKNASSYPAAGEYDAWIEQMRMRF-------------RLCPDIPKKQKEPR 1427

  Fly  2064 GESLPAPALLKVEQFIHQAESTTAVPAREQLHLPLQNNSSVKKRWLRQAISEETTPVDELQQSQN 2128
               |..|..    :|:....:..||.|             .|||                     
 Worm  1428 ---LNRPGC----EFVSHGLTDMAVRA-------------TKKR--------------------- 1451

  Fly  2129 QSVTATPSPQPVPTVSPLANGFSTPLKKRRLVVVSNGTNVESDETHIDVIGEPKDEAEENVAMTE 2193
                           :||...|.....||       ||.:..:|          :..|:::...:
 Worm  1452 ---------------TPLVGEFGAMRVKR-------GTRLFGNE----------ERGEKSIMFQD 1484

  Fly  2194 LKVEIENHHQEQDDDVDILRSPSPGTHQIVAEDNLVKIEPE---------DTSAAADDVKIDVER 2249
            |                                ||.::||:         ......|||..|   
 Worm  1485 L--------------------------------NLYQVEPQIRLFALYNNPLPTMEDDVFRD--- 1514

  Fly  2250 EESQACDKFEEMVKVKREEEEQREKEIKQLQERQEH-EQPKVEPAPVEPKL-ENTVAKAEPKVEP 2312
            ||.|..||....::....::......:..::.|..: |:..:.|||..... ||..|:.|..|| 
 Worm  1515 EEDQIIDKPTSALQKLLNKKRGASGAMDHIRSRARYMEETNIPPAPERGMFYENVEAEEEVTVE- 1578

  Fly  2313 SQEIVSKKEPTKVEPKPGESLLRSTATVTATPTAATIAATTLLDVSK-------------VAFKT 2364
                                |:.:|..:|...:         :|..|             :|.|.
 Worm  1579 --------------------LVFNTCDITEESS---------VDEKKDVCGRLHEQIRDLLAIKD 1614

  Fly  2365 RPPLKLEDEPQKKKPKLESILPAPVATVPPVSVPPIPAASNATTSAVTNTAAASLTTTTAPSSTK 2429
            .....:||.|.:.                |||..|.|   .||..||..|:    :|:.|||.. 
 Worm  1615 EVAWSMEDTPPES----------------PVSRSPEP---EATVGAVQQTS----STSRAPSEA- 1655

  Fly  2430 NLTEHDIQERLLSFHAANISYLQSRNKKATAALTSASPSQKSNSSSGGSGTESKKSSKDKDEKRD 2494
              ||.:| :|.:...||.::....|.        ...|||..|||                :.::
 Worm  1656 --TEREI-KREVEEEAAPVAPEIKRE--------IVEPSQSQNSS----------------QCKN 1693

  Fly  2495 KEKQLKKSKKEKKKSKDKEKQKAAVNVNSTSQIVDTKKKTTQPSKPDSKSSIAPVLVPPSLPVAT 2559
            .:|.|:........:...||    :|:..|..:|.|:.....|..|.:          |..|:|.
 Worm  1694 CQKALESHSSTSIVTVKAEK----LNLAPTGSVVTTRAAPVPPGVPGA----------PGAPIAP 1744

  Fly  2560 ANGKTKHTAYNNVDQQQQQQMRRRTMSMCITPVTPTPVVTPSPLHGTPPSTKKRQTNFEQELTKP 2624
            :..|||....:...::...::...|.:    |:|...|..             .:.:..:|:...
 Worm  1745 SEEKTKEELASFCSKKCYYELASATRA----PLTEEEVAA-------------AEQHVSEEVYNK 1792

  Fly  2625 NSQILSSSILLNSSKGLGLPLAAPTVVSVPTAVQQQQHRKENNHQEATPASGGPMSLAAAIASGK 2689
            ..|:|:.:|:...|:|                       |:.:.|..:|                
 Worm  1793 LKQVLTENIVKAVSQG-----------------------KKPDPQLTSP---------------- 1818

  Fly  2690 LNAISRRRESMC----GSRQQQALIAAALKKEKKEKKKSKKKDREKQKHDKQKGKEKEREKDKEK 2750
                   |::.|    |.|:...::..|......|..|.....|..:..:..|...|........
 Worm  1819 -------RDTRCMMDEGRRENVTIVPVASLIGAVEAPKEAPSQRAAEAAEDWKAYTKSIWDSFVN 1876

  Fly  2751 DNKQKTNHIQKP----AHPTTVPANSMPISAPAPVPVL---VPTPVTTPKAAPIPVL-------- 2800
            ..:|..:||..|    .||        |......:.|.   :....||.....|.:.        
 Worm  1877 IQQQHAHHILSPKIGVPHP--------PYHLDKRICVFCGGIGDGETTRCGRLISLTEFYWVHVN 1933

  Fly  2801 ---------------ITQPTPSPIHVTQPLVNNCSTKVASLPFY--------------------- 2829
                           :|....:.:...|...::|....||:..:                     
 Worm  1934 CALWSAEVFENQTGGLTNVDRAVLRAAQTACDHCKRPGASVKCHKMNCGVNYHVLCAMQNNGFFI 1998

  Fly  2830 ---------------NTIYGKL---------QDPSTPTSSPIPVTNTMPSLAEYLESTKSKTTA- 2869
                           ..|.|:|         :|           .|||  |....|.|...|.. 
 Worm  1999 KDRTFICKQHEKVSNQAIVGRLDALRRIYVKRD-----------ENTM--LTRLFELTDGPTLCM 2050

  Fly  2870 -LSAVKPIGIAAVTP--LSSAITPAKVAPSSLEMPPPATTPLKLYTRTASHDPRL---------- 2921
             |.|.....|.::||  |....|...:.|::..:       .:|:....||..|:          
 Worm  2051 RLGAFTFYKIGSITPKQLKRFHTKDYIFPNNYRI-------TRLFWSPKSHRERMMFECIIEDRN 2108

  Fly  2922 -NPMLTV---PDPTPMPKRKLSISE---------YRMRHRPSVDTA------------------P 2955
             .|:..|   .||| :..:.:|.|:         :::|.:...|:.                  .
 Worm  2109 NQPIFVVKSLEDPT-ICYKAVSASKAWQPIYEKVHQLREQQQGDSLKFFGSQICGETLFGLNENA 2172

  Fly  2956 TTPTTPTTPTTPTTPPGSNKDRSFAKPQTINKCSLQSP--ERFQAAIR-ERRNSISAHH------ 3011
            .|..|.:.|...|.....::.:        |...|:.|  |......| |.||.....|      
 Worm  2173 ITKITESLPGFDTIFTYQHRHQ--------NSPVLELPLAENLMGCARAEPRNRTIGQHFRTKPQ 2229

  Fly  3012 PQQNAHHNLNNNKGGISNK-----SGSSSGNHLQQALGVAGGRLQSKNAIVDPAATTLSTVNS 3069
            |....||:: .:..|:|::     |.|||.|.          .|||:.     |||::::.||
 Worm  2230 PMGGTHHHI-GSASGLSSQATIIASSSSSANE----------SLQSRQ-----AATSVTSANS 2276

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
upSETNP_001261819.1 PHD_MLL5 856..899 CDD:277025 13/84 (15%)
SET <1221..1273 CDD:214614 10/57 (18%)
set-16NP_499819.3 PHD_SF 42..84 CDD:276966
PHD4_KMT2C_like 427..477 CDD:276987 6/49 (12%)
PHD5_KMT2C_like 479..524 CDD:276988 8/47 (17%)
PHD6_KMT2C_like 554..604 CDD:276989 5/49 (10%)
DUF1351 1060..>1163 CDD:284492 19/118 (16%)
ePHD2_KMT2C_like 1904..2008 CDD:277136 9/103 (9%)
FYRN 2055..2104 CDD:283589 10/55 (18%)
FYRC 2112..2199 CDD:197781 13/95 (14%)
SET 2333..2457 CDD:214614
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.030

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