DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment upSET and Y14H12B.2

DIOPT Version :9

Sequence 1:	NP_001261819.1	Gene:	upSET / 39551	FlyBaseID:	FBgn0036398	Length:	3146	Species:	Drosophila melanogaster
Sequence 2:	NP_494697.1	Gene:	Y14H12B.2 / 173735	WormBaseID:	WBGene00021192	Length:	414	Species:	Caenorhabditis elegans

Alignment Length:	310	Identity:	67/310 - (21%)
Similarity:	110/310 - (35%)	Gaps:	68/310 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly  2318 SKKEPTKVEPKPGESLLRSTATVTATPTAATIAATTLLD-VSKVAFKTRPPLKLEDEPQKKKPKL 2381
            :|....||..|.|:|             |..:..:..|| ::|.:.....||.|:|.....|.
Worm     4 NKSSGRKVMKKRGKS-------------AKAVDMSHFLDFLAKKSKNISRPLMLKDLFSAYKE-- 53

  Fly  2382 ESILPAPVATVP-----PVSVPPIPAASNATTSAVTNTAAASLTTTTAPSS-TKNLTEH-----D 2435
            |:..|..|||:.     .::| .||.|:|...........|  |:|:|... .|.|.|.     |
Worm    54 EAGYPGTVATLRLKLRWDLAV-KIPLAANFEDDEKAQMLFA--TSTSAKEEFLKRLREKATVDVD 115

  Fly  2436 IQERLLSFHAANISYLQSRNKKATAALTSASPSQKSNSSSGGSGTESKK-SSKDKDEKRDKEKQL 2499
            ..:|:..:.:..:.:.....|...|.|:....|..||.|...|..:.:: :|.|..|:.|:::.:
Worm   116 NLQRITYYKSTKLEFKGKHAKGNFADLSQRRSSSASNQSVAQSPPQLQQINSADLQEEEDEDEII 180

  Fly  2500 KKSKKEKKKSKDKEKQKAAVNVNSTSQI-VDTKKKTTQPSKPDSKSSIAPVLVPPSLPVATANGK 2563
            ...          :....|:|.....|| |.|:.:..:...|.|..|       .::.|...|..
Worm   181 VID----------QTSNPAINYPKMKQIAVKTEFQEPRIDYPPSDGS-------DTISVINVNAG 228

  Fly  2564 -----TKHTAYNNVDQ--------------QQQQQMRRRTMSMCITPVTP 2594
                 .:...|.|||:              |.|.||.:..::...|...|
Worm   229 YSLYCPQPAFYPNVDRSMFTAMGQMMTGVLQMQSQMMKEVLNRGSTSAPP 278

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
upSET	NP_001261819.1	PHD_MLL5	856..899	CDD:277025
upSET	NP_001261819.1	SET	<1221..1273	CDD:214614
Y14H12B.2	NP_494697.1	SPK	27..131	CDD:367941	27/108 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1844
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900